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Conserved domains on  [gi|302318878|ref|NP_001103864|]
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breast cancer type 2 susceptibility protein [Danio rerio]

Protein Classification

single-stranded DNA-binding protein( domain architecture ID 11101627)

single-stranded DNA (ssDNA)-binding protein plays a key role in DNA replication, recombination, and repair

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2350-2597 1.64e-106

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


:

Pssm-ID: 239940  Cd Length: 251  Bit Score: 340.97  E-value: 1.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2350 LSSLYASGGLVSCVNLLVLRSYPTQWMEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQFEKEMEGKKKKR 2429
Cdd:cd04494     2 LSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQRR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2430 AQRRTFSRHEIETLQDGDELYEAMEQ---DAAVETRLSHKQMEAVSKYRCCREEKRQAELQERVQKAVMEAQEAEGGcPN 2506
Cdd:cd04494    82 PRSRTRTRQNVTDLQDGAELYEALEAaadPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGL-SK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2507 RDVTPVWKLSVIDASDMQSNcVYTLNIWRPTRELQGLLTEGHRYRAYHLASSEGKKRSGVAHIQLTATKKTLFQDIEVSP 2586
Cdd:cd04494   161 RDVTPVWKLRVTDYRSKPEK-SGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQ 239

                         250
                  ....*....|.
gi 302318878 2587 EWLHQHFRARE 2597
Cdd:cd04494   240 RELFQPFQPRK 250
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2026-2212 3.80e-104

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462700  Cd Length: 187  Bit Score: 331.23  E-value: 3.80e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2026 QESLQLARDMQDMRLRKKKRQTIRPVPGSLYLAKTSGVSRKSLRDAVGCTCPSQYTQDELSQHGVHHKVLEITSENAESF 2105
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2106 RFDCSDYFTCEHLMESGALQLADGGWLVPDSKGTVGKEEFFSALCDTPGVDPKLISDVWVFNHYRWIIWKRASMERTFPN 2185
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 302318878  2186 LIGGLCLTPEQVLLQLKFRYDVEVDHS 2212
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 2596-2733 3.31e-63

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


:

Pssm-ID: 462679  Cd Length: 139  Bit Score: 212.14  E-value: 3.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2596 RECVRFRELQNPHFSSPCGEVDIVGYIVSIEGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQV 2675
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNQYAYEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 302318878  2676 R-VLSGPVPSLYAGEQALFSINPKESYLQEAMAHLKTFAQNYEQFFNLAEEKVSDVVPS 2733
Cdd:pfam09104   81 RrESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2215-2341 2.29e-62

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462678  Cd Length: 123  Bit Score: 208.96  E-value: 2.29e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2215 SALRRIMERDDTPAKTLVLCVCGIVQTCQNPEKTmkddKSPSAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIGD 2294
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEET----GSGTVDNTKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 302318878  2295 KIVTSGAELVGSQEACPPLEAPESLMLKISANSTRRARWDTKLGYYR 2341
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1620-1648 9.58e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 9.58e-06
                           10        20
                   ....*....|....*....|....*....
gi 302318878  1620 SNIGFSTAGGKKVTISSTALQRAQTLFKD 1648
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 900-925 1.61e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.59  E-value: 1.61e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878   900 GFKTAKGKAISVSEKSLNKAKHFFEE 925
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1244-1267 1.83e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.59  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....
gi 302318878  1244 GFSTASGKKVSVSAEALQRAKDVL 1267
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLF 27
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1451-1476 5.28e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.43  E-value: 5.28e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1451 GFSTAGGKKVTISDTSLQRTMNLFQD 1476
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1577-1603 5.99e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 5.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 302318878  1577 CKGFTTASGKNVTVSETALNEVKAVFA 1603
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1492-1518 6.11e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 6.11e-05
                           10        20
                   ....*....|....*....|....*..
gi 302318878  1492 CKGFTTASGKNVTVSEKALSEVRAVFA 1518
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1300-1325 6.17e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 6.17e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1300 KGFCTAGGKKVAFSATGLQKAKNLFR 1325
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1135-1160 1.98e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.51  E-value: 1.98e-04
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1135 GFQTASGKGVSVLPSALKKAKAIFKD 1160
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1009-1034 1.06e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.58  E-value: 1.06e-03
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1009 GFSTARGAKLKVSEKALEQARMFLND 1034
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 super family cl02912
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1407-1431 1.40e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


