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    IDH-VI isocitrate dehydrogenase VI [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820139, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IDH-VI
    Official Full Name
    isocitrate dehydrogenase VI
    Primary source
    TAIR:AT3G09810
    Locus tag
    AT3G09810
    See related
    Araport:AT3G09810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT3G09805; F8A24.14; F8A24_14; isocitrate dehydrogenase VI
    Summary
    Encodes a catalytic subunit of the mitochondrially-localized NAD+- dependent isocitrate dehydrogenase
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    Genomic context

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    See IDH-VI in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (3008499..3011465)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene CRINKLY4 related 1 Neighboring gene ubiquitin 8 Neighboring gene SNARE-like superfamily protein Neighboring gene adenosine kinase 1 Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of Arabidopsis thaliana NAD-dependent isocitrate dehydrogenase genes shows the presence of a functional subunit that is mainly expressed in the pollen and absent from vegetative organs. Lemaitre T, et al. Plant Cell Physiol, 2006 May. PMID 16527867
    2. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article
    3. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article
    4. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_180218.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isocitrate dehydrogenase (NAD+) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within isocitrate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    isocitrate dehydrogenase VI
    NP_850549.1
    • isocitrate dehydrogenase VI (IDH-VI); CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NAD-dependent, mitochondrial (InterPro:IPR004434), Isocitrate/isopropylmalate dehydrogenase, conserved site (InterPro:IPR019818); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase V (TAIR:AT5G03290.1); Has 17175 Blast hits to 17053 proteins in 2733 species: Archae - 398; Bacteria - 9669; Metazoa - 935; Fungi - 952; Plants - 360; Viruses - 0; Other Eukaryotes - 4861 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3008499..3011465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180218.2 → NP_850549.1  isocitrate dehydrogenase VI [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG77, Q9SF84
      UniProtKB/TrEMBL
      A0A178V9M1, A0A5S9XBS1
      Conserved Domains (1) summary
      PLN00118
      Location:3 → 374
      PLN00118; isocitrate dehydrogenase (NAD+)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LG77.2

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