NCBI Conserved Domain Search

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

252-509

5.58e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 73.47 E-value: 5.58e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 252 PQFWLFFGLLIFSWIGMAVVVSIGDAICFGIL--GDRHHLYGKQRLCGSLGWGVFALLAGLLVDHMSlgevnknYTAVFW 329
Cdd:COG2814   96 PSLWLLLAARFLQGLGAGALFPAALALIADLVppERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-------WRWVFL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 330 MALLIMGFDVFASSK-LRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELdkafegCDSSI 408
Cdd:COG2814  169 VNAVLALLALLLLLRlLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV------LGLSA 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 409 KTLeGLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASY 488
Cdd:COG2814  243 SAA-GLLLALFGLGG-VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                        250       260
                 ....*....|....*....|.
gi 221331084 489 ASIVAPPGTDATMQSLVGAIF 509
Cdd:COG2814  321 VAELAPPEARGRASGLYNSAF 341

lacY

PRK09528

galactoside permease; Reviewed

290-547

3.17e-05

galactoside permease; Reviewed

Pssm-ID: 236549 Cd Length: 420 Bit Score: 46.43 E-value: 3.17e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 290 YGKQRLCGSLGWGVFALLAGLLvdhmslgeVNKNYTAVFWMA-------LLIMGF---DVFASSKLRHTPTHLSSNI-LK 358
Cdd:PRK09528 143 YGRARMWGSLGWALCAFIAGIL--------FNINPQINFWLGsgsalilLVLLFFakpDAPSTAKVANALGANASAVsLK 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 359 DVGQMFLSVRCVIFFLWCVaiglGTALIW--------NF---LFIYLEELDKAFEGCDSSIKTLEGLVMgiqcfggelpf 427
Cdd:PRK09528 215 DALALLKLPKFWFLVLYVI----GVACFYdvfdqqfpNFfasFFATPEQGTRVFGYLNSFQVFLEALIM----------- 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 428 fFLSGWILKKIGHVNAMsvVLFGF--GVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQsLV 505
Cdd:PRK09528 280 -FFAPFIINRIGAKNAL--LLAGTimAVRIIGSGFATGPLEVSILKLLHAFEVPFLLVGVFKYITLNFDVRLSATIY-LV 355

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 221331084 506 G-AIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:PRK09528 356 GfQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLI 398

2A0105

TIGR00882

oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...

290-549

1.80e-03

oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 211613 Cd Length: 396 Bit Score: 40.89 E-value: 1.80e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  290 YGKQRLCGSLGWGVFALLAGLLVDhmslgeVNKNYtaVFWM----ALLIMGFDVFASSKLRHTPTHL-------SSNILK 358
Cdd:TIGR00882 135 YGKARMFGCVGWALCASIAGILFS------IDPQI--VFWLgsgfALILMLLLMFAKPKAPSSATVAnalganaSAFSLK 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  359 DVGQMFLSVRCVIFFLWCVaiglGTALIWNF-----------LFIYLEELDKAFEGCDSSIKTLEGLVMgiqcfggelpf 427
Cdd:TIGR00882 207 LALELFRQRKFWMFVLYVV----GVACVYDVfdqqfanfftsFFATPQQGTRVFGYVTTMGELLNALIM----------- 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  428 fFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGA 507
Cdd:TIGR00882 272 -FCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQ 350

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 221331084  508 IFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHV 549
Cdd:TIGR00882 351 FAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISV 392

Name

Accession

Description

Interval

E-value

MFS_MFSD6

cd17335

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...

11-553

1.29e-104

Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 320.30 E-value: 1.29e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  11 PMKAHYFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLI 90
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  91 MFVPGmekplpkvefhchqgvsdiprfcseygecvernleryygnrtlecelnceaqpfmwdivcedwlknntencaanr 170
Cdd:cd17335   81 FFVAQ--------------------------------------------------------------------------- 85

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 171 tntqmefgasitmqkiendgscmffmiphdqgqiagqnvtlycpkekeyfksnctmdcredylkeqlaesavintssavt 250
Cdd:cd17335      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 251 mpQFWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHHLYGKQRLCGSLGWGVFALLAGLLVDHMSLgevNKNYTAVFWM 330
Cdd:cd17335   86 --IFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSST---YKNYTIAFYV 160

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 331 ALLIMGFDVFASSKLRHTPTHLSSNI-LKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELdkafegcdSSIK 409
Cdd:cd17335  161 FAVLMLLALLLALKFPFRPKHPEPNEnTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDL--------GGSK 232

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 410 TLEGLVMGIQCFGgELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYA 489
Cdd:cd17335  233 TLIGLLWTVGVVS-EIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYA 311

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221331084 490 SIVAPPGTDATMQSLVGAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHVCIQL 553
Cdd:cd17335  312 SAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375

MFS_1_like

pfam12832

MFS_1 like family; This family contains proteins related to the MFS superfamily.

254-534

2.22e-51

MFS_1 like family; This family contains proteins related to the MFS superfamily.

Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 180.52 E-value: 2.22e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  254 FWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHHLYGKQRLCGSLGWGVFALLAGLLVDHMSlgeVNKNYTAVFWMALL 333
Cdd:pfam12832  91 FWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYS---VGLLPSVLFYLFAA 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  334 IMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELDKAfegcdssiKTLEG 413
Cdd:pfam12832 168 LMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGAS--------NTLLG 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  414 LVMGIQCFGgELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYS-MLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:pfam12832 240 ALWALGVVA-EIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAfFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRI 318

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 221331084  493 APPGTDATMQSLVGAIFEGVGVSMGSLIAGQLFESVTARTTF 534
Cdd:pfam12832 319 FPGSLQGTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTF 360

MFS_MFSD6L

cd17479

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the ...

290-522

2.07e-26

Major facilitator superfamily domain-containing protein 6-like and similar transporters of the Major Facilitator Superfamily; Major facilitator superfamily domain-containing protein 6-like (MFSD6L) protein family includes a group uncharacterized proteins similar to human major facilitator superfamily domain-containing protein 6 (MFSD6). MFSD6 is also called Macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. The MFSD6L family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341032 [Multi-domain] Cd Length: 376 Bit Score: 111.25 E-value: 2.07e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 290 YGKQRLCGSLGWGVFALLAGLLVDHMS--LGEVNKNYTAVFWMALLIMGFDVFASSKLR-HTP--THLSSNILKDVGQMF 364
Cdd:cd17479  121 YGKLKVWSALGAAFGPCGITLLVDNLDcfLPPKISRILLHFYTYGGFMILTFLLSFFYPiPVPkkEEHSSKVVKGLRLLG 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 365 LSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELDKAfegcdssiktleGLVMGIQ---CFGGELPFFFLSGWILKKIGHV 441
Cdd:cd17479  201 GDGRAILYALTVFLVGFVGSTVQNFLFWLMQDKGGS------------ELHMGLSialALLSEILMSFFGNWLLRKLGHA 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 442 NAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFEGVGVSMGSLIA 521
Cdd:cd17479  269 GCVVLGLLGLGAQLLYYSFLWTPWAVLPIELLHAFSNGALWWAVNSQVEFLASPGMERSLQLVLRALYYGIGFALGSFVS 348


                 .
gi 221331084 522 G 522
Cdd:cd17479  349 G 349

AraJ

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

252-509

5.58e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 73.47 E-value: 5.58e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 252 PQFWLFFGLLIFSWIGMAVVVSIGDAICFGIL--GDRHHLYGKQRLCGSLGWGVFALLAGLLVDHMSlgevnknYTAVFW 329
Cdd:COG2814   96 PSLWLLLAARFLQGLGAGALFPAALALIADLVppERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-------WRWVFL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 330 MALLIMGFDVFASSK-LRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELdkafegCDSSI 408
Cdd:COG2814  169 VNAVLALLALLLLLRlLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV------LGLSA 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 409 KTLeGLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASY 488
Cdd:COG2814  243 SAA-GLLLALFGLGG-VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320

                        250       260
                 ....*....|....*....|.
gi 221331084 489 ASIVAPPGTDATMQSLVGAIF 509
Cdd:COG2814  321 VAELAPPEARGRASGLYNSAF 341

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

298-547

1.92e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.22 E-value: 1.92e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 298 SLGWGVFALLAGLLVDHMSlgevnknYTAVFWMALLIMGFDVFASSKLRHTP------THLSSNILKDVGQMFLSVRCVI 371
Cdd:cd17325  130 GLGFLIGPLLGGLLADALG-------YRAPFLVCAALALLALVLALLLLPEPrpppnkRAVSAARLRSGLRLLLRDRRLL 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 372 FFLWCVAI-GLGTALIWNFLFIYLEELDKAfegcdsSIKTLeGLVMGIQcFGGELPFFFLSGWILKKIGHVNAMSVVLFG 450
Cdd:cd17325  203 ALFLAIFVlAFAFGALEPFLPLYAAELGGL------SPAQI-GLLFGAQ-GLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 451 FGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTA 530
Cdd:cd17325  275 SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF-SLGMVLGPLLGGFLYDAFGF 353

                        250
                 ....*....|....*..
gi 221331084 531 RTTFEIFGIGAFIVFVI 547
Cdd:cd17325  354 ATPFLAAAALLLLAAVL 370

MelB

COG2211

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

244-546

2.54e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];

Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.16 E-value: 2.54e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 244 NTSSAVTMPQFWLFFGLLIFSWIGMAVVVsigdaICFGILG--------DRHHLYGKQRLCGSLGWGVFALLAGLLVDHM 315
Cdd:COG2211  100 TAPDLSPTGKLIYALVTYLLLGLAYTLVN-----IPYSALGaeltpdyeERTRLSSWRFAFAGLGGLLASVLPPPLVAAF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 316 SlGEVNKNYTAVFWM---ALLIMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFI 392
Cdd:COG2211  175 G-GDAALGYRLTALIfavLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLY 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 393 YLE---ELDKAFEGcdssiktleglVMGIQCFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQ--NPWYI 467
Cdd:COG2211  254 YFKyvlGLSAALVG-----------LLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLL 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 468 LPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIF------EGVGVSMGSLIAGQL-----FESVTARTTFEI 536
Cdd:COG2211  323 LVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFgiftfaIKLGQALAGALAGLLlalfgYVAGAAQSPSAL 402

