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    Tenm4 teneurin transmembrane protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 23966, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tenm4provided by MGI
    Official Full Name
    teneurin transmembrane protein 4provided by MGI
    Primary source
    MGI:MGI:2447063
    See related
    Ensembl:ENSMUSG00000048078 AllianceGenome:MGI:2447063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Doc4; ELM2; Odz4; l7Rn3; Ten-m4; l(7)-3Rn; mKIAA1302
    Summary
    Enables protein homodimerization activity. Involved in several processes, including central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in several cellular components, including neuron projection; nucleus; and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; future brain; somite; and upper leg. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 25.2), subcutaneous fat pad adult (RPKM 11.8) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tenm4 in Genome Data Viewer
    Location:
    7 E1; 7 52.53 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (95550262..96560300)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (96171244..96911093)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57510 Neighboring gene STARR-seq mESC enhancer starr_19553 Neighboring gene predicted gene, 39049 Neighboring gene STARR-seq mESC enhancer starr_19555 Neighboring gene frataxin pseudogene Neighboring gene STARR-seq mESC enhancer starr_19557 Neighboring gene STARR-seq mESC enhancer starr_19558 Neighboring gene STARR-seq mESC enhancer starr_19562 Neighboring gene STARR-seq mESC enhancer starr_19563 Neighboring gene STARR-seq mESC enhancer starr_19564 Neighboring gene STARR-seq mESC enhancer starr_19567 Neighboring gene predicted gene 8319 Neighboring gene STARR-seq mESC enhancer starr_19570 Neighboring gene microRNA 708 Neighboring gene microRNA 6394 Neighboring gene predicted gene 15412 Neighboring gene STARR-seq mESC enhancer starr_19572 Neighboring gene ribosomal protein S11, pseudogene 5 Neighboring gene VISTA enhancer mm2003 Neighboring gene STARR-seq mESC enhancer starr_19576 Neighboring gene STARR-seq mESC enhancer starr_19579 Neighboring gene STARR-seq mESC enhancer starr_19580 Neighboring gene predicted gene 15413 Neighboring gene STARR-seq mESC enhancer starr_19583 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104099810-104100111 Neighboring gene STARR-positive B cell enhancer mm9_chr7:104119017-104119317 Neighboring gene STARR-seq mESC enhancer starr_19585 Neighboring gene predicted gene, 22226 Neighboring gene asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (0 hits/59 screens)

    Associated conditions

    Description Tests
    lethal, Chr 7, Rinchik 3
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding  
    enables identical protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac cell fate specification PubMed 
    acts_upstream_of_or_within cardiac muscle cell proliferation PubMed 
    involved_in central nervous system myelin formation PubMed 
    involved_in central nervous system myelin formation  
    involved_in central nervous system myelin formation  
    acts_upstream_of_or_within gastrulation with mouth forming second PubMed 
    involved_in neuron development  
    involved_in neuron development  
    involved_in neuron development  
    involved_in positive regulation of gastrulation PubMed 
    involved_in positive regulation of myelination PubMed 
    involved_in positive regulation of oligodendrocyte differentiation PubMed 
    involved_in regulation of myelination  
    involved_in regulation of myelination  
    involved_in signal transduction  
    involved_in synaptic membrane adhesion PubMed 
    involved_in synaptic membrane adhesion PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in neuron projection  
    located_in neuron projection PubMed 
    located_in nucleus PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    teneurin-4
    Names
    downstream of CHOP4
    odd Oz/ten-m homolog 4
    protein Odd Oz/ten-m homolog 4
    ten-4
    tenascin-M4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310760.1NP_001297689.1  teneurin-4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC073599, AC162370, AK147579, BE980985
      Consensus CDS
      CCDS80753.1
      UniProtKB/Swiss-Prot
      Q3UHK6
      Related
      ENSMUSP00000102783.2, ENSMUST00000107165.8
      Conserved Domains (8) summary
      COG3209
      Location:16662362
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12961335
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24462525
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12861627
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:808850
      DSL; Delta serrate ligand
      pfam01500
      Location:691839
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:36402
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27492826
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    2. NM_001310762.1NP_001297691.1  teneurin-4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses a downstream start codon, and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC073599, AC116683, AC158136, AC162370, AK147579, BE980985
      Consensus CDS
      CCDS80754.1
      UniProtKB/Swiss-Prot
      Q3UHK6
      Related
      ENSMUSP00000102780.2, ENSMUST00000107162.8
      Conserved Domains (10) summary
      COG3209
      Location:17382494
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13331382
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:17321772
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:24382517
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:699847
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:703729
      EGF_2; EGF-like domain
      pfam15636
      Location:27432818
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:12851619
      NHL; NHL repeat unit of beta-propeller proteins
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    3. NM_011858.4NP_035988.2  teneurin-4 isoform 2

