U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    fign fidgetin [ Danio rerio (zebrafish) ]

    Gene ID: 553599, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    fignprovided by ZNC
    Official Full Name
    fidgetinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-339
    See related
    Ensembl:ENSDARG00000008662 AllianceGenome:ZFIN:ZDB-GENE-050522-339
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110229
    Summary
    Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nuclear matrix. Is expressed in lens placode; nervous system; solid lens vesicle; and somite. Orthologous to human FIGN (fidgetin, microtubule severing factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See fign in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (50599362..50754521)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (50906990..51313049)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496436 Neighboring gene uncharacterized LOC137496505 Neighboring gene uncharacterized LOC137496437 Neighboring gene uncharacterized LOC137496438 Neighboring gene potassium voltage-gated channel subfamily H member 7

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative genomics using Fugu reveals insights into regulatory subfunctionalization. Woolfe A, et al. Genome Biol, 2007. PMID 17428329, Free PMC Article
    2. A comparative study of the expression patterns of Fign family members in zebrafish embryonic development. Dong Z, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Jan. PMID 33069857
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC110229

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    fidgetin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020575.1 → NP_001018411.1  fidgetin

      See identical proteins and their annotated locations for NP_001018411.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095207
      UniProtKB/Swiss-Prot
      Q503S1
      UniProtKB/TrEMBL
      B2GQM4
      Related
      ENSDARP00000006334.7, ENSDART00000023105.8
      Conserved Domains (4) summary
      smart00382
      Location:497 → 631
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:500 → 629
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:700 → 733
      Vps4_C; Vps4 C terminal oligomerization domain
      cl23718
      Location:168 → 273
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      50599362..50754521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478666.2 → XP_021334341.1  fidgetin isoform X1

      UniProtKB/TrEMBL
      A0A8M9QFE1
      Related
      ENSDARP00000152560.1, ENSDART00000187567.1
      Conserved Domains (3) summary
      COG0464
      Location:464 → 734
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam06070
      Location:270 → 444
      Herpes_UL32; Herpesvirus large structural phosphoprotein UL32
      cl27975
      Location:174 → 300
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q503S1.1 GenPept UniProtKB/Swiss-Prot:Q503S1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools