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Conserved domains on  [gi|30681023|ref|NP_850549|]
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isocitrate dehydrogenase VI [Arabidopsis thaliana]

Protein Classification

isocitrate/isopropylmalate dehydrogenases family protein( domain architecture ID 10010635)

isocitrate/isopropylmalate dehydrogenases family protein similar to Arabidopsis thaliana isocitrate dehydrogenase (NAD(+)) catalytic subunit, and Solanum tuberosum 3-isopropylmalate dehydrogenase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 3-374 0e+00

isocitrate dehydrogenase (NAD+)


:

Pssm-ID: 215062  Cd Length: 372  Bit Score: 733.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    3 MTAFLARRLIGNGSSQILGTSSSSSGPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGT 82
Cdd:PLN00118   1 MAAQLLRRLLGNRLAQILGASSSSSGAFSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   83 EVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTE 162
Cdd:PLN00118  81 TVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  163 GEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKV 242
Cdd:PLN00118 161 GEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  243 VIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLS 322
Cdd:PLN00118 241 IIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLS 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 30681023  323 GVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSSTTTDFTKAICDHL 374
Cdd:PLN00118 321 AVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
 
Name Accession Description Interval E-value
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 3-374 0e+00

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 733.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    3 MTAFLARRLIGNGSSQILGTSSSSSGPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGT 82
Cdd:PLN00118   1 MAAQLLRRLLGNRLAQILGASSSSSGAFSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   83 EVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTE 162
Cdd:PLN00118  81 TVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  163 GEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKV 242
Cdd:PLN00118 161 GEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  243 VIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLS 322
Cdd:PLN00118 241 IIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLS 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 30681023  323 GVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSSTTTDFTKAICDHL 374
Cdd:PLN00118 321 AVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 42-374 7.22e-176

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 492.28  E-value: 7.22e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    42 TPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFltwDN-LQSVLKNKVGLKGPMATPIGKG-H 119
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEIP---DEaVESIKRNKVALKGPLETPIGKGgH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   120 RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYA 199
Cdd:TIGR00175  79 RSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   200 KTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLV 279
Cdd:TIGR00175 159 RKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   280 GGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGG 359
Cdd:TIGR00175 239 GGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|....*
gi 30681023   360 SSTTTDFTKAICDHL 374
Cdd:TIGR00175 319 TATTSDFTEAVIKRL 333
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 45-374 9.22e-162

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 456.78  E-value: 9.22e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  45 KATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPI---GK 117
Cdd:COG0473   3 KIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKwddGV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 118 GHRSLNLTLRKELNLYANVRPCYSLPGYKTRY-----DDVDLITIRENTEGEYSGLEHQVVKG----VVESLKIITRKAS 188
Cdd:COG0473  83 RPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTRKGI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 189 MRVAEYAFLYAKTHgRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYG 268
Cdd:COG0473 163 ERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLFG 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 269 DIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIA 348
Cdd:COG0473 242 DILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVLA 321

                       330       340
                ....*....|....*....|....*.
gi 30681023 349 EGkYRTADLGGSSTTTDFTKAICDHL 374
Cdd:COG0473 322 EG-VRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
45-370 1.30e-130

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 377.79  E-value: 1.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    45 KATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIG--KG 118
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAlekaPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   119 HRSLN--LTLRKELNLYANVRPCYSLPG------YKTRYDDVDLITIRENTEGEYSGLEHQVVKG---VVESLKIITRKA 187
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   188 SMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLY 267
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   268 GDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRH-LKLNKQAEQIHSAIINT 346
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*..
gi 30681023   347 IAEGkYRTADLGGSST---TTDFTKAI 370
Cdd:pfam00180 321 LESG-IRTGDLAGSATyvsTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
44-370 1.27e-116

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 341.71  E-value: 1.27e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   44 IKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPM-ATPigkGHRSL 122
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVtSTP---GQKSP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  123 NLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTH 202
Cdd:NF040626  79 IITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFEYAIKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  203 GRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGL 282
Cdd:NF040626 159 GRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGGL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  283 GLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSST 362
Cdd:NF040626 239 GLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317


                 ....*...
gi 30681023  363 TTDFTKAI 370
Cdd:NF040626 318 TMEMANEI 325
AksF_Meth NF040619
homoisocitrate dehydrogenase;
45-370 3.46e-88

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 269.32  E-value: 3.46e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   45 KATLFPGDGIGPE-IAESVKQVFTAADVVIDWDEqfVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATP-----IGKG 118
Cdd:NF040619   3 KICVIEGDGIGKEvIPETVRVLKELGDFEFIKGE--AGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPkptelKNKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  119 HRSLNLTLRKELNLYANVRPCYSLpGYKTRYDDVDLITIRENTEGEYSGLEHQVVKG-VVESLKIITRKASMRVAEYAFL 197
Cdd:NF040619  81 YKSPILTLRKELDLYANVRPINNF-GDGQDVKNIDFVIIRENTEGLYVGREYYDEENeIAIAERIISKKGSERIIKFAFE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  198 YAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPE--IYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLC 275
Cdd:NF040619 160 YAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDILSDEA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  276 AGLVGGLGLTPSMNIGEDgIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGkYRTA 355
Cdd:NF040619 240 SGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENG-KVTP 317

                        330
                 ....*....|....*
gi 30681023  356 DLGGSSTTTDFTKAI 370
Cdd:NF040619 318 DLGGNLKTKEVTDKI 332
 
Name Accession Description Interval E-value
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 3-374 0e+00

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 733.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    3 MTAFLARRLIGNGSSQILGTSSSSSGPFISVSRAFFSSSTPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGT 82
Cdd:PLN00118   1 MAAQLLRRLLGNRLAQILGASSSSSGAFSSSARAFSSSSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   83 EVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTE 162
Cdd:PLN00118  81 TVDPRTGSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  163 GEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKV 242
Cdd:PLN00118 161 GEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  243 VIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLS 322
Cdd:PLN00118 241 IIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLS 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 30681023  323 GVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSSTTTDFTKAICDHL 374
Cdd:PLN00118 321 AVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 42-374 7.22e-176

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 492.28  E-value: 7.22e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    42 TPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFltwDN-LQSVLKNKVGLKGPMATPIGKG-H 119
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEIP---DEaVESIKRNKVALKGPLETPIGKGgH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   120 RSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYA 199
Cdd:TIGR00175  79 RSLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   200 KTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLV 279
Cdd:TIGR00175 159 RKNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   280 GGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGG 359
Cdd:TIGR00175 239 GGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGG 318

                         330
                  ....*....|....*
gi 30681023   360 SSTTTDFTKAICDHL 374
Cdd:TIGR00175 319 TATTSDFTEAVIKRL 333
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 45-374 9.22e-162

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 456.78  E-value: 9.22e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  45 KATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPI---GK 117
Cdd:COG0473   3 KIAVLPGDGIGPEVVAAALKVLEAAaerfGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKwddGV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 118 GHRSLNLTLRKELNLYANVRPCYSLPGYKTRY-----DDVDLITIRENTEGEYSGLEHQVVKG----VVESLKIITRKAS 188
Cdd:COG0473  83 RPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTRKGI 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 189 MRVAEYAFLYAKTHgRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYG 268
Cdd:COG0473 163 ERIARYAFELARKR-RKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLFG 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 269 DIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIA 348
Cdd:COG0473 242 DILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAAVEKVLA 321

                       330       340
                ....*....|....*....|....*.
gi 30681023 349 EGkYRTADLGGSSTTTDFTKAICDHL 374
Cdd:COG0473 322 EG-VRTPDLGGKAGTSEMGDAIIAAL 346
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 45-374 8.42e-141

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 403.33  E-value: 8.42e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   45 KATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNL 124
Cdd:PRK08997   4 TITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTSINV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  125 TLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVK--GVVESLKIITRKASMRVAEYAFLYAKTH 202
Cdd:PRK08997  84 TLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTVSEdgETAEATSIITRKGAERIVRFAYELARKE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  203 GRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGL 282
Cdd:PRK08997 164 GRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  283 GLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSST 362
Cdd:PRK08997 244 GMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGGTHG 322

