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    Usp30 Ubiquitin specific protease 30 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31519, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp30provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 30provided by FlyBase
    Primary source
    FLYBASE:FBgn0029819
    Locus tag
    Dmel_CG3016
    See related
    AllianceGenome:FB:FBgn0029819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3016; Dmel\CG3016; dUSP30; Q9W462; USP30
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Involved in negative regulation of mitophagy. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and nucleus. Is expressed in adult head. Orthologous to human USP30 (ubiquitin specific peptidase 30). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp30 in Genome Data Viewer
    Location:
    5C5-5C6; 1-14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5877000..5879787, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5771033..5773820, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Glycosylphosphatidylinositol anchor attachment 1 Neighboring gene males absent on the first Neighboring gene long non-coding RNA:CR45668 Neighboring gene uncharacterized protein Neighboring gene Actin 5C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial dynamics and mitophagy in Parkinson's disease: A fly point of view. Von Stockum S, et al. Neurobiol Dis, 2016 Jun. PMID 26550693
    2. Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila. Cornelissen T, et al. Elife, 2018 May 29. PMID 29809156, Free PMC Article
    3. FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. Sanchez-Martinez A, et al. PLoS Biol, 2023 Aug. PMID 37535686, Free PMC Article
    4. Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction, oxidative stress, and motor phenotypes in C9orf72 ALS/FTD models. Au WH, et al. Life Sci Alliance, 2024 Sep. PMID 38906677, Free PMC Article
    5. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Bingol B, et al. Nature, 2014 Jun 19. PMID 24896179

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of mitophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K6-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 30
    Names
    CG3016-PA
    CG3016-PB
    Usp30-PA
    Usp30-PB
    ubiquitin specific peptidase 30
    NP_001284912.1
    NP_572274.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5877000..5879787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132046.3 → NP_572274.1  ubiquitin specific protease 30, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W462
      Related
      FBpp0070793
      Conserved Domains (3) summary
      cd02662
      Location:323 → 548
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:39 → 139
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:304 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001297983.1 → NP_001284912.1  ubiquitin specific protease 30, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284912.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W462
      Conserved Domains (3) summary
      cd02662
      Location:323 → 548
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:39 → 139
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:304 → 547
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W462.1 Q9W462

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