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Conserved domains on  [gi|25154132|ref|NP_505901|]
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Metalloprotease mig-17 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 162-361 1.88e-63

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


:

Pssm-ID: 239795  Cd Length: 192  Bit Score: 204.96  E-value: 1.88e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 162 RRLEEKERDLNSTFVDDTFFMNSTDSDNSSTDalissdmpkkLRKFVDITLEEMQENNSTEMTLKIDSKKAIDKFTIWLK 241
Cdd:cd04267  12 RMVSYFNSDENILQAYITELINIANSIYRSTN----------LRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSFW 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 242 EQTGLPRHEHAVLITKFDLIsingNSATQGMAYVGNICENGDSSSVVEDIG-AGLTSLIMAHEIGHSLGALHDGAYETA- 319
Cdd:cd04267  82 RAEGPIRHDNAVLLTAQDFI----EGDILGLAYVGSMCNPYSSVGVVEDTGfTLLTALTMAHELGHNLGAEHDGGDELAf 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 25154132 320 ECDSNDNYLMAVAVSGsadrqsfLNSRRMSNCSINSIIENLK 361
Cdd:cd04267 158 ECDGGGNYIMAPVDSG-------LNSYRFSQCSIGSIREFLD 192
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 388-460 7.70e-21

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 86.24  E-value: 7.70e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25154132   388 PGELVKITRQCQVAFGPTFIPCLHIGyfheQSICERIWCSDGESDECQTlNYFPAFDGTECGYNMWCLEGSCV 460
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNGD----EDVCSKLWCSNPGGSTCTT-KNLPAADGTPCGNKKWCLNGKCV 68
 
Name Accession Description Interval E-value
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 162-361 1.88e-63

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 204.96  E-value: 1.88e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 162 RRLEEKERDLNSTFVDDTFFMNSTDSDNSSTDalissdmpkkLRKFVDITLEEMQENNSTEMTLKIDSKKAIDKFTIWLK 241
Cdd:cd04267  12 RMVSYFNSDENILQAYITELINIANSIYRSTN----------LRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSFW 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 242 EQTGLPRHEHAVLITKFDLIsingNSATQGMAYVGNICENGDSSSVVEDIG-AGLTSLIMAHEIGHSLGALHDGAYETA- 319
Cdd:cd04267  82 RAEGPIRHDNAVLLTAQDFI----EGDILGLAYVGSMCNPYSSVGVVEDTGfTLLTALTMAHELGHNLGAEHDGGDELAf 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 25154132 320 ECDSNDNYLMAVAVSGsadrqsfLNSRRMSNCSINSIIENLK 361
Cdd:cd04267 158 ECDGGGNYIMAPVDSG-------LNSYRFSQCSIGSIREFLD 192
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 388-460 7.70e-21

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 86.24  E-value: 7.70e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25154132   388 PGELVKITRQCQVAFGPTFIPCLHIGyfheQSICERIWCSDGESDECQTlNYFPAFDGTECGYNMWCLEGSCV 460
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNGD----EDVCSKLWCSNPGGSTCTT-KNLPAADGTPCGNKKWCLNGKCV 68
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 218-313 8.15e-11

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 59.31  E-value: 8.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132   218 NNSTEMTLKIDSKKAIDKFTIWLKEQTGLPRHEHAVLITKfdlisiNGNSATQGMAYVGNICENGDSSSVVEDIGA-GLT 296
Cdd:pfam13582  31 TSADTPYTSSDALEILDELQEVNDTRIGQYGYDLGHLFTG------RDGGGGGGIAYVGGVCNSGSKFGVNSGSGPvGDT 104

                          90
                  ....*....|....*...
gi 25154132   297 SLI-MAHEIGHSLGALHD 313
Cdd:pfam13582 105 GADtFAHEIGHNFGLNHT 122
 
Name Accession Description Interval E-value
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 162-361 1.88e-63

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 204.96  E-value: 1.88e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 162 RRLEEKERDLNSTFVDDTFFMNSTDSDNSSTDalissdmpkkLRKFVDITLEEMQENNSTEMTLKIDSKKAIDKFTIWLK 241
Cdd:cd04267  12 RMVSYFNSDENILQAYITELINIANSIYRSTN----------LRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSFW 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 242 EQTGLPRHEHAVLITKFDLIsingNSATQGMAYVGNICENGDSSSVVEDIG-AGLTSLIMAHEIGHSLGALHDGAYETA- 319
Cdd:cd04267  82 RAEGPIRHDNAVLLTAQDFI----EGDILGLAYVGSMCNPYSSVGVVEDTGfTLLTALTMAHELGHNLGAEHDGGDELAf 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 25154132 320 ECDSNDNYLMAVAVSGsadrqsfLNSRRMSNCSINSIIENLK 361
Cdd:cd04267 158 ECDGGGNYIMAPVDSG-------LNSYRFSQCSIGSIREFLD 192
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 228-368 6.99e-21

