Dg Dystroglycan [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dgprovided by FlyBase
Official Full Name: Dystroglycanprovided by FlyBase
Primary source: FLYBASE:FBgn0034072
Locus tag: Dmel_CG18250
See related: AllianceGenome:FB:FBgn0034072
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alpha-DG; atu; CG18250; CT41273; dg; DG; dgn; DmDG; Dmel\CG18250; dys
Summary: Enables laminin receptor activity. Involved in several processes, including imaginal disc-derived wing vein specification; nervous system development; and oogenesis. Located in several cellular components, including T-tubule; Z disc; and basal plasma membrane. Part of dystroglycan complex. Is expressed in several structures, including ectodermal derivative; epithelium; germ layer; gut section; and visceral mesoderm derivative. Used to study lissencephaly; muscular dystrophy; and muscular dystrophy-dystroglycanopathy. Human ortholog(s) of this gene implicated in bronchopulmonary dysplasia; inclusion body myositis; and muscular dystrophy (multiple). Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 52E2-52E4; 2-77 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16081176..16098564, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11968681..11986069, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization.
Title: Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization.
Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
Title: Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
in Drosophila the microRNA complex miR-310s acts as an executive mechanism to buffer levels of the muscular dystrophy-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR
Title: miRNA-based buffering of the cobblestone-lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR.
photoreceptor(R) cell differentiation defects appear at the same stage in a deficiency line Df(2R)Dg(248) that affects Dystroglycan (DG) and the neighboring mitochondrial ribosomal gene, mRpL34; findings discussed in view of recent work implicating DG as a regulator of cell metabolism and its genetic interaction with mRpL34
Title: Dystroglycan and mitochondrial ribosomal protein L34 regulate differentiation in the Drosophila eye.
Nrk, mbl, capt and Cam genetically interact with dystrophin and/or dystroglycan in the process of axon path-finding in the eye.
Title: New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye.
differential splicing of Dystroglycan is developmentally regulated and tissue-specific
Title: Differential expression of Dystroglycan-spliceforms with and without the mucin-like domain during Drosophila embryogenesis.
only dystroglycan, but not dystrophin deficiency causes myodegeneration induced by energetic stress suggesting that dystroglycan might be a component of the low-energy pathway and act as a transducer of energetic stress in normal and dystrophic muscles
Title: Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components.
Study finds that both WW binding sites are important for maintaining full Dg function in the establishment of oocyte polarity in Drosophila.
Title: The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function.
reduced expression of dystroglycan induced tolerance to cold as well as preference for low temperature; sustained increase in mitochondrial oxidative metabolism caused by reduced expression of DmDG accounted for the cryophilic phenotype of the atu mutant
Title: Changes in temperature preferences and energy homeostasis in dystroglycan mutants.
The synaptic role of Dystroglycan (Dg) in Drosophila, is studied.
Title: Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of polarity of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth of a germarium-derived egg chamber	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of an epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycolytic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of dystroglycan complex	IBA Inferred from Biological aspect of Ancestor more info
part_of dystroglycan complex	IDA Inferred from Direct Assay more info	PubMed
part_of dystroglycan complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of dystrophin-associated glycoprotein complex	IEA Inferred from Electronic Annotation more info
part_of dystrophin-associated glycoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dystroglycan

Names: CG18250-PA; CG18250-PB; CG18250-PC; CG18250-PD; Dg-PA; Dg-PB; Dg-PC; Dg-PD; alphaDystroglycan; atsugari; dystroglican; dystroglycan-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16081176..16098564 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176183.3 → NP_788363.1 dystroglycan, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788363.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0C4DHF6

Conserved Domains (3) summary

cd11303
Location:885 → 986

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:60 → 190

alpha_DG_C; C-terminal domain of alpha dystroglycan

pfam05454
Location:989 → 1262

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
NM_166138.5 → NP_725523.3 dystroglycan, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725523.3

Status: REVIEWED

UniProtKB/TrEMBL

A1ZA89, Q8WR09

Related

FBpp0086395

Conserved Domains (3) summary

cd11303
Location:537 → 638

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:60 → 190

alpha_DG_C; C-terminal domain of alpha dystroglycan

pfam05454
Location:641 → 914

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
NM_079032.4 → NP_523756.1 dystroglycan, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523756.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8STB9, Q8WR09, Q9V7I7

Related

FBpp0086394

Conserved Domains (3) summary

cd11303
Location:620 → 721

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:60 → 190

alpha_DG_C; C-terminal domain of alpha dystroglycan

pfam05454
Location:724 → 997

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
NM_176184.4 → NP_788364.2 dystroglycan, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788364.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8WR08

Related

FBpp0086396

Conserved Domains (3) summary

cd11303
Location:802 → 903

Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan

cd11305
Location:60 → 190

alpha_DG_C; C-terminal domain of alpha dystroglycan

pfam05454
Location:906 → 1179

DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)