      See identical proteins and their annotated locations for NP_035988.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC162370, AK147329, BE980985
      Consensus CDS
      CCDS40024.1
      UniProtKB/Swiss-Prot
      Q3UHK6
      Related
      ENSMUSP00000102784.2, ENSMUST00000107166.8
      Conserved Domains (8) summary
      COG3209
      Location:16292325
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12591298
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24092488
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12491590
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36365
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27122789
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:593728
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:772813
      DSL; Delta serrate ligand

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      95550262..96560300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153061.1XP_036008954.1  teneurin-4 isoform X10

      Conserved Domains (8) summary
      COG3209
      Location:16992395
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13291368
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24792558
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13191660
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36435
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27822859
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:663798
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:842883
      DSL; Delta serrate ligand
    2. XM_006507806.4XP_006507869.1  teneurin-4 isoform X10

      See identical proteins and their annotated locations for XP_006507869.1

      Conserved Domains (8) summary
      COG3209
      Location:16992395
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13291368
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24792558
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13191660
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36435
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27822859
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:663798
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:842883
      DSL; Delta serrate ligand
    3. XM_030242548.1XP_030098408.1  teneurin-4 isoform X14

      Conserved Domains (8) summary
      COG3209
      Location:16292325
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12591298
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24092488
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12491590
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36365
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27122789
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:593728
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:772813
      DSL; Delta serrate ligand
    4. XM_036153067.1XP_036008960.1  teneurin-4 isoform X16

      Conserved Domains (8) summary
      COG3209
      Location:15962292
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12261265
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23762455
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12161557
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36332
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26792756
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:560695
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:739780
      DSL; Delta serrate ligand
    5. XM_036153070.1XP_036008963.1  teneurin-4 isoform X17

      Conserved Domains (7) summary
      COG3209
      Location:15872283
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12171256
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23672446
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12071548
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36332
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26702747
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:560821
      exchanger_TraA; outer membrane exchange protein TraA
    6. XM_006507804.2XP_006507867.1  teneurin-4 isoform X10

      See identical proteins and their annotated locations for XP_006507867.1

      Conserved Domains (8) summary
      COG3209
      Location:16992395
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13291368
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24792558
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13191660
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36435
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27822859
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:663798
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:842883
      DSL; Delta serrate ligand
    7. XM_030242546.1XP_030098406.1  teneurin-4 isoform X13

      Conserved Domains (8) summary
      COG3209
      Location:16662362
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12961335
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24462525
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12861627
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:808850
      DSL; Delta serrate ligand
      pfam01500
      Location:691839
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:36402
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27492826
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    8. XM_030242544.1XP_030098404.1  teneurin-4 isoform X11

      Conserved Domains (8) summary
      COG3209
      Location:16742370
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13041343
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542533
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12941635
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27572834
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:638773
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    9. XM_030242550.1XP_030098410.1  teneurin-4 isoform X15

      UniProtKB/Swiss-Prot
      O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
      Conserved Domains (8) summary
      COG3209
      Location:16042300
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12341273
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23842463
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12241565
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11340
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26872764
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:568703
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:747788
      DSL; Delta serrate ligand
    10. XM_030242545.1XP_030098405.1  teneurin-4 isoform X11

      Conserved Domains (8) summary
      COG3209
      Location:16742370
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13041343
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542533
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12941635
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27572834
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:638773
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    11. XM_030242551.1XP_030098411.1  teneurin-4 isoform X15

      UniProtKB/Swiss-Prot
      O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
      Conserved Domains (8) summary
      COG3209
      Location:16042300
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12341273
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23842463
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12241565
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11340
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26872764
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:568703
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:747788
      DSL; Delta serrate ligand
    12. XM_036153062.1XP_036008955.1  teneurin-4 isoform X11

      Conserved Domains (8) summary
      COG3209
      Location:16742370
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13041343
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542533
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12941635
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27572834
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:638773
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    13. XM_036153066.1XP_036008959.1  teneurin-4 isoform X15

