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Conserved domains on  [gi|66472602|ref|NP_001018411|]
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fidgetin [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 465-627 1.27e-103

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 314.13  E-value: 1.27e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKI 544
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 545 VQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVNRIKSELLLQLDGVLSSPEEHVLVVCSTSKPEEIDESLRRYFVKR 624
Cdd:cd19523  81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                ...
gi 66472602 625 LLV 627
Cdd:cd19523 161 LLV 163
Vps4_C super family cl07827
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 700-733 4.02e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


The actual alignment was detected with superfamily member pfam09336:

Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 41.71  E-value: 4.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 66472602   700 PVSYQDFENVFCKIQPSISQKELDTYTEWNKMFG 733
Cdd:pfam09336  28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
PHA03378 super family cl33729
EBNA-3B; Provisional
 163-289 5.25e-04

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  163 IPSQEFASSYNGSYLHSTYSG-GQSTPALPSPHPSPLHSAGLLQPPPPPPPTLVPSYNTSSPNLSSYNYPPAGYPPQTPV 241
Cdd:PHA03378 672 IPYQPSPTGANTMLPIQWAPGtMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP 751

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 66472602  242 APGYSPGGAPPPSAYLPSGIAAPTPLPPSTIPGYSYQSHNHAPiAPTP 289
Cdd:PHA03378 752 GRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAP-TPQP 798
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 658-683 7.04e-03

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 35.21  E-value: 7.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 66472602   658 LVQRTDGFSGLDVVRLCQEALVGPLH 683
Cdd:pfam17862   7 LAERTEGFSGADLEALCREAALAALR 32
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 465-627 1.27e-103

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 314.13  E-value: 1.27e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKI 544
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 545 VQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVNRIKSELLLQLDGVLSSPEEHVLVVCSTSKPEEIDESLRRYFVKR 624
Cdd:cd19523  81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                ...
gi 66472602 625 LLV 627
Cdd:cd19523 161 LLV 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 461-677 1.71e-49

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 176.74  E-value: 1.71e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 461 VDWSDIAGLEMAKATIKDEVLWPILRPDMFS--GLaTLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWL 538
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGI-EPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYI 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 539 GEGEKIVQASFLIARCRQPSVVFISDVDLLLS--SQLSEESPVNRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDES 616
Cdd:COG1222 154 GEGARNVREVFELAREKAPSIIFIDEIDAIAArrTDDGTSGEVQRTVNQLLAELDGF--ESRGDVLIIAATNRPDLLDPA 231

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66472602 617 LRRY--FVKRLLVPLPDATARHQIISQLLSqhNYCLSDkEVTL--LVQRTDGFSGLDVVRLCQEA 677
Cdd:COG1222 232 LLRPgrFDRVIEVPLPDEEAREEILKIHLR--DMPLAD-DVDLdkLAKLTEGFSGADLKAIVTEA 293
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 453-733 9.39e-43

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 165.85  E-value: 9.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   453 EILQQTSPVDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGS 531
Cdd:TIGR01243 442 EVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGiRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGP 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   532 ALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESP--VNRIKSELLLQLDGVlsSPEEHVLVVCSTSK 609
Cdd:TIGR01243 522 EILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTsvTDRIVNQLLTEMDGI--QELSNVVVIAATNR 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   610 PEEIDESLRR--YFVKRLLVPLPDATARHQIIsQLLSQHNYCLSDKEVTLLVQRTDGFSGLDVVRLCQEALVGPLHGMPG 687
Cdd:TIGR01243 600 PDILDPALLRpgRFDRLILVPPPDEEARKEIF-KIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIG 678

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 66472602   688 ADLSGMIPGQMRP------VSYQDFENVFCKIQPSISQKELDTYTEWNKMFG 733
Cdd:TIGR01243 679 SPAKEKLEVGEEEflkdlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 461-677 3.63e-32

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 129.11  E-value: 3.63e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  461 VDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLAT-LPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLG 539
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIdPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  540 EGEKIVQASFLIARCRQPSVVFISDVDLL----LSSQLSEESPVNRIKSELLLQLDGVLSSpeEHVLVVCSTSKPEEIDE 615
Cdd:PTZ00454 222 EGPRMVRDVFRLARENAPSIIFIDEVDSIatkrFDAQTGADREVQRILLELLNQMDGFDQT--TNVKVIMATNRADTLDP 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66472602  616 SLRR--YFVKRLLVPLPDATARHQIISQLLSQHNycLSDkEVTL--LVQRTDGFSGLDVVRLCQEA 677
Cdd:PTZ00454 300 ALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMN--LSE-EVDLedFVSRPEKISAADIAAICQEA 362
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 500-629 2.22e-31

