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    Spef2 sperm flagellar 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64555, updated on 9-Dec-2024

    Summary

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    Symbol
    Spef2provided by RGD
    Full Name
    sperm flagellar 2provided by RGD
    Primary source
    RGD:620450
    See related
    EnsemblRapid:ENSRNOG00000058275 AllianceGenome:RGD:620450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kpl2
    Summary
    Predicted to enable protein dimerization activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including brain morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and sperm flagellum assembly. Predicted to be located in Golgi apparatus and sperm flagellum. Predicted to be active in manchette and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 39.0), Lung (RPKM 24.1) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spef2 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (60239655..60421850, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (58512489..58694718, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (58901937..59084194, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene calcyphosine-like Neighboring gene interleukin 7 receptor Neighboring gene E3 SUMO-protein ligase KIAA1586-like Neighboring gene uncharacterized LOC120100738 Neighboring gene uncharacterized LOC120100559 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells. Ostrowski LE, et al. Am J Respir Cell Mol Biol, 1999 Apr. PMID 10100999
    2. Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein. Sironen A, et al. Biol Reprod, 2010 Mar. PMID 19889948
    3. Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Sironen A, et al. Biol Reprod, 2011 Oct. PMID 21715716, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebrospinal fluid circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mucociliary clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within respiratory system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in manchette IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sperm flagellar protein 2
    Names
    sperm flagellar protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415008.1 → NP_001401937.1  sperm flagellar protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q4V8M1, Q9R095
      UniProtKB/TrEMBL
      A0A0G2JXL6
      Related
      ENSRNOP00000070321.2, ENSRNOT00000086323.3

    2. NM_001415009.1 → NP_001401938.1  sperm flagellar protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    3. NM_022620.2 → NP_072142.2  sperm flagellar protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q4V8M1, Q9R095

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      60239655..60421850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103075.2 → XP_038959003.1  sperm flagellar protein 2 isoform X3

      UniProtKB/Swiss-Prot
      Q4V8M1, Q9R095
      Conserved Domains (2) summary
      pfam06294
      Location:5 → 97
      CH_2; CH-like domain in sperm protein
      cl17190
      Location:616 → 799
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_063282495.1 → XP_063138565.1  sperm flagellar protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q4V8M1, Q9R095

    3. XM_063282493.1 → XP_063138563.1  sperm flagellar protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q4V8M1, Q9R095

    4. XM_039103076.2 → XP_038959004.1  sperm flagellar protein 2 isoform X4

      UniProtKB/TrEMBL
      A6KGK0
      Conserved Domains (1) summary
      cl17190
      Location:438 → 621
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    5. XM_039103077.2 → XP_038959005.1  sperm flagellar protein 2 isoform X6

      UniProtKB/TrEMBL
      A6KGK0
      Conserved Domains (1) summary
      cl17190
      Location:177 → 360
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    6. XM_063282496.1 → XP_063138566.1  sperm flagellar protein 2 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R095.2 GenPept UniProtKB/Swiss-Prot:Q9R095

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