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    B52 B52 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41670, updated on 9-Dec-2024

    Summary

    Official Symbol
    B52provided by FlyBase
    Official Full Name
    B52provided by FlyBase
    Primary source
    FLYBASE:FBgn0004587
    Locus tag
    Dmel_CG10851
    See related
    AllianceGenome:FB:FBgn0004587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    B52/dSRp55; B52/SRp55; CG10851; Dmel\CG10851; dSRp55; E(Dfd); E726; l(3)s2249; MabB52; Rbp8; rrm8; RRM8; RSp55; SR55; SRp55; SRSF6
    Summary
    Enables mRNA binding activity. Involved in several processes, including defense response to virus; mitotic G1/S transition checkpoint signaling; and regulation of RNA metabolic process. Located in euchromatin; nuclear speck; and polytene chromosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; adult heart; embryonic brain; and primary neurons. Human ortholog(s) of this gene implicated in proliferative diabetic retinopathy and spermatogenic failure 3. Orthologous to several human genes including SRSF4 (serine and arginine rich splicing factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See B52 in Genome Data Viewer
    Location:
    87F7-87F7; 3-54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13661311..13666891)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9487033..9492613)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 4 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 87F Neighboring gene TWIK-related acid-sensitive K[+] channel 6 Neighboring gene uncharacterized protein Neighboring gene Lkb1 kinase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    enables mRNA binding  
    enables mRNA binding PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome PubMed 
    is_active_in cytoplasm  
    located_in euchromatin PubMed 
    located_in nuclear speck PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in polytene chromosome PubMed 
    part_of precatalytic spliceosome PubMed 

    General protein information

    Preferred Names
    B52
    Names
    B52-PA
    B52-PB
    B52-PC
    B52-PD
    B52-PF
    B52-PI
    B52-PK
    B52-PM
    B52-PN
    B52-PO
    CG10851-PA
    CG10851-PB
    CG10851-PC
    CG10851-PD
    CG10851-PF
    CG10851-PI
    CG10851-PK
    CG10851-PM
    CG10851-PN
    CG10851-PO
    Monoclonal-antibody-B52
    RNA-binding protein 8
    Serine/arginine rich protein 55
    enhancer of deformed
    serine-arginine protein 55
    splicing factor B52

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13661311..13666891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176490.3 → NP_788667.2  B52, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788667.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:115 → 186
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    2. NM_176494.4 → NP_788671.2  B52, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788671.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHG5
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:120 → 191
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    3. NM_176491.3 → NP_788668.1  B52, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Related
      FBpp0082270
      Conserved Domains (3) summary
      COG0724
      Location:4 → 128
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:120 → 191
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    4. NM_001014619.3 → NP_001014619.2  B52, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014619.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHG5
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:120 → 191
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    5. NM_001170133.2 → NP_001163604.1  B52, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Conserved Domains (3) summary
      COG0724
      Location:4 → 78
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:115 → 129
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. NM_001170132.2 → NP_001163603.1  B52, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163603.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:106 → 131
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_176492.4 → NP_788669.1  B52, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788669.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Related
      FBpp0082271
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 (RRM1) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:106 → 131
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. NM_176488.3 → NP_788665.1  B52, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788665.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Related
      FBpp0082269
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:115 → 186
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    9. NM_176493.4 → NP_788670.1  B52, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788670.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Related
      FBpp0082272
      Conserved Domains (3) summary
      COG0724
      Location:4 → 78
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cl17169
      Location:115 → 129
      RRM_SF; RNA recognition motif (RRM) superfamily
    10. NM_176489.3 → NP_788666.1  B52, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P26686
      Related
      FBpp0082274
      Conserved Domains (2) summary
      cd12337
      Location:5 → 74
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:115 → 186
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
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