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Conserved domains on  [gi|688609062|ref|XP_009294546|]
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transducin-like enhancer protein 2a isoform X5 [Danio rerio]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10511324)

WD40 domain-containing protein similar to Drosophila melanogaster protein groucho and Homo sapiens transducin-like enhancer proteins; also contains a Groucho/TLE N-terminal Q-rich domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 38-152 1.69e-87

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 271.61  E-value: 1.69e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062   38 LKLTYPETLDRIKEEFQFLQTQYHSLKLECEKLATEKTEIQRHYVMYYEMSYGLNIEMHKQTEIAKRLNVICAQLIPFLS 117
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 688609062  118 QEHQQQVVQAMERAKQVTMGELNASIG--QQLQAQHL 152
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
499-784 5.48e-47

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 5.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 499 HGEVVCAVTISTSTRHVYTGGK-GCVKVWDISqpgSKSPMAQLDclNRDNYIRSCKLLPDGRTLIVGGEASTLSIWDLAT 577
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 578 PTPRikAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 657
Cdd:COG2319  194 GKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 658 CWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKD 735
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 688609062 736 NLLNAWRTPYGSSIFQSKE-SSSVLSCDISPDDQFIVTGSGDKKATVYEV 784
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 219-354 6.80e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 219 PGPSSLSNGDKGRS--SDYLSNGKKRKA-DEKEFMTDYGSDAEKSDDNLVV-------DEDPSSPRSVQS-YSSRENGLD 287
Cdd:PTZ00449 524 PGDKEGEEGEHEDSkeSDEPKEGGKPGEtKEGEVGKKPGPAKEHKPSKIPTlskkpefPKDPKHPKDPEEpKKPKRPRSA 603

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688609062 288 KLPPSRKEP-LPQASPTSLASSSSAASPSRsKEPPPREKSSTPgMKPGTPMSQESSTPGPSVPPQFRP 354
Cdd:PTZ00449 604 QRPTRPKSPkLPELLDIPKSPKRPESPKSP-KRPPPPQRPSSP-ERPEGPKIIKSPKPPKSPKPPFDP 669
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 38-152 1.69e-87

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 271.61  E-value: 1.69e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062   38 LKLTYPETLDRIKEEFQFLQTQYHSLKLECEKLATEKTEIQRHYVMYYEMSYGLNIEMHKQTEIAKRLNVICAQLIPFLS 117
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 688609062  118 QEHQQQVVQAMERAKQVTMGELNASIG--QQLQAQHL 152
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
499-784 5.48e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 5.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 499 HGEVVCAVTISTSTRHVYTGGK-GCVKVWDISqpgSKSPMAQLDclNRDNYIRSCKLLPDGRTLIVGGEASTLSIWDLAT 577
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 578 PTPRikAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 657
Cdd:COG2319  194 GKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 658 CWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKD 735
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 688609062 736 NLLNAWRTPYGSSIFQSKE-SSSVLSCDISPDDQFIVTGSGDKKATVYEV 784
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 494-783 4.44e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.19  E-value: 4.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 494 IHTL-SHGEVVCAVTISTSTRHVYTGGK-GCVKVWDISqpgSKSPMAQLdCLNRDNyIRSCKLLPDGRTLIVGGEASTLS 571
Cdd:cd00200    2 RRTLkGHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 572 IWDLatPTPRIKAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGG 651
Cdd:cd00200   77 LWDL--ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 652 LDNTVRCWDLREGR---QLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPD-KYQLHLHESCVLSLKFAYCGK 727
Cdd:cd00200  155 QDGTIKLWDLRTGKcvaTLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 688609062 728 WFVSTGKDNLLNAWRTPYGSSIFQ-SKESSSVLSCDISPDDQFIVTGSGDKKATVYE 783
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 621-660 2.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 2.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 688609062   621 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWD 660
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
623-660 3.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 688609062  623 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWD 660
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 520-782 2.77e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 520 KGCVKVWDISQPGSKSPMAQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLSIWDLATPtprIKAELTSSAPACYALAIS 599
Cdd:PLN00181 457 EGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRS 533

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 600 PDNKVCF---------SCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRCWDLREGRQLQQ 669
Cdd:PLN00181 534 KLSGICWnsyiksqvaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGT 613

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 670 HDFTSQIFSLGY-CPTGEWLAVGMESSNVEVLHVSKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAW-- 741
Cdd:PLN00181 614 IKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWdl 689