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 118.85  E-value: 2.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   500 ILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPV 579
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 66472602   580 -NRIKSELLLQLDGVlSSPEEHVLVVCSTSKPEEIDESLRRYFVKRLLVPL 629
Cdd:pfam00004  81 sRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 497-631 1.97e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.83  E-value: 1.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602    497 PRSILLFGPQGTGRTLLGRCMASQL---GAAFLLLSGSAL------------VTKWLGEGEKIVQASFLIARCRQ--PSV 559
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDIleevldqllliiVGGKKASGSGELRLRLALALARKlkPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66472602    560 VFISDVDLLLSSQLSEESPVNRIKSELLLQLdgvlssPEEHVLVVCSTSKPEEIDES-LRRYFVKRLLVPLPD 631
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLK------SEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 700-733 4.02e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 41.71  E-value: 4.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 66472602   700 PVSYQDFENVFCKIQPSISQKELDTYTEWNKMFG 733
Cdd:pfam09336  28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
PHA03378 PHA03378
EBNA-3B; Provisional
 163-289 5.25e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  163 IPSQEFASSYNGSYLHSTYSG-GQSTPALPSPHPSPLHSAGLLQPPPPPPPTLVPSYNTSSPNLSSYNYPPAGYPPQTPV 241
Cdd:PHA03378 672 IPYQPSPTGANTMLPIQWAPGtMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP 751

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 66472602  242 APGYSPGGAPPPSAYLPSGIAAPTPLPPSTIPGYSYQSHNHAPiAPTP 289
Cdd:PHA03378 752 GRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAP-TPQP 798
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 658-683 7.04e-03

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 35.21  E-value: 7.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 66472602   658 LVQRTDGFSGLDVVRLCQEALVGPLH 683
Cdd:pfam17862   7 LAERTEGFSGADLEALCREAALAALR 32
 
Name Accession Description Interval E-value
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 465-627 1.27e-103

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 314.13  E-value: 1.27e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKI 544
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 545 VQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVNRIKSELLLQLDGVLSSPEEHVLVVCSTSKPEEIDESLRRYFVKR 624
Cdd:cd19523  81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSKR 160


                ...
gi 66472602 625 LLV 627
Cdd:cd19523 161 LLV 163
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 443-627 6.85e-75

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 239.89  E-value: 6.85e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 443 DANLVEMVTTEILQQTSPVDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLG 522
Cdd:cd19525   1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 523 AAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQL-SEESPVNRIKSELLLQLDGVLSSPEEHV 601
Cdd:cd19525  81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGeGEHESSRRIKTEFLVQLDGATTSSEDRI 160

                       170       180
                ....*....|....*....|....*.
gi 66472602 602 LVVCSTSKPEEIDESLRRYFVKRLLV 627
Cdd:cd19525 161 LVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 466-627 2.30e-72

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 232.24  E-value: 2.30e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 466 IAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIV 545
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 546 QASFLIARCRQPSVVFISDVDLLLSSQLSEE-SPVNRIKSELLLQLDGVLSSPEEHVLVVCSTSKPEEIDESLRRYFVKR 624
Cdd:cd19509  81 RALFALARELQPSIIFIDEIDSLLSERGSGEhEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFEKR 160


                ...
gi 66472602 625 LLV 627
Cdd:cd19509 161 IYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 461-677 1.71e-49

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 176.74  E-value: 1.71e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 461 VDWSDIAGLEMAKATIKDEVLWPILRPDMFS--GLaTLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWL 538
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGI-EPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYI 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 539 GEGEKIVQASFLIARCRQPSVVFISDVDLLLS--SQLSEESPVNRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDES 616
Cdd:COG1222 154 GEGARNVREVFELAREKAPSIIFIDEIDAIAArrTDDGTSGEVQRTVNQLLAELDGF--ESRGDVLIIAATNRPDLLDPA 231

