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Conserved domains on  [gi|530416122|ref|XP_005258770|]
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zinc finger protein 324A isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 5.16e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.92  E-value: 5.16e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530416122     6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLGLSTSRPRVVIQLERGEEPWV 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-468 7.18e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 268 SKVFVKSSDLLKHLRTHTGER-PYECAQCGKAFSQTSHLTQHQR--IHSGE--TPYACPV--CGKAFRHSSSLVRHQRIH 340
Cdd:COG5048  267 TASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 341 TAEKSFRC--SECGKAFSHGSNLSQHRKIHAggrpyacaqcgrrFCRNSHLIQHERTHTGekpfvcalCGAAFSQGSSLF 418
Cdd:COG5048  347 TSISPAKEklLNSSSKFSPLLNNEPPQSLQQ-------------YKDLKNDKKSETLSNS--------CIRNFKRDSNLS 405

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530416122 419 KHQRVHTGEKP--FACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKAFA 468
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 5.16e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.92  E-value: 5.16e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530416122     6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLGLSTSRPRVVIQLERGEEPWV 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-46 3.00e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.00e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530416122    6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLG 46
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 5.35e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 5.35e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530416122   6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-468 7.18e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 268 SKVFVKSSDLLKHLRTHTGER-PYECAQCGKAFSQTSHLTQHQR--IHSGE--TPYACPV--CGKAFRHSSSLVRHQRIH 340
Cdd:COG5048  267 TASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 341 TAEKSFRC--SECGKAFSHGSNLSQHRKIHAggrpyacaqcgrrFCRNSHLIQHERTHTGekpfvcalCGAAFSQGSSLF 418
Cdd:COG5048  347 TSISPAKEklLNSSSKFSPLLNNEPPQSLQQ-------------YKDLKNDKKSETLSNS--------CIRNFKRDSNLS 405

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530416122 419 KHQRVHTGEKP--FACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKAFA 468
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 1.33e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.33e-05
                          10        20
                  ....*....|....*....|....*.
gi 530416122  276 DLLKHLRTHTGERPYECAQCGKAFSQ 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 265-336 7.74e-05

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 42.56  E-value: 7.74e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416122 265 RACSKVFVKSSDLLKH------LRTHTGERPYECAQCGKAFSQTSHLTQHqrIHSGETPYACPVCGKAFRHSSSLVRH 336
Cdd:PHA00733  43 RAVVKTLIYNPQLLDEssylykLLTSKAVSPYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 323-364 5.19e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 530416122 323 CGKAFRHSSSLVRHQRihtaEKSFRCSECGKAFSHGSNLSQH 364
Cdd:cd20908    7 CDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
ZnF_C2H2 smart00355
zinc finger;
318-340 6.95e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.95e-03
                           10        20
                   ....*....|....*....|...
gi 530416122   318 YACPVCGKAFRHSSSLVRHQRIH 340
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
6-66 5.16e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 111.92  E-value: 5.16e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530416122     6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLGLSTSRPRVVIQLERGEEPWV 66
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-46 3.00e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.00e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 530416122    6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASLG 46
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-45 5.35e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 5.35e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530416122   6 MAFEDVAVYFSQEEWGLLDTAQRALYRRVMLDNFALVASL 45
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-468 7.18e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 7.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 268 SKVFVKSSDLLKHLRTHTGER-PYECAQCGKAFSQTSHLTQHQR--IHSGE--TPYACPV--CGKAFRHSSSLVRHQRIH 340
Cdd:COG5048  267 TASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 341 TAEKSFRC--SECGKAFSHGSNLSQHRKIHAggrpyacaqcgrrFCRNSHLIQHERTHTGekpfvcalCGAAFSQGSSLF 418
Cdd:COG5048  347 TSISPAKEklLNSSSKFSPLLNNEPPQSLQQ-------------YKDLKNDKKSETLSNS--------CIRNFKRDSNLS 405

