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    Sugb Sugar baby [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sugbprovided by FlyBase
    Official Full Name
    Sugar babyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036191
    Locus tag
    Dmel_CG7334
    See related
    AllianceGenome:FB:FBgn0036191
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7334; Dmel\CG7334; sug; Sug
    Summary
    Predicted to enable transmembrane transporter activity. Involved in determination of adult lifespan. Predicted to be active in membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic hindgut; and epithelium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sugb in Genome Data Viewer
    Location:
    68D2-68D2; 3-36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11683980..11690155)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11677080..11683255)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45884 Neighboring gene Transcription factor IIEalpha Neighboring gene antisense RNA:CR45885 Neighboring gene long non-coding RNA:CR43887 Neighboring gene Pallidin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Landis GN, et al. Genome Biol, 2003. PMID 12620118, Free PMC Article
    2. Pallidin function in Drosophila surface glia regulates sleep and is dependent on amino acid availability. Li H, et al. Cell Rep, 2023 Sep 26. PMID 37682712
    3. The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods. Denecke SM, et al. Genome Biol Evol, 2020 Aug 1. PMID 32681801, Free PMC Article
    4. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Whitaker R, et al. Aging (Albany NY), 2014 May. PMID 24864304, Free PMC Article
    5. Post-transcriptional repression of the Drosophila midkine and pleiotrophin homolog miple by HOW is essential for correct mesoderm spreading. Toledano-Katchalski H, et al. Development, 2007 Oct. PMID 17728343

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sugar baby
    Names
    CG7334-PC
    CG7334-PE
    CG7334-PF
    Sug
    Sugar-baby
    Sugb-PC
    Sugb-PE
    Sugb-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11683980..11690155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206335.3 → NP_996057.3  sugar baby, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996057.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUF9, Q86PB0
      Conserved Domains (3) summary
      cd06174
      Location:254 → 547
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:252 → 518
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:9 → 82
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. NM_001144462.2 → NP_001137934.1  sugar baby, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0G4, Q86PB0
      Conserved Domains (3) summary
      cd06174
      Location:254 → 547
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:252 → 518
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:9 → 82
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_140236.4 → NP_648493.3  sugar baby, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648493.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PB0, Q9VTL9
      Conserved Domains (3) summary
      cd06174
      Location:254 → 547
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:252 → 518
      MFS_1; Major Facilitator Superfamily
      cl21472
      Location:9 → 82
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z0G4 B7Z0G4
    Q7KUF9 Q7KUF9
    Q86PB0 Q86PB0
    Q95S75 Q95S75
    Q9VTL9 Q9VTL9

    Gene LinkOut

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