|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
36-332 |
3.25e-155 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 485.63 E-value: 3.25e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 36 SLT-RRRDAERRYTSSSADSEEGKGP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGTNFTLRELGLGEM 113
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 114 TPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETD--- 190
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNeng 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 191 ---HPSS----------------------------------------------------------------LQNHPRLRT 203
Cdd:pfam06484 161 ppiPPSSsssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppnFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 204 PPPPLPHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPagSAQEPTHAQDNWLLNSNIPLETRHFLFKPG- 282
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQ--STQESVQLQDSWVLNSNVPLETRHFLFKTGt 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1907180993 283 GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFSRPAFNLKKPSKYCNWK 332
Cdd:pfam06484 318 GTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1216-1557 |
2.62e-47 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 173.49 E-value: 2.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1216 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYY----LATDPmSGA 1285
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1286 VFLSDTNSRRVFKVKSTTVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1363
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1364 RRVDQNGIISTLLGsndlTSARPLSCDSVMeiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1441
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1442 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1521
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 1907180993 1522 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1557
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2679-2756 |
3.13e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.43 E-value: 3.13e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180993 2679 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 2756
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1590-2455 |
1.49e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1590 LYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALRSVTTQGHELAMMTY 1669
Cdd:COG3209 191 LATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGAS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1670 HGNSGLLATKSNENGW--TTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQ 1747
Cdd:COG3209 271 GAGLDASTGTGGAGGSnaAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1748 DQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRV 1827
Cdd:COG3209 351 GGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGG 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1828 HNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRI 1907
Cdd:COG3209 431 TATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTT 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1908 TSRIFADgkmWSYTYLEKSMVLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFT 1987
Cdd:COG3209 511 TTTAGAR---GLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGG 587
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1988 EDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTVNLQNEGFTCTIRYRQIGPLIDRQIFRFTE 2067
Cdd:COG3209 588 TATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGT 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2068 EGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKE 2147
Cdd:COG3209 668 GVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2148 VQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSAR 2227
Cdd:COG3209 747 TSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGG 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2228 LTPL-----RYDLRDRITRLgdvqykmdEDGFLRQRGGDVFEYNSAGLLIKAynRASGWSVRYRYDGLGRRVSSKSSHSH 2302
Cdd:COG3209 826 GTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSA--TDPGTTESYTYDANGNLTSRTDGGTT 895
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2303 HLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYTAYGEI 2382
Cdd:COG3209 896 TYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNL 954
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180993 2383 YMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 2455
Cdd:COG3209 955 LAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2376-2455 |
2.83e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 58.67 E-value: 2.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2376 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNN 2449
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 1907180993 2450 NPISNS 2455
Cdd:TIGR03696 67 NPVNWV 72
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1874-2292 |
3.26e-09 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 62.71 E-value: 3.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1874 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRITSRIFADGKMWSYTyleksmvLHLHSqrqyifefdknDR 1946
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYS-------LNVVS-----------GD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1947 LSSVTMPNVarqtletiRSVGYYRNiyqppegnasviqdfteDGHLLHTFYLGTGRRVIYKYGKLSKL-AETLYDTTKVS 2025
Cdd:NF041261 461 ITDITTPDG--------RETKFYYN-----------------DGNQLTSVTSPDGLESRREYDEPGRLvSETSRSGETTR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2026 FTYDETAGMLKTVNLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR-Y 2104
Cdd:NF041261 516 YRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYRrY 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2105 DD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKKEL 2175
Cdd:NF041261 584 DNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTLTN 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2176 KvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYKMD 2250
Cdd:NF041261 657 E-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQYD 729
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1907180993 2251 EDGFLRQrggdvFEYNSAGLLIkaynrasgwSVRYRYDGLGR 2292
Cdd:NF041261 730 EHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1226-1557 |
3.63e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.42 E-value: 3.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1226 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilEMRNKDFRHSHSpahkyyLATDPmSGAVFLSDTNSRRVFKVKST 1302
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIDPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1303 TvvkdlvKNSEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRVD-QNGIISTLLGsn 1379
Cdd:COG4257 89 T------GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1380 DLTSARplscdsvmeisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAIHA 1459
Cdd:COG4257 141 PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1460 TLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLAVC 1539
Cdd:COG4257 186 PGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVAVD 239
|
330
....*....|....*...
