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Conserved domains on  [gi|145337810|ref|NP_178164|]
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TOPLESS-related 1 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-666 7.85e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  358 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 437
Cdd:cd00200    13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  438 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSICPHykE 517
Cdd:cd00200    73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  518 NIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 597
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  598 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 666
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
822-1034 2.97e-16

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  822 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 900
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  901 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ- 979
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145337810  980 LAIYETTKLECMKQWpvRESAAPITHATFSCDSQLIYTSFMDATICVFSSANLRL 1034
Cdd:COG2319   312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.82e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


:

Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.45  E-value: 1.82e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 145337810     34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.24e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.24e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 145337810      4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 200-359 1.56e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  200 VDHSCRLPNDARAPSPVNNPllgslpkAEGFPPLGAHGPFQPTPSPVPTPLAGWMSSPSSVPHPAVSGGPIALGAPsiqa 279
Cdd:PHA03247  244 ISHPLRGDIAAPAPPPVVGE-------GADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAP---- 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  280 lkhPRTPPSNSAVD-----------------------YPSGdsdhVSKRTRPMGISdevslgvnmlPMTFPGQAHGHNQT 336
Cdd:PHA03247  313 ---PDPPPPAPAGDaeeeddedgamevvsplprprqhYPLG----FPKRRRPTWTP----------PSSLEDLSAGRHHP 375

                         170       180
                  ....*....|....*....|...
gi 145337810  337 FKAPddLPKTVARTLSQGSSPMS 359
Cdd:PHA03247  376 KRAS--LPTRKRRSARHAATPFA 396
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-666 7.85e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  358 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 437
Cdd:cd00200    13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  438 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSICPHykE 517
Cdd:cd00200    73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  518 NIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 597
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  598 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 666
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
392-678 1.16e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 1.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  392 QKTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFSt 471
Cdd:COG2319    99 DGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---TLTGHSGAVTSVAFS- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  472 PNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPG 549
Cdd:COG2319   172 PDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfsP----DGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  550 RWCTTMAYSADGTRLFSCgtSKDGESFIveWNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLA-AGDDFSIKFWDMDTI 628
Cdd:COG2319   247 GSVRSVAFSPDGRLLASG--SADGTVRL--WDLATGELLRTLTG-HSGGVNSVAF-SPDGKLLAsGSDDGTVRLWDLATG 320

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 145337810  629 QLLTAIDADGGLQASprIRFNKEGSLLAVSANDNMIKVMaNSDGLRLLHT 678
Cdd:COG2319   321 KLLRTLTGHTGAVRS--VAFSPDGKTLASGSDDGTVRLW-DLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
822-1034 2.97e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  822 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 900
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  901 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ- 979
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145337810  980 LAIYETTKLECMKQWpvRESAAPITHATFSCDSQLIYTSFMDATICVFSSANLRL 1034
Cdd:COG2319   312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 826-1081 8.05e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 8.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  826 VPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLK 904
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  905 GHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQKSKVLQ-----------IPQGR--STSSLSDT-RV------- 963
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRghtdwvnsvafSPDGTfvASSSQDGTiKLwdlrtgk 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  964 -----QFHQDQVHFLVVHET-----------QLAIYETTKLECMKQwpVRESAAPITHATFSCDSQLIYTSFMDATICVF 1027
Cdd:cd00200   169 cvatlTGHTGEVNSVAFSPDgekllssssdgTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 145337810 1028 SSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPqESNMFAVGLSDGGVHIFE 1081
Cdd:cd00200   247 DLRTGECV----------QTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.82e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.45  E-value: 1.82e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 145337810     34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.24e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.24e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 145337810      4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 898-935 2.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.57e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 145337810    898 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 935
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 450-491 3.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.16e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 145337810    450 DMRQHLEIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 491
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFS-PDGKYLAS-GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
456-491 9.91e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 9.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145337810   456 EIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 491
Cdd:pfam00400    6 TLEGHTGSVTSLAFS-PDGKLLAS-GSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 200-359 1.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  200 VDHSCRLPNDARAPSPVNNPllgslpkAEGFPPLGAHGPFQPTPSPVPTPLAGWMSSPSSVPHPAVSGGPIALGAPsiqa 279
Cdd:PHA03247  244 ISHPLRGDIAAPAPPPVVGE-------GADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAP---- 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  280 lkhPRTPPSNSAVD-----------------------YPSGdsdhVSKRTRPMGISdevslgvnmlPMTFPGQAHGHNQT 336
Cdd:PHA03247  313 ---PDPPPPAPAGDaeeeddedgamevvsplprprqhYPLG----FPKRRRPTWTP----------PSSLEDLSAGRHHP 375

