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Conserved domains on  [gi|1958752555|ref|XP_038959004|]
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sperm flagellar protein 2 isoform X4 [Rattus norvegicus]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 438-621 1.81e-15

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 76.51  E-value: 1.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  438 RAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTgykrkslqlkkkka 511
Cdd:cd01428     35 REEIASGTELgkkakeYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELLD-------------- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  512 qmptlalspttsKEVPLlpsafDFAILLDISDNSSLARINDIIAKEISHEISHENVSGPTITSSEEKSEDRNlrDHIQHR 591
Cdd:cd01428    101 ------------EGIKP-----DKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNE--ETIKKR 161

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958752555  592 IVGFLDN-WPLLEewFTEPRNILKKVNAEID 621
Cdd:cd01428    162 LEVYKEQtAPLID--YYKKKGKLVEIDGSGD 190
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 438-621 1.81e-15

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 76.51  E-value: 1.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  438 RAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTgykrkslqlkkkka 511
Cdd:cd01428     35 REEIASGTELgkkakeYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELLD-------------- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  512 qmptlalspttsKEVPLlpsafDFAILLDISDNSSLARINDIIAKEISHEISHENVSGPTITSSEEKSEDRNlrDHIQHR 591
Cdd:cd01428    101 ------------EGIKP-----DKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNE--ETIKKR 161

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958752555  592 IVGFLDN-WPLLEewFTEPRNILKKVNAEID 621
Cdd:cd01428    162 LEVYKEQtAPLID--YYKKKGKLVEIDGSGD 190
ADK pfam00406
Adenylate kinase;
437-497 2.40e-08

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 55.39  E-value: 2.40e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752555  437 MRAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALT 497
Cdd:pfam00406   31 LRAEIKSGTELgkeakeYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELLE 97
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 437-550 4.21e-08

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 55.52  E-value: 4.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  437 MRAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTGYKRKslqlkkkk 510
Cdd:COG0563     35 LRAAVKAGTELgkkakeYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALDELLAELGIK-------- 106

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958752555  511 aqmptlalspttskevpllpsaFDFAILLDISDNSSLARI 550
Cdd:COG0563    107 ----------------------LDAVIELDVDDEELVERL 124
PRK14531 PRK14531
adenylate kinase; Provisional
 429-496 6.55e-06

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 48.27  E-value: 6.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958752555  429 SNSFLSLS----MRAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPvNQSWVLDGFPMTVNQAKLLEEAL 496
Cdd:PRK14531    25 AHGLRHLStgdlLRSEVAAGSALgqeaeaVMNRGELVSDALVLAIVESQLKALN-SGGWLLDGFPRTVAQAEALEPLL 101
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 438-621 1.81e-15

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 76.51  E-value: 1.81e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  438 RAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTgykrkslqlkkkka 511
Cdd:cd01428     35 REEIASGTELgkkakeYIDSGKLVPDEIVIKLLKERLKKPDCKKGFILDGFPRTVDQAEALDELLD-------------- 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  512 qmptlalspttsKEVPLlpsafDFAILLDISDNSSLARINDIIAKEISHEISHENVSGPTITSSEEKSEDRNlrDHIQHR 591
Cdd:cd01428    101 ------------EGIKP-----DKVIELDVPDEVLIERILGRRICPVSGRVYHLGKDDVTGEPLSQRSDDNE--ETIKKR 161

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1958752555  592 IVGFLDN-WPLLEewFTEPRNILKKVNAEID 621
Cdd:cd01428    162 LEVYKEQtAPLID--YYKKKGKLVEIDGSGD 190
ADK pfam00406
Adenylate kinase;
437-497 2.40e-08

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 55.39  E-value: 2.40e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752555  437 MRAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALT 497
Cdd:pfam00406   31 LRAEIKSGTELgkeakeYMDKGELVPDEVVVGLVKERLEQNDCKNGFLLDGFPRTVPQAEALEELLE 97
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 437-550 4.21e-08

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 55.52  E-value: 4.21e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  437 MRAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTGYKRKslqlkkkk 510
Cdd:COG0563     35 LRAAVKAGTELgkkakeYMDAGELVPDEIVIGLVKERLAQPDCANGFILDGFPRTVAQAEALDELLAELGIK-------- 106

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1958752555  511 aqmptlalspttskevpllpsaFDFAILLDISDNSSLARI 550
Cdd:COG0563    107 ----------------------LDAVIELDVDDEELVERL 124
PRK14531 PRK14531
adenylate kinase; Provisional
 429-496 6.55e-06

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 48.27  E-value: 6.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958752555  429 SNSFLSLS----MRAQLGAKSEL------MLRRGKSVPDVLLVNILVNAIKKIPvNQSWVLDGFPMTVNQAKLLEEAL 496
Cdd:PRK14531    25 AHGLRHLStgdlLRSEVAAGSALgqeaeaVMNRGELVSDALVLAIVESQLKALN-SGGWLLDGFPRTVAQAEALEPLL 101
adk PRK02496
adenylate kinase; Provisional
 441-497 7.69e-06

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 48.21  E-value: 7.69e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752555  441 LGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALT 497
Cdd:PRK02496    46 LGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLDELLQ 102
adk PRK00279
adenylate kinase; Reviewed
 438-502 9.65e-06

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 48.22  E-value: 9.65e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958752555  438 RAQLGAKSELMLR------RGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTGYKRK 502
Cdd:PRK00279    36 RAAVKAGTELGKEaksymdAGELVPDEIVIGLVKERLAQPDCKNGFLLDGFPRTIPQAEALDEMLKELGIK 106
PLN02674 PLN02674
adenylate kinase
 434-496 1.19e-05

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 48.73  E-value: 1.19e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958752555  434 SLSMRAQLGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEAL 496
Cdd:PLN02674    69 AVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKGFILDGFPRTVVQAQKLDEML 131
PRK14526 PRK14526
adenylate kinase; Provisional
 441-500 1.48e-04

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 44.84  E-value: 1.48e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958752555  441 LGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTGYK 500
Cdd:PRK14526    45 LGKEIKQIVENGQLVPDSITIKIVEDKINTIKNNDNFILDGFPRNINQAKALDKFLPNIK 104
PRK14528 PRK14528
adenylate kinase; Provisional
 441-496 1.49e-03

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 41.54  E-value: 1.49e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958752555  441 LGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEAL 496
Cdd:PRK14528    46 MGIEAKRYMDAGDLVPDSVVIGIIKDRIREADCKNGFLLDGFPRTVEQADALDALL 101
PRK14529 PRK14529
adenylate kinase; Provisional
 440-496 1.77e-03

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 41.63  E-value: 1.77e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958752555  440 QLGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNqSWVLDGFPMTVNQAKLLEEAL 496
Cdd:PRK14529    44 ELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKN-GWLLDGFPRNKVQAEKLWEAL 99
PRK13808 PRK13808
adenylate kinase; Provisional
 441-506 2.12e-03

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 42.18  E-value: 2.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958752555  441 LGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALtgyKRKSLQL 506
Cdd:PRK13808    45 VGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAANGFILDGFPRTVPQAEALDALL---KDKQLKL 107
AAA_17 pfam13207
AAA domain;
442-496 9.50e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 37.99  E-value: 9.50e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1958752555  442 GAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEAL 496
Cdd:pfam13207   39 LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGGVIVDGHPRIKTPAGYLPGLP 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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