gi 1907180993 1540 ADGELYVADLGNIRIRFI 1557
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2102-2438 |
2.43e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 53.47 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2102 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2163
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2164 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2234
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2235 lrDRITRLGDVqyKMDEDGFLRQrggdvFEYNSAGLLIkAYNRASGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2314
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2315 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2394
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180993 2395 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWKRLSSNSI 2438
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1261-1561 |
1.03e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.39 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1261 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDTNSRRVfkvksttVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1334
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1335 kateATLTNPRGITVDKFGLIYFVDGT---MIRRVD-QNGIISTLLGS----NDLTSARPLScdsvmeiSQVrLEWPTDL 1406
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1407 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1454
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1455 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1506
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1907180993 1507 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1561
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
740-783 |
5.04e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 42.61 E-value: 5.04e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907180993 740 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 783
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1674-1706 |
5.91e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.91e-04
10 20 30
....*....|....*....|....*....|...
gi 1907180993 1674 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1706
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
621-769 |
1.30e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 621 TNQCIDVACSSHGTCimGTCICNPGYKGESCEEVDCMDPTCS----SRGVCVRGECHCSVgwgGTNCETPraTCLDQCS- 695
Cdd:pfam01500 6 TSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCqpttFQSSCCRPTCQPCC---QTSCCQP--TCCQTSSc 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 696 -------GHGTfLPDTGLCNCDPSWTGHDCSIEICAADCGGHGVCVGGTCrCEDGWMGAACdqraCHPRCAEHGTCRDGK 768
Cdd:pfam01500 79 qtgcggiGYGQ-EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC-CQLHHAQASC----CRPSYCGQSCCRPAC 152
|
.
gi 1907180993 769 C 769
Cdd:pfam01500 153 C 153
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1467-1653 |
1.62e-03 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 43.02 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1467 LAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCADGELYV 1546
Cdd:cd14957 23 IAVDSAGNIYVADTGN---NRIQVFTSSGVYSYSIG----------------SGGTG---SGQFNSPYGIAVDSNGNIYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1547 ADLGNIRIRfirknkpFLNTQNMYElsspidqelYLFDTSGkhlytQSLPTGDYLYNFTYTGDGDItHITDNNGNMVNVr 1626
Cdd:cd14957 81 ADTDNNRIQ-------VFNSSGVYQ---------YSIGTGG-----SGDGQFNGPYGIAVDSNGNI-YVADTGNHRIQV- 137
|
170 180
....*....|....*....|....*..
gi 1907180993 1627 RDSTGmplwlvvpdgqVYWVTMGTNSA 1653
Cdd:cd14957 138 FTSSG-----------TFSYSIGSGGT 153
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
629-652 |
3.89e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.89e-03
10 20
....*....|....*....|....*...
gi 1907180993 629 CSSHGTCIMG----TCICNPGYKGESCE 652
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
36-332 |
3.25e-155 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 485.63 E-value: 3.25e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 36 SLT-RRRDAERRYTSSSADSEEGKGP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGTNFTLRELGLGEM 113
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 114 TPPHGTLYRTDIGLPHCGYSMGASSDADLEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENTETD--- 190
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNeng 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 191 ---HPSS----------------------------------------------------------------LQNHPRLRT 203
Cdd:pfam06484 161 ppiPPSSsssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapseqppnFQNHSRLRT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 204 PPPPLPHAHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPagSAQEPTHAQDNWLLNSNIPLETRHFLFKPG- 282
Cdd:pfam06484 241 PPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQ--STQESVQLQDSWVLNSNVPLETRHFLFKTGt 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1907180993 283 GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFSRPAFNLKKPSKYCNWK 332
Cdd:pfam06484 318 GTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1216-1557 |
2.62e-47 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 173.49 E-value: 2.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1216 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHKYY----LATDPmSGA 1285
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1286 VFLSDTNSRRVFKVKSTTVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1363