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66472602 617 LRRY--FVKRLLVPLPDATARHQIISQLLSqhNYCLSDkEVTL--LVQRTDGFSGLDVVRLCQEA 677
Cdd:COG1222 232 LLRPgrFDRVIEVPLPDEEAREEILKIHLR--DMPLAD-DVDLdkLAKLTEGFSGADLKAIVTEA 293
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 465-627 3.20e-49

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 170.42  E-value: 3.20e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKI 544
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 545 VQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVN-RIKSELLLQLDGVLSSPEEHVLVVCSTSKPEEIDESLRRYFVK 623
Cdd:cd19524  81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASrRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                ....
gi 66472602 624 RLLV 627
Cdd:cd19524 161 RVYV 164
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 452-677 4.46e-44

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 163.54  E-value: 4.46e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 452 TEILQQTSPVDWSDIAGLEMAKATIKDEVLWPILRPDMFS--GLaTLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLS 529
Cdd:COG0464 145 EEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREeyGL-PPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVD 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 530 GSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPV-NRIKSELLLQLDGVlsspEEHVLVVCSTS 608
Cdd:COG0464 224 LSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVgRRVVNTLLTEMEEL----RSDVVVIAATN 299

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66472602 609 KPEEIDESLRRYFVKRLLVPLPDATARHQIISQLLSQHNYclsDKEVTL--LVQRTDGFSGLDVVRLCQEA 677
Cdd:COG0464 300 RPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPL---DEDVDLeeLAEATEGLSGADIRNVVRRA 367
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 453-733 9.39e-43

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 165.85  E-value: 9.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   453 EILQQTSPVDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGS 531
Cdd:TIGR01243 442 EVLVEVPNVRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGiRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGP 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   532 ALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESP--VNRIKSELLLQLDGVlsSPEEHVLVVCSTSK 609
Cdd:TIGR01243 522 EILSKWVGESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTsvTDRIVNQLLTEMDGI--QELSNVVVIAATNR 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   610 PEEIDESLRR--YFVKRLLVPLPDATARHQIIsQLLSQHNYCLSDKEVTLLVQRTDGFSGLDVVRLCQEALVGPLHGMPG 687
Cdd:TIGR01243 600 PDILDPALLRpgRFDRLILVPPPDEEARKEIF-KIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIG 678

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 66472602   688 ADLSGMIPGQMRP------VSYQDFENVFCKIQPSISQKELDTYTEWNKMFG 733
Cdd:TIGR01243 679 SPAKEKLEVGEEEflkdlkVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 461-627 1.59e-42

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 151.94  E-value: 1.59e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 461 VDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGE 540
Cdd:cd19521   4 VKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 541 GEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEES-PVNRIKSELLLQLDGVlSSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19521  84 SEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESeASRRIKTELLVQMNGV-GNDSQGVLVLGATNIPWQLDSAIRR 162


                ....*...
gi 66472602 620 YFVKRLLV 627
Cdd:cd19521 163 RFEKRIYI 170
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 465-627 1.24e-38

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 140.89  E-value: 1.24e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKI 544
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 545 VQASFLIARCRQPSVVFISDVDLLLSSQ--LSEESPVNRIKSELLLQLDGVLSSPEEH-----VLVVCSTSKPEEIDESL 617
Cdd:cd19522  81 VRLLFEMARFYAPTTIFIDEIDSICSRRgtSEEHEASRRVKSELLVQMDGVGGASENDdpskmVMVLAATNFPWDIDEAL 160

                       170
                ....*....|
gi 66472602 618 RRYFVKRLLV 627
Cdd:cd19522 161 RRRLEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 465-627 2.99e-38

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 139.87  E-value: 2.99e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMF--SGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGE 542
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFdnSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 543 KIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVNR-IKSELLLQLDGVLSSPEEHVLVVCSTSKPEEIDESLRRYF 621
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAmMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                ....*.
gi 66472602 622 VKRLLV 627
Cdd:cd19520 161 PKRFHI 166
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 465-619 1.57e-34

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 129.33  E-value: 1.57e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGL-ATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEK 543
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRALgLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66472602 544 IVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPV-NRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19503  81 NLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVeRRVVAQLLTLMDGM--SSRGKVVVIAATNRPDAIDPALRR 155
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 472-619 1.58e-32

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 123.16  E-value: 1.58e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 472 AKATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLI 551
Cdd:cd19481   1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 552 ARCRQPSVVFISDVDLLLS--SQLSEESPVNRIKSELLLQLDGVLSspEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19481  81 ARRLAPCILFIDEIDAIGRkrDSSGESGELRRVLNQLLTELDGVNS--RSKVLVIAATNRPDLLDPALLR 148
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 472-619 3.51e-32