      UniProtKB/Swiss-Prot
      O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
      Conserved Domains (8) summary
      COG3209
      Location:16042300
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12341273
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23842463
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12241565
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11340
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26872764
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:568703
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:747788
      DSL; Delta serrate ligand
    14. XM_036153052.1XP_036008945.1  teneurin-4 isoform X1

      Conserved Domains (8) summary
      COG3209
      Location:18172513
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14471486
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25972676
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:14371778
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154553
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:29002977
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:781916
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:9601001
      DSL; Delta serrate ligand
    15. XM_036153053.1XP_036008946.1  teneurin-4 isoform X2

      Conserved Domains (8) summary
      COG3209
      Location:18102506
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14471475
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25902669
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:14371771
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154553
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28932970
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:781916
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:9601001
      DSL; Delta serrate ligand
    16. XM_036153054.1XP_036008947.1  teneurin-4 isoform X3

      Conserved Domains (7) summary
      COG3209
      Location:18082504
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14381477
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25882667
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:14281769
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154553
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28912968
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:7811042
      exchanger_TraA; outer membrane exchange protein TraA
    17. XM_036153055.1XP_036008948.1  teneurin-4 isoform X4

      Conserved Domains (7) summary
      COG3209
      Location:18012497
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14381466
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25812660
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:14281762
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154553
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28842961
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:7811042
      exchanger_TraA; outer membrane exchange protein TraA
    18. XM_036153056.1XP_036008949.1  teneurin-4 isoform X5

      Conserved Domains (8) summary
      COG3209
      Location:17842480
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14141453
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25642643
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:14041745
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154520
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28672944
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:748883
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:927968
      DSL; Delta serrate ligand
    19. XM_036153072.1XP_036008965.1  teneurin-4 isoform X21

      Conserved Domains (8) summary
      COG3209
      Location:17772473
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14141442
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25572636
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:14041738
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154520
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28602937
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:748883
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:927968
      DSL; Delta serrate ligand
    20. XM_036153057.1XP_036008950.1  teneurin-4 isoform X6

      Conserved Domains (7) summary
      COG3209
      Location:17752471
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:14051444
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25552634
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13951736
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154520
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28582935
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:7481009
      exchanger_TraA; outer membrane exchange protein TraA
    21. XM_036153058.1XP_036008951.1  teneurin-4 isoform X7

      Conserved Domains (8) summary
      COG3209
      Location:17472443
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13771416
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25272606
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13671708
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154483
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28302907
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:711846
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:890931
      DSL; Delta serrate ligand
    22. XM_036153059.1XP_036008952.1  teneurin-4 isoform X9

      Conserved Domains (8) summary
      COG3209
      Location:17142410
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13441383
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24942573
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13341675
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:154450
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27972874
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:678813
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:857898
      DSL; Delta serrate ligand
    23. XM_030242552.1XP_030098412.1  teneurin-4 isoform X18

      Conserved Domains (8) summary
      COG3209
      Location:15712267
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12011240
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23512430
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11911532
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26542731
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:535670
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:714755
      DSL; Delta serrate ligand
    24. XM_006507805.3XP_006507868.1  teneurin-4 isoform X10

      See identical proteins and their annotated locations for XP_006507868.1

      Conserved Domains (8) summary
      COG3209
      Location:16992395
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13291368
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24792558
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13191660
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36435
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27822859
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:663798
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:842883
      DSL; Delta serrate ligand
    25. XM_030242549.2XP_030098409.1  teneurin-4 isoform X14

      Conserved Domains (8) summary
      COG3209
      Location:16292325
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12591298
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24092488
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12491590
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36365
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27122789
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:593728
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:772813
      DSL; Delta serrate ligand
    26. XM_036153060.1XP_036008953.1  teneurin-4 isoform X10

      Conserved Domains (8) summary
      COG3209
      Location:16992395
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13291368
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24792558
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13191660
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36435
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27822859
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:663798
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:842883
      DSL; Delta serrate ligand
    27. XM_036153069.1XP_036008962.1  teneurin-4 isoform X16

      Conserved Domains (8) summary
      COG3209
      Location:15962292
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12261265
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23762455
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12161557
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36332
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26792756
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:560695
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:739780
      DSL; Delta serrate ligand
    28. XM_006507807.5XP_006507870.1  teneurin-4 isoform X11