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1364 RRVDQNGIISTLLGsndlTSARPLSCDSVMeiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1441
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1442 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1521
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 1907180993 1522 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1557
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2679-2756 |
3.13e-37 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 135.43 E-value: 3.13e-37
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180993 2679 EEKVRVLELARQRAVRQAWAREQQRLREGEEGLRAWTDGEKQQVLNTGRVQGYDGFFVTSVEQYPELSDSANNIHFMR 2756
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1590-2455 |
1.49e-33 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 142.59 E-value: 1.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1590 LYTQSLPTGDYLYNFTYTGDGDITHITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALRSVTTQGHELAMMTY 1669
Cdd:COG3209 191 LATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTGAS 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1670 HGNSGLLATKSNENGW--TTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAFYTLLQ 1747
Cdd:COG3209 271 GAGLDASTGTGGAGGSnaAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTTVG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1748 DQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFGRRLRV 1827
Cdd:COG3209 351 GGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTAGG 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1828 HNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSLWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYDQAGRI 1907
Cdd:COG3209 431 TATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGGTT 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1908 TSRIFADgkmWSYTYLEKSMVLHLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASVIQDFT 1987
Cdd:COG3209 511 TTTAGAR---GLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGG 587
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1988 EDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTVNLQNEGFTCTIRYRQIGPLIDRQIFRFTE 2067
Cdd:COG3209 588 TATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGTGT 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2068 EGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAYGRMKE 2147
Cdd:COG3209 668 GVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2148 VQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSPGNSAR 2227
Cdd:COG3209 747 TSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSGG 825
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2228 LTPL-----RYDLRDRITRLgdvqykmdEDGFLRQRGGDVFEYNSAGLLIKAynRASGWSVRYRYDGLGRRVSSKSSHSH 2302
Cdd:COG3209 826 GTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSA--TDPGTTESYTYDANGNLTSRTDGGTT 895
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2303 HLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYTAYGEI 2382
Cdd:COG3209 896 TYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGNL 954
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180993 2383 YMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnSIVP---FHLYMFKNNNPISNS 2455
Cdd:COG3209 955 LAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD----------PIGLaggLNLYAYVGNNPVNYV 1020
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1221-1557 |
5.17e-19 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 89.69 E-value: 5.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1221 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPAHkyyLATDPmSGAVFLSDTNSRRVFK 1298
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1299 VKSTTVVKDlvknseVVAGTGDQCLPFDdtrcgdggkateatltNPRGITVDKFGLIYFVDgTM---IRRVDQNGIISTL 1375
Cdd:cd05819 81 FDPDGNFLA------SFGGSGDGDGEFN----------------GPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1376 LGSNDLTSARplscdsvmeisqvrLEWPTDLAINPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGiDHFLL--- 1452
Cdd:cd05819 138 FGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFD--------PD-GNFLTtfg 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1453 SKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfsgdDGYAKDAKLNT 1532
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNG-------------------NFLGSDGQFNR 244
|
330 340
....*....|....*....|....*
gi 1907180993 1533 PSSLAVCADGELYVADLGNIRIRFI 1557
Cdd:cd05819 245 PSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1341-1651 |
2.84e-17 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 84.29 E-value: 2.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1341 LTNPRGITVDKFGLIYFVDGTM--IRRVDQNGIISTLLGSNDltsarplscdsvmeISQVRLEWPTDLAINPmDNSLYVL 1418
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1419 D--NNVVLQISENHQVRIVAGRPmhcqvpGIDHFLLSkvaihatleSATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1496
Cdd:cd05819 72 DtgNHRIQKFDPDGNFLASFGGS------GDGDGEFN---------GPRGIAVDSSGNIYVADTGN---HRIQKFDPDGE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1497 ISLVAGAPSGCDckndancdcfsgddgyakdAKLNTPSSLAVCADGELYVADLGNIRIRFIrknkpflntqnmyelsSPI 1576
Cdd:cd05819 134 FLTTFGSGGSGP-------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVF----------------DPD 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1577 DQELYLFDTSGKHLYTQSLPTG------DYLYnFTYTGDGDITHITDN------NGNmVNVRRDSTGMPLWLVV-PDGQV 1643
Cdd:cd05819 179 GNFLTTFGSTGTGPGQFNYPTGiavdsdGNIY-VADSGNNRVQVFDPDgagfggNGN-FLGSDGQFNRPSGLAVdSDGNL 256
|
....*...