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 122.39  E-value: 3.51e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 472 AKATIKDEVLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFL 550
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGiRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66472602 551 IARCRQPSVVFISDVDLLLS--SQLSEESPVNRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19511  81 KARQAAPCIIFFDEIDSLAPrrGQSDSSGVTDRVVSQLLTELDGI--ESLKGVVVIAATNRPDMIDPALLR 149
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 461-677 3.63e-32

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 129.11  E-value: 3.63e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  461 VDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLAT-LPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLG 539
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIdPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  540 EGEKIVQASFLIARCRQPSVVFISDVDLL----LSSQLSEESPVNRIKSELLLQLDGVLSSpeEHVLVVCSTSKPEEIDE 615
Cdd:PTZ00454 222 EGPRMVRDVFRLARENAPSIIFIDEVDSIatkrFDAQTGADREVQRILLELLNQMDGFDQT--TNVKVIMATNRADTLDP 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66472602  616 SLRR--YFVKRLLVPLPDATARHQIISQLLSQHNycLSDkEVTL--LVQRTDGFSGLDVVRLCQEA 677
Cdd:PTZ00454 300 ALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMN--LSE-EVDLedFVSRPEKISAADIAAICQEA 362
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 500-629 2.22e-31

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 118.85  E-value: 2.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   500 ILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPV 579
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 66472602   580 -NRIKSELLLQLDGVlSSPEEHVLVVCSTSKPEEIDESLRRYFVKRLLVPL 629
Cdd:pfam00004  81 sRRVVNQLLTELDGF-TSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 462-619 3.94e-31

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 119.75  E-value: 3.94e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 462 DWSDIAGLEMAKATIKDEVLWPILRPDMFSGLATL-PRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGE 540
Cdd:cd19502   1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEpPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 541 GEKIVQASFLIARCRQPSVVFISDVDLL----LSSQLSEESPVNRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDES 616
Cdd:cd19502  81 GARLVRELFEMAREKAPSIIFIDEIDAIgakrFDSGTGGDREVQRTMLELLNQLDGF--DPRGNIKVIMATNRPDILDPA 158


                ...
gi 66472602 617 LRR 619
Cdd:cd19502 159 LLR 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 441-677 7.13e-31

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 129.26  E-value: 7.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   441 NSDANLVEMVTTEILQQTSP-VDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLATLP-RSILLFGPQGTGRTLLGRCMA 518
Cdd:TIGR01243 154 ATEVEIREKPVREEIERKVPkVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPpKGVLLYGPPGTGKTLLAKAVA 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   519 SQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPV-NRIKSELLLQLDGVlsSP 597
Cdd:TIGR01243 234 NEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVeKRVVAQLLTLMDGL--KG 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   598 EEHVLVVCSTSKPEEIDESLRR--YFVKRLLVPLPDATARHQIIsQLLSQHNYCLSDKEVTLLVQRTDGFSGLDVVRLCQ 675
Cdd:TIGR01243 312 RGRVIVIGATNRPDALDPALRRpgRFDREIVIRVPDKRARKEIL-KVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAK 390


                  ..
gi 66472602   676 EA 677
Cdd:TIGR01243 391 EA 392
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 459-733 1.17e-30

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 124.56  E-value: 1.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  459 SP-VDWSDIAGLEMAKATIKDEVLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTK 536
Cdd:PRK03992 125 SPnVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGiEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  537 WLGEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQL----SEESPVNRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEE 612
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTdsgtSGDREVQRTLMQLLAEMDGF--DPRGNVKIIAATNRIDI 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  613 IDESLRR--YFvKRLL-VPLPDATARHQIisqlLSQHNYCLS-DKEVTL--LVQRTDGFSGLDVVRLCQEAlvgplhgmp 686
Cdd:PRK03992 283 LDPAILRpgRF-DRIIeVPLPDEEGRLEI----LKIHTRKMNlADDVDLeeLAELTEGASGADLKAICTEA--------- 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 66472602  687 gadlsGM--IPGQMRPVSYQDFENVFCKIQpsiSQKELDTYTEWNKMFG 733
Cdd:PRK03992 349 -----GMfaIRDDRTEVTMEDFLKAIEKVM---GKEEKDSMEEPGVMFA 389
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 472-619 3.72e-30