                        330
                 ....*....|
gi 221331084 537 FGIGAFIVFV 546
Cdd:COG2211  403 TGIRLLFFLL 412

MFS

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

250-547

4.60e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 67.84 E-value: 4.60e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 250 TMPQFWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRH--HLYGKQRLCGSLGWGVFALLAGLLVDHMSLGevnknYTAV 327
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERErgRALGLLQAFGSVGGILGPLLGGILASSLGFG-----WRAV 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 328 FWMALLIMGFDVFASSKLRHTPTHLSSN---------ILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELD 398
Cdd:cd06174  155 FLIAAALALLAAILLLLVVPDPPESARAkneeassksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 399 KAFEgcdssiktLEGLVMGIQCFGGELPFFFLSGWILKK-IGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVT 477
Cdd:cd06174  235 GLSV--------AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 478 FGLFYATMASYASIVAPPGTDATMQSLVGAiFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:cd06174  307 LGGLLPLSFALIAELFPPEIRGTAFGLLNT-FGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375

MFS_1

Major Facilitator Superfamily;

252-518

4.60e-10

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 61.28 E-value: 4.60e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  252 PQFWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHH--LYGKQRLCGSLGWGVFALLAGLLVDHMSlgevnknYTAVFW 329
Cdd:pfam07690  83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERgrALGLVSAGFGLGAALGPLLGGLLASLFG-------WRAAFL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  330 MALLIMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIF---FLWCVAIGLGTALIWNFLFIYLEELDKAFeGCDs 406
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLrdpVLWLLLALLLFGFAFFGLLTYLPLYQEVL-GLS- 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  407 siKTLEGLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGF---GVRFILYSMLQNPWYILPIELMNGVTFGLFYA 483
Cdd:pfam07690 234 --ALLAGLLLGLGGLLG-AIGRLLLGRLSDRLGRRRRLLLALLLLilaALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 221331084  484 TMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGS 518
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAG-SLGGALGP 344

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

379-549

9.86e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.62 E-value: 9.86e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 379 IGLGTALIWNFLFIYL-EELDKAFegcdssikTLEGLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGFGVRFIL 457
Cdd:cd17329   11 NRLGFFMVWPFMAIYLhQQLGLSA--------SIVGLVLALSAVAG-IVASLIGGRLADRFGRKPVMLAGLLLRALGFAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 458 YSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESvTARTTFEIF 537
Cdd:cd17329   82 LGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAI-NLGVAIGPLLGGLLLLY-SFRLLFLAA 159

                        170
                 ....*....|..
gi 221331084 538 GIGAFIVFVIHV 549
Cdd:cd17329  160 AVLFLLAALVLL 171

AraJ

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

413-547

6.52e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.59 E-value: 6.52e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 413 GLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:COG2814   48 GLVVTAYLLGA-ALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 221331084 493 APPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:COG2814  127 VPPERRGRALGLLGAGL-GLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLL 180

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

17-95

7.84e-08

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 7.84e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  17 FLFNAGTAPVVPFMPTLAGQL-GYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:cd17325  209 FVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLATS 287

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

247-547

1.20e-07

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.16 E-value: 1.20e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 247 SAVTMPQFWLFFGLLIFSWIGMAVVVSIGDAIcfgiLGD------RHHLYGKQRLCGSLGWGVFALLAGLLVDHmslgev 320
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAM----IADvttpenRTRAFSLLYWAINLGVAIGPLLGGLLLLY------ 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 321 nkNYTAVFWMALLIM-GFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLF----IYLE 395
Cdd:cd17329  151 --SFRLLFLAAAVLFlLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEstlpVYVV 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 396 ELDKAFEGCDSSIKTLEG-LVMGIQcfggelpfFFLSGWIlKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIelMN 474
Cdd:cd17329  229 EILGLGESLLGLLLALNAlLIVLLQ--------FPVARLV-ERFRLRKILMIGILLFAIGFAVLAFANTLAVLILA--MI 297

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221331084 475 GVTFG-LFYATMAS-YASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:cd17329  298 VLTLGeMLVFPAVQtLVAALAPPDKRGSYMGFYALAW-GLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAAL 371

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

16-95

2.74e-07

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.95 E-value: 2.74e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:COG2807  224 FGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG 303

MFS_1

Major Facilitator Superfamily;

413-547

5.14e-07

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 5.14e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  413 GLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:pfam07690  35 GLLLTLFSLGY-ALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADW 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 221331084  493 APPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:pfam07690 114 FPPEERGRALGLVSAGF-GLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

427-549

8.84e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.41 E-value: 8.84e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 427 FFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVG 506
Cdd:COG2271   61 GQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFN 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 221331084 507 AIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHV 549
Cdd:COG2271  141 AGG-PLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF 182

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

16-95

1.19e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 1.19e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHR-PLFLGGQVLTGIAFFLIMFV 93
Cdd:COG2271  189 YFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALALLLLALL 268


                 ..
gi 221331084  94 PG 95
Cdd:COG2271  269 PS 270

MFS_MdtH_MDR_like

cd17329

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...