gi 1907180993 1644 YWVTMGTN 1651
Cdd:cd05819 257 YVADTGNN 264
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1213-1426 |
1.87e-14 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 77.19 E-value: 1.87e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1213 SCNGLADGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNilemrnkdfrhshspahkyylatdpmsgavflsd 1290
Cdd:cd14953 176 AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTT---------------------------------- 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1291 tnsrrvfkvksttvvkdlvknsevVAGTGDQclPFddtrcGDGGKATEATLTNPRGITVDKFGLIYFVD---GTmIRRVD 1367
Cdd:cd14953 222 ------------------------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAGNLYVADsgnHR-IRKIT 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907180993 1368 QNGIISTLLGSndlTSARPLSCDSVmeiSQVRLEWPTDLAINPmDNSLYVLD--NNVVLQI 1426
Cdd:cd14953 270 PAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1219-1488 |
1.83e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 73.12 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1219 DGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRHSHSPahkYYLATDPmSGAVFLSDTNSRRV 1296
Cdd:cd05819 50 GDGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGP---RGIAVDS-SGNIYVADTGNHRI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1297 FKVKSttvvkdlvkNSEVVAGTGdqclpfddtrcgdGGKATEATLTNPRGITVDKFGLIYFVDGT--MIRRVDQNGIIST 1374
Cdd:cd05819 126 QKFDP---------DGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGNFLT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1375 LLGSNDLTSArplscdsvmeisqvRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGrpmhcqvpgidhfll 1452
Cdd:cd05819 184 TFGSTGTGPG--------------QFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG--------------- 233
|
250 260 270
....*....|....*....|....*....|....*.
gi 1907180993 1453 SKVAIHATLESATALAVSHNGVLYIAETDEKKINRI 1488
Cdd:cd05819 234 NFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2376-2455 |
2.83e-10 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 58.67 E-value: 2.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2376 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwkrlssnsivPF------HLYMFKNN 2449
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 1907180993 2450 NPISNS 2455
Cdd:TIGR03696 67 NPVNWV 72
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1277-1554 |
1.46e-09 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 61.07 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1277 LATDPmSGAVFLSDTNSRRVFKVksttvvkdlvknsevVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLI 1355
Cdd:cd14952 15 VAVDA-AGNVYVADSGNNRVLKL---------------AAGSTTQTvLPFTG-------------LYQPQGVAVDAAGTV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1356 YFVDGtmirrvDQNGIISTLLGSNDLTsarPLSCDSvmeisqvrLEWPTDLAINPMDNsLYVLD--NNVVLqisenhqvR 1433
Cdd:cd14952 66 YVTDF------GNNRVLKLAAGSTTQT---VLPFTG--------LNDPTGVAVDAAGN-VYVADtgNNRVL--------K 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1434 IVAGRPMHCQVPgidhFllskvaihATLESATALAVSHNGVLYIAETDEkkiNRIRQvttsgeisLVAGA------Psgc 1507
Cdd:cd14952 120 LAAGSNTQTVLP----F--------TGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSttqtvlP--- 173
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1907180993 1508 dckndancdcFSGddgyakdakLNTPSSLAVCADGELYVADLGNIRI 1554
Cdd:cd14952 174 ----------FTG---------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1874-2292 |
3.26e-09 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 62.71 E-value: 3.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1874 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRITSRIFADGKMWSYTyleksmvLHLHSqrqyifefdknDR 1946
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYS-------LNVVS-----------GD 460
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1947 LSSVTMPNVarqtletiRSVGYYRNiyqppegnasviqdfteDGHLLHTFYLGTGRRVIYKYGKLSKL-AETLYDTTKVS 2025
Cdd:NF041261 461 ITDITTPDG--------RETKFYYN-----------------DGNQLTSVTSPDGLESRREYDEPGRLvSETSRSGETTR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2026 FTYDETAGMLKTVNLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR-Y 2104
Cdd:NF041261 516 YRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYRrY 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2105 DD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKKEL 2175
Cdd:NF041261 584 DNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTLTN 656
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2176 KvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYKMD 2250
Cdd:NF041261 657 E-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQYD 729
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1907180993 2251 EDGFLRQrggdvFEYNSAGLLIkaynrasgwSVRYRYDGLGR 2292
Cdd:NF041261 730 EHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1226-1557 |
3.63e-09 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 60.42 E-value: 3.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1226 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilEMRNKDFRHSHSpahkyyLATDPmSGAVFLSDTNSRRVFKVKST 1302
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIDPK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1303 TvvkdlvKNSEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRVD-QNGIISTLLGsn 1379
Cdd:COG4257 89 T------GEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1380 DLTSARplscdsvmeisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAIHA 1459
Cdd:COG4257 141 PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYALPT 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1460 TLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLAVC 1539
Cdd:COG4257 186 PGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVAVD 239
|
330
....*....|....*...