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 688609062 742 --------RTPYGSSIFQSKESSSVlscDISPDDQFIVTGSGDKKATVY 782
Cdd:PLN00181 690 smsisginETPLHSFMGHTNVKNFV---GLSVSDGYIATGSETNEVFVY 735
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 219-354 6.80e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 219 PGPSSLSNGDKGRS--SDYLSNGKKRKA-DEKEFMTDYGSDAEKSDDNLVV-------DEDPSSPRSVQS-YSSRENGLD 287
Cdd:PTZ00449 524 PGDKEGEEGEHEDSkeSDEPKEGGKPGEtKEGEVGKKPGPAKEHKPSKIPTlskkpefPKDPKHPKDPEEpKKPKRPRSA 603

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688609062 288 KLPPSRKEP-LPQASPTSLASSSSAASPSRsKEPPPREKSSTPgMKPGTPMSQESSTPGPSVPPQFRP 354
Cdd:PTZ00449 604 QRPTRPKSPkLPELLDIPKSPKRPESPKSP-KRPPPPQRPSSP-ERPEGPKIIKSPKPPKSPKPPFDP 669
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 38-152 1.69e-87

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 271.61  E-value: 1.69e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062   38 LKLTYPETLDRIKEEFQFLQTQYHSLKLECEKLATEKTEIQRHYVMYYEMSYGLNIEMHKQTEIAKRLNVICAQLIPFLS 117
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 688609062  118 QEHQQQVVQAMERAKQVTMGELNASIG--QQLQAQHL 152
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
499-784 5.48e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.40  E-value: 5.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 499 HGEVVCAVTISTSTRHVYTGGK-GCVKVWDISqpgSKSPMAQLDclNRDNYIRSCKLLPDGRTLIVGGEASTLSIWDLAT 577
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 578 PTPRikAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 657
Cdd:COG2319  194 GKLL--RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 658 CWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKD 735
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 688609062 736 NLLNAWRTPYGSSIFQSKE-SSSVLSCDISPDDQFIVTGSGDKKATVYEV 784
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 494-783 4.44e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.19  E-value: 4.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 494 IHTL-SHGEVVCAVTISTSTRHVYTGGK-GCVKVWDISqpgSKSPMAQLdCLNRDNyIRSCKLLPDGRTLIVGGEASTLS 571
Cdd:cd00200    2 RRTLkGHTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 572 IWDLatPTPRIKAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGG 651
Cdd:cd00200   77 LWDL--ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 652 LDNTVRCWDLREGR---QLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPD-KYQLHLHESCVLSLKFAYCGK 727
Cdd:cd00200  155 QDGTIKLWDLRTGKcvaTLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGY 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 688609062 728 WFVSTGKDNLLNAWRTPYGSSIFQ-SKESSSVLSCDISPDDQFIVTGSGDKKATVYE 783
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
492-744 6.28e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 6.28e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 492 RQIHTLS-HGEVVCAVTISTSTRHVYTGGK-GCVKVWDISqpgSKSPMAQLDclNRDNYIRSCKLLPDGRTLIVGGEAST 569
Cdd:COG2319  153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 570 LSIWDLATPTPRikAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWT 649
Cdd:COG2319  228 VRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 650 GGLDNTVRCWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHV-SKPDKYQLHLHESCVLSLKFAYCGK 727
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 688609062 728 WFVSTGKDNLLNAWRTP 744
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 593-784 6.75e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 6.75e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 593 CYALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWDLREGRQLQQ-HD 671
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 672 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPD-KYQLHLHESCVLSLKFAyCGKWFVSTGK-DNLLNAWRTPYGSSI 749
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFS-PDGTFVASSSqDGTIKLWDLRTGKCV 170

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 688609062 750 --FQSkESSSVLSCDISPDDQFIVTGSGDKKATVYEV 784
Cdd:cd00200  171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 624-784 5.65e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 5.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 624 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVL 700
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 701 HVSKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGSSI--FQSKEsSSVLSCDISPDDQFIVTGSGDK 777
Cdd:cd00200   79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                 ....*..
gi 688609062 778 KATVYEV 784
Cdd:cd00200  158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
554-784 2.26e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 554 LLPDGRTLIVGGEASTLSIWDLATPTPRIKAELTSSAPAcyALAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTD 633
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 634 GASCIDISNDGTKLWTGGLDNTVRCWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVSKPDK-YQLH 711
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLT 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688609062 712 LHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGSSIFQ-SKESSSVLSCDISPDDQFIVTGSGDKKATVYEV 784
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
492-621 4.19e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 4.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 492 RQIHTLS-HGEVVCAVTISTSTRHVYTGGKGC-VKVWDISqpgSKSPMAQLDclNRDNYIRSCKLLPDGRTLIVGGEAST 569
Cdd:COG2319  279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 688609062 570 LSIWDLATPTPRikAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWDLHN 621
Cdd:COG2319  354 VRLWDLATGELL--RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 621-660 2.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 2.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 688609062   621 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWD 660
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
623-660 3.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 3.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 688609062  623 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRCWD 660
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
554-661 8.55e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.77  E-value: 8.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 554 LLPDGRTLIVGGEAS-TLSIWDLATPTP--RIKaelTSSAPacYALAISPDNKVCFSCCSDGN-----IVVWDLHNQTLV 625
Cdd:COG3391  117 VDPDGGRLYVADSGNgRVSVIDTATGKVvaTIP---VGAGP--HGIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVV 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 688609062 626 RQFQGHtDGASCIDISNDGTKLW--------TGGLDNTVRCWDL 661
Cdd:COG3391  192 ATIPVG-GGPVGVAVSPDGRRLYvanrgsntSNGGSNTVSVIDL 234
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 520-782 2.77e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 520 KGCVKVWDISQPGSKSPMAQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLSIWDLATPtprIKAELTSSAPACYALAIS 599
Cdd:PLN00181 457 EGLCKYLSFSKLRVKADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRS 533