17-93

1.38e-06

Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.69 E-value: 1.38e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221331084  17 FLFNAGTAPVVPFMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFV 93
Cdd:cd17329    9 FLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR-KPVMLAGLLLRALGFALLGFA 85

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

297-547

1.49e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.65 E-value: 1.49e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 297 GSLGWGVFALLAGLLVDHMSLgevnknYTAVFWMALLIMGFDVFASSKLRHTPTHL---SSNILKDVGQMFLSVRCVIFF 373
Cdd:COG2223  138 GNLGAAVAAFLAPLLIAAFGW------RNAFLILGILLLVVAVLAWLFLRDPPAGAaaaAKASLRDQLEALRDPRFWLLS 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 374 LWCVAIGLGTALIWNFLFIYLEELDKAfegcdsSIKTLEGLVMGIQCFGGelPFFFLSGWILKKIGHVNAMSVVLFGFGV 453
Cdd:COG2223  212 LLYFGTFGSFIGFSSWLPPYLVDQFGL------SAATAGLLAALFALLGA--LGRPLGGWLSDRIGGRRVLLIVFALMAL 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 454 RFILYSMLQ-NPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESV-TAR 531
Cdd:COG2223  284 GLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAG-GLGGFLGPLLFGALLDATgSYT 362

                        250
                 ....*....|....*.
gi 221331084 532 TTFEIFGIGAFIVFVI 547
Cdd:COG2223  363 AAFLVFAVLALVALVL 378

MFS_MdtG_SLC18_like

cd17325

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...

369-547

1.87e-06

Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.87e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 369 CVIFFLwcvaIGLGTALIWNFLFIYLEELDKAfegcdssiKTLEGLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVL 448
Cdd:cd17325    2 SLALFL----DMLGYGIIIPILPLYAESLGAS--------VAQIGLIVAAYALAQ-LLFSPPAGRLSDRFGRKRLLLLGL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 449 FGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESV 528
Cdd:cd17325   69 LLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAI-GLGFLIGPLLGGLLADAL 147

                        170
                 ....*....|....*....
gi 221331084 529 TARTTFEIFGIGAFIVFVI 547
Cdd:cd17325  148 GYRAPFLVCAALALLALVL 166

MFS_1

Major Facilitator Superfamily;

16-96

1.99e-06

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.99e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084   16 YFLFNAGTAPVVPFMP-TLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVP 94
Cdd:pfam07690   5 AFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-RRVLLIGLLLFALGLLLLLFAS 83


                  ..
gi 221331084   95 GM 96
Cdd:pfam07690  84 SL 85

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

16-95

2.31e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 2.31e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPTLA-GQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGqVLTGIAFFLIMFVP 94
Cdd:COG2223  214 YFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF-ALMALGLLLLALAL 292


                 .
gi 221331084  95 G 95
Cdd:COG2223  293 G 293

AraJ

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

17-95

2.56e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];

Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.97 E-value: 2.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  17 FLFNAGTAPVVPFMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:COG2814  217 FLLGFGFFALFTYLPLyLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR-RRLLLIGLLLLALGLLLLALAGS 295

Nuc_H_symport

pfam03825

Nucleoside H+ symporter;

241-558

2.78e-06

Nucleoside H+ symporter;

Pssm-ID: 461066 [Multi-domain] Cd Length: 399 Bit Score: 49.77 E-value: 2.78e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  241 AVINTSSAVTM------PQFWLFFG-LLIFSWIGMAVVvSIGDAICFGILGDRHHLYGKQRLCGSLGWGVFALLAGLLVd 313
Cdd:pfam03825  72 AVCHLIGAITLfmaaqvTTFEAFFLvILVNSLAYMPTL-ALTNSIAFANLQDPVTDFPPIRVWGTIGWIMASWPFVMWV- 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  314 hMSLGEVNKNYTAVFWMALLIMGFDVFASSkLRHTP------THLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIW 387
Cdd:pfam03825 150 -VSLAGFELSHMQLLIAAGLSALLVLFALT-LPHTPakqkanQSWTTLLGLDAFALLKNKRMAVFFIFSFLLGAELQIYN 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  388 NFLFIYLEELDKaFEGCDSSIktleglVMGIQCFGgELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYI 467
Cdd:pfam03825 228 VFANTFLTSFDK-FIVKHASI------IMSLGQIS-EILFMLTLPFFLKRFGIKNVMLIGIVAWALRFAFFAYGADPTPF 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  468 LPIELM-----NGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFEGVGVSMGSLIAGQLFESVTARTTFE---IFGI 539
Cdd:pfam03825 300 GTALLLlsmivHGVAYDFFNITGYIFVDKEVPPAIRASAQGLFLLMTNGFGCILGSILSGMVVEMFTQDGITDwqtVWLV 379

                         330
                  ....*....|....*....
gi 221331084  540 GAFIVFVIHVCIQLYLQRN 558
Cdd:pfam03825 380 FAGMALVLAVLFMAFFRYK 398

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

26-95

2.94e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 2.94e-06

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  26 VVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGqVLTGIAFFLIMFVPG 95
Cdd:cd17478   15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGP-LLTGLGLSLLGFAPN 83

MFS

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

16-95

3.18e-06

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.73 E-value: 3.18e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:cd06174    5 FFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFAFAPS 83

MFS_NHS

cd06177

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...