gi 1907180993 1540 ADGELYVADLGNIRIRFI 1557
Cdd:COG4257 240 GDGRVWFAESGANRIVRF 257
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1343-1554 |
7.40e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 53.44 E-value: 7.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1343 NPRGITVDKFGLIYFVD--GTMIRRVDQNGIISTLLGSndlTSARPLScdsvmeisqvrLEWPTDLAINPmDNSLYVLDn 1420
Cdd:cd14956 108 APRGVAVDADGNLYVADfgNQRIQKFDPDGSFLRQWGG---TGIEPGS-----------FNYPRGVAVDP-DGTLYVAD- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1421 nvvlqiSENHQVrivagrpmhcQVPGIDHFLLSKVAIHAT----LESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1496
Cdd:cd14956 172 ------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---NRIQKFTADGT 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180993 1497 ISLVAGAPSGcdckndancdcfsgddgyaKDAKLNTPSSLAVCADGELYVADLGNIRI 1554
Cdd:cd14956 233 FLTSWGSPGT-------------------GPGQFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2102-2438 |
2.43e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 53.47 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2102 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2163
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2164 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2234
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2235 lrDRITRLGDVqyKMDEDGFLRQrggdvFEYNSAGLLIkAYNRASGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2314
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 2315 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2394
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1907180993 2395 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWKRLSSNSI 2438
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1339-1557 |
4.16e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 51.17 E-value: 4.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1339 ATLTNPRGITVDKFGLIYFVD--GTMIRRVD-QNGIIStllgsndltsarplscdsvmEISQVRLEWPTDLAINPmDNSL 1415
Cdd:COG4257 14 APGSGPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFT--------------------EYPLGGGSGPHGIAVDP-DGNL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1416 YVLD--NNVVLQIS-ENHQVRIVAGrpmhcqvPGIDHFLlskvaihatlesaTALAVSHNGVLYIAETDekkINRIRQVT 1492
Cdd:COG4257 73 WFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNP-------------HGIAFDPDGNLWFTDQG---GNRIGRLD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1493 T-SGEISLV-----AGAPSGCDCKND---------ANC-DCFSGDDG----YAKDAKLNTPSSLAVCADGELYVADLGNI 1552
Cdd:COG4257 130 PaTGEVTEFplptgGAGPYGIAVDPDgnlwvtdfgANAiGRIDPDTGtlteYALPTPGAGPRGLAVDPDGNLWVADTGSG 209
|
....*
gi 1907180993 1553 RIRFI 1557
Cdd:COG4257 210 RIGRF 214
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1261-1561 |
1.03e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.39 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1261 RNKDFRHSHSPAhKY--YLATDPMSGAVFLSDTNSRRVfkvksttVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1334
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1335 kateATLTNPRGITVDKFGLIYFVDGT---MIRRVD-QNGIISTLLGS----NDLTSARPLScdsvmeiSQVrLEWPTDL 1406
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1407 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1454
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1455 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1506
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1907180993 1507 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1561
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1344-1651 |
2.25e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 48.80 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1344 PRGITVDKFGLIYFVD--GTMIRRVDQNGIISTLLGSNDltsarplscdsvmeISQVRLEWPTDLAINPMDNsLYVLDnn 1421
Cdd:cd14957 20 PRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVAD-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1422 vvlqiSENHQVRIvagrpmhcqvpgidhFLLSKVAIHA---------TLESATALAVSHNGVLYIAETDEkkiNRIrQVT 1492
Cdd:cd14957 83 -----TDNNRIQV---------------FNSSGVYQYSigtggsgdgQFNGPYGIAVDSNGNIYVADTGN---HRI-QVF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1493 TSgeislvAGAPsgcdckndancdCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRfirknkpflntqnmyel 1572
Cdd:cd14957 139 TS------SGTF------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ----------------- 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1573 sspidqelyLFDTSGKHLYT-QSLPTGDYLYNFTY----TGDGDItHITDNNGNMVNVrRDSTGmplwlvvpdgqVYWVT 1647
Cdd:cd14957 184 ---------VFTSSGTFQYTfGSSGSGPGQFSDPYgiavDSDGNI-YVADTGNHRIQV-FTSSG-----------AYQYS 241
|
....