                         170       180
                  ....*....|....*....|...
gi 145337810  337 FKAPddLPKTVARTLSQGSSPMS 359
Cdd:PHA03247  376 KRAS--LPTRKRRSARHAATPFA 396
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.53e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 145337810     5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
PTZ00420 PTZ00420
coronin; Provisional
 870-958 2.66e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  870 LAFHPQDNNIIAIGMDDSTIQIYNVR-----VDEVKSK---LKGHSKRITGLAFsNVLN--VLVSSGADAQLCVWNTdgw 939
Cdd:PTZ00420   80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDW-NPMNyyIMCSSGFDSFVNIWDI--- 155

                          90
                  ....*....|....*....
gi 145337810  940 EKQKsKVLQIPQGRSTSSL 958
Cdd:PTZ00420  156 ENEK-RAFQINMPKKLSSL 173
WD40 pfam00400
WD domain, G-beta repeat;
898-935 3.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145337810   898 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 935
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 35-135 9.44e-03

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 37.94  E-value: 9.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810    35 FFNMKYFEDEVHNGNWDEVEKYL----SGFTKVDDNrysmkIFFEIRKQKYLEALDRHDRPKAVDIlVKdlKVFSTFNEE 110
Cdd:pfam10607    2 FKERNRILEAILNGDITEAIEWCnenkPELLKINSN-----LEFELRLQQFIELIRSGKILEALEY-AR--ENLAPFNEE 73

                           90       100
                   ....*....|....*....|....*
gi 145337810   111 LFKEITQLLTLENFRENEQLSKYGD 135
Cdd:pfam10607   74 HLKELEKLMGLLAFPDPTDSSPYKS 98
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 358-666 7.85e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 7.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  358 MSMDFHPIKQTLLlvgtnvgdiglweVGSRerlvQKTFKVWDLSKCSMPLQaalVKEPVVSVNRVIWSPDGSLFGVAYSR 437
Cdd:cd00200    13 TCVAFSPDGKLLA-------------TGSG----DGTIKVWDLETGELLRT---LKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  438 HIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSICPHykE 517
Cdd:cd00200    73 KTIRLWDLETGECVR---TLTGHTSYVSSVAFS-PDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--P 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  518 NIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTskDGESFIveWNESEGAVKRTYQGfHKR 597
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS--DGTIKL--WDLSTGKCLGTLRG-HEN 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  598 SLGVVQFDTTKNRYLAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 666
Cdd:cd00200   221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTS---LAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
392-678 1.16e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.65  E-value: 1.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  392 QKTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFSt 471
Cdd:COG2319    99 DGTVRLWDLAT---GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR---TLTGHSGAVTSVAFS- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  472 PNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPG 549
Cdd:COG2319   172 PDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfsP----DGKLLASGSADGTVRLWDLATGKLLRTLTGHS 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  550 RWCTTMAYSADGTRLFSCgtSKDGESFIveWNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLA-AGDDFSIKFWDMDTI 628
Cdd:COG2319   247 GSVRSVAFSPDGRLLASG--SADGTVRL--WDLATGELLRTLTG-HSGGVNSVAF-SPDGKLLAsGSDDGTVRLWDLATG 320

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 145337810  629 QLLTAIDADGGLQASprIRFNKEGSLLAVSANDNMIKVMaNSDGLRLLHT 678
Cdd:COG2319   321 KLLRTLTGHTGAVRS--VAFSPDGKTLASGSDDGTVRLW-DLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
330-666 1.16e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.79  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  330 AHGHNQTFKAPDDLPKTVARTLSQGSSPMSMDFHPIKQTLLLVGTNvGDIGLWEVGSRERLVQ----------------- 392
Cdd:COG2319    54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD-GTVRLWDLATGLLLRTltghtgavrsvafspdg 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  393 ---------KTFKVWDLSKcsmPLQAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGG 463
Cdd:COG2319   133 ktlasgsadGTVRLWDLAT---GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---TLTGHTGA 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  464 VNDIAFStPNKQLcVTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGS 541
Cdd:COG2319   207 VRSVAFS-PDGKL-LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAfsP----DGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  542 RVDYEAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIK 621
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLAS--GSDDGT--VRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 145337810  622 FWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 666
Cdd:COG2319   356 LWDLATGELLRTLTGhTGAVTS---VAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
408-680 3.86e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 3.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  408 QAALVKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRQhleIDAHVGGVNDIAFStPNKQLCVTTcGDDKTI 487
Cdd:COG2319    70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---LTGHTGAVRSVAFS-PDGKTLASG-SADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  488 KVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLF 565
Cdd:COG2319   145 RLWDLATGKLLRTLTGHSGAVTSVAfsP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  566 SCgtSKDGEsfIVEWNESEGAVKRTYQGFHKRSLGVVqFdTTKNRYLA-AGDDFSIKFWDMDTIQLLTAIDADGGLQASp 644
Cdd:COG2319   221 SG--SADGT--VRLWDLATGKLLRTLTGHSGSVRSVA-F-SPDGRLLAsGSADGTVRLWDLATGELLRTLTGHSGGVNS- 293