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 600 PDNKVCF---------SCCSDGNIVVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRCWDLREGRQLQQ 669
Cdd:PLN00181 534 KLSGICWnsyiksqvaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGT 613

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 670 HDFTSQIFSLGY-CPTGEWLAVGMESSNVEVLHVSKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAW-- 741
Cdd:PLN00181 614 IKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWdl 689

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 688609062 742 --------RTPYGSSIFQSKESSSVlscDISPDDQFIVTGSGDKKATVY 782
Cdd:PLN00181 690 smsisginETPLHSFMGHTNVKNFV---GLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 579-618 2.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.77e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 688609062   579 TPRIKAELTSSAPACYALAISPDNKVCFSCCSDGNIVVWD 618
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 584-665 1.30e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.60  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062  584 AELTSSAPACYALAISPDNKVCFSCcsdGNivvWD-------LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV 656
Cdd:pfam20426  75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148


                  ....*....
gi 688609062  657 RCWDLREGR 665
Cdd:pfam20426 149 MVWEVLRGR 157
COG5276 COG5276
Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...
 558-662 1.89e-03

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];


Pssm-ID: 444087 [Multi-domain]  Cd Length: 320  Bit Score: 41.08  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 558 GRTLIVGGEASTLSIWDLATPT-PRIKAELTSSAPACYALAISpDNKVCFSCCSDGNIVVWDLHNQ---TLVRQFQghTD 633
Cdd:COG5276   29 GEYAYVAGGSNGLAIVDVSDPAnPVLVGSLPTPGGTWRDVKVS-GDYLYVASEGSEGLQIFDISDPanpKLVGRYD--TG 105

                         90       100       110
                 ....*....|....*....|....*....|
gi 688609062 634 GASCIDISNDGTKLW-TGGLDNTVRCWDLR 662
Cdd:COG5276  106 GSGAHNIAVDGNYAYvAGGSDNGLVIVDIS 135
WD40 pfam00400
WD domain, G-beta repeat;
594-618 2.68e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.68e-03
                          10        20
                  ....*....|....*....|....*
gi 688609062  594 YALAISPDNKVCFSCCSDGNIVVWD 618
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 755-783 4.68e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.68e-03
                           10        20
                   ....*....|....*....|....*....
gi 688609062   755 SSSVLSCDISPDDQFIVTGSGDKKATVYE 783
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 219-354 6.80e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.06  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688609062 219 PGPSSLSNGDKGRS--SDYLSNGKKRKA-DEKEFMTDYGSDAEKSDDNLVV-------DEDPSSPRSVQS-YSSRENGLD 287
Cdd:PTZ00449 524 PGDKEGEEGEHEDSkeSDEPKEGGKPGEtKEGEVGKKPGPAKEHKPSKIPTlskkpefPKDPKHPKDPEEpKKPKRPRSA 603

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688609062 288 KLPPSRKEP-LPQASPTSLASSSSAASPSRsKEPPPREKSSTPgMKPGTPMSQESSTPGPSVPPQFRP 354
Cdd:PTZ00449 604 QRPTRPKSPkLPELLDIPKSPKRPESPKSP-KRPPPPQRPSSP-ERPEGPKIIKSPKPPKSPKPPFDP 669
WD40 pfam00400
WD domain, G-beta repeat;
755-783 9.56e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.56e-03
                          10        20
                  ....*....|....*....|....*....
gi 688609062  755 SSSVLSCDISPDDQFIVTGSGDKKATVYE 783
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 572-638 9.65e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 9.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688609062  572 IWDLATPTPriKAELTSsapacyaLAISPDNKVCFSCCSDGNIVVWDLHNQTLVRQFQGHTDGASCI 638
Cdd:pfam12894  29 VWTLSPDKE--DLEVTS-------LAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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