248-547

3.55e-06

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 49.55 E-value: 3.55e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 248 AVTMPQFWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHHLYGKQRLCGSLGWgvfaLLAGLLVDHmsLGEVNKNYTav 327
Cdd:cd06177   81 AATVTDFSVFFWVMLLYSLCYMPTLALTNSIAFSNLEDPVKDFPPIRVWGTIGW----IAAGWPVGF--LGWEASNLQ-- 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 328 FWMAL---LIMGFDVFAsskLRHTP-------THLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEEL 397
Cdd:cd06177  153 FYIAAgasLLLGLYSLT---LPHTPpkkagkgVSKRSLLGLDAFVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDF 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 398 DKAFEgcdssiktlegLVMGIQCFG--GELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSML---QNPWYILPIEL 472
Cdd:cd06177  230 GMIVK-----------NPAGIMSLGqiSEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYGdpsPGVWMLVLSII 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 473 MNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFEGVGVSMGSLIAGQLFESVTA-------RTTFEIFGIGAFIVF 545
Cdd:cd06177  299 LHGVCYDFFFVTGYIYVDKKAPKDIRASAQGLFMLMTNGVGALVGSILSGKVVDKFTTvegtkdwQTIWLVPAIYALVLA 378


                 ..
gi 221331084 546 VI 547
Cdd:cd06177  379 IL 380

MFS_LacY

cd06172

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...

286-547

3.94e-06

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 49.54 E-value: 3.94e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 286 RHHL-YGKQRLCGSLGWGVFALLAGLLvdhmslgeVNKNYTAVFWM----ALLIMGFDVFASSKLRHTPTHLSSN----I 356
Cdd:cd06172  127 RFNFeYGRARMWGSLGWALAAFFAGIL--------FNINPNINFWLgsgfALILLLLLLFAKPEDSDTAAAAGANassvS 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 357 LKDVGQMFLSVRcviFFLWCVAIgLGTALIWNF----LFIYLEEL-------DKAFEGCDSSIKTLEGLVMgiqcfggel 425
Cdd:cd06172  199 LKDVLELFRMPK---FWFFILFV-IGVSCFYDVfdqqFPPYFTSLfatpeqgNRVFGYLNSAQVFLEAGMM--------- 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 426 pffFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLV 505
Cdd:cd06172  266 ---FLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYITSHFDTRLSATLYLVG 342

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 221331084 506 GAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:cd06172  343 FQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLI 384

MFS_1

Major Facilitator Superfamily;

17-94

4.53e-06

Major Facilitator Superfamily;

Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.95 E-value: 4.53e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221331084   17 FLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFVP 94
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL 287

MFS_SLC18B1

cd17385

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...

31-90

4.63e-06

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 49.14 E-value: 4.63e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221331084  31 PTLA---GQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLI 90
Cdd:cd17385  222 PTLSphlRQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVIGSIITGVGFLLL 284

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

28-94

5.56e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.72 E-value: 5.56e-06

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331084  28 PFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVP 94
Cdd:COG2223   26 VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP-RRVLLIGLLLLGIGLLLLALAV 91

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

254-547

7.06e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.36 E-value: 7.06e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 254 FWLFFGLLIFSWIGMAVVVSIGDAICFGILGDRHH-----LYGkqrLCGSLGWGVFALLAGLLVDHMSlgevnknYTAVF 328
Cdd:cd17489   84 VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRgegigYYG---LATTLAMALGPALGLFLYQHLG-------FAVLF 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 329 WMALLIM--GFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIFFLWCVAIGLGTALIWNFLFIYLEELdkafeGCDS 406
Cdd:cd17489  154 IVAAVLAllALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER-----GISN 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 407 SiktleGLVMGIQCfGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMA 486
Cdd:cd17489  229 A-----GLFFTVYA-IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ 302

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221331084 487 SYASIVAPPGTDATMQSLVgAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:cd17489  303 ALAVDLVPPHRRGAANGTF-FIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

251-549

8.09e-06

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 48.31 E-value: 8.09e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 251 MPQFWLFFGLLIFSWIGMAVVvsigDAICFGILGDRHHLYGKQRL-----CGSLGWGVFALLAGLLVdhmsLGEVNKNYT 325
Cdd:COG0738   93 APSYPLLLLALFLLGLGLGLL----DVAANPYVAALGPETAASRLnllhaFFSLGALLGPLLGGLLI----LLGLSLSWH 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 326 AVFW--MALLIMGFDVFASSKLRHTPTHLSSNILKDVGQMF-LSVRCVIFFLWCVAIGLGT-ALIWNFLFIYLEELDKAF 401
Cdd:COG0738  165 LPYLilAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSlLKNPRLLLGGLAIFLYVGAeGAIGDWLPLYLKDVLGLS 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 402 EgcdssikTLEGLVMGIqCFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLF 481
Cdd:COG0738  245 E-------ATAALGLSL-FWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221331084 482 YATMASYASIVAPPGTDATMQSLvgAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHV 549
Cdd:COG0738  317 FPTIFSLALDGLGKRTAAAVSAV--LIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382

MFS_MefA_like

cd06173

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...