gi 1907180993 1648 MGTN 1651
Cdd:cd14957 242 IGTS 245
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1333-1554 |
3.76e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 48.05 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1333 GGKATEA-TLTNPRGITVDKFGLIYFVDGT--MIRRVDQNGIISTLLGSNdltSARPLSCDSvmeisqvrlewPTDLAIN 1409
Cdd:cd14956 50 GTTGDGPgQFGRPRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSS---GSGPGQFNA-----------PRGVAVD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1410 PmDNSLYVLD--NNVVLQISENHQ-VRIVAGRPmhcQVPGidHFLlskvaihatleSATALAVSHNGVLYIAETdekKIN 1486
Cdd:cd14956 116 A-DGNLYVADfgNQRIQKFDPDGSfLRQWGGTG---IEPG--SFN-----------YPRGVAVDPDGTLYVADT---YND 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907180993 1487 RIRQVTTSGEISLVAGAPSGcdckndancdcFSGDdgyakdakLNTPSSLAVCADGELYVADLGNIRI 1554
Cdd:cd14956 176 RIQVFDNDGAFLRKWGGRGT-----------GPGQ--------FNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
740-783 |
5.04e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 42.61 E-value: 5.04e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1907180993 740 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 783
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1226-1367 |
5.50e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.71 E-value: 5.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1226 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILEMRNKDFRhshsPahkYYLATDPmSGAVFLSDTNSRRVFKVKSTT 1303
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFgaNAIGRIDPDTGTLTEYALPTPGAG----P---RGLAVDP-DGNLWVADTGSGRIGRFDPKT 218
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1304 vvkdlvknsevvagtgdqclpfddtrcgdgGKATEATLTN----PRGITVDKFGLIYFVDGT--MIRRVD 1367
Cdd:COG4257 219 ------------------------------GTVTEYPLPGggarPYGVAVDGDGRVWFAESGanRIVRFD 258
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1497-1557 |
5.96e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.91 E-value: 5.96e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907180993 1497 ISLVAGAPSGcdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1557
Cdd:cd14953 1 VSTVAGSGTA------------GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKI 49
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1670-1710 |
2.89e-04 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 40.65 E-value: 2.89e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1907180993 1670 HGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSF 1710
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1468-1558 |
3.27e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 45.65 E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1468 AVSHNGVLYIAETdekKINRIRQV-TTSGEISLVAGapsgcdckndancdcfSGDDGYA-KDAKLNTPSSLAVCADGELY 1545
Cdd:cd14951 202 AALPDGSVYVADT---YNHKIKRVdPATGEVSTLAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLY 262
|
90
....*....|...
gi 1907180993 1546 VADLGNIRIRFIR 1558
Cdd:cd14951 263 VADTNNHRIRRLD 275
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1674-1706 |
5.91e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.91e-04
10 20 30
....*....|....*....|....*....|...
gi 1907180993 1674 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1706
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1222-1480 |
1.27e-03 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.43 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1222 KLLAPVALTCGSDGSLYVGDFnYIRRI--F-PSGNVTNILEmRNKDFRHSHSPAHkyyLATDpmSGAVFLSDTNSRRVfk 1298
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKV-- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1299 vksttVVKDLvknsevvagTGDQCLPFddtrcGDGGKAtEATLTNPRGITVDKFGLIYFVDgTMIRRV---DQNG-IIST 1374
Cdd:cd14963 125 -----IVFDL---------EGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVAD-SGNGRIqvfDKNGkFIKE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1375 LLGSNDLTSArplscdsvmeisqvrLEWPTDLAINPmDNSLYVLDN--NVVLQISENHQVRIVAGRpmhcqvPGIDhfll 1452
Cdd:cd14963 184 LNGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD---- 237
|
250 260
....*....|....*....|....*...
gi 1907180993 1453 skvaiHATLESATALAVSHNGVLYIAET 1480
Cdd:cd14963 238 -----DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| Keratin_B2 |
pfam01500 |
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ... |
621-769 |
1.30e-03 |
|
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.