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 116.44  E-value: 3.72e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 472 AKATIKDEVLWPILRPDMFSGL-ATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFL 550
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVFKRLgIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66472602 551 IARCRQPSVVFISDVDLL-------LSSQLSEespvnRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19529  81 KARQVAPCVIFFDEIDSIaprrgttGDSGVTE-----RVVNQLLTELDGL--EEMNGVVVIAATNRPDIIDPALLR 149
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 463-677 5.13e-29

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 120.65  E-value: 5.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  463 WSDIAGLEMAKATIKDEVLWPILRPDMFSGLATLP-RSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEG 541
Cdd:PTZ00361 182 YADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPpKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDG 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  542 EKIVQASFLIARCRQPSVVFISDVDLL----LSSQLSEESPVNRIKSELLLQLDGVLSSPEehVLVVCSTSKPEEIDESL 617
Cdd:PTZ00361 262 PKLVRELFRVAEENAPSIVFIDEIDAIgtkrYDATSGGEKEIQRTMLELLNQLDGFDSRGD--VKVIMATNRIESLDPAL 339

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66472602  618 RR--YFVKRLLVPLPDATARHQIISQLLSQHNYClSDKEVTLLVQRTDGFSGLDVVRLCQEA 677
Cdd:PTZ00361 340 IRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLA-EDVDLEEFIMAKDELSGADIKAICTEA 400
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
497-678 1.99e-28

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 114.60  E-value: 1.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 497 PRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARcRQPSVVFISDVDLLLS--SQLS 574
Cdd:COG1223  35 PRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFAR-RAPCVIFFDEFDAIAKdrGDQN 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 575 EESPVNRIKSELLLQLDGvlssPEEHVLVVCSTSKPEEIDESLRRYFVKRLLVPLPDATARHQIISQLLSQHnYCLSDKE 654
Cdd:COG1223 114 DVGEVKRVVNALLQELDG----LPSGSVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILELNLKKF-PLPFELD 188

                       170       180
                ....*....|....*....|....
gi 66472602 655 VTLLVQRTDGFSGLDVVRLCQEAL 678
Cdd:COG1223 189 LKKLAKKLEGLSGADIEKVLKTAL 212
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 465-620 1.03e-27

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 109.83  E-value: 1.03e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEK 543
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPELFKAIGiKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66472602 544 IVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVN-RIKSELLLQLDGVLSSpeEHVLVVCSTSKPEEIDESLRRY 620
Cdd:cd19519  81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVErRIVSQLLTLMDGLKQR--AHVIVMAATNRPNSIDPALRRF 156
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 480-619 1.82e-23

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 97.56  E-value: 1.82e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 480 VLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPS 558
Cdd:cd19530  12 ILRPIKRPDIYKALGiDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRARASAPC 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66472602 559 VVFISDVDLLLSSQLSEESPVN-RIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19530  92 VIFFDEVDALVPKRGDGGSWASeRVVNQLLTEMDGL--EERSNVFVIAATNRPDIIDPAMLR 151
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 465-619 7.71e-23

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 96.04  E-value: 7.71e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGA-----AFLLLSGSALVTKWL 538
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKiTPPRGVLFHGPPGTGKTLMARALAAECSKggqkvSFFMRKGADCLSKWV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 539 GEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPV-NRIKSELLLQLDGVLSSPEehVLVVCSTSKPEEIDESL 617
Cdd:cd19517  81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIhASIVSTLLALMDGLDNRGQ--VVVIGATNRPDALDPAL 158


                ..
gi 66472602 618 RR 619
Cdd:cd19517 159 RR 160
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
449-677 7.44e-22

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 100.49  E-value: 7.44e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  449 MVTTEILQQTspvdWSDIAGLEMAKATIKDEVLWpILRPDMFSGLA-TLPRSILLFGPQGTGRTLLGRCMASQLGAAFLL 527
Cdd:PRK10733 141 MLTEDQIKTT----FADVAGCDEAKEEVAELVEY-LREPSRFQKLGgKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFT 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  528 LSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDL--------LLSSQLSEESPVNriksELLLQLDGVlsSPEE 599
Cdd:PRK10733 216 ISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAvgrqrgagLGGGHDEREQTLN----QMLVEMDGF--EGNE 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  600 HVLVVCSTSKPEEIDESLRR--YFVKRLLVPLPDATARHQIISQLLSQHNYClSDKEVTLLVQRTDGFSGLDVVRLCQEA 677
Cdd:PRK10733 290 GIIVIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLA-PDIDAAIIARGTPGFSGADLANLVNEA 368
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 473-619 7.84e-22