                        330
                 ....*....|..
gi 30681023  363 TTDFTKAICDHL 374
Cdd:PRK08997 323 TTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
39-374 2.32e-135

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 395.03  E-value: 2.32e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   39 SSSTPIkaTLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSF----LTWDnlqSVLKNKVGLKGPMATP 114
Cdd:PRK09222   2 AEKTPI--TVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEKVYKKGWTSgispSAWE---SIRRTKVLLKAPITTP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  115 IGKGHRSLNLTLRKELNLYANVRPCYSL-PGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAE 193
Cdd:PRK09222  77 QGGGYKSLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  194 YAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISD 273
Cdd:PRK09222 157 YAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  274 LCAGLVGGLGLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYr 353
Cdd:PRK09222 237 IAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDGIH- 314

                        330       340
                 ....*....|....*....|....*..
gi 30681023  354 TADLGGSST------TTDFTKAICDHL 374
Cdd:PRK09222 315 TADIYNEGVskkkvgTKEFAEAVIENL 341
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 43-374 2.89e-131

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 379.98  E-value: 2.89e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   43 PIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFV--GTEVDPRtnsfltwDNLQSVLKNKVGLKGPMATPIGKGHR 120
Cdd:PLN00123  30 PRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVhgDMKKVPE-------EVLESIRRNKVCLKGGLATPVGGGVS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  121 SLNLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAK 200
Cdd:PLN00123 103 SLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAY 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  201 THGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVG 280
Cdd:PLN00123 183 LNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAG 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  281 GLGLTPSMNIGEDGIAL---AEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADL 357
Cdd:PLN00123 263 GTGVMPGGNVGADHAVFeqgASAGNVGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDL 342

                        330
                 ....*....|....*..
gi 30681023  358 GGSSTTTDFTKAICDHL 374
Cdd:PLN00123 343 GGSSTTQEVVDAVIANL 359
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
45-370 1.30e-130

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 377.79  E-value: 1.30e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    45 KATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIG--KG 118
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAAlekaPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWdpAG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   119 HRSLN--LTLRKELNLYANVRPCYSLPG------YKTRYDDVDLITIRENTEGEYSGLEHQVVKG---VVESLKIITRKA 187
Cdd:pfam00180  81 VRPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   188 SMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLY 267
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   268 GDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRH-LKLNKQAEQIHSAIINT 346
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEAAVLKV 320

                         330       340
                  ....*....|....*....|....*..
gi 30681023   347 IAEGkYRTADLGGSST---TTDFTKAI 370
Cdd:pfam00180 321 LESG-IRTGDLAGSATyvsTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
44-370 1.27e-116

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 341.71  E-value: 1.27e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   44 IKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPM-ATPigkGHRSL 122
Cdd:NF040626   2 YKITVIPGDGIGKEVMEAALYVLDALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVtSTP---GQKSP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  123 NLTLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAKTH 202
Cdd:NF040626  79 IITLRKELDLYANLRPIKSYEGINCLFKDLDFLIVRENTEGLYSGLEEEYTEEKAIAERVITRKASERICKFAFEYAIKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  203 GRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGL 282
Cdd:NF040626 159 GRKKVTAVHKANVLKKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVIVTTNLFGDILSDEAAGLVGGL 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  283 GLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYRTADLGGSST 362
Cdd:NF040626 239 GLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDYLGETYEANKLENALEKVLREGKVVTPDLGGNAK 317


                 ....*...
gi 30681023  363 TTDFTKAI 370
Cdd:NF040626 318 TMEMANEI 325
ICDH_alpha TIGR02924
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ...
 42-374 5.60e-108

isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]


Pssm-ID: 274353 [Multi-domain]  Cd Length: 473  Bit Score: 324.79  E-value: 5.60e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    42 TPIkaTLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPR------TNSflTWDNLQsvlKNKVGLKGPMATPI 115
Cdd:TIGR02924   1 IPI--TVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIGEKVYKKgwpsgiSPS--SWESIR---RTKVLLKAPITTPQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   116 GKGHRSLNLTLRKELNLYANVRPCYSL-PGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEY 194
Cdd:TIGR02924  74 GGGHKSLNVTLRKTLGLYANIRPCVSYhPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRY 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   195 AFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDL 274
Cdd:TIGR02924 154 AFEYARKHNRKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   275 CAGLVGGLGLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYrT 354
Cdd:TIGR02924 234 AAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGQNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLEDGVH-T 311