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 90.76  E-value: 6.99e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 228 DSKKAIDKFTIWLKEQ-----TGLPRHEHAVLITKFDLISINGNSATQGMAYVGNICENGDSSSVVEDIGAGlTSLIMAH 302
Cdd:cd04273  68 NAQKSLKSFCRWQKKLnppndSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLS-SAFTIAH 146

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25154132 303 EIGHSLGALHDGAYETAECDSNDNYLMAVAVSGSADRQSFlnsrrmSNCSINSIIENLKEPTANCV 368
Cdd:cd04273 147 ELGHVLGMPHDGDGNSCGPEGKDGHIMSPTLGANTGPFTW------SKCSRRYLTSFLDTGDGNCL 206
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 388-460 7.70e-21

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 86.24  E-value: 7.70e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 25154132   388 PGELVKITRQCQVAFGPTFIPCLHIGyfheQSICERIWCSDGESDECQTlNYFPAFDGTECGYNMWCLEGSCV 460
Cdd:pfam17771   1 PGQLYSADEQCRLIFGPGSTFCPNGD----EDVCSKLWCSNPGGSTCTT-KNLPAADGTPCGNKKWCLNGKCV 68
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 227-367 6.39e-18

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 82.40  E-value: 6.39e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 227 IDSKKAIDKFTIWLKEQTGLPRHEHAVLITKFDLISINGNSA---TQGMAYVGNICeNGDSSSVVEDIGAGLTSLI-MAH 302
Cdd:cd04272  73 IDAAETLENFNEYVKKKRDYFNPDVVFLVTGLDMSTYSGGSLqtgTGGYAYVGGAC-TENRVAMGEDTPGSYYGVYtMTH 151

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25154132 303 EIGHSLGALHDGAYET---------AECDSNDNYLMAVAVSGsadrqsfLNSRRMSNCSINSIIENLKEPTANC 367
Cdd:cd04272 152 ELAHLLGAPHDGSPPPswvkghpgsLDCPWDDGYIMSYVVNG-------ERQYRFSQCSQRQIRNVFRRLGASC 218
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 228-367 6.97e-13

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 67.26  E-value: 6.97e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 228 DSKKAIDKFTIWLKEQTGLP-RHEHAVLITKfdlisINGNSATQGMAYVGNICENGDSSSVVEDIGAGLTSL--IMAHEI 304
Cdd:cd04269  65 DAGETLNRFLDWKRSNLLPRkPHDNAQLLTG-----RDFDGNTVGLAYVGGMCSPKYSGGVVQDHSRNLLLFavTMAHEL 139

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25154132 305 GHSLGALHDGAYetaeCD-SNDNYLMAVAVSGSadrqsflnSRRMSNCSINSIIENLKEPTANC 367
Cdd:cd04269 140 GHNLGMEHDDGG----CTcGRSTCIMAPSPSSL--------TDAFSNCSYEDYQKFLSRGGGQC 191
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 218-313 8.15e-11

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 59.31  E-value: 8.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132   218 NNSTEMTLKIDSKKAIDKFTIWLKEQTGLPRHEHAVLITKfdlisiNGNSATQGMAYVGNICENGDSSSVVEDIGA-GLT 296
Cdd:pfam13582  31 TSADTPYTSSDALEILDELQEVNDTRIGQYGYDLGHLFTG------RDGGGGGGIAYVGGVCNSGSKFGVNSGSGPvGDT 104

                          90
                  ....*....|....*...
gi 25154132   297 SLI-MAHEIGHSLGALHD 313
Cdd:pfam13582 105 GADtFAHEIGHNFGLNHT 122
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 236-367 1.06e-10

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 61.16  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132   236 FTIWLKEQ-TGLPRHEHAVLITKFDLisingNSATQGMAYVGNICENGDSSSVVED--IGAGLTSLIMAHEIGHSLGALH 312
Cdd:pfam01421  73 FLKWRQEYlKKRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEDhsKNLESFAVTMAHELGHNLGMQH 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 25154132   313 DGAYETAECDSNDNYLMAVAVSGSAdrqsflnSRRMSNCSINSIIENLKEPTANC 367
Cdd:pfam01421 148 DDFNGGCKCPPGGGCIMNPSAGSSF-------PRKFSNCSQEDFEQFLTKQKGAC 195
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
266-341 2.81e-10

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 59.74  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132   266 NSATQGMAYVGNICENGDSSSVVED-------IGAGLTSLIMAHEIGHSLGALHDGAYETAE---------CDSNDNYLM 329
Cdd:pfam13688 100 NCSGGGLAWLGQLCNSGSAGSVSTRvsgnnvvVSTATEWQVFAHEIGHNFGAVHDCDSSTSSqccppsnstCPAGGRYIM 179

                          90
                  ....*....|..
gi 25154132   330 AVAVSGSADRQS 341
Cdd:pfam13688 180 NPSSSPNSTDFS 191
ZnMc_TACE_like cd04270
Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha ...
 269-367 9.51e-10

Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.


Pssm-ID: 239798 [Multi-domain]  Cd Length: 244  Bit Score: 58.92  E-value: 9.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 269 TQGMAYV--------GNICENGD--SSSVVEDIGAGLTS--------------LIMAHEIGHSLGALHDgaYETAEC--- 321
Cdd:cd04270 116 TLGLAYVgsprdnsaGGICEKAYyySNGKKKYLNTGLTTtvnygkrvptkesdLVTAHELGHNFGSPHD--PDIAECapg 193

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 25154132 322 -DSNDNYLM-AVAVSGSADrqsflNSRRMSNCSINSIIENLKEPTANC 367
Cdd:cd04270 194 eSQGGNYIMyARATSGDKE-----NNKKFSPCSKKSISKVLEVKSNSC 236
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 256-356 2.50e-09

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 56.38  E-value: 2.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 256 TKFDLISINGNSATQGMAYVGNICENGDSSSVVEDIGAG--LTSLIMAHEIGHSLGALHDGAYE-----------TAECD 322
Cdd:cd00203  54 IAILVTRQDFDGGTGGWAYLGRVCDSLRGVGVLQDNQSGtkEGAQTIAHELGHALGFYHDHDRKdrddyptiddtLNAED 133

                        90       100       110
                ....*....|....*....|....*....|....
gi 25154132 323 SNDNYLMavavSGSADRQSFLNSRRMSNCSINSI 356
Cdd:cd00203 134 DDYYSVM----SYTKGSFSDGQRKDFSQCDIDQI 163
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 268-356 1.69e-07

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 51.48  E-value: 1.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132   268 ATQGMAYVGNICENGDSSS-----VVEDIGAGLTS------LIMAHEIGHSLGALHDGAYE------------TAECDSN 324
Cdd:pfam13574  85 GELGLAYVGQICQKGASSPktntgLSTTTNYGSFNyptqewDVVAHEVGHNFGATHDCDGSqyassgcernaaTSVCSAN 164

                          90       100       110
                  ....*....|....*....|....*....|..
gi 25154132   325 DNYLMAVAvSGSadrqsflNSRRMSNCSINSI 356
Cdd:pfam13574 165 GSFIMNPA-SKS-------NNDLFSPCSISLI 188
Reprolysin_4 pfam13583
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 252-354 4.65e-06

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 404471  Cd Length: 203  Bit Score: 47.61  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132   252 AVLITKFDLISINGnsatqGMAYVGNICENGDSS---SVVEDIGAGLTslIMAHEIGHSLGALHDGAYE-----TAECDS 323
Cdd:pfam13583  95 AYLTLMTGPSGQNV-----GVAWVGALCSSARQNakaSGVARSRDEWD--IFAHEIGHTFGAVHDCSSQgeglsSSTEDG 167

                          90       100       110
                  ....*....|....*....|....*....|.
gi 25154132   324 NDNYLMAVAvsgSADRQSFLNSRRMSNCSIN 354
Cdd:pfam13583 168 SGQTIMSYA---STASQTAFSPCTIRNINGN 195
ZnMc_ADAM_fungal cd04271
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A ...
 271-362 6.19e-05

Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.


Pssm-ID: 239799 [Multi-domain]  Cd Length: 228  Bit Score: 44.33  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25154132 271 GMAYVGNICENGDS----SSVVEDIGAGLTS---LIMAHEIGHSLGALHD----------------GAYETAECDSNDNY 327
Cdd:cd04271 113 GVAWLGQLCRTGASdqgnETVAGTNVVVRTSnewQVFAHEIGHTFGAVHDctsgtcsdgsvgsqqcCPLSTSTCDANGQY 192

                        90       100       110
                ....*....|....*....|....*....|....*
gi 25154132 328 LMavAVSGSADRQSFlnsrrmSNCSINSIIENLKE 362
Cdd:cd04271 193 IM--NPSSSSGITEF------SPCTIGNICSLLGR 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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