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 92.57  E-value: 7.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 473 KATIKDEVLWPILRPDMFSGLATLP-RSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLI 551
Cdd:cd19528   2 KRELQELVQYPVEHPDKFLKFGMTPsKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66472602 552 ARCRQPSVVFISDVDLLL----SSQLSEESPVNRIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19528  82 ARAAAPCVLFFDELDSIAkargGNIGDAGGAADRVINQILTEMDGM--NTKKNVFIIGATNRPDIIDPAILR 151
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 473-619 1.62e-21

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 91.81  E-value: 1.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 473 KATIKDEVLWPILRPDMFSGLATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIA 552
Cdd:cd19527   2 KKEILDTIQLPLEHPELFSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 553 RCRQPSVVFISDVDLLLSS---QLSEESPVNRIKSELLLQLDGvLSSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19527  82 RDAKPCVIFFDELDSLAPSrgnSGDSGGVMDRVVSQLLAELDG-MSSSGQDVFVIGATNRPDLLDPALLR 150
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 461-619 2.92e-21

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 91.53  E-value: 2.92e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 461 VDWSDIAGLEMAKATIKdEVLWPILRPDMFSGL-ATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLG 539
Cdd:cd19501   1 VTFKDVAGCEEAKEELK-EVVEFLKNPEKFTKLgAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 540 EGEKIVQASFLIARCRQPSVVFISDVD--------LLLSSQLSEESPVNriksELLLQLDGVLSSpeEHVLVVCSTSKPE 611
Cdd:cd19501  80 VGASRVRDLFEQAKKNAPCIVFIDEIDavgrkrgaGLGGGHDEREQTLN----QLLVEMDGFESN--TGVIVIAATNRPD 153


                ....*...
gi 66472602 612 EIDESLRR 619
Cdd:cd19501 154 VLDPALLR 161
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 465-619 5.22e-21

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 90.54  E-value: 5.22e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKATIKDEVLWPILRPDMFSGLATLP-RSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEK 543
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPpRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66472602 544 IVQASFLIARCRQPSVVFISDVDLLLSSQLSEESPVN-RIKSELLLQLDGV--LSSPEEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19518  81 KIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMErRIVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPALRR 159
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 472-619 8.52e-19

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 84.02  E-value: 8.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 472 AKATIKDEVLWPILRPDMFSGLAT-LPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFL 550
Cdd:cd19526   1 VKKALEETIEWPSKYPKIFASSPLrLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 551 IARCRQPSVVFISDVDLLLSSQLSEESPV-NRIKSELLLQLDGVLSSpeEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19526  81 RAQSAKPCILFFDEFDSIAPKRGHDSTGVtDRVVNQLLTQLDGVEGL--DGVYVLAATSRPDLIDPALLR 148
ftsH CHL00176
cell division protein; Validated
 461-679 3.73e-16

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 82.41  E-value: 3.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  461 VDWSDIAGLEMAKATIkDEVLWPILRPDMFSGL-ATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLG 539
Cdd:CHL00176 180 ITFRDIAGIEEAKEEF-EEVVSFLKKPERFTAVgAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  540 EGEKIVQASFLIARCRQPSVVFISDVDL--------LLSSQLSEESPVNriksELLLQLDGVlsSPEEHVLVVCSTSKPE 611
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAvgrqrgagIGGGNDEREQTLN----QLLTEMDGF--KGNKGVIVIAATNRVD 332

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  612 EIDESLRR--YFVKRLLVPLPDATARHQIISQLLSQHNYcLSDKEVTLLVQRTDGFSGLDVVRLCQEALV 679
Cdd:CHL00176 333 ILDAALLRpgRFDRQITVSLPDREGRLDILKVHARNKKL-SPDVSLELIARRTPGFSGADLANLLNEAAI 401
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 497-629 4.49e-14