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 145337810  645 rIRFNKEGSLLAVSANDNMIKVMANSDGlRLLHTVE 680
Cdd:COG2319   294 -VAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
344-627 3.36e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 3.36e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  344 PKTVARTLSQGSSPMSMDFHPiKQTLLLVGTNVGDIGLWEVGSRERLVQ--------------------------KTFKV 397
Cdd:COG2319   110 GLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTltghsgavtsvafspdgkllasgsddGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  398 WDLSkcSMPLQAALvKEPVVSVNRVIWSPDGSLFGVAYSRHIVQLYSYHGGEDMRqhlEIDAHVGGVNDIAFStPNKQLc 477
Cdd:COG2319   189 WDLA--TGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFS-PDGRL- 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  478 VTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIC--PhykeNIQFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTM 555
Cdd:COG2319   261 LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAfsP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 145337810  556 AYSADGTRLFSCgtSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRYLAAGDDFSIKFWDMDT 627
Cdd:COG2319   337 AFSPDGKTLASG--SDDGT--VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 454-666 5.71e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 106.27  E-value: 5.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  454 HLEIDAHVGGVNDIAFSTPNKQLCvtTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSI--CPHYkeniQFIFSTALDGKI 531
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLA--TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSADG----TYLASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  532 KAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTSKDgesfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 611
Cdd:cd00200    76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT----IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 145337810  612 LAAGDDFSIKFWDMDTIQLLTAIDA-DGGLQAsprIRFNKEGSLLAVSANDNMIKV 666
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCVATLTGhTGEVNS---VAFSPDGEKLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
452-940 2.90e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 2.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  452 RQHLEIDAHVGGVNDIAFSTPNKQLcvTTCGDDKTIKVWDAATGVKRYTFEGHEAPVYSIcpHYKENIQFIFSTALDGKI 531
Cdd:COG2319    27 ALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV--AFSPDGRLLASASADGTV 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  532 KAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFScgTSKDGEsfIVEWNESEGAVKRTYQGfHKRSLGVVQFDTTKNRY 611
Cdd:COG2319   103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLAS--GSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLL 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  612 LAAGDDFSIKFWDMDTIQLLTAIDADGGLQASprIRFNKEGSLLAVSANDNMIKVmansdglrllhtvenlssesskpai 691
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPDGKLLASGSADGTVRL------------------------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  692 nsipmverpasvvsipgmngdsrnmvdvkpviteesndkskvWKLtevgepsqcrslrlpenmrvtkisrliftnsgnai 771
Cdd:COG2319   231 ------------------------------------------WDL----------------------------------- 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  772 lalasnaihllwkwqrndrnATGKATASLPPQQWqpasgilmtndvaetnpeeAVPCFALSKNDSYVMSASG-GKISLFN 850
Cdd:COG2319   234 --------------------ATGKLLRTLTGHSG-------------------SVRSVAFSPDGRLLASGSAdGTVRLWD 274

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  851 MMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQ 930
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                         490
                  ....*....|
gi 145337810  931 LCVWNTDGWE 940
Cdd:COG2319   354 VRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 500-935 3.81e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 3.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  500 TFEGHEAPVYSICPHYKENiqFIFSTALDGKIKAWLYDNMGSRVDYEAPGRWCTTMAYSADGTRLFSCGTSKdgesFIVE 579
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK----TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  580 WNESEGAVKRTYQGfHKRSLGVVQFdTTKNRYLAA-GDDFSIKFWDMDTIQLLTAIDadgGLQASPR-IRFNKEGSLLAV 657
Cdd:cd00200    78 WDLETGECVRTLTG-HTSYVSSVAF-SPDGRILSSsSRDKTIKVWDVETGKCLTTLR---GHTDWVNsVAFSPDGTFVAS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  658 SANDNMIKVmANSDGLRLLHTvenlssesskpainsipmverpasvvsIPGMNGDsrnmvdvkpviteesndkskvwklt 737
Cdd:cd00200   153 SSQDGTIKL-WDLRTGKCVAT---------------------------LTGHTGE------------------------- 179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  738 evgepsqcrslrlpenmrvtkISRLIFTNSGNAILAlasnaihllwkwqrndrnatgkataslppqqwqpasgilmtndv 817
Cdd:cd00200   180 ---------------------VNSVAFSPDGEKLLS-------------------------------------------- 194