429-547

1.03e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 1.03e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 429 FLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAI 508
Cdd:cd06173  262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL 341

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 221331084 509 FeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:cd06173  342 N-SGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALL 379

MFS_arabinose_efflux_permease_like

cd17473

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...

256-547

1.09e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 1.09e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 256 LFFGLLIFSWIGMA--------------VVVSIGDA----ICFGILGD------RHHLYGKQRLCGSLGWGVFALLAGLL 311
Cdd:cd17473   68 LIAGLLLYGIGGVAglfldslyallasrALLGIGVAgimtLATALIGDyfegeeRAKMLGLQSAAMSLGGVVFLLLGGAL 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 312 VDHmslgevnkNYTAVFWMALLIMGFDVFASSKLRHTPTHLSSNILKDVgQMFLSVRCVIFFLWCVAIGLGTALIWnFLF 391
Cdd:cd17473  148 AEI--------GWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGA-ATAAALPWKRVLPIYFLAFLAMLLFY-VIP 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 392 IYLEELDKAFEGCDSSiktLEGLVMGIQCFGGELPFFFLsGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIE 471
Cdd:cd17473  218 IQLPFLLQERGGGSAA---LIGLALAIASLAGAIGALLF-GRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGA 293

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 472 LMNGVTFGLFYATMASYASIVAPPgtdatmqSLVGAifeGVGVSMGSLIAGQLF----------ESVTARTTFEIFGIGA 541
Cdd:cd17473  294 ILAGLGFGLLLPTLNSWAMSLVPP-------ELRGR---AMGIVTSAFFLGQFLsplvlgplvnLTGGLSGAFLILGVLA 363


                 ....*.
gi 221331084 542 FIVFVI 547
Cdd:cd17473  364 LVLAIV 369

UhpC

Sugar phosphate permease [Carbohydrate transport and metabolism];

29-95

1.64e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];

Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.64e-05

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331084  29 FMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGqVLTGIAFFLIMFVPG 95
Cdd:COG2271   32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL-LLWGLATLLFGFATS 97

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

17-96

2.33e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.78 E-value: 2.33e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  17 FLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPGM 96
Cdd:cd17477  198 FVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR-RRVLLGCALLGALAALLLPLVPGL 276

lacY

PRK09528

galactoside permease; Reviewed

290-547

3.17e-05

galactoside permease; Reviewed

Pssm-ID: 236549 Cd Length: 420 Bit Score: 46.43 E-value: 3.17e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 290 YGKQRLCGSLGWGVFALLAGLLvdhmslgeVNKNYTAVFWMA-------LLIMGF---DVFASSKLRHTPTHLSSNI-LK 358
Cdd:PRK09528 143 YGRARMWGSLGWALCAFIAGIL--------FNINPQINFWLGsgsalilLVLLFFakpDAPSTAKVANALGANASAVsLK 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 359 DVGQMFLSVRCVIFFLWCVaiglGTALIW--------NF---LFIYLEELDKAFEGCDSSIKTLEGLVMgiqcfggelpf 427
Cdd:PRK09528 215 DALALLKLPKFWFLVLYVI----GVACFYdvfdqqfpNFfasFFATPEQGTRVFGYLNSFQVFLEALIM----------- 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 428 fFLSGWILKKIGHVNAMsvVLFGF--GVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQsLV 505
Cdd:PRK09528 280 -FFAPFIINRIGAKNAL--LLAGTimAVRIIGSGFATGPLEVSILKLLHAFEVPFLLVGVFKYITLNFDVRLSATIY-LV 355

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 221331084 506 G-AIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:PRK09528 356 GfQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLI 398

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

17-95

3.25e-05

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 3.25e-05

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221331084  17 FLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGR-KRLLLIGLLIFALATLLYLLATS 83

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

298-481

4.61e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 4.61e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 298 SLGWGVFALLAGLLVDHMSlgevnknYTAVFWMALLIMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVI--FFLW 375
Cdd:cd17471  135 SLAWVIGPPLAFLLLDVLG-------FTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVKAPVNRRLllLFAA 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 376 CVAIGLGTALIWNFLFIYL-EELDKAfegcdssiKTLEGLVMGIqCFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVR 454
Cdd:cd17471  208 FTLLFAANSMYIIAMPLYVtNELGGS--------ESWVGLLFGL-AAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLF 278

                        170       180
                 ....*....|....*....|....*..
gi 221331084 455 FILYSMLQNPWYILPIELMNGVTFGLF 481
Cdd:cd17471  279 YLGLALATSLWQLIALQLLNAIFIGIT 305

NarK

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

413-547

5.00e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];

Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 5.00e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 413 GLVMGIQCFGGELpFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:COG2223   43 GLLFAIPVLVGAL-LRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKW 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 221331084 493 APPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVI 547
Cdd:COG2223  122 FPPDRRGLALGLAAGGG-NLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVL 175

ProP

COG0477

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...

