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    Csf3r colony stimulating factor 3 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csf3rprovided by RGD
    Official Full Name
    colony stimulating factor 3 receptorprovided by RGD
    Primary source
    RGD:1309114
    See related
    EnsemblRapid:ENSRNOG00000008759 AllianceGenome:RGD:1309114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine receptor activity and granulocyte colony-stimulating factor binding activity. Involved in amelogenesis. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 32.8), Lung (RPKM 24.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csf3r in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143583126..143604382)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138298605..138318224)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144031353..144051966)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene chaperonin containing Tcp1, subunit 7 (eta), pseudogene 2 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 5 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein S14, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain. Zhang E, et al. Mol Med Rep, 2017 Aug. PMID 28656207, Free PMC Article
    2. Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Dong F, et al. Leukemia, 1997 Jan. PMID 9001427
    3. Abnormalities of primitive myeloid progenitor cells expressing granulocyte colony-stimulating factor receptor in patients with severe congenital neutropenia. Nakamura K, et al. Blood, 2000 Dec 15. PMID 11110716
    4. Expression and functional analysis of granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukaemia. Sultana TA, et al. Br J Haematol, 2003 Apr. PMID 12670333
    5. Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs. Makam M, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19293384, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the expression of GCSFR in neurons following peripheral nerve injury may be involved in the induction and maintenance of neuropathic pain through the STAT3 and TRPV1 signaling pathway.
      Title: Expression of granulocyte colony-stimulating factor 3 receptor in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables granulocyte colony-stimulating factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in amelogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    granulocyte colony-stimulating factor receptor
    Names
    colony stimulating factor 3 receptor (granulocyte)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106685.1 → NP_001100155.1  granulocyte colony-stimulating factor receptor precursor

      See identical proteins and their annotated locations for NP_001100155.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6IS82
      Conserved Domains (4) summary
      smart00060
      Location:532 → 609
      FN3; Fibronectin type 3 domain
      cd00063
      Location:433 → 521
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      143583126..143604382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109618.2 → XP_038965546.1  granulocyte colony-stimulating factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6B3M3
      Conserved Domains (4) summary
      smart00060
      Location:571 → 648
      FN3; Fibronectin type 3 domain
      cd00063
      Location:472 → 560
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_039109621.2 → XP_038965549.1  granulocyte colony-stimulating factor receptor isoform X2

      Conserved Domains (4) summary
      smart00060
      Location:571 → 648
      FN3; Fibronectin type 3 domain
      cd00063
      Location:472 → 560
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_039109625.2 → XP_038965553.1  granulocyte colony-stimulating factor receptor isoform X7

      Conserved Domains (2) summary
      smart00060
      Location:438 → 515
      FN3; Fibronectin type 3 domain
      cd00063
      Location:339 → 427
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_039109619.2 → XP_038965547.1  granulocyte colony-stimulating factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6B3M3
      Conserved Domains (4) summary
      smart00060
      Location:571 → 648
      FN3; Fibronectin type 3 domain
      cd00063
      Location:472 → 560
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_039109617.2 → XP_038965545.1  granulocyte colony-stimulating factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6B3M3
      Conserved Domains (4) summary
      smart00060
      Location:571 → 648
      FN3; Fibronectin type 3 domain
      cd00063
      Location:472 → 560
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. XM_017593289.3 → XP_017448778.1  granulocyte colony-stimulating factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6B3M3
      Related
      ENSRNOP00000096023.1, ENSRNOT00000102077.2
      Conserved Domains (4) summary
      smart00060
      Location:571 → 648
      FN3; Fibronectin type 3 domain
      cd00063
      Location:472 → 560
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    7. XM_039109622.2 → XP_038965550.1  granulocyte colony-stimulating factor receptor isoform X3

      Conserved Domains (4) summary
      smart00060
      Location:560 → 637
      FN3; Fibronectin type 3 domain
      cd00063
      Location:461 → 549
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    8. XM_039109623.2 → XP_038965551.1  granulocyte colony-stimulating factor receptor isoform X4

      UniProtKB/TrEMBL
      D4A3R0
      Related
      ENSRNOP00000011694.6, ENSRNOT00000011694.8
      Conserved Domains (4) summary
      smart00060
      Location:543 → 620
      FN3; Fibronectin type 3 domain
      cd00063
      Location:444 → 532
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    9. XM_063287439.1 → XP_063143509.1  granulocyte colony-stimulating factor receptor isoform X6

    10. XM_063287437.1 → XP_063143507.1  granulocyte colony-stimulating factor receptor isoform X5

      UniProtKB/TrEMBL
      A6IS82

    11. XM_008764007.4 → XP_008762229.1  granulocyte colony-stimulating factor receptor isoform X5

      See identical proteins and their annotated locations for XP_008762229.1

      UniProtKB/TrEMBL
      A6IS82
      Conserved Domains (4) summary
      smart00060
      Location:532 → 609
      FN3; Fibronectin type 3 domain
      cd00063
      Location:433 → 521
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    12. XM_063287438.1 → XP_063143508.1  granulocyte colony-stimulating factor receptor isoform X5

      UniProtKB/TrEMBL
      A6IS82

    13. XM_039109620.2 → XP_038965548.1  granulocyte colony-stimulating factor receptor isoform X1

      UniProtKB/TrEMBL
      A0A8I6B3M3
      Conserved Domains (4) summary
      smart00060
      Location:571 → 648
      FN3; Fibronectin type 3 domain
      cd00063
      Location:472 → 560
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 → 111
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:123 → 221
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    14. XM_039109626.2 → XP_038965554.1  granulocyte colony-stimulating factor receptor isoform X8

      Conserved Domains (2) summary
      smart00060
      Location:393 → 470
      FN3; Fibronectin type 3 domain
      cd00063
      Location:294 → 382
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    15. XM_039109627.2 → XP_038965555.1  granulocyte colony-stimulating factor receptor isoform X9

      Conserved Domains (2) summary
      smart00060
      Location:252 → 329
      FN3; Fibronectin type 3 domain
      cd00063
      Location:153 → 241
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
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