The actual alignment was detected with superfamily member pfam00634:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.20  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*
gi 302318878  1407 GFTTASGKNVFVSEKALSEVRAVFA 1431
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 super family cl02912
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1367-1392 1.99e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


The actual alignment was detected with superfamily member pfam00634:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 37.81  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1367 GFSTAGGRKMDISVTALQKANNLFKD 1392
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2350-2597 1.64e-106

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 340.97  E-value: 1.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2350 LSSLYASGGLVSCVNLLVLRSYPTQWMEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQFEKEMEGKKKKR 2429
Cdd:cd04494     2 LSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQRR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2430 AQRRTFSRHEIETLQDGDELYEAMEQ---DAAVETRLSHKQMEAVSKYRCCREEKRQAELQERVQKAVMEAQEAEGGcPN 2506
Cdd:cd04494    82 PRSRTRTRQNVTDLQDGAELYEALEAaadPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGL-SK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2507 RDVTPVWKLSVIDASDMQSNcVYTLNIWRPTRELQGLLTEGHRYRAYHLASSEGKKRSGVAHIQLTATKKTLFQDIEVSP 2586
Cdd:cd04494   161 RDVTPVWKLRVTDYRSKPEK-SGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQ 239

                         250
                  ....*....|.
gi 302318878 2587 EWLHQHFRARE 2597
Cdd:cd04494   240 RELFQPFQPRK 250
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2026-2212 3.80e-104

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 331.23  E-value: 3.80e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2026 QESLQLARDMQDMRLRKKKRQTIRPVPGSLYLAKTSGVSRKSLRDAVGCTCPSQYTQDELSQHGVHHKVLEITSENAESF 2105
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2106 RFDCSDYFTCEHLMESGALQLADGGWLVPDSKGTVGKEEFFSALCDTPGVDPKLISDVWVFNHYRWIIWKRASMERTFPN 2185
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 302318878  2186 LIGGLCLTPEQVLLQLKFRYDVEVDHS 2212
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 2596-2733 3.31e-63

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 212.14  E-value: 3.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2596 RECVRFRELQNPHFSSPCGEVDIVGYIVSIEGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQV 2675
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNQYAYEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 302318878  2676 R-VLSGPVPSLYAGEQALFSINPKESYLQEAMAHLKTFAQNYEQFFNLAEEKVSDVVPS 2733
Cdd:pfam09104   81 RrESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2215-2341 2.29e-62

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 208.96  E-value: 2.29e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2215 SALRRIMERDDTPAKTLVLCVCGIVQTCQNPEKTmkddKSPSAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIGD 2294
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEET----GSGTVDNTKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 302318878  2295 KIVTSGAELVGSQEACPPLEAPESLMLKISANSTRRARWDTKLGYYR 2341
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2227-2339 2.67e-44

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 156.62  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2227 PAKTLVLCVCGIVQTCQnpektmkddkspsAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIGDKIVTSGAELVGS 2306
Cdd:cd04493     1 ASRLMVLCVSGINSEER-------------LSPHMPIIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                          90       100       110
                  ....*....|....*....|....*....|...
gi 302318878 2307 QEACPPLEAPESLMLKISANSTRRARWDTKLGY 2339
Cdd:cd04493    68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 2617-2714 1.56e-39

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 142.93  E-value: 1.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2617 DIVGYIVSI-EGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQVRVLSGP-VPSLYAGEQALFS 2694
Cdd:cd04495     1 DTVGVVISVgKPIEGKFPAVYLADECLNLLCVKFWSSLEQYAYEDVVKRRVLLAASNLQWRTESTSgVPTLFAGEYSTFS 80