      See identical proteins and their annotated locations for XP_006507870.1

      Conserved Domains (8) summary
      COG3209
      Location:16742370
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13041343
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542533
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12941635
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27572834
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:638773
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    29. XM_036153065.1XP_036008958.1  teneurin-4 isoform X15

      UniProtKB/Swiss-Prot
      O70465, Q3TSI0, Q3UH52, Q3UHK6, Q80TF5, Q9WTS7
      Conserved Domains (8) summary
      COG3209
      Location:16042300
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12341273
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23842463
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12241565
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11340
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26872764
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:568703
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:747788
      DSL; Delta serrate ligand
    30. XM_036153071.1XP_036008964.1  teneurin-4 isoform X18

      Conserved Domains (8) summary
      COG3209
      Location:15712267
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12011240
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23512430
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:11911532
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11307
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26542731
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:535670
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:714755
      DSL; Delta serrate ligand
    31. XM_006507803.5XP_006507866.1  teneurin-4 isoform X10

      See identical proteins and their annotated locations for XP_006507866.1

      Conserved Domains (8) summary
      COG3209
      Location:16992395
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13291368
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24792558
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13191660
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36435
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27822859
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:663798
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:842883
      DSL; Delta serrate ligand
    32. XM_036153064.1XP_036008957.1  teneurin-4 isoform X14

      Conserved Domains (8) summary
      COG3209
      Location:16292325
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12591298
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24092488
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12491590
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36365
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27122789
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:593728
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:772813
      DSL; Delta serrate ligand
    33. XM_036153068.1XP_036008961.1  teneurin-4 isoform X16

      Conserved Domains (8) summary
      COG3209
      Location:15962292
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12261265
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:23762455
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12161557
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:36332
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:26792756
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:560695
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:739780
      DSL; Delta serrate ligand
    34. XM_006507808.5XP_006507871.1  teneurin-4 isoform X11

      See identical proteins and their annotated locations for XP_006507871.1

      Conserved Domains (8) summary
      COG3209
      Location:16742370
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13041343
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542533
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12941635
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27572834
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:638773
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    35. XM_006507801.5XP_006507864.1  teneurin-4 isoform X8

      Conserved Domains (8) summary
      COG3209
      Location:17402436
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13701409
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:25202599
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:13601701
      NHL; NHL repeat unit of beta-propeller proteins
      pfam01414
      Location:882924
      DSL; Delta serrate ligand
      pfam01500
      Location:765913
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam06484
      Location:77476
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:28232900
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    36. XM_036153063.1XP_036008956.1  teneurin-4 isoform X12

      Conserved Domains (8) summary
      COG3209
      Location:16702366
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13001339
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24502529
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12901631
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:77406
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27532830
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:634769
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:813854
      DSL; Delta serrate ligand
    37. XM_011241793.1XP_011240095.1  teneurin-4 isoform X11

      See identical proteins and their annotated locations for XP_011240095.1

      Conserved Domains (8) summary
      COG3209
      Location:16742370
      RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:13041343
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:24542533
      Rhs_assc_core; RHS repeat-associated core domain
      cl18310
      Location:12941635
      NHL; NHL repeat unit of beta-propeller proteins
      pfam06484
      Location:11410
      Ten_N; Teneurin Intracellular Region
      pfam15636
      Location:27572834
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      NF033759
      Location:638773
      exchanger_TraA; outer membrane exchange protein TraA
      cl19567
      Location:817858
      DSL; Delta serrate ligand
    38. XM_006507812.5XP_006507875.1  teneurin-4 isoform X19

      Conserved Domains (7) summary
      COG3209
      Location:8521548
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:5180
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:482521
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:16321711
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:1036
      EGF_2; EGF-like domain
      cl18310
      Location:472813
      NHL; NHL repeat unit of beta-propeller proteins
      pfam15636
      Location:19352012
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    39. XM_006507813.5XP_006507876.1  teneurin-4 isoform X20

      Conserved Domains (7) summary
      COG3209
      Location:8431539
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd00054
      Location:4271
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd05819
      Location:473512
      NHL; NHL repeat [structural motif]
      TIGR03696
      Location:16231702
      Rhs_assc_core; RHS repeat-associated core domain
      pfam07974
      Location:1036
      EGF_2; EGF-like domain
      cl18310
      Location:463804
      NHL; NHL repeat unit of beta-propeller proteins
      pfam15636
      Location:19262003
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
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