                         330       340
                  ....*....|....*....|....*.
gi 30681023   355 ADLGGSST------TTDFTKAICDHL 374
Cdd:TIGR02924 312 ADIYNEKTskqkvgTKEFAEAVTANL 337
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 45-374 6.16e-106

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 314.38  E-value: 6.16e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   45 KATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPmatpIGKGHRSLNL 124
Cdd:PRK14025   3 KICVIEGDGIGKEVVPAALHVLEATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGA----AGETAADVIV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  125 TLRKELNLYANVRPCYSLPGYKTRYDDVDLITIRENTEGEYSGLEHQVVKGVVESLKIITRKASMRVAEYAFLYAK---- 200
Cdd:PRK14025  79 KLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKrrkk 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  201 THGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVG 280
Cdd:PRK14025 159 MGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  281 GLGLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKyRTADLGGS 360
Cdd:PRK14025 239 GLGLAPSANIGDKY-GLFEPVHGSAPDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL-TTPDLGGN 316

                        330
                 ....*....|....
gi 30681023  361 STTTDFTKAICDHL 374
Cdd:PRK14025 317 LSTMEMAEEVAKRV 330
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 50-370 1.36e-104

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 310.93  E-value: 1.36e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    50 PGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLNLTLRKE 129
Cdd:TIGR02088   5 PGDGIGPEVIEAAIRILNKLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPANPGYKSVIVTLRKE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   130 LNLYANVRPCYSLPGYKTRY-DDVDLITIRENTEGEYSGLEhQVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKkVS 208
Cdd:TIGR02088  85 LDLYANVRPAKSLPGIPDLYpNGKDIVIVRENTEGLYAGFE-FGFSDRAIAIRVITREGSERIARFAFNLAKERNRK-VT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   209 AIHKANIMQKTDGLFLQCCDEVAAKYpEIYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSM 288
Cdd:TIGR02088 163 CVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSLGLAPSA 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   289 NIGEDgIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGkYRTADLGGSSTTTDFTK 368
Cdd:TIGR02088 242 NIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEG-KKTPDLGGTAKTKEVGD 319


                  ..
gi 30681023   369 AI 370
Cdd:TIGR02088 320 EI 321
AksF_Meth NF040619
homoisocitrate dehydrogenase;
45-370 3.46e-88

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 269.32  E-value: 3.46e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   45 KATLFPGDGIGPE-IAESVKQVFTAADVVIDWDEqfVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATP-----IGKG 118
Cdd:NF040619   3 KICVIEGDGIGKEvIPETVRVLKELGDFEFIKGE--AGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPkptelKNKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  119 HRSLNLTLRKELNLYANVRPCYSLpGYKTRYDDVDLITIRENTEGEYSGLEHQVVKG-VVESLKIITRKASMRVAEYAFL 197
Cdd:NF040619  81 YKSPILTLRKELDLYANVRPINNF-GDGQDVKNIDFVIIRENTEGLYVGREYYDEENeIAIAERIISKKGSERIIKFAFE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  198 YAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPE--IYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLC 275
Cdd:NF040619 160 YAKKNNRKKVSCIHKANVLRVTDGLFLEIFNEIKKKYKNfnIEADDYLVDATAMYLIKNPEMFDVIVTTNLFGDILSDEA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  276 AGLVGGLGLTPSMNIGEDgIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGkYRTA 355
Cdd:NF040619 240 SGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDYLGMKEKGDLIREAVKKCLENG-KVTP 317

                        330
                 ....*....|....*
gi 30681023  356 DLGGSSTTTDFTKAI 370
Cdd:NF040619 318 DLGGNLKTKEVTDKI 332
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 51-374 2.74e-87