                          90       100
                  ....*....|....*....|
gi 302318878 2695 INPKESYLQEAMAHLKTFAQ 2714
Cdd:cd04495    81 ANPKESHLQEEFNNLKHLIE 100
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2376-2417 8.01e-17

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 76.25  E-value: 8.01e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 302318878  2376 MEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQ 2417
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQAE 42
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1620-1648 9.58e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 9.58e-06
                           10        20
                   ....*....|....*....|....*....
gi 302318878  1620 SNIGFSTAGGKKVTISSTALQRAQTLFKD 1648
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 900-925 1.61e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.59  E-value: 1.61e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878   900 GFKTAKGKAISVSEKSLNKAKHFFEE 925
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1244-1267 1.83e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.59  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....
gi 302318878  1244 GFSTASGKKVSVSAEALQRAKDVL 1267
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLF 27
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1451-1476 5.28e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.43  E-value: 5.28e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1451 GFSTAGGKKVTISDTSLQRTMNLFQD 1476
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1577-1603 5.99e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 5.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 302318878  1577 CKGFTTASGKNVTVSETALNEVKAVFA 1603
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1492-1518 6.11e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 6.11e-05
                           10        20
                   ....*....|....*....|....*..
gi 302318878  1492 CKGFTTASGKNVTVSEKALSEVRAVFA 1518
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1300-1325 6.17e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 6.17e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1300 KGFCTAGGKKVAFSATGLQKAKNLFR 1325
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1135-1160 1.98e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.51  E-value: 1.98e-04
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1135 GFQTASGKGVSVLPSALKKAKAIFKD 1160
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1009-1034 1.06e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.58  E-value: 1.06e-03
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1009 GFSTARGAKLKVSEKALEQARMFLND 1034
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1407-1431 1.40e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.20  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*
gi 302318878  1407 GFTTASGKNVFVSEKALSEVRAVFA 1431
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1367-1392 1.99e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 37.81  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1367 GFSTAGGRKMDISVTALQKANNLFKD 1392
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2350-2597 1.64e-106

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 340.97  E-value: 1.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2350 LSSLYASGGLVSCVNLLVLRSYPTQWMEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQFEKEMEGKKKKR 2429
Cdd:cd04494     2 LSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQRR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2430 AQRRTFSRHEIETLQDGDELYEAMEQ---DAAVETRLSHKQMEAVSKYRCCREEKRQAELQERVQKAVMEAQEAEGGcPN 2506
Cdd:cd04494    82 PRSRTRTRQNVTDLQDGAELYEALEAaadPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGL-SK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2507 RDVTPVWKLSVIDASDMQSNcVYTLNIWRPTRELQGLLTEGHRYRAYHLASSEGKKRSGVAHIQLTATKKTLFQDIEVSP 2586
Cdd:cd04494   161 RDVTPVWKLRVTDYRSKPEK-SGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQ 239

                         250
                  ....*....|.
gi 302318878 2587 EWLHQHFRARE 2597
Cdd:cd04494   240 RELFQPFQPRK 250
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2026-2212 3.80e-104

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 331.23  E-value: 3.80e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2026 QESLQLARDMQDMRLRKKKRQTIRPVPGSLYLAKTSGVSRKSLRDAVGCTCPSQYTQDELSQHGVHHKVLEITSENAESF 2105
Cdd:pfam09169    1 QSNLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2106 RFDCSDYFTCEHLMESGALQLADGGWLVPDSKGTVGKEEFFSALCDTPGVDPKLISDVWVFNHYRWIIWKRASMERTFPN 2185
Cdd:pfam09169   81 QFFDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPK 160

                          170       180
                   ....*....|....*....|....*..
gi 302318878  2186 LIGGLCLTPEQVLLQLKFRYDVEVDHS 2212
Cdd:pfam09169  161 EFGRRCLTPERVLLQLKYRYDVEIDKS 187
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 2596-2733 3.31e-63

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 212.14  E-value: 3.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2596 RECVRFRELQNPHFSSPCGEVDIVGYIVSIEGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQV 2675
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNQYAYEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 302318878  2676 R-VLSGPVPSLYAGEQALFSINPKESYLQEAMAHLKTFAQNYEQFFNLAEEKVSDVVPS 2733
Cdd:pfam09104   81 RrESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2215-2341 2.29e-62