16-97

6.92e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];

Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.19 E-value: 6.92e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:COG0477   23 TFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGR-KRVLLIGLLLFGLASLLCGLAPS 101


                 ..
gi 221331084  96 ME 97
Cdd:COG0477  102 PE 103

FucP

COG0738

Fucose permease [Carbohydrate transport and metabolism];

413-547

7.39e-05

Fucose permease [Carbohydrate transport and metabolism];

Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 45.23 E-value: 7.39e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 413 GLVMGIQcFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:COG0738   46 GLLLFAF-FLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAAL 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 221331084 493 aPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLF---ESVTARTTFEIFGIGAFIVFVI 547
Cdd:COG0738  125 -GPETAASRLNLLHAFF-SLGALLGPLLGGLLIllgLSLSWHLPYLILAVLLLLLALL 180

MFS_MMR_MDR_like

cd17321

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...

17-96

1.05e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.86 E-value: 1.05e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  17 FLFNAGTAPVVPFMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHrHRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:cd17321  178 FLLGAALGGLLFLLPLyLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG-PRLVLVAGLLLTAVGLLLLALLGA 256


                 .
gi 221331084  96 M 96
Cdd:cd17321  257 D 257

MFS_CsbX

cd17337

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...

29-94

1.28e-04

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 44.41 E-value: 1.28e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331084  29 FMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFVP 94
Cdd:cd17337  230 FMPLyFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLLFYYVP 296

MFS_FsR

cd17478

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...

29-95

1.42e-04

Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 1.42e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 221331084  29 FMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:cd17478  217 FLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGR-RRVIIASLLLAAPFLLLFLLTPG 282

MFS_YcaD_like

cd17477

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...

429-546

1.95e-04

Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.95e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 429 FLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAI 508
Cdd:cd17477   49 PLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTV 128

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 221331084 509 FegvgvsMGSLIAGQLFESVTARTTFEIFGIGAFIVFV 546
Cdd:cd17477  129 L------GLGFALGPLLLALVGTAGALPFLIAAVLLLL 160

MFS_MelB_like

cd17332

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...

37-96

2.48e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.75 E-value: 2.48e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221331084  37 LGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYH----RHRPLFLGGQVLTGIAFFLIMFVPGM 96
Cdd:cd17332   30 LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRsrwgRFRPWLLWGAIPLALLFVLLFTTPDG 93

MFS

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

16-94

3.60e-04

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.18 E-value: 3.60e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPTLAGQ-LGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFVP 94
Cdd:cd06174  212 IFLVNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP 291

MFS_SLC45_SUC

cd17313

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...

29-95

4.13e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 43.00 E-value: 4.13e-04

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 221331084  29 FMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADR----YHRHRPLFLGGQVLTGIAFFLIMFVPG 95
Cdd:cd17313   21 YVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRRPFILVGAPLAALGLILIPNAAD 91

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

298-547

5.88e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 42.56 E-value: 5.88e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 298 SLGWGVFALLAGLLVDHmslgevnkNYTAVFWMALLIMGFDVFASSKL----RHTPTHLSSNILKDVGQMFLSVRCVIFF 373
Cdd:cd17474  133 GLGIAVGPLLGGLLAAI--------SWRYPFFLLAALIPVAFLAILFLlpepKEKAKSSSATKLRDLKKALRGRGLLTFL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 374 LwcvaiglgTALIWNFLFI----YLEELDKAFEGCDSSIKtleGLVMGIQCFGGELPFFFLSGWILKKIGHVNAMSVVLF 449
Cdd:cd17474  205 V--------SAFLYFFLYFafltYLPFLLELLYGISPIII---GLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLL 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 450 GFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVT 529
Cdd:cd17474  274 LYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVR-FLGQAVGPLLFGLLLEIFG 352

                        250
                 ....*....|....*...
gi 221331084 530 ARTTFEIFGIGAFIVFVI 547
Cdd:cd17474  353 LSAPFLVGAAIALAAAVL 370

MFS_SLC46_TetA_like

cd17330

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...

25-90

6.00e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 6.00e-04

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 221331084  25 PVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLI 90
Cdd:cd17330   17 PVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGR-KPVLLLSLAGSAVSYVLL 81

MFS

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...

413-546

9.99e-04

Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 9.99e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 413 GLVMGIqCFGGELPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:cd06174   34 GLLFAL-FSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADL 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 221331084 493 APPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTA--RTTFEIFGIGAFIVFV 546
Cdd:cd06174  113 FPERERGRALGLLQAFG-SVGGILGPLLGGILASSLGFgwRAVFLIAAALALLAAI 167

MFS_YfcJ_like

cd17489

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...

