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Conserved domains on  [gi|17535023|ref|NP_495285|]
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F-box/WD repeat-containing protein lin-23 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-500 1.63e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 254.18  E-value: 1.63e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQYDDDK--IVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:cd00200   9 TGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRF--ANGIMVTCSKDRSIAVWDMVSPRDITirrVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:cd00200  89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLT---TLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 374 TLEFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRFDEKR--IVSGAYDGKIKV 449
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535023 450 WDLQaaldpralsSEICLCSLVQHTGRVFRLQFDD--FQIVSSSHDDTILIWD 500
Cdd:cd00200 246 WDLR---------TGECVQTLSGHTNSVTSLAWSPdgKRLASGSADGTIRIWD 289
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 41-80 1.50e-17

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


:

Pssm-ID: 198096  Cd Length: 40  Bit Score: 76.38  E-value: 1.50e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023     41 IEEVLKWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQ 80
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
F-box_SF super family cl45894
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 80-126 5.27e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


The actual alignment was detected with superfamily member cd22130:

Pssm-ID: 459239  Cd Length: 51  Bit Score: 46.70  E-value: 5.27e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535023  80 QRDFISNLPA----HLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKK 126
Cdd:cd22130   1 QRDFISALPAkgldHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-500 1.63e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 254.18  E-value: 1.63e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQYDDDK--IVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:cd00200   9 TGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRF--ANGIMVTCSKDRSIAVWDMVSPRDITirrVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:cd00200  89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLT---TLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 374 TLEFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRFDEKR--IVSGAYDGKIKV 449
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535023 450 WDLQaaldpralsSEICLCSLVQHTGRVFRLQFDD--FQIVSSSHDDTILIWD 500
Cdd:cd00200 246 WDLR---------TGECVQTLSGHTNSVTSLAWSPdgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
222-500 5.91e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 246.36  E-value: 5.91e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQYDDD--KIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:COG2319 120 TGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRFA-NG-IMVTCSKDRSIAVWDMVSPRditIRRVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:COG2319 200 LTGHTGAVRSVAFSpDGkLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 374 TLEFVRTLAGHRRGIACLQYR--GRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKV 449
Cdd:COG2319 277 TGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRL 356

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535023 450 WDLQaaldpralsSEICLCSLVQHTGRVFRLQF--DDFQIVSSSHDDTILIWD 500
Cdd:COG2319 357 WDLA---------TGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 41-80 1.50e-17

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 76.38  E-value: 1.50e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023     41 IEEVLKWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQ 80
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 358-512 5.00e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.88  E-value: 5.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  358 IVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYRG---RLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVrCIRFD 434
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  435 E---KRIVSGAYDGKIKVWDLQaalDPRalsseICLCSLVQHTGRVFRLQF-DDFQIVSSSHDDTILIWDfLDAPPSGLP 510
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDLR---NPK-----LPLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWD-LSMSISGIN 697


                 ..
gi 17535023  511 SS 512
Cdd:PLN00181 698 ET 699
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 46-80 5.54e-09

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 51.99  E-value: 5.54e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17535023    46 KWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQ 80
Cdd:pfam12125   5 KWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 414-451 1.98e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.98e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023    414 SGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKVWD 451
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 80-126 5.27e-07

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 46.70  E-value: 5.27e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535023  80 QRDFISNLPA----HLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKK 126
Cdd:cd22130   1 QRDFISALPAkgldHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
WD40 pfam00400
WD domain, G-beta repeat;
415-451 6.09e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 6.09e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17535023   415 GVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKVWD 451
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 222-500 1.63e-79

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 254.18  E-value: 1.63e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQYDDDK--IVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:cd00200   9 TGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRF--ANGIMVTCSKDRSIAVWDMVSPRDITirrVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:cd00200  89 LTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLT---TLRGHTDWVNSVAFspDGTFVASSSQDGTIKLWDLR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 374 TLEFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRFDEKR--IVSGAYDGKIKV 449
Cdd:cd00200 166 TGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSEDGTIRV 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535023 450 WDLQaaldpralsSEICLCSLVQHTGRVFRLQFDD--FQIVSSSHDDTILIWD 500
Cdd:cd00200 246 WDLR---------TGECVQTLSGHTNSVTSLAWSPdgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
222-500 5.91e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 246.36  E-value: 5.91e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQYDDD--KIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:COG2319 120 TGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRFA-NG-IMVTCSKDRSIAVWDMVSPRditIRRVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:COG2319 200 LTGHTGAVRSVAFSpDGkLLASGSADGTVRLWDLATGK---LLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 374 TLEFVRTLAGHRRGIACLQYR--GRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKV 449
Cdd:COG2319 277 TGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRL 356