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530416122 419 KHQRVHTGEKP--FACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKAFA 468
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
299-504 6.16e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 6.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 299 FSQTSHLTQHQRIHSGETP-YACPVCGKAFRHSSSLVRHQRIHTAE----------KSFRCSECGKAFSHGSNLSQHR-- 365
Cdd:COG5048  232 NSQLSPKSLLSQSPSSLSSsDSSSSASESPRSSLPTASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHLrs 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 366 KIH--AGGRPYAC--AQCGRRFCRNSHLIQHERTHTGEKPFVCAL--CGAAFSQGSSLFKHQRVH-----TGEKPFAC-- 432
Cdd:COG5048  312 VNHsgESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETls 391

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530416122 433 PQCGRAFSHSSNLTQHQLLHTGERP--FRCVDCGKAFAKGAVLLSHRRIHTgEKPFVCTQCGRAFRERPALFHH 504
Cdd:COG5048  392 NSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
288-349 1.49e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.49e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530416122 288 RPYECAQCGKAFSQTSHLTQHQRIHSGETPYACPV--CGKAFRHSSSLVRHQRIHTAEKSFRCS 349
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
273-461 2.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 273 KSSDLLKHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSGETPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCSECG 352
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 353 KAFSHGSNLSQHRKIHaggrpyacaqcgrrFCRNSHLIQherthtgEKPFVCALCGAAFSQGSSLFKHQR--VHTGE--K 428
Cdd:COG5048  262 RSSLPTASSQSSSPNE--------------SDSSSEKGF-------SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslK 320

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 530416122 429 PFACP--QCGRAFSHSSNLTQHQLLHTGERPFRCV 461
Cdd:COG5048  321 PFSCPysLCGKLFSRNDALKRHILLHTSISPAKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-301 1.33e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.33e-05
                          10        20
                  ....*....|....*....|....*.
gi 530416122  276 DLLKHLRTHTGERPYECAQCGKAFSQ 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
316-368 2.87e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.87e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530416122 316 TPYACPVCGKAFRHSSSLVRHQRIHTAEKSFRCS--ECGKAFSHGSNLSQHRKIH 368
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
304-329 3.12e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.12e-05
                          10        20
                  ....*....|....*....|....*.
gi 530416122  304 HLTQHQRIHSGETPYACPVCGKAFRH 329
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-441 4.07e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.07e-05
                          10        20
                  ....*....|....*....|....*.
gi 530416122  416 SLFKHQRVHTGEKPFACPQCGRAFSH 441
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-357 5.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.68e-05
                          10        20
                  ....*....|....*....|....*.
gi 530416122  332 SLVRHQRIHTAEKSFRCSECGKAFSH 357
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
372-437 6.50e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 6.50e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416122 372 RPYACAQCGRRFCRNSHLIQHERTHTGEKPFVCAL--CGAAFSQGSSLFKHQRVHTGEKPFACPQCGR 437
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
PHA00733 PHA00733
hypothetical protein
 265-336 7.74e-05

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 42.56  E-value: 7.74e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416122 265 RACSKVFVKSSDLLKH------LRTHTGERPYECAQCGKAFSQTSHLTQHqrIHSGETPYACPVCGKAFRHSSSLVRH 336
Cdd:PHA00733  43 RAVVKTLIYNPQLLDEssylykLLTSKAVSPYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
400-460 1.32e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.32e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530416122 400 KPFVCALCGAAFSQGSSLFKHQRVHTGEKPFACPQCGRA--FSHSSNLTQHQLLHTGERPFRC 460
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 318-340 1.34e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|...
gi 530416122  318 YACPVCGKAFRHSSSLVRHQRIH 340
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-524 2.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 255 LHAGEKSFECRA--CSKVFVKSSDLLKHLRTHTGERPYECAQ----------------CGKAFSQTSHLTQH---QRIHS 313
Cdd:COG5048   55 SHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasssslssSSSNSNDNNLLSSHslpPSSRD 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 314 GETPYACPVC--GKAFRHSSSLVRHQRIHTAEKSFRC---SECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRR------ 382
Cdd:COG5048  135 PQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLpanSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSysipss 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 383 ---------------------------FCRNSHLIQHERTHTGEKPFVCALCGAAFSQGSSLFKHQRVHTG-EKPFACPQ 434
Cdd:COG5048  215 ssdqnlensssslplttnsqlspksllSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQ 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 435 CGRAFSHSSNLTQHQ--LLHTGE--RPFRCV--DCGKAFAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPAL------- 501
Cdd:COG5048  295 CNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqs 374

