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    bra-1 MYND-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bra-1
    Official Full Name
    MYND-type domain-containing protein
    Primary source
    WormBase:WBGene00000262
    Locus tag
    CELE_F54B11.6
    See related
    AllianceGenome:WB:WBGene00000262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables signaling receptor binding activity. Involved in determination of adult lifespan and negative regulation of transforming growth factor beta receptor signaling pathway. Located in axon and dendrite. Is expressed in neurons. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 30. Orthologous to human ZMYND11 (zinc finger MYND-type containing 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bra-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (13598449..13599687)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene CCHC-type domain-containing protein Neighboring gene Yippee domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling. Morita K, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11353865, Free PMC Article
    2. The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif. Ansieau S, et al. J Biol Chem, 2002 Feb 15. PMID 11733528
    3. BIP, a BRAM-interacting protein involved in TGF-beta signalling, regulates body length in Caenorhabditis elegans. Sugawara K, et al. Genes Cells, 2001 Jul. PMID 11473578
    4. The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Shaw WM, et al. Curr Biol, 2007 Oct 9. PMID 17900898, Free PMC Article
    5. Targets of TGF beta-related signaling in Caenorhabditis elegans. Savage-Dunn C. Cytokine Growth Factor Rev, 2001 Dec. PMID 11544101

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MYND-type domain-containing protein
    NP_510277.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13598449..13599687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077876.6 → NP_510277.1  MYND-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510277.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20741
      Conserved Domains (2) summary
      PRK12704
      Location:39 → 116
      PRK12704; phosphodiesterase; Provisional
      pfam01753
      Location:125 → 159
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version

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