Replication interactions
Interaction |
Pubs |
Knockdown of N-myristoyltransferase 1 (NMT1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Nef
|
nef
|
HIV-1 Nef is identified to have a physical interaction with N-myristoyltransferase 1 (NMT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses |
PubMed
|
|
nef
|
The N-terminal glycine of HIV-1 Nef is myristoylated by N-myristoyltransferase |
PubMed
|
|
nef
|
p65 N-myristoyltransferase isoform 1 coimmunoprecipitates with HIV-1 Nef in experiments using antibodies to Nef, and this interaction requires an intact myristoylation signal in Nef |
PubMed
|
matrix
|
gag
|
NMR studies of membrane binding-defective V7R and L8A HIV-1 Matrix mutants reveal minor structural changes that appear to be responsible for stabilizing the myristate-sequestered (myr(s)) species and inhibiting exposure |
PubMed
|
|
gag
|
HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding |
PubMed
|
Go to the HIV-1, Human Interaction Database