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 269.67  E-value: 2.74e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  51 GDGIGPEIAESVKQVFTAA-------DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLN 123
Cdd:COG0538  26 GDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLTTPVGGGWRSLN 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 124 LTLRKELNLYANVRPCYSLPGYKT---RYDDVDLITIRENTEGEYSGLEHQV----VKGVVESL---------------- 180
Cdd:COG0538 106 VTIRQILDLYVCRRPVRYFKGVPSpvkHPEKVDIVIFRENTEDIYAGIEWKAgspeALKLIFFLedemgvtvirfpedsg 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 181 ---KIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAK-YPE-------------------I 237
Cdd:COG0538 186 igiKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEeFGDkfitegpwekykgpkpagkI 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023 238 YYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPT 317
Cdd:COG0538 266 VYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGGAEFEATHGTAPKYAGKDSTNPG 345

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30681023 318 ALLLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYrTADL-----GGSS-TTTDFTKAICDHL 374
Cdd:COG0538 346 SLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDLarlmeGATElSTSEFGDAIIENL 407
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 45-374 1.51e-83

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 258.11  E-value: 1.51e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   45 KATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVGTEVDPRTNSFLT----------------------WDNLQ 98
Cdd:PRK00772   4 KIAVLPGDGIGPEVMAEAVKVLDAVaekfGFDFEFEEALVGGAAIDAHGVPLPeetleacraadavllgavggpkWDNLP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   99 SVLKNKVGLkgpmatpigkghrslnLTLRKELNLYANVRPCYSLPGYKT-------RYDDVDLITIRENTEGEYSGlEHq 171
Cdd:PRK00772  84 PDVRPERGL----------------LALRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFG-EP- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  172 vvKGVVESLK--------IITRKASMRVAEYAFLYAKTHgRKKVSAIHKANIMqKTDGLFLQCCDEVAAKYPEIYYEKVV 243
Cdd:PRK00772 146 --RGREGLGGeerafdtmVYTREEIERIARVAFELARKR-RKKVTSVDKANVL-ESSRLWREVVTEVAKEYPDVELSHMY 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  244 IDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSG 323
Cdd:PRK00772 222 VDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSA 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 30681023  324 VMMLRH-LKLNKQAEQIHSAIINTIAEGkYRTADL---GGSSTTTDFTKAICDHL 374
Cdd:PRK00772 302 AMMLRYsLGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAAL 355
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 45-374 1.10e-74

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 234.99  E-value: 1.10e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    45 KATLFPGDGIGPEIAESVKQVFTAAD----VVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPI-GKGH 119
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAerfgLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKwDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   120 RSLN-----LTLRKELNLYANVRPCYSLPGY------KTRY-DDVDLITIRENTEGEYSGLEhqvvKGVVESLKII---- 183
Cdd:TIGR00169  81 RDQRpeqglLKLRKSLDLFANLRPAKVFPGLedlsplKEEIaKGVDFVVVRELTGGIYFGEP----KGREGEGEAWdtev 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   184 -TRKASMRVAEYAFLYAKTHgRKKVSAIHKANIMQkTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLV 262
Cdd:TIGR00169 157 yTVPEIERIARVAFEMARKR-RKKVTSVDKANVLE-SSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   263 MPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRH-LKLNKQAEQIHS 341
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEA 314

                         330       340       350
                  ....*....|....*....|....*....|...
gi 30681023   342 AIINTIAEGkYRTADLGGSSTTTDFTKAICDHL 374
Cdd:TIGR00169 315 AVKKVLAEG-YRTPDLGSSATTAVGTAEMGEEL 346
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 40-358 1.05e-69

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 222.11  E-value: 1.05e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   40 SSTPIKATLFPGDGIGPE-IAESVK--QVFTAADVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPM---AT 113
Cdd:PRK03437   1 MAKTMKLAVIPGDGIGPEvVAEALKvlDAVAAGGPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIgdpSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  114 PIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRY---DDVDLITIRENTEGEYSGLEHQVVKG----VVESLKIITRK 186
Cdd:PRK03437  81 PSGVLERGLLLKLRFALDHYVNLRPSKLYPGVTSPLagpGDIDFVVVREGTEGPYTGNGGALRVGtpheVATEVSVNTAF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  187 ASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNL 266
Cdd:PRK03437 161 GVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  267 YGDIISDLCAGLVGGLGLTPSMNIGEDGIALA--EAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAII 344
Cdd:PRK03437 241 FGDIITDLAAAVTGGIGLAASGNINPTGTNPSmfEPVHGSAPDIAGQGIADPTAAILSVALLLDHLGEEDAAARIEAAVE 320