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 530416122 502 -FHHQRIHTGEK-----------TVRRSRASLHPQ 524
Cdd:COG5048  375 lQQYKDLKNDKKsetlsnscirnFKRDSNLSLHII 409
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 290-312 6.08e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.08e-04
                          10        20
                  ....*....|....*....|...
gi 530416122  290 YECAQCGKAFSQTSHLTQHQRIH 312
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
260-381 7.19e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 7.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 260 KSFECRACSKVFVKSSDLLKHLRT--HTGE--RPYEC--AQCGKAFSQTSHLTQHQRIHSGETPYACP--VCGKAFRHSS 331
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 332 SLVRHQRI--------------------------HTAEKS-----------FRCSECGKAFSHGSNLSQHRKIHAGGRPY 374
Cdd:COG5048  368 NNEPPQSLqqykdlkndkksetlsnscirnfkrdSNLSLHiithlsfrpynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                 ....*..
gi 530416122 375 ACAQCGR 381
Cdd:COG5048  448 LCSILKS 454
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 261-381 1.12e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 41.78  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 261 SFECRACsKVFVKSSDLLKH-------------------LRTHTGERPYECAQCGKAFSQTsHLTQHQRIHsgETPYACP 321
Cdd:PLN03086 407 TVECRNC-KHYIPSRSIALHeaycsrhnvvcphdgcgivLRVEEAKNHVHCEKCGQAFQQG-EMEKHMKVF--HEPLQCP 482

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416122 322 vCGKAFrHSSSLVRHQRIHTAEKSFRCSECGKAFSHGS----------NLSQHRKIhAGGRPYACAQCGR 381
Cdd:PLN03086 483 -CGVVL-EKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGMSEHESI-CGSRTAPCDSCGR 549
PHA00733 PHA00733
hypothetical protein
 316-364 1.19e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 530416122 316 TPYACPVCGKAFRHSSSLVRHqrIHTAEKSFRCSECGKAFSHGSNLSQH 364
Cdd:PHA00733  72 SPYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
PHA00733 PHA00733
hypothetical protein
 401-448 1.30e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.30e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 530416122 401 PFVCALCGAAFSQGSSLFKHQRVHTGEKpfACPQCGRAFSHSSNLTQH 448
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
428-493 1.45e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416122 428 KPFACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKAFAKGAVLLSHR--RIHTGEKPFVCTQCGR 493
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhlRTHHNNPSDLNSKSLP 99
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 374-396 2.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.47e-03
                          10        20
                  ....*....|....*....|...
gi 530416122  374 YACAQCGRRFCRNSHLIQHERTH 396
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 346-368 2.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|...
gi 530416122  346 FRCSECGKAFSHGSNLSQHRKIH 368
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
444-469 4.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 530416122  444 NLTQHQLLHTGERPFRCVDCGKAFAK 469
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 323-364 5.19e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 530416122 323 CGKAFRHSSSLVRHQRihtaEKSFRCSECGKAFSHGSNLSQH 364
Cdd:cd20908    7 CDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
ZnF_C2H2 smart00355
zinc finger;
318-340 6.95e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 34.36  E-value: 6.95e-03
                           10        20
                   ....*....|....*....|...
gi 530416122   318 YACPVCGKAFRHSSSLVRHQRIH 340
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
PHA00733 PHA00733
hypothetical protein
 429-476 8.58e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 8.58e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 530416122 429 PFACPQCGRAFSHSSNLTQHqlLHTGERPFRCVDCGKAFAKGAVLLSH 476
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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