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 208.96  E-value: 2.29e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878  2215 SALRRIMERDDTPAKTLVLCVCGIVQTCQNPEKTmkddKSPSAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIGD 2294
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEET----GSGTVDNTKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 302318878  2295 KIVTSGAELVGSQEACPPLEAPESLMLKISANSTRRARWDTKLGYYR 2341
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQR 123
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2227-2339 2.67e-44

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 156.62  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2227 PAKTLVLCVCGIVQTCQnpektmkddkspsAKMESCVIWLTDGWYSIKSLLDPPLSAMLNKGRLKIGDKIVTSGAELVGS 2306
Cdd:cd04493     1 ASRLMVLCVSGINSEER-------------LSPHMPIIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                          90       100       110
                  ....*....|....*....|....*....|...
gi 302318878 2307 QEACPPLEAPESLMLKISANSTRRARWDTKLGY 2339
Cdd:cd04493    68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 2617-2714 1.56e-39

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 142.93  E-value: 1.56e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 302318878 2617 DIVGYIVSI-EGKQGHCPVLHLVDENFDLVTVRTYSSLEQLAVEELVKPRALVAICNLQVRVLSGP-VPSLYAGEQALFS 2694
Cdd:cd04495     1 DTVGVVISVgKPIEGKFPAVYLADECLNLLCVKFWSSLEQYAYEDVVKRRVLLAASNLQWRTESTSgVPTLFAGEYSTFS 80

                          90       100
                  ....*....|....*....|
gi 302318878 2695 INPKESYLQEAMAHLKTFAQ 2714
Cdd:cd04495    81 ANPKESHLQEEFNNLKHLIE 100
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2376-2417 8.01e-17

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 76.25  E-value: 8.01e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 302318878  2376 MEKKPNSVFIFRNDRAEDREARKHSNSKHKSLDLLISKIQTQ 2417
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQAE 42
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1620-1648 9.58e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 44.36  E-value: 9.58e-06
                           10        20
                   ....*....|....*....|....*....
gi 302318878  1620 SNIGFSTAGGKKVTISSTALQRAQTLFKD 1648
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 900-925 1.61e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.59  E-value: 1.61e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878   900 GFKTAKGKAISVSEKSLNKAKHFFEE 925
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1244-1267 1.83e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.59  E-value: 1.83e-05
                           10        20
                   ....*....|....*....|....
gi 302318878  1244 GFSTASGKKVSVSAEALQRAKDVL 1267
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLF 27
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1451-1476 5.28e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.43  E-value: 5.28e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1451 GFSTAGGKKVTISDTSLQRTMNLFQD 1476
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1577-1603 5.99e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 5.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 302318878  1577 CKGFTTASGKNVTVSETALNEVKAVFA 1603
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1492-1518 6.11e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 6.11e-05
                           10        20
                   ....*....|....*....|....*..
gi 302318878  1492 CKGFTTASGKNVTVSEKALSEVRAVFA 1518
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1300-1325 6.17e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 42.05  E-value: 6.17e-05
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1300 KGFCTAGGKKVAFSATGLQKAKNLFR 1325
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1135-1160 1.98e-04

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 40.51  E-value: 1.98e-04
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1135 GFQTASGKGVSVLPSALKKAKAIFKD 1160
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1009-1034 1.06e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.58  E-value: 1.06e-03
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1009 GFSTARGAKLKVSEKALEQARMFLND 1034
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1407-1431 1.40e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.20  E-value: 1.40e-03
                           10        20
                   ....*....|....*....|....*
gi 302318878  1407 GFTTASGKNVFVSEKALSEVRAVFA 1431
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1367-1392 1.99e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 37.81  E-value: 1.99e-03
                           10        20
                   ....*....|....*....|....*.
gi 302318878  1367 GFSTAGGRKMDISVTALQKANNLFKD 1392
Cdd:pfam00634    4 GFQTASGKKISVSEESLQKAKKLFRD 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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