Pssm-ID: 366678 [Multi-domain] Cd Length: 161 Bit Score: 42.09 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 621 TNQCIDVACSSHGTCimGTCICNPGYKGESCEEVDCMDPTCS----SRGVCVRGECHCSVgwgGTNCETPraTCLDQCS- 695
Cdd:pfam01500 6 TSFCGFPTCSTGGTC--GSGCCQPCCCQSSCCRPSCCQTSCCqpttFQSSCCRPTCQPCC---QTSCCQP--TCCQTSSc 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 696 -------GHGTfLPDTGLCNCDPSWTGHDCSIEICAADCGGHGVCVGGTCrCEDGWMGAACdqraCHPRCAEHGTCRDGK 768
Cdd:pfam01500 79 qtgcggiGYGQ-EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTC-CQLHHAQASC----CRPSYCGQSCCRPAC 152
|
.
gi 1907180993 769 C 769
Cdd:pfam01500 153 C 153
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1467-1653 |
1.62e-03 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 43.02 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1467 LAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCADGELYV 1546
Cdd:cd14957 23 IAVDSAGNIYVADTGN---NRIQVFTSSGVYSYSIG----------------SGGTG---SGQFNSPYGIAVDSNGNIYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1547 ADLGNIRIRfirknkpFLNTQNMYElsspidqelYLFDTSGkhlytQSLPTGDYLYNFTYTGDGDItHITDNNGNMVNVr 1626
Cdd:cd14957 81 ADTDNNRIQ-------VFNSSGVYQ---------YSIGTGG-----SGDGQFNGPYGIAVDSNGNI-YVADTGNHRIQV- 137
|
170 180
....*....|....*....|....*..
gi 1907180993 1627 RDSTGmplwlvvpdgqVYWVTMGTNSA 1653
Cdd:cd14957 138 FTSSG-----------TFSYSIGSGGT 153
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1221-1305 |
1.86e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 42.70 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1221 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTNilemrnkdFRHSHSPAHKYYLATDPmSGAVFLSDTNSRRVF 1297
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
....*...
gi 1907180993 1298 KVKSTTVV 1305
Cdd:COG4257 256 RFDPDTEL 263
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1334-1436 |
3.50e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 42.18 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1334 GKATEATLTNPRGITVDKFGLIYFVDgTM---IRRVD-QNGIISTLLGSNDLTSArplscdsvmeISQVRLEWPTDLAIN 1409
Cdd:cd14951 188 GPGAEALLQHPLGVAALPDGSVYVAD-TYnhkIKRVDpATGEVSTLAGTGKAGYK----------DLEAQFSEPSGLVVD 256
|
90 100
....*....|....*....|....*..
gi 1907180993 1410 PmDNSLYVLDNNvvlqiseNHQVRIVA 1436
Cdd:cd14951 257 G-DGRLYVADTN-------NHRIRRLD 275
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
758-780 |
3.78e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.78e-03
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
629-652 |
3.89e-03 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 3.89e-03
10 20
....*....|....*....|....*...
gi 1907180993 629 CSSHGTCIMG----TCICNPGYKGESCE 652
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1226-1427 |
4.15e-03 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.42 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1226 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILemrnkDFRHSHSPahkYYLATDPmSGAVFLSDTNSRRVFKVkstt 1303
Cdd:cd14952 96 PTGVAVDAAGNVYVADTgnNRVLKLAAGSNTQTVL-----PFTGLSNP---DGVAVDG-AGNVYVTDTGNNRVLKL---- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907180993 1304 vvkdlvknsevVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLIYFVDGtmirrvDQNGIISTLLGSNDLT 1382
Cdd:cd14952 163 -----------AAGSTTQTvLPFTG-------------LNSPSGVAVDTAGNVYVTDH------GNNRVLKLAAGSTTPT 212
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1907180993 1383 sARPLScdsvmeisqvRLEWPTDLAINPmDNSLYVLD--NNVVLQIS 1427
Cdd:cd14952 213 -VLPFT----------GLNGPLGVAVDA-AGNVYVADrgNDRVVKLP 247
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
628-651 |
6.36e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.17 E-value: 6.36e-03
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
2265-2294 |
9.48e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.04 E-value: 9.48e-03
10 20 30
....*....|....*....|....*....|
gi 1907180993 2265 YNSAGLLIKAYNrASGWSVRYRYDGLGRRV 2294
Cdd:pfam05593 1 YDAAGRLTSVTD-PDGRVTTYTYDAAGRLT 29
|
|
| |