                        330
                 ....*....|....*..
gi 30681023  345 NTIAE---GKYRTADLG 358
Cdd:PRK03437 321 ADLAErgkMGRSTAEVG 337
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 45-374 1.87e-67

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 216.62  E-value: 1.87e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023    45 KATLFPGDGIGPEIAESVKQVFTAA-----DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIG-KG 118
Cdd:TIGR02089   5 RIAAIPGDGIGKEVVAAALQVLEAAakrhgGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPALvPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   119 HRSLN---LTLRKELNLYANVRPCYSLPGYKT-----RYDDVDLITIRENTEGEYSGLEHQVVKG----VVESLKIITRK 186
Cdd:TIGR02089  85 HISLWgllLKIRREFDQYANVRPAKLLPGVTSplrncGPGDFDFVVVRENSEGEYSGVGGRIHRGtdeeVATQNAIFTRK 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   187 ASMRVAEYAFLYAKTHgRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVLVMPNL 266
Cdd:TIGR02089 165 GVERIMRFAFELAQKR-RKHLTSATKSNGIRHSMPFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVIVASNL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   267 YGDIISDLCAGLVGGLGLTPSMNIGEDGIA--LAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIHSAII 344
Cdd:TIGR02089 244 FGDILSDLGAALMGSLGVAPSANINPEGKFpsMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAKIMDAIE 323

                         330       340       350
                  ....*....|....*....|....*....|
gi 30681023   345 NTIAEGkYRTADLGGSSTTTDFTKAICDHL 374
Cdd:TIGR02089 324 RVTAAG-ILTPDVGGKATTSEVTEAVCNAL 352
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
51-372 2.38e-65

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 213.15  E-value: 2.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   51 GDGIGPEIAESVKQVFTAA-------DVVIDWDEQFVGTEVDPRTNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRSLN 123
Cdd:PRK06451  31 GDGIGPEITHAAMKVINKAvekaygsDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKGWKSIN 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  124 LTLRKELNLYANVRPCYSLPGYKT---RYDDVDLITIRENTEGEYSGLEH--------QVVKGVVESLKI---------- 182
Cdd:PRK06451 111 VAIRLMLDLYANIRPVKYIPGIESplkNPEKIDLIIFRENTDDLYRGIEYpydseeakKIRDFLRKELGVeveddtgigi 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  183 --ITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAAK---------------YPEIYYEKVVI- 244
Cdd:PRK06451 191 klISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKefrdyvvteeevtknYNGVPPSGKVIi 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  245 -----DNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGiALAEAVHGSAPDIAGMNLANPTAL 319
Cdd:PRK06451 271 ndriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEAIHGTAPKYAGKNVANPTGI 349

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 30681023  320 LLSGVMMLRHLKLNKQAEQIHSAIINTIAEGKYrTADLG-----GSSTTTDFTKAICD 372
Cdd:PRK06451 350 IKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDLArfmgvRALSTTEYTDELIS 406
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 51-348 9.24e-61

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 201.06  E-value: 9.24e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   51 GDGIGPEIAESVKQVFTAA-------DVVIDWDEQFVGTEVDPRT--NSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRS 121
Cdd:PRK07006  27 GDGIGPDITPAMLKVVDAAvekaykgERKISWMEIYAGEKATKVYgeDVWLPEETLDLIREYRVAIKGPLTTPVGGGIRS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  122 LNLTLRKELNLYANVRPCYSLPGYKT---RYDDVDLITIRENTEGEYSGLEHQV----VKGVVESL-------------- 180
Cdd:PRK07006 107 LNVALRQELDLYVCLRPVRYFKGVPSpvkRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvkkirfpet 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  181 -----KIITRKASMRVAEYAFLYAKTHGRKKVSAIHKANIMQKTDGLFLQCCDEVAA----------------KYPE--- 236
Cdd:PRK07006 187 sgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEeefgdelidggpwdkiKNPEtgk 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  237 -IYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGeDGIALAEAVHGSAPDIAGMNLAN 315
Cdd:PRK07006 267 eIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN-DGHAIFEATHGTAPKYAGLDKVN 345

