CAX3 cation exchanger 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CAX3
Official Full Name: cation exchanger 3
Primary source: TAIR:AT3G51860
Locus tag: AT3G51860
See related: Araport:AT3G51860
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCAX3; ATHCX1; CALCIUM/PROTON EXCHANGER CAX1-LIKE PROTEIN; cation exchanger 3; CAX1-LIKE
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See CAX3 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 10

Sequence:: Chromosome: 3; NC_003074.8 (19239305..19242913)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAX3 (cation/proton exchanger) mediates a Cd tolerance by decreasing ROS through Ca elevation in Arabidopsis.
Title: CAX3 (cation/proton exchanger) mediates a Cd tolerance by decreasing ROS through Ca elevation in Arabidopsis.
Expression of CAX1 and CAX3 occurs in guard cells. Additionally, CAX1 and CAX3 are co-expressed in mesophyll tissue in response to wounding or flg22 treatment, due to the induction of CAX3 expression. The authors demonstrate that CAX1 and CAX3 can form homomeric and heteromeric complexes in plants.
Title: Heterodimerization of Arabidopsis calcium/proton exchangers contributes to regulation of guard cell dynamics and plant defense responses.
cax1/cax3 mutants have a higher apoplastic pH than the wild type, further supporting the hypothesis that there is a defect in auxin import in the cax mutants.
Title: Vacuolar CAX1 and CAX3 influence auxin transport in guard cells via regulation of apoplastic pH.
The role of CAX3 in elemental distribution and abundance in Arabidopsis seed
Title: The role of CAX1 and CAX3 in elemental distribution and abundance in Arabidopsis seed.
CAX1 and CAX3 mediate a shoot-derived signal that modulates the activity of the root phosphate [P(i)] transporter system, likely in part via posttranslational regulation of PHT1;1 P(i) transporters.
Title: Vacuolar Ca2+/H+ transport activity is required for systemic phosphate homeostasis involving shoot-to-root signaling in Arabidopsis.
Deletions identified in the N-terminal regulatory region (NRR) of CAX3 activate calcium ion (Ca2+) transport in both yeast and plants.
Title: Characterization of Arabidopsis Ca2+/H+ exchanger CAX3.
analysis of interactions between CAX protein domains through the use of nonfunctional halves of CAX transporters
Title: Functional studies of split Arabidopsis Ca2+/H+ exchangers.
Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3.
Title: Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3.
cax3 but not cax1 mutants sensitive to salt, lithium, and low pH
Title: The Arabidopsis cax3 mutants display altered salt tolerance, pH sensitivity and reduced plasma membrane H+-ATPase activity.
The functional roles of calcium exchanger 1 (CAX1), a vacuolar H+/Ca2+ transporter, and the closely related transporter CAX3 are reported.
Title: Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001339537.1

Supported by ESTs:

NM_115045.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium:monoatomic cation antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables calcium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular manganese ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular zinc ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lithium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphate ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphorus metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within priming of cellular response to stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	HEP more info	PubMed
acts_upstream_of_or_within sodium ion transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plant-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cation exchanger 3

NP_190754.2

cation exchanger 3 (CAX3); CONTAINS InterPro DOMAIN/s: Sodium/calcium exchanger membrane region (InterPro:IPR004837), Calcium/proton exchanger superfamily (InterPro:IPR004798), Calcium/proton exchanger (InterPro:IPR004713); BEST Arabidopsis thaliana protein match is: cation exchanger 1 (TAIR:AT2G38170.1); Has 3567 Blast hits to 3405 proteins in 1022 species: Archae - 24; Bacteria - 2167; Metazoa - 14; Fungi - 725; Plants - 252; Viruses - 0; Other Eukaryotes - 385 (source: NCBI BLink).