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Conserved domains on  [gi|1958775602|ref|XP_038965546|]
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granulocyte colony-stimulating factor receptor isoform X1 [Rattus norvegicus]

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 11162515)

protein containing domains Lep_receptor_Ig, and FN3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-111 2.15e-25

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 100.39  E-value: 2.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602  24 EGCGQIRISPPIVHLGDPVLASCTISPN-CSKLDRQPK-ILWRLQDEpNQPGDRQHHLPDGSqeSIITLPHLNYTQAFLF 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLE-LIPGSQYTVLNDTV--SSVTLPNLNSTRALLT 77

                          90
                  ....*....|
gi 1958775602 102 CLVPWNNSFQ 111
Cdd:pfam06328  78 CCLLWGGQLQ 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 571-648 4.64e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 4.64e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775602  571 PELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGS 648
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-221 8.28e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 39.71  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 123 PPASPSNLSCLMYlTTNSLVCQWEPGPETHLPTSFILkSFRsrtgcqYQGGTILDCMPKKR---HSN----CSIPRKHLL 195
Cdd:pfam09067   7 LPEKPEDIKCFSR-EKEDFTCFWEEEEDGGLPTTYSF-SYA------YENETVKECPLYSTsgaNSTrlfiCFFPKNDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 1958775602 196 LYQNMVIWVQAENMLGSSESPKLCID 221
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 472-560 4.12e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 472 PAVTSLHAMAQDLGSIWVDWEAPSLLP---QGYLIEWGPDShkysNNSWRI--EPNGNTTGILLeDNIHPFQLYRITVAP 546
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKG----SGDWKEveVTPGSETSYTL-TGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1958775602 547 LYPGTVGPPVNVYT 560
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-111 2.15e-25

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 100.39  E-value: 2.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602  24 EGCGQIRISPPIVHLGDPVLASCTISPN-CSKLDRQPK-ILWRLQDEpNQPGDRQHHLPDGSqeSIITLPHLNYTQAFLF 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLE-LIPGSQYTVLNDTV--SSVTLPNLNSTRALLT 77

                          90
                  ....*....|
gi 1958775602 102 CLVPWNNSFQ 111
Cdd:pfam06328  78 CCLLWGGQLQ 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 571-648 4.64e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 4.64e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775602  571 PELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGS 648
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 568-658 1.05e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 568 PHAPE-LYLKHVGRTWAQLEWVPETPWLGmiPLTNYTIFWTDARDHSFSV--TLNISFHDFVLDHLKPASLYHVYLMATS 644
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGG--PITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1958775602 645 RAG-STNSTGLTLMT 658
Cdd:cd00063    79 GGGeSPPSESVTVTT 93
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 123-221 8.28e-04

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 39.71  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 123 PPASPSNLSCLMYlTTNSLVCQWEPGPETHLPTSFILkSFRsrtgcqYQGGTILDCMPKKR---HSN----CSIPRKHLL 195
Cdd:pfam09067   7 LPEKPEDIKCFSR-EKEDFTCFWEEEEDGGLPTTYSF-SYA------YENETVKECPLYSTsgaNSTrlfiCFFPKNDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 1958775602 196 LYQNMVIWVQAENMLGSSESPKLCID 221
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 472-560 4.12e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 472 PAVTSLHAMAQDLGSIWVDWEAPSLLP---QGYLIEWGPDShkysNNSWRI--EPNGNTTGILLeDNIHPFQLYRITVAP 546
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKG----SGDWKEveVTPGSETSYTL-TGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1958775602 547 LYPGTVGPPVNVYT 560
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Name Accession Description Interval E-value
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 24-111 2.15e-25

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 100.39  E-value: 2.15e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602  24 EGCGQIRISPPIVHLGDPVLASCTISPN-CSKLDRQPK-ILWRLQDEpNQPGDRQHHLPDGSqeSIITLPHLNYTQAFLF 101
Cdd:pfam06328   1 EPCGHISPSPPVVRLGSNVTASCILKENcCSHLGVEAQiIVWKLGLE-LIPGSQYTVLNDTV--SSVTLPNLNSTRALLT 77

                          90
                  ....*....|
gi 1958775602 102 CLVPWNNSFQ 111
Cdd:pfam06328  78 CCLLWGGQLQ 87
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 571-648 4.64e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 4.64e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958775602  571 PELYLKHVGRTWAQLEWVPETPWLGMIPLTNYTIFWTDARDHSFSVTLNISFHDFVLDHLKPASLYHVYLMATSRAGS 648
Cdd:smart00060   5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 568-658 1.05e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 568 PHAPE-LYLKHVGRTWAQLEWVPETPWLGmiPLTNYTIFWTDARDHSFSV--TLNISFHDFVLDHLKPASLYHVYLMATS 644
Cdd:cd00063     1 PSPPTnLRVTDVTSTSVTLSWTPPEDDGG--PITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1958775602 645 RAG-STNSTGLTLMT 658
Cdd:cd00063    79 GGGeSPPSESVTVTT 93
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 123-221 8.28e-04

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 39.71  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 123 PPASPSNLSCLMYlTTNSLVCQWEPGPETHLPTSFILkSFRsrtgcqYQGGTILDCMPKKR---HSN----CSIPRKHLL 195
Cdd:pfam09067   7 LPEKPEDIKCFSR-EKEDFTCFWEEEEDGGLPTTYSF-SYA------YENETVKECPLYSTsgaNSTrlfiCFFPKNDVS 78

                          90       100
                  ....*....|....*....|....*.
gi 1958775602 196 LYQNMVIWVQAENMLGSSESPKLCID 221
Cdd:pfam09067  79 LFVPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 472-560 4.12e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.48  E-value: 4.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958775602 472 PAVTSLHAMAQDLGSIWVDWEAPSLLP---QGYLIEWGPDShkysNNSWRI--EPNGNTTGILLeDNIHPFQLYRITVAP 546
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKG----SGDWKEveVTPGSETSYTL-TGLKPGTEYEFRVRA 76

                          90
                  ....*....|....
gi 1958775602 547 LYPGTVGPPVNVYT 560
Cdd:cd00063    77 VNGGGESPPSESVT 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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