413-549

1.22e-03

Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 1.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 413 GLVMGIQCFGGeLPFFFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIV 492
Cdd:cd17489   34 GLVVGLFTLAA-LLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 221331084 493 APP-------GTDATMQSLVGAIFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHV 549
Cdd:cd17489  113 IPPsrrgegiGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPV 176

MFS_Set

cd17471

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...

17-93

1.36e-03

Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 41.38 E-value: 1.36e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 221331084  17 FLFNAGTAPVVPFMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGQVLTGIAFFLIMFV 93
Cdd:cd17471    6 LLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLFAFL 83

2A0105

TIGR00882

oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...

290-549

1.80e-03

oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]

Pssm-ID: 211613 Cd Length: 396 Bit Score: 40.89 E-value: 1.80e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  290 YGKQRLCGSLGWGVFALLAGLLVDhmslgeVNKNYtaVFWM----ALLIMGFDVFASSKLRHTPTHL-------SSNILK 358
Cdd:TIGR00882 135 YGKARMFGCVGWALCASIAGILFS------IDPQI--VFWLgsgfALILMLLLMFAKPKAPSSATVAnalganaSAFSLK 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  359 DVGQMFLSVRCVIFFLWCVaiglGTALIWNF-----------LFIYLEELDKAFEGCDSSIKTLEGLVMgiqcfggelpf 427
Cdd:TIGR00882 207 LALELFRQRKFWMFVLYVV----GVACVYDVfdqqfanfftsFFATPQQGTRVFGYVTTMGELLNALIM----------- 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  428 fFLSGWILKKIGHVNAMSVVLFGFGVRFILYSMLQNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGA 507
Cdd:TIGR00882 272 -FCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQ 350

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 221331084  508 IFEGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFIVFVIHV 549
Cdd:TIGR00882 351 FAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISV 392

MFS_YxlH_like

cd17490

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...

306-547

1.97e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.97e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 306 LLAGLLVDHMSlgevnknYTAVFWMALL--IMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRCVIF-FLWCVAIGLG 382
Cdd:cd17490  138 LIGGLIAEHFG-------MRAPFLLAALagVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFsLLAILQQMIT 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 383 TALIWNFLFIYLEELDKAfegcDSSIKTLEGLVMGIQCFGGelpffFLSGWIL-KKIGHVNAMSVVLFGFGVRFILYSML 461
Cdd:cd17490  211 FSTTFGFTPLIAKQLGAS----SFQLGLLSIIYLLPNALAS-----LLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFA 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 462 QNPWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGA 541
Cdd:cd17490  282 PNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIY-ALGMFLGPVLVGIISEAFGLQTGFFVIGVIA 360


                 ....*.
gi 221331084 542 FIVFVI 547
Cdd:cd17490  361 LLAAIL 366

CynX

COG2807

Cyanate permease [Inorganic ion transport and metabolism];

26-95

2.42e-03

Cyanate permease [Inorganic ion transport and metabolism];

Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 2.42e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  26 VVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLFLGGqVLTGIAFFLIMFVPG 95
Cdd:COG2807   37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL-LLLAAGLLLRSLAPS 105

MFS_SV2_like

cd17316

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...

16-100

2.62e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.28 E-value: 2.62e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084  16 YFLFNAGTAPVVPFMPT-LAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRhRPLFLGGQVLTGIAFFLIMFVP 94
Cdd:cd17316  186 WFFISFGYYGLTTFLPTyLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR-KKTLVIGLILSGILALPLFYLL 264


                 ....*.
gi 221331084  95 GMEKPL 100
Cdd:cd17316  265 SGSPTL 270

MFS_MJ1317_like

cd17370

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...

306-549

3.30e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.

Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 3.30e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 306 LLAGLLvdhmsLGEVNKNYTAVFWMALL--IMGFDVFASSKLRHTPTHLSSNILKDVGQMFLSVRcviFFLWCVAIGLGT 383
Cdd:cd17370  142 LLAALL-----LYLLGGNYRTIFLLAAIpaLLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKA---FWLYLLAVALFA 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 384 ALIWNFLFIYLEELDKAFEgcDSSIKTLEGLVMGIQCFGGeLPFfflsGWILKKIGHVNAMSVVLFGFGVRFILYSMLQN 463
Cdd:cd17370  214 LGNFSFAFLILRAQELGLS--AALIPLLYALFNLVYALAA-YPA----GRLSDRIGRKKLLILGYLSLALAYLGFALGSS 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221331084 464 PWYILPIELMNGVTFGLFYATMASYASIVAPPGTDATMQSLVGAIFeGVGVSMGSLIAGQLFESVTARTTFEIFGIGAFI 543
Cdd:cd17370  287 LWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVV-GIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365


                 ....*.
gi 221331084 544 VFVIHV 549
Cdd:cd17370  366 ALLLLL 371

MFS_YfmO_like

cd17474

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...

22-94

3.71e-03

Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 39.86 E-value: 3.71e-03

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 221331084  22 GTAPVVPFMPTLAGQLGYSPAVVGTMYTILPIIGMLAKPLFGYIADRYHRHRPLfLGGQVLTGIAFFLIMFVP 94
Cdd:cd17474   14 GVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVL-LPGLLLFGIGGLLCGLSD 85

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