mig-17 Metalloprotease mig-17 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mig-17
Official Full Name: Metalloprotease mig-17
Primary source: WormBase:WBGene00003248
Locus tag: CELE_F57B7.4
See related: AllianceGenome:WB:WBGene00003248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables metallopeptidase activity. Involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration. Located in basement membrane and extracellular space. Is expressed in several structures, including body wall musculature; gonad; hypodermis; intestine; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mig-17 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (11446685..11449249)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans.
Title: Mutations in fibulin-1 and collagen IV suppress the short healthspan of mig-17/ADAMTS mutants in Caenorhabditis elegans.
Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.
Title: Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.
It plays a role in cell migration in C. elegans. (review)
Title: [Role of ADAMTSs in cell migration in the nematode C. elegans].
FBL-1C and LET-2 act downstream of MIG-17-dependent proteolysis to recruit NID-1 and that LET-2 also activates a NID-1-independent pathway, thereby inducing the remodeling of the BM required for directional control of leader cell migration.
Title: MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.
activation of MIG-17 is regulated in a spatiotemporal manner during C. elegans development. This is the first report demonstrating the regulated activation of an ADAMTS protein in vivo
Title: Stage-specific activation of MIG-17/ADAMTS controls cell migration in Caenorhabditis elegans.
Prodomain-dependent tissue targeting of MIG-17, an ADAMTS protease, controls cell migration in Caenorhabditis elegans.
Title: Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans.

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General gene information

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Markers

F57B7.4 (e-PCR)
- UniSTS:307721

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in gonad morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of distal tip cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zymogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in zymogen activation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Metalloprotease mig-17

NP_505901.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11446685..11449249

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073500.8 → NP_505901.2 Metalloprotease mig-17 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505901.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20930, Q9NDL4

Conserved Domains (1) summary

cd04267
Location:162 → 361

ZnMc_ADAM_like; Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor ...