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    brca2 BRCA2 DNA repair associated [ Danio rerio (zebrafish) ]

    Gene ID: 566758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brca2provided by ZNC
    Official Full Name
    BRCA2 DNA repair associatedprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060510-3
    See related
    Ensembl:ENSDARG00000079015 AllianceGenome:ZFIN:ZDB-GENE-060510-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fancd1
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within several processes, including female gonad development; kidney development; and regulation of oogenesis. Predicted to be active in nucleus. Is expressed in gonad; heart; intermediate cell mass of mesoderm; intermediate mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); esophagus squamous cell carcinoma; hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See brca2 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (31911944..31928519)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (32053981..32070682)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 2b Neighboring gene furry homolog a (Drosophila) Neighboring gene uncharacterized LOC137487768 Neighboring gene dachsous cadherin-related 1a Neighboring gene ADP-ribosylation factor interacting protein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. BRCA2 and TP53 collaborate in tumorigenesis in zebrafish. Shive HR, et al. PLoS One, 2014. PMID 24489863, Free PMC Article
    2. Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential. Allen TA, et al. J Cell Sci, 2019 Sep 9. PMID 31409692, Free PMC Article
    3. Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model. Mensah L, et al. J Oncol, 2019. PMID 30930946, Free PMC Article
    4. Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm. Vierstraete J, et al. Sci Rep, 2017 Nov 28. PMID 29184099, Free PMC Article
    5. brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Shive HR, et al. Proc Natl Acad Sci U S A, 2010 Nov 9. PMID 20974951, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.
      Title: brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury.
    2. the data suggest for the first time that brca2/fancd1 is essential for vertebrate kidney ontogeny.
      Title: The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development.
    3. Carcinogenesis in zebrafish with combined mutations in tp53 and brca2 typically requires biallelic mutation or loss of at least one of these genes.
      Title: BRCA2 and TP53 collaborate in tumorigenesis in zebrafish.
    4. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer
      Title: Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish.
    5. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues
      Title: brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    breast cancer type 2 susceptibility protein
    Names
    breast and ovarian cancer susceptibility protein 2
    breast cancer 2, early onset

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110394.2 → NP_001103864.2  breast cancer type 2 susceptibility protein

      See identical proteins and their annotated locations for NP_001103864.2

      Status: VALIDATED

      Source sequence(s)
      CR536612, CR628361
      UniProtKB/TrEMBL
      A0A8M2B481, F1R8E8
      Related
      ENSDARP00000099674.2, ENSDART00000111472.3
      Conserved Domains (5) summary
      cd04494
      Location:2350 → 2597
      BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
      pfam00634
      Location:1239 → 1267
      BRCA2; BRCA2 repeat
      pfam09103
      Location:2215 → 2338
      BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
      pfam09104
      Location:2600 → 2733
      BRCA-2_OB3; BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
      pfam09169
      Location:2026 → 2212
      BRCA-2_helical; BRCA2, helical

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      31911944..31928519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213572.1 → XP_068069673.1  breast cancer type 2 susceptibility protein isoform X2

    2. XM_005157363.4 → XP_005157420.1  breast cancer type 2 susceptibility protein isoform X1

      See identical proteins and their annotated locations for XP_005157420.1

      UniProtKB/TrEMBL
      A0A8M2B481, F1R8E8
      Conserved Domains (5) summary
      cd04494
      Location:2350 → 2597
      BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...
      pfam00634
      Location:1239 → 1267
      BRCA2; BRCA2 repeat
      pfam09103
      Location:2215 → 2338
      BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
      pfam09104
      Location:2600 → 2733
      BRCA-2_OB3; BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
      pfam09169
      Location:2026 → 2212
      BRCA-2_helical; BRCA2, helical
    Nucleotide Protein
    Heading Accession and Version

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