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    AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836457, updated on 18-Sep-2024

    Summary

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    Official Full Name
    AMP-dependent synthetase and ligase family protein
    Primary source
    TAIR:AT5G63380
    Locus tag
    AT5G63380
    See related
    Araport:AT5G63380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    K9H21.11; K9H21_11
    Summary
    Encodes a peroxisomal protein involved in the activation of fatty acids through esterification with CoA. At5g63380 preferentially activates fatty acids with increased chain length (C9:0 to C8:0) and thus shares characteristics with long-chain fatty acyl-CoA synthases. Also able to catalyze the conversion of OPDA to its CoA ester and is therefore thought to be involved in the peroxisomal beta-oxidation steps of jasmonic acid biosynthesis.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (25387411..25390227, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene von willebrand factor A domain protein Neighboring gene Protein kinase superfamily protein Neighboring gene uncharacterized protein Neighboring gene O-fucosyltransferase family protein Neighboring gene adenylate kinase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid. Schneider K, et al. J Biol Chem, 2005 Apr 8. PMID 15677481
    2. Jasmonates meet fatty acids: functional analysis of a new acyl-coenzyme A synthetase family from Arabidopsis thaliana. Kienow L, et al. J Exp Bot, 2008. PMID 18267944
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data demonstrate that At4g05160 and At5g63380 have the capacity to contribute to jasmonic acid biosynthesis by initiating the beta-oxidative chain shortening of its precursors.
      Title: A new type of peroxisomal acyl-coenzyme A synthetase from Arabidopsis thaliana has the catalytic capacity to activate biosynthetic precursors of jasmonic acid.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_125733.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-coumarate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty-acyl-CoA synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in auxin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in auxin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AMP-dependent synthetase and ligase family protein
    NP_201143.1
    • AMP-dependent synthetase and ligase family protein; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: OPC-8:0 CoA ligase1 (TAIR:AT1G20510.1); Has 81844 Blast hits to 74712 proteins in 3773 species: Archae - 1219; Bacteria - 53606; Metazoa - 3425; Fungi - 4605; Plants - 2698; Viruses - 1; Other