                        330       340       350
                 ....*....|....*....|....*....|...
gi 30681023  316 PTALLLSGVMMLRHLKLNKQAEQIHSAIINTIA 348
Cdd:PRK07006 346 PGSVILSAEMMLRHMGWTEAADLIIKSMEKTIA 378
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 44-374 8.54e-58

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 191.47  E-value: 8.54e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   44 IKATLFPGDGIGPEI-AESVKQVFTAADVviDWDEQFVGTEVDPRTNSFL------------TWDNLQSVLKNKVGlkGP 110
Cdd:PRK08194   4 FKIAVIPGDGVGKEVvPAAVRVLKAVAEV--HGGLKFEFTEFPWSCEYYLehgemmpedgleQLKQFDAIFLGAVG--NP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  111 MATPigkGHRSL---NLTLRKELNLYANVRPCYSLPGYK---TRYDDVDLITIRENTEGEYS---GLEHQVVKGVVESLK 181
Cdd:PRK08194  80 KLVP---DHISLwglLIKIRREFEQVINIRPAKQLRGIKsplANPKDFDLLVVRENSEGEYSevgGRIHRGEDEIAIQNA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  182 IITRKASMRVAEYAFLYAKTHgRKKVSAIHKANIMQKTDGLFLQCCDEVAAKYPEIYYEKVVIDNCCMMLVKNPALFDVL 261
Cdd:PRK08194 157 VFTRKGTERAMRYAFELAAKR-RKHVTSATKSNGIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFDVI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  262 VMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGI--ALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQI 339
Cdd:PRK08194 236 VASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDHFGEEELGSHL 315

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 30681023  340 HSAIINTIAEGkYRTADLGGSSTTTDFTKAICDHL 374
Cdd:PRK08194 316 LDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
51-357 4.21e-43

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 156.03  E-value: 4.21e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   51 GDGIGPEIAESVKQVFTAA-------DVVIDWDEQFVGTEVDPR--TNSFLTWDNLQSVLKNKVGLKGPMATPIGKGHRS 121
Cdd:PRK07362  36 GDGTGVDIWPATQKVLDAAvakayggERKINWFKVYAGDEACDLygTYQYLPEDTLEAIREYGVAIKGPLTTPIGGGIRS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  122 LNLTLRKELNLYANVRPCYSLPGYKT---RYDDVDLITIRENTEGEYSGLE----------------------------H 170
Cdd:PRK07362 116 LNVALRQIFDLYSCVRPCRYYAGTPSphkNPEKLDVIVYRENTEDIYMGIEweagdeigdklikhlneevipaspelgkR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  171 QVVKGVVESLKIITRKASMRVAEYAFLYAKTHGRKK--VSAIHKANIMQKTDGLFLQCCDEVAA---------------- 232
Cdd:PRK07362 196 QIPLGSGIGIKPVSKTGSQRHIRRAIEHALRLPGDKrhVTLVHKGNIMKYTEGAFRDWGYELATtefrdecvtereswil 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  233 ----KYPEIYYE-------------------------KVVIDNCC----------MMLVKN-------------PALFDV 260
Cdd:PRK07362 276 snkeKNPNISIEdnarmiepgydsltpekkaaicaevKEVLDSIWsshgngkwkeKVLVDDriadsifqqiqtrPQEYSI 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  261 LVMPNLYGDIISDLCAGLVGGLGLTPSMNIGeDGIALAEAVHGSAPDIAGMNLANPTALLLSGVMMLRHLKLNKQAEQIH 340
Cdd:PRK07362 356 LATLNLNGDYISDAAAAIVGGLGMAPGANIG-DNAAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEYLGWQEAADLIT 434

                        410
                 ....*....|....*..
gi 30681023  341 SAIINTIAEGKYrTADL 357
Cdd:PRK07362 435 KGLSAAIANKQV-TYDL 450
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 39-357 1.62e-40

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 147.53  E-value: 1.62e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   39 SSSTPIKA----TLFPGDGIGPEIAESVKQVFTAADVV--IDWDEQ---FVGTEVD--------------PRTNSFL--- 92
Cdd:PLN02329  38 AAASPGKKryniALLPGDGIGPEVISVAKNVLQKAGSLegLEFDFQempVGGAALDlvgvplpeetftaaKQSDAILlga 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023   93 ----TWDNLQSVLKNKVGLkgpmatpigkghrslnLTLRKELNLYANVRPCYSLPGY-------KTRYDDVDLITIRENT 161
Cdd:PLN02329 118 iggyKWDKNEKHLRPEMAL----------------FYLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELT 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  162 EGEYSGLEHQVV-----KGVVESLKIITRKASMRVAEYAFLYAKTHgRKKVSAIHKANIMQKTDgLFLQCCDEVAAKYPE 236
Cdd:PLN02329 182 GGIYFGEPRGITinengEEVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPD 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  237 IYYEKVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLVGGLGLTPSMNIGEDGIALAEAVHGSAPDIAGMNLANP 316
Cdd:PLN02329 260 VELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANP 339

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 30681023  317 TALLLSGVMMLRH-LKLNKQAEQIHSAIINTIAEGkYRTADL 357
Cdd:PLN02329 340 LATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKG-FRTGDI 380
PLN03065 PLN03065
isocitrate dehydrogenase (NADP+); Provisional
 212-366 8.08e-09

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 178617 [Multi-domain]  Cd Length: 483  Bit Score: 56.81  E-value: 8.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  212 KANIMQKTDGLFLQCCDEV-----AAKYPE--IYYEKVVIDNCCMMLVKNPALFdVLVMPNLYGDIISDLCAGLVGGLGL 284
Cdd:PLN03065 281 KNTILKKYDGRFKDIFQEVyeeqwKQKFEEhsIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDVQSDLLAQGFGSLGL 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  285 TPSMNIGEDGIAL-AEAVHGSAP------DIAGMNLANPTALLLSGVMMLRH-LKLNKQAE------QIHSAIINTIAEG 350
Cdd:PLN03065 360 MTSVLLSSDGKTLeAEAAHGTVTrhfrlhQKGQETSTNSIASIFAWTRGLEHrAKLDKNEElldfvhKLESACIETVESG 439

                        170       180
                 ....*....|....*....|
gi 30681023  351 KYrTADLG----GSSTTTDF 366
Cdd:PLN03065 440 KM-TKDLAilihGPKVSREF 458
PLN00103 PLN00103
isocitrate dehydrogenase (NADP+); Provisional
 212-366 2.73e-05

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177720  Cd Length: 410  Bit Score: 45.98  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  212 KANIMQKTDGLFLQCCDEV-----AAKYPE--IYYEKVVIDNCCMMLVKNPALFdVLVMPNLYGDIISDLCAGLVGGLGL 284
Cdd:PLN00103 214 KNTILKKYDGRFKDIFQEVyeaqwKSKFEAagIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLGL 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  285 TPSMNIGEDGIAL-AEAVHGSAP------DIAGMNLANPTALLLSGVMMLRH-------LKLNKQAEQIHSAIINTIAEG 350
Cdd:PLN00103 293 MTSVLVCPDGKTIeAEAAHGTVTrhyrvhQKGGETSTNSIASIFAWSRGLAHrakldgnARLLDFTEKLEAACVGTVESG 372

                        170       180
                 ....*....|....*....|
gi 30681023  351 KYrTADLG----GSSTTTDF 366
Cdd:PLN00103 373 KM-TKDLAllihGPKVSRDQ 391
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 212-304 1.11e-03

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 40.74  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30681023  212 KANIMQKTDGLFLQCCDEV-AAKYPE------IYYEKVVIDNCCMMLVKNPALFdVLVMPNLYGDIISDLCAGLVGGLGL 284
Cdd:PTZ00435 213 KNTILKKYDGRFKDIFQEIyDEEYKAkfekagLWYEHRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGL 291

                         90       100
                 ....*....|....*....|.
gi 30681023  285 TPSMNIGEDG-IALAEAVHGS 304
Cdd:PTZ00435 292 MTSVLVCPDGkTVEAEAAHGT 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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