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  818 aetnpeeavpcfalskndsyvmSASGGKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVD 897
Cdd:cd00200   195 ----------------------SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTG 251

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 145337810  898 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 935
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
822-1034 2.97e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  822 PEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVK 900
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLL 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  901 SKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ- 979
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL--RTLTGHSGGVNS------VAFSPDGKLLASGSDDGt 311

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145337810  980 LAIYETTKLECMKQWpvRESAAPITHATFSCDSQLIYTSFMDATICVFSSANLRL 1034
Cdd:COG2319   312 VRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 826-1081 8.05e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 8.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  826 VPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLK 904
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  905 GHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQKSKVLQ-----------IPQGR--STSSLSDT-RV------- 963
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRghtdwvnsvafSPDGTfvASSSQDGTiKLwdlrtgk 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  964 -----QFHQDQVHFLVVHET-----------QLAIYETTKLECMKQwpVRESAAPITHATFSCDSQLIYTSFMDATICVF 1027
Cdd:cd00200   169 cvatlTGHTGEVNSVAFSPDgekllssssdgTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 145337810 1028 SSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPqESNMFAVGLSDGGVHIFE 1081
Cdd:cd00200   247 DLRTGECV----------QTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
CTLH smart00668
C-terminal to LisH motif; Alpha-helical motif of unknown function.
 34-92 1.82e-15

C-terminal to LisH motif; Alpha-helical motif of unknown function.


Pssm-ID: 128914  Cd Length: 58  Bit Score: 71.45  E-value: 1.82e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 145337810     34 FFFNMKYFEDEVHNGNWDEVEKYLSGFTKVDDNRYSmKIFFEIRKQKYLEALDRHDRPK 92
Cdd:smart00668    1 EFDERKRIRELILKGDWDEALEWLSSLKPPLLERNS-KLEFELRKQKFLELVRQGKLEE 58
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 758-1028 2.20e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 2.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  758 KISRLIFTNSGNAILALASNAIHLLWKWQRNDRNATGK------ATASLPPQQWQPASG---------ILMTNDVAET-- 820
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKghtgpvRDVAASADGTYLASGssdktirlwDLETGECVRTlt 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  821 NPEEAVPCFALSKNDSYVMSASG-GKISLFNMMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEV 899
Cdd:cd00200    91 GHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKC 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  900 KSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTDgwEKQKSKVLQIPQGRSTSslsdtrVQFHQDQVHFLVVHETQ 979
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNS------VAFSPDGYLLASGSEDG 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 145337810  980 -LAIYETTKLECMKQwpVRESAAPITHATFSCDSQLIYTSFMDATICVFS 1028
Cdd:cd00200   242 tIRVWDLRTGECVQT--LSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
772-1115 9.91e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 9.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  772 LALASNAIHLLWKWQRNDRNATGKATASLPPQQWQPASGILMTNDVAETNPEEAVPCFALSKNDSYVMSASG-GKISLFN 850
Cdd:COG2319    27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWD 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  851 MMTFKTMATFMPPPPAATFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQ 930
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  931 LCVWNTDGWEKQksKVLQIPQGRSTSslsdtrVQFHQDQvHFLVV--HETQLAIYETTKLECMKQWPVRESaaPITHATF 1008
Cdd:COG2319   186 VRLWDLATGKLL--RTLTGHTGAVRS------VAFSPDG-KLLASgsADGTVRLWDLATGKLLRTLTGHSG--SVRSVAF 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810 1009 SCDSQLIYTSFMDATICVFSSANLRLRcrvnpsaylpASLSNSNVHPLVIAAHPqESNMFAVGLSDGGVHIFEPleSEGK 1088
Cdd:COG2319   255 SPDGRLLASGSADGTVRLWDLATGELL----------RTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL--ATGK 321

                         330       340       350
                  ....*....|....*....|....*....|
gi 145337810 1089 WGVAPPPENGSASAVTATPSvG---ASASD 1115
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPD-GktlASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 868-1089 2.09e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  868 TFLAFHPqDNNIIAIGMDDSTIQIYNVRVDEVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWNTdgwekQKSKVL 947
Cdd:cd00200    13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-----ETGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  948 QIPQGrSTSSLSDtrVQFHQDQvHFLVV--HETQLAIYETTKLECMKQWPVREsaAPITHATFSCDSQLIYTSFMDATIC 1025
Cdd:cd00200    87 RTLTG-HTSYVSS--VAFSPDG-RILSSssRDKTIKVWDVETGKCLTTLRGHT--DWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145337810 1026 VFSSANLRLRcrvnpsaylpASLS--NSNVHplVIAAHPQESNMFAVGlSDGGVHIFEPleSEGKW 1089
Cdd:cd00200   161 LWDLRTGKCV----------ATLTghTGEVN--SVAFSPDGEKLLSSS-SDGTIKLWDL--STGKC 211
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 4-34 9.24e-06

