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    ZNF324 zinc finger protein 324 [ Homo sapiens (human) ]

    Gene ID: 25799, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF324provided by HGNC
    Official Full Name
    zinc finger protein 324provided by HGNC
    Primary source
    HGNC:HGNC:14096
    See related
    Ensembl:ENSG00000083812 MIM:617477; AllianceGenome:HGNC:14096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZF5128; ZNF324A
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a positive effect on G1/S transition of mitotic cell cycle and cell population proliferation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 2.5), ovary (RPKM 2.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF324 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58467080..58475436)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61563017..61571403)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58978447..58986803)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 324B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58952208-58952717 Neighboring gene ZNF132 divergent transcript Neighboring gene zinc finger protein 250 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58962695-58963021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978178-58978794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58978795-58979409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15201 Neighboring gene Sharpr-MPRA regulatory region 9894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15203 Neighboring gene uncharacterized LOC112268251 Neighboring gene zinc finger protein 446 Neighboring gene RNA, U6 small nuclear 1337, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4347 Neighboring gene RNA, 7SL, cytoplasmic 693, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence and cell cycle-associated differential expression of ZF5128, a novel Kruppel type zinc finger protein gene. Rue SW, et al. Biochim Biophys Acta, 2001 Dec 30. PMID 11779640
    2. Biological functions of miRNA-203b-3p/ZNF324 in laryngeal carcinoma. Wang L, et al. Cell Mol Biol (Noisy-le-grand), 2023 Dec 20. PMID 38279443
    3. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
    4. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Jirawatnotai S, et al. Nature, 2011 Jun 8. PMID 21654808, Free PMC Article
    5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biological functions of miRNA-203b-3p/ZNF324 in laryngeal carcinoma.
      Title: Biological functions of miRNA-203b-3p/ZNF324 in laryngeal carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect G1/S transition of mitotic cell cycle IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within_positive_effect cell population proliferation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 324A
    Names
    zinc finger protein ZF5128

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014347.3 → NP_055162.1  zinc finger protein 324A

      See identical proteins and their annotated locations for NP_055162.1

      Status: VALIDATED

      Source sequence(s)
      AC012313
      Consensus CDS
      CCDS12981.1
      UniProtKB/Swiss-Prot
      B3KRX1, O75467
      Related
      ENSP00000196482.3, ENST00000196482.4
      Conserved Domains (6) summary
      smart00349
      Location:1 → 61
      KRAB; krueppel associated box
      COG5048
      Location:263 → 463
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:369 → 391
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1 → 40
      KRAB; KRAB box
      pfam13465
      Location:271 → 296
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58467080..58475436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258713.5 → XP_005258770.1  zinc finger protein 324A isoform X1

      Conserved Domains (6) summary
      smart00349
      Location:6 → 66
      KRAB; krueppel associated box
      COG5048
      Location:268 → 468
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:264 → 284
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:374 → 396
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:276 → 301
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61563017..61571403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320471.1 → XP_054176446.1  zinc finger protein 324A isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75467.1 GenPept UniProtKB/Swiss-Prot:O75467

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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