lin-23 F-box domain-containing protein;F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lin-23
Official Full Name: F-box domain-containing protein;F-box/WD repeat-containing protein lin-23
Primary source: WormBase:WBGene00003009
Locus tag: CELE_K10B2.1
See related: AllianceGenome:WB:WBGene00003009
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables beta-catenin binding activity and phosphatase binding activity. Involved in several processes, including negative regulation of centrosome duplication; regulation of protein stability; and ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Part of cytoplasmic SCF ubiquitin ligase complex. Is expressed in several structures, including blast cell; body wall musculature; enteric muscle; germ line; and hypodermal cell. Orthologous to several human genes including FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lin-23 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (6371303..6374776)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that LIN-23 physically interacts with both CDC-25.1 and CDC-25.2 and facilitates ubiquitination for timely regulation of their activities during the intestinal development.
Title: LIN-23, an E3 Ubiquitin Ligase Component, Is Required for the Repression of CDC-25.2 Activity during Intestinal Development in Caenorhabditis elegans.
In C. elegans, similar to Drosophila and humans, the Slimb/betaTrCP homolog LIN-23 regulates ZYG-1 levels.
Title: The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
Lin-23 has two distinct cellular processes: cell cycle control and axon patterning. It targets distinct substrates for protein ubiquination within each process.
Title: A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K10B2.1 (e-PCR)
- UniSTS:311517

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of proteasomal protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: F-box domain-containing protein;F-box/WD repeat-containing protein lin-23

NP_001300561.1

Confirmed by transcript evidence

NP_001300562.1

Confirmed by transcript evidence

NP_001300563.1

Confirmed by transcript evidence

NP_495285.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

6371303..6374776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001313632.4 → NP_001300561.1 F-box domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AUM4

Conserved Domains (4) summary

smart01028
Location:41 → 80

Beta-TrCP_D; D domain of beta-TrCP

COG2319
Location:168 → 515

WD40; WD40 repeat [General function prediction only]

cd00200
Location:222 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:225 → 260

7WD40; WD40 repeat [structural motif]
NM_062884.7 → NP_495285.1 F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495285.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09990, Q9GNN6

Conserved Domains (4) summary

smart01028
Location:41 → 80

Beta-TrCP_D; D domain of beta-TrCP

COG2319
Location:168 → 515

WD40; WD40 repeat [General function prediction only]

cd00200
Location:222 → 500

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:225 → 260

7WD40; WD40 repeat [structural motif]
NM_001313633.3 → NP_001300562.1 F-box domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AWY7

Conserved Domains (4) summary

smart01028
Location:1 → 25

Beta-TrCP_D; D domain of beta-TrCP

COG2319
Location:113 → 460

WD40; WD40 repeat [General function prediction only]

cd00200
Location:167 → 445

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:170 → 205

7WD40; WD40 repeat [structural motif]
NM_001313634.3 → NP_001300563.1 F-box domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ARM6

Conserved Domains (4) summary

smart01028
Location:1 → 25

Beta-TrCP_D; D domain of beta-TrCP

COG2319
Location:113 → 460

WD40; WD40 repeat [General function prediction only]

cd00200
Location:167 → 445

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:170 → 205

7WD40; WD40 repeat [structural motif]