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535023 450 WDLQaaldpralsSEICLCSLVQHTGRVFRLQF--DDFQIVSSSHDDTILIWD 500
Cdd:COG2319 357 WDLA---------TGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
222-453 1.95e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 226.33  E-value: 1.95e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQYDDD--KIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:COG2319 162 SGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRT 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRFA-NG-IMVTCSKDRSIAVWDMVSPRditIRRVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:COG2319 242 LTGHSGSVRSVAFSpDGrLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDLA 318

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 374 TLEFVRTLAGHRRGIACLQYR--GRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKV 449
Cdd:COG2319 319 TGKLLRTLTGHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRL 398


                ....
gi 17535023 450 WDLQ 453
Cdd:COG2319 399 WDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 254-500 5.87e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.35  E-value: 5.87e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 254 CSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKTLIHHCEAVLHLRF-ANGI-MVTCSKDRSIAVWDM 329
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsADGTyLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 330 VSPRDItirRVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYR--GRLVVSGSSDN 405
Cdd:cd00200  81 ETGECV---RTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSpdGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 406 TIRLWDIHSGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKVWDlqaaldpraLSSEICLCSLVQHTGRVFRLQFD 483
Cdd:cd00200 158 TIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWD---------LSTGKCLGTLRGHENGVNSVAFS 228

                       250
                ....*....|....*....
gi 17535023 484 DFQ--IVSSSHDDTILIWD 500
Cdd:cd00200 229 PDGylLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
231-500 1.27e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 1.27e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 231 DDDKIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKTLIHHCEAVLHL 308
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 309 RFA--NGIMVTCSKDRSIAVWDMVSPRditIRRVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMDTLEFVRTLAGH 384
Cdd:COG2319  85 AFSpdGRLLASASADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 385 RRGIACLQYR--GRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKVWDLQaaldpra 460
Cdd:COG2319 162 SGAVTSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLA------- 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 17535023 461 lsSEICLCSLVQHTGRVFRLQF--DDFQIVSSSHDDTILIWD 500
Cdd:COG2319 235 --TGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
222-414 1.22e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.18  E-value: 1.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 222 SKGVYCLQY--DDDKIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWDVETGECIKT 297
Cdd:COG2319 204 TGAVRSVAFspDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATGELLRT 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 298 LIHHCEAVLHLRFA-NG-IMVTCSKDRSIAVWDMVSPRDItirRVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWSMD 373
Cdd:COG2319 284 LTGHSGGVNSVAFSpDGkLLASGSDDGTVRLWDLATGKLL---RTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLA 360

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 17535023 374 TLEFVRTLAGHRRGIACLQYR--GRLVVSGSSDNTIRLWDIHS 414
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 338-501 3.15e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.02  E-value: 3.15e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 338 RRVLVGHRAAVNVVDFDD--RYIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWDIH 413
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 414 SGVCLRVLEGHEELVRCIRFDEKR--IVSGAYDGKIKVWDLQaaldpralsSEICLCSLVQHTGRVFRLQFDDFQ--IVS 489
Cdd:cd00200  82 TGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVE---------TGKCLTTLRGHTDWVNSVAFSPDGtfVAS 152

                       170
                ....*....|..
gi 17535023 490 SSHDDTILIWDF 501
Cdd:cd00200 153 SSQDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
271-503 2.27e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 2.27e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 271 DNRVIISGSSDATVRVWDVETGECIKTLIHHCEAVLHLRFA--NGIMVTCSKDRSIAVWDmvsPRDITIRRVLVGHRAAV 348
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASpdGARLAAGAGDLTLLLLD---AAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 349 NVVDF--DDRYIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYR--GRLVVSGSSDNTIRLWDIHSGVCLRVLEGH 424
Cdd:COG2319  82 LSVAFspDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17535023 425 EELVRCIRFdekrivSGayDGKikvwdlqaaldpralsseiclcslvqhtgrvfrlqfddfQIVSSSHDDTILIWDFLD 503
Cdd:COG2319 162 SGAVTSVAF------SP--DGK---------------------------------------LLASGSDDGTVRLWDLAT 193
Beta-TrCP_D smart01028
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 41-80 1.50e-17