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 43.19  E-value: 9.24e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 145337810      4 LSRELVFLILQFLDEEKFKETVHKLEQESGF 34
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGL 32
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 898-935 2.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.57e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 145337810    898 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 935
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 450-491 3.16e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 3.16e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 145337810    450 DMRQHLEIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 491
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFS-PDGKYLAS-GSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
456-491 9.91e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 9.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145337810   456 EIDAHVGGVNDIAFStPNKQLCVTtCGDDKTIKVWD 491
Cdd:pfam00400    6 TLEGHTGSVTSLAFS-PDGKLLAS-GSDDGTVKVWD 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 200-359 1.56e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  200 VDHSCRLPNDARAPSPVNNPllgslpkAEGFPPLGAHGPFQPTPSPVPTPLAGWMSSPSSVPHPAVSGGPIALGAPsiqa 279
Cdd:PHA03247  244 ISHPLRGDIAAPAPPPVVGE-------GADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAP---- 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  280 lkhPRTPPSNSAVD-----------------------YPSGdsdhVSKRTRPMGISdevslgvnmlPMTFPGQAHGHNQT 336
Cdd:PHA03247  313 ---PDPPPPAPAGDaeeeddedgamevvsplprprqhYPLG----FPKRRRPTWTP----------PSSLEDLSAGRHHP 375

                         170       180
                  ....*....|....*....|...
gi 145337810  337 FKAPddLPKTVARTLSQGSSPMS 359
Cdd:PHA03247  376 KRAS--LPTRKRRSARHAATPFA 396
LisH_TPL pfam17814
LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal ...
 5-33 2.53e-04

LisH-like dimerization domain; TOPLESS (TPL) proteins have a highly conserved N-terminal domain containing a lissencephaly homologous (LisH) dimerization motif.


Pssm-ID: 375350  Cd Length: 30  Bit Score: 39.30  E-value: 2.53e-04
                           10        20
                   ....*....|....*....|....*....
gi 145337810     5 SRELVFLILQFLDEEKFKETVHKLEQESG 33
Cdd:pfam17814    1 SQDVVRLILQFLKENGLHRTLQALQTESG 29
PTZ00420 PTZ00420
coronin; Provisional
 870-958 2.66e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810  870 LAFHPQDNNIIAIGMDDSTIQIYNVR-----VDEVKSK---LKGHSKRITGLAFsNVLN--VLVSSGADAQLCVWNTdgw 939
Cdd:PTZ00420   80 LQFNPCFSEILASGSEDLTIRVWEIPhndesVKEIKDPqciLKGHKKKISIIDW-NPMNyyIMCSSGFDSFVNIWDI--- 155

                          90
                  ....*....|....*....
gi 145337810  940 EKQKsKVLQIPQGRSTSSL 958
Cdd:PTZ00420  156 ENEK-RAFQINMPKKLSSL 173
WD40 pfam00400
WD domain, G-beta repeat;
898-935 3.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.04e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145337810   898 EVKSKLKGHSKRITGLAFSNVLNVLVSSGADAQLCVWN 935
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
495-534 3.39e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 145337810   495 GVKRYTFEGHEAPVYSICPHYKENiqFIFSTALDGKIKAW 534
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
CTLH pfam10607
CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in ...
 35-135 9.44e-03

CTLH/CRA C-terminal to LisH motif domain; RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.


Pssm-ID: 402305 [Multi-domain]  Cd Length: 143  Bit Score: 37.94  E-value: 9.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337810    35 FFNMKYFEDEVHNGNWDEVEKYL----SGFTKVDDNrysmkIFFEIRKQKYLEALDRHDRPKAVDIlVKdlKVFSTFNEE 110
Cdd:pfam10607    2 FKERNRILEAILNGDITEAIEWCnenkPELLKINSN-----LEFELRLQQFIELIRSGKILEALEY-AR--ENLAPFNEE 73

                           90       100
                   ....*....|....*....|....*
gi 145337810   111 LFKEITQLLTLENFRENEQLSKYGD 135
Cdd:pfam10607   74 HLKELEKLMGLLAFPDPTDSSPYKS 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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