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 70.25  E-value: 4.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 497 PRSILLFGPQGTGRTLLGRCMASQL---GAAFLLLSGSALVTKWLGEGEK---IVQASFLIARCRQPSVVFISDVDLLLs 570
Cdd:cd00009  19 PKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDSLS- 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66472602 571 sqlseespvNRIKSELLLQLDGVLSSPE--EHVLVVCSTSKPEEIDESLRRY--FVKRLLVPL 629
Cdd:cd00009  98 ---------RGAQNALLRVLETLNDLRIdrENVRVIGATNRPLLGDLDRALYdrLDIRIVIPL 151
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 494-627 8.23e-10

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 58.31  E-value: 8.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 494 ATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEG--EKIVQASFLIARCRQPSVVFISDVDLLLSS 571
Cdd:cd19506  23 APLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYK 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 572 QLSEESPVN---RIKSELLLQLDGVlsSPEEHVLVVCSTSKPEEID-ESLRRYFVKRLLV 627
Cdd:cd19506 103 KVPKTEKQLdpkRLKKDLPKILKSL--KPEDRVLIVGTTSRPFEADlKSFCKVYNKIILI 160
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 498-619 1.68e-07

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 51.20  E-value: 1.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 498 RSILLFGPQGTGRTLLGRCMASQLGAAFLLLSgsaLVTKWLGEGEKivqaSFLIARCRQPSVVFISDVDLLLSS------ 571
Cdd:cd19510  24 RGYLLYGPPGTGKSSFIAALAGELDYDICDLN---LSEVVLTDDRL----NHLLNTAPKQSIILLEDIDAAFESrehnkk 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 66472602 572 QLSEESPVNRIK-SELLLQLDGVLSSPEEhvLVVCSTSKPEEIDESLRR 619
Cdd:cd19510  97 NPSAYGGLSRVTfSGLLNALDGVASSEER--IVFMTTNHIERLDPALIR 143
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 497-631 1.97e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 50.83  E-value: 1.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602    497 PRSILLFGPQGTGRTLLGRCMASQL---GAAFLLLSGSAL------------VTKWLGEGEKIVQASFLIARCRQ--PSV 559
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDIleevldqllliiVGGKKASGSGELRLRLALALARKlkPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66472602    560 VFISDVDLLLSSQLSEESPVNRIKSELLLQLdgvlssPEEHVLVVCSTSKPEEIDES-LRRYFVKRLLVPLPD 631
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRLLLLLK------SEKNLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 498-619 3.81e-07

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 50.95  E-value: 3.81e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 498 RSILLFGPQGTGRTLLGRCMASQLGAAF-LLLSGSALVTKWLGEGEKIVQASFLIARCRQPS--------VVFISDVDLL 568
Cdd:cd19504  36 KGILLYGPPGTGKTLMARQIGKMLNAREpKIVNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 66472602 569 LSSQLS--EESPV-NRIKSELLLQLDGVLSSpeEHVLVVCSTSKPEEIDESLRR 619
Cdd:cd19504 116 CKQRGSmaGSTGVhDTVVNQLLSKIDGVEQL--NNILVIGMTNRKDLIDEALLR 167
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 491-624 5.85e-07

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 50.52  E-value: 5.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 491 SGLATLPRSILLFGPQGTGRTLLGRCMASQLG---------AAFLLLSGSALVTKWLGEGEKIVQASF-----LIARCRQ 556
Cdd:cd19508  46 TNLITWNRLVLLHGPPGTGKTSLCKALAQKLSirlssryryGQLIEINSHSLFSKWFSESGKLVTKMFqkiqeLIDDKDA 125

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66472602 557 PSVVFISDVDLLLSSQL-----SEESPVNRIKSELLLQLDGVLSSPeeHVLVVCSTSKPEEIDESlrryFVKR 624
Cdd:cd19508 126 LVFVLIDEVESLAAARSasssgTEPSDAIRVVNAVLTQIDRIKRYH--NNVILLTSNLLEKIDVA----FVDR 192
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 465-572 6.37e-07

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 49.67  E-value: 6.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 465 DIAGLEMAKAtikdevlWPILRPDMFS------GLATlPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWL 538
Cdd:cd19507   1 DVGGLDNLKD-------WLKKRKAAFSkqasayGLPT-PKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLV 72

                        90       100       110
                ....*....|....*....|....*....|....
gi 66472602 539 GEGEKIVQASFLIARCRQPSVVFISDVDLLLSSQ 572
Cdd:cd19507  73 GESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNA 106
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
464-677 7.07e-06

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 49.26  E-value: 7.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 464 SDIAGLEMAKATIKDevlwpI---LR-PDMFSGL-ATLPRSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWL 538
Cdd:COG0465 142 DDVAGVDEAKEELQE-----IvdfLKdPEKFTRLgAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFV 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 539 GegekiVQAS-----FLIARCRQPSVVFISDVDLL-------LSSQLSE-ESPVNriksELLLQLDGVlsSPEEHVLVVC 605
Cdd:COG0465 217 G-----VGASrvrdlFEQAKKNAPCIIFIDEIDAVgrqrgagLGGGHDErEQTLN----QLLVEMDGF--EGNEGVIVIA 285

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66472602 606 STSKPEEIDESLRR--YFVKRLLVPLPDATARHQIisqlLSQH--NYCLSDkEVTL--LVQRTDGFSGLDVVRLCQEA 677
Cdd:COG0465 286 ATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAI----LKVHarKKPLAP-DVDLevIARRTPGFSGADLANLVNEA 358
ycf46 CHL00195
Ycf46; Provisional
 438-667 9.65e-06

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 48.86  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  438 QLKNSDANLVEMVTTE---ILQQTS-----PVDW--SDIAGLEMAKatikdevLWPILRPDMFS------GLATlPRSIL 501
Cdd:CHL00195 192 TYKTIDENSIPLILEEkkqIISQTEilefySVNEkiSDIGGLDNLK-------DWLKKRSTSFSkqasnyGLPT-PRGLL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  502 LFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTKWLGEGEKIVQASFLIARCRQPSVVFISDVDLLLS-SQLSEES-PV 579
Cdd:CHL00195 264 LVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSnSESKGDSgTT 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  580 NRIKSELLLQldgvLSSPEEHVLVVCSTSK----PEEIdesLRR-YFVKRLLVPLPDATARHQIISQLLSQ------HNY 648
Cdd:CHL00195 344 NRVLATFITW----LSEKKSPVFVVATANNidllPLEI---LRKgRFDEIFFLDLPSLEEREKIFKIHLQKfrpkswKKY 416

                        250
                 ....*....|....*....
gi 66472602  649 clsdkEVTLLVQRTDGFSG 667
Cdd:CHL00195 417 -----DIKKLSKLSNKFSG 430
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 700-733 4.02e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 41.71  E-value: 4.02e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 66472602   700 PVSYQDFENVFCKIQPSISQKELDTYTEWNKMFG 733
Cdd:pfam09336  28 PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 498-614 2.90e-04

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 41.74  E-value: 2.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602 498 RSILLFGPQGTGRTLLGRCMASQLGAAFLLLSGSALVTkwLG-EGEKIVQASFLIA-RCRQPSVVFISDVDLLLSSQLSE 575
Cdd:cd19512  23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAP--MGrEGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKRSTE 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 66472602 576 EspvnrIKSELLLQLDGVLSSPEEH---VLVVCSTSKPEEID 614
Cdd:cd19512 101 K-----ISEDLRAALNAFLYRTGEQsnkFMLVLASNQPEQFD 137
PHA03378 PHA03378
EBNA-3B; Provisional
 163-289 5.25e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602  163 IPSQEFASSYNGSYLHSTYSG-GQSTPALPSPHPSPLHSAGLLQPPPPPPPTLVPSYNTSSPNLSSYNYPPAGYPPQTPV 241
Cdd:PHA03378 672 IPYQPSPTGANTMLPIQWAPGtMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP 751

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 66472602  242 APGYSPGGAPPPSAYLPSGIAAPTPLPPSTIPGYSYQSHNHAPiAPTP 289
Cdd:PHA03378 752 GRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAP-TPQP 798
PHA03247 PHA03247
large tegument protein UL36; Provisional
 231-300 1.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66472602   231 PPAGYPPQTPVAPGYSPGGAPPPSAyLPSGIAAPTPLPPSTIPGYSYQSHNHAPIAPTPLNGSSANTLKR 300
Cdd:PHA03247 2592 PPQSARPRAPVDDRGDPRGPAPPSP-LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR 2660
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 658-683 7.04e-03

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 35.21  E-value: 7.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 66472602   658 LVQRTDGFSGLDVVRLCQEALVGPLH 683
Cdd:pfam17862   7 LAERTEGFSGADLEALCREAALAALR 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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