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 198096  Cd Length: 40  Bit Score: 76.38  E-value: 1.50e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023     41 IEEVLKWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQ 80
Cdd:smart01028   1 VKYFEKWSESDQVDFVEHLISRMCHYQHGHINSYLKPMLQ 40
WD40 COG2319
WD40 repeat [General function prediction only];
350-500 7.63e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 7.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 350 VVDFDDRYIVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHEEL 427
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17535023 428 VRCIRF--DEKRIVSGAYDGKIKVWDLQAALdpralsseiCLCSLVQHTGRVFRLQF--DDFQIVSSSHDDTILIWD 500
Cdd:COG2319  81 VLSVAFspDGRLLASASADGTVRLWDLATGL---------LLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWD 148
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 358-512 5.00e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.88  E-value: 5.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  358 IVSASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYRG---RLVVSGSSDNTIRLWDIHSGVCLRVLEGHEELVrCIRFD 434
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFP 626

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  435 E---KRIVSGAYDGKIKVWDLQaalDPRalsseICLCSLVQHTGRVFRLQF-DDFQIVSSSHDDTILIWDfLDAPPSGLP 510
Cdd:PLN00181 627 SesgRSLAFGSADHKVYYYDLR---NPK-----LPLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWD-LSMSISGIN 697


                 ..
gi 17535023  511 SS 512
Cdd:PLN00181 698 ET 699
Beta-TrCP_D pfam12125
D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids ...
 46-80 5.54e-09

D domain of beta-TrCP; This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with pfam00646, pfam00400. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerization of the protein. dimerization is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.


Pssm-ID: 463465  Cd Length: 39  Bit Score: 51.99  E-value: 5.54e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17535023    46 KWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQ 80
Cdd:pfam12125   5 KWNESDQVDFVEHLLSRMCHYQHGHINSYLKPMLQ 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 414-451 1.98e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.98e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023    414 SGVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKVWD 451
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW1 cd22130
F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; ...
 80-126 5.27e-07

F-box domain found in F-box/WD repeat-containing proteins, FBXW1A, FBXW1B and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438902  Cd Length: 51  Bit Score: 46.70  E-value: 5.27e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535023  80 QRDFISNLPA----HLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKK 126
Cdd:cd22130   1 QRDFISALPAkgldHIAENILSYLDAKSLCAAELVCKEWYRVIADGMLWKK 51
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 253-288 6.06e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 6.06e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17535023    253 SCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWD 288
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
415-451 6.09e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 6.09e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17535023   415 GVCLRVLEGHEELVRCIRF--DEKRIVSGAYDGKIKVWD 451
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
F-box_FBXW1A cd22182
F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; ...
 78-133 7.86e-07

F-box domain found in F-box/WD repeat-containing protein 1A (FBXW1A) and similar proteins; FBXW1A, also called E3RSIkappaB, epididymis tissue protein Li 2a, F-box and WD repeats protein beta-TrCP, or pIkappaBalpha-E3 receptor subunit, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CTNNB1, NFKBIA, NFKBIB and NFKBIE, as well as phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438953  Cd Length: 60  Bit Score: 46.60  E-value: 7.86e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  78 MLQRDFISNLPA----HLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKKLIEKNVR 133
Cdd:cd22182   1 MLQRDFITALPArgldHIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVR 60
WD40 pfam00400
WD domain, G-beta repeat;
253-288 1.92e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.92e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17535023   253 SCSRILSGHTGSVLCLQY--DNRVIISGSSDATVRVWD 288
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 374-411 4.06e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.06e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023    374 TLEFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWD 411
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
F-box_FBXW1B cd22183
F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; ...
 80-126 6.95e-06

F-box domain found in F-box/WD repeat-containing protein 1B (FBXW1B) and similar proteins; FBXW1B, also called F-box/WD repeat-containing protein 11 (FBXW11), F-box and WD repeats protein beta-TrCP2, or homologous to Slimb protein (HOS), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as IFNAR1, CEP68 and CDC25A, as well as phosphorylated CTNNB1, NFKBIA, PER1 and PER2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438954  Cd Length: 51  Bit Score: 43.74  E-value: 6.95e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535023  80 QRDFISNLPA----HLVELILFNVNSDSLKSCEEVSTSWRCALARGQHWKK 126
Cdd:cd22183   1 QRDFITALPAkgldHIAENILSYLDAESLCAAELVCKEWQRVISEGMLWKK 51
WD40 pfam00400
WD domain, G-beta repeat;
376-411 1.09e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17535023   376 EFVRTLAGHRRGIACLQY--RGRLVVSGSSDNTIRLWD 411
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 339-371 2.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.22e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 17535023    339 RVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWS 371
Cdd:smart00320   6 KTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 264-412 3.61e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  264 SVLCLQ-YDNRVIISGSSDATVRVWDVETGECIKTLIHHCEAVLHLRFANG---IMVTCSKDRSIAVWDMVSPRDI-TIR 338
Cdd:PLN00181 536 SGICWNsYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQGVSIgTIK 615

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17535023  339 RvlvghRAAVNVVDFDD---RYIVSASGDRTIKVWSMDTLEF-VRTLAGHRRGIACLQY-RGRLVVSGSSDNTIRLWDI 412
Cdd:PLN00181 616 T-----KANICCVQFPSesgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDL 689
PTZ00421 PTZ00421
coronin; Provisional
 310-451 3.82e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  310 FANGIMVTCSKDRSIAVWDMvsPRDITIRRV------LVGHRAAVNVVDFD---DRYIVSASGDRTIKVWSMDTLEFVRT 380
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGI--PEEGLTQNIsdpivhLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEV 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  381 LAGHRRGIACLQY--RGRLVVSGSSDNTIRLWDIHSGVCLRVLEGHE--ELVRCIRFDEKRIV-----SGAYDGKIKVWD 451
Cdd:PTZ00421 164 IKCHSDQITSLEWnlDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAsaKSQRCLWAKRKDLIitlgcSKSQQRQIMLWD 243
WD40 pfam00400
WD domain, G-beta repeat;
339-371 7.61e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 7.61e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17535023   339 RVLVGHRAAVNVVDF--DDRYIVSASGDRTIKVWS 371
Cdd:pfam00400   5 KTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 291-328 1.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17535023    291 TGECIKTLIHHCEAVLHLRFA--NGIMVTCSKDRSIAVWD 328
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 230-337 1.37e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  230 YDDDKIVSGLRDNTIKIWDRKD----YSCSRI---LSGHTGSVLCLQYD---NRVIISGSSDATVRVWDVETGECIKTLI 299
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIPEegltQNISDPivhLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVERGKAVEVIK 165

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 17535023  300 HHCEAVLHLRF--ANGIMVTCSKDRSIAVWDmvsPRDITI 337
Cdd:PTZ00421 166 CHSDQITSLEWnlDGSLLCTTSKDKKLNIID---PRDGTI 202
F-box_FBXW10 cd22136
F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; ...
 83-117 4.62e-04

F-box domain found in F-box/WD repeat-containing protein 10 (FBXW10) and similar proteins; FBXW10, also called F-box and WD-40 domain-containing protein 10, or ubiquitin ligase-specificity factor, is a probable substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Its overexpression leads to degradation of CBX5 and CBX1. FBXW10 is negatively regulated in transcription and expression levels by protein O-GlcNAcylation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438908  Cd Length: 40  Bit Score: 37.99  E-value: 4.62e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 17535023  83 FISNLPAHLVELILFNVNSDSLKSCEEVSTSWRCA 117
Cdd:cd22136   1 FIRCLPVHLSKYILSMLDKKSLNNCLCVSQHWRAL 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
321-415 6.71e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 6.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023 321 DRSIAVWDMVSPRDITIRRVLVGHRAAVNVVDFDDRYI-VSASGDRTIKVWSMDTLEFVRTLA--GHRRGIACLQYRGRL 397
Cdd:COG3391  45 VGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPvgGGPRGLAVDPDGGRL 124

                        90
                ....*....|....*...
gi 17535023 398 VVSGSSDNTIRLWDIHSG 415
Cdd:COG3391 125 YVADSGNGRVSVIDTATG 142
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 466-500 1.34e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 17535023    466 CLCSLVQHTGRVFRLQF--DDFQIVSSSHDDTILIWD 500
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
292-328 2.29e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.29e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17535023   292 GECIKTLIHHCEAVLHLRFA--NGIMVTCSKDRSIAVWD 328
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 287-373 3.66e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 3.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535023  287 WDVETGECIKT--------------LIHHCEAVLHLRFA---NGIMVTCSKDRSIAVWDmVSPRDITIRRV------LVG 343
Cdd:PTZ00420  45 WEVEGGGLIGAirlenqmrkppvikLKGHTSSILDLQFNpcfSEILASGSEDLTIRVWE-IPHNDESVKEIkdpqciLKG 123

                         90       100       110
                 ....*....|....*....|....*....|...
gi 17535023  344 HRAAVNVVDFD--DRYIVSASG-DRTIKVWSMD 373
Cdd:PTZ00420 124 HKKKISIIDWNpmNYYIMCSSGfDSFVNIWDIE 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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