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    TPR1 TOPLESS-related 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844388, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPR1
    Official Full Name
    TOPLESS-related 1
    Primary source
    TAIR:AT1G80490
    Locus tag
    AT1G80490
    See related
    Araport:AT1G80490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T21F11.18; T21F11_18; TOPLESS-related 1
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    Genomic context

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    See TPR1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Sequence:
    Chromosome: 1; NC_003070.9 (30260818..30267125, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Actin-like ATPase superfamily protein Neighboring gene F-box/RNI-like/FBD-like domains-containing protein Neighboring gene plastid transcriptionally active 17 Neighboring gene SNARE-like superfamily protein Neighboring gene Transmembrane amino acid transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity. Griebel T, et al. New Phytol, 2023 Aug. PMID 37306028
    2. SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis. Niu D, et al. Mol Plant, 2019 Feb 4. PMID 30543996
    3. Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor. Zhu Z, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20647385, Free PMC Article
    4. AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription. Nguyen NH, et al. Biochem Biophys Res Commun, 2018 Dec 9. PMID 30448055
    5. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis. Xie B, et al. New Phytol, 2024 Jan. PMID 37786257,

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
      Title: NUA positively regulates plant immunity by coordination with ESD4 to deSUMOylate TPR1 in Arabidopsis.
    2. Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity.
      Title: Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity.
    3. SIZ1-mediated SUMOylation of TPR1 represses plant immunity
      Title: SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis.
    4. AtMYB44 forms a complex with TPR corepressors and recruits histone deacetylase(s) to suppress PP2C gene transcription in a signal-independent manner.
      Title: AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription.
    5. GAF1 interacts with the corepressor TPR and that DELLAs and TPR act as coactivators and a corepressor of GAF1, respectively. Gibberellin (GA) converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLAs.
      Title: DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis.
    6. overexpression of TPR1 constitutively activates SNC1-mediated immune responses.
      Title: Arabidopsis resistance protein SNC1 activates immune responses through association with a transcriptional corepressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001334989.1
    NM_106697.5
    NM_179582.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within primary shoot apical meristem specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    TOPLESS-related 1
    NP_001319429.1
    • TOPLESS-related 1 (TPR1); INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: cytosol; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT1G15750.4); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_178164.3
    • TOPLESS-related 1 (TPR1); INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: cytosol; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT1G15750.4); Has 22237 Blast hits to 13013 proteins in 584 species: Archae - 42; Bacteria - 4724; Metazoa - 7551; Fungi - 4719; Plants - 2339; Viruses - 15; Other Eukaryotes - 2847 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      30260818..30267125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001334989.1 → NP_001319429.1  TOPLESS-related 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MR25, Q0WV90, Q9M8L7
      UniProtKB/TrEMBL
      A0A178W7I7, A0A5S9WW23
      Conserved Domains (6) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      PTZ00249
      Location:190 → 314
      PTZ00249; variable surface protein Vir28; Provisional
      cd00200
      Location:359 → 667
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:421 → 460
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:827 → 1082
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_106697.5 → NP_178164.3  TOPLESS-related 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178164.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W9I5
      Conserved Domains (6) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      COG2319
      Location:594 → 1052
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:358 → 666
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:420 → 459
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:826 → 1081
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_179582.2 → NP_849913.2  TOPLESS-related 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849913.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MR25, Q0WV90, Q9M8L7
      UniProtKB/TrEMBL
      A0A178W7I7, A0A5S9WW23
      Conserved Domains (6) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      PTZ00249
      Location:190 → 314
      PTZ00249; variable surface protein Vir28; Provisional
      cd00200
      Location:359 → 667
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:421 → 460
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:827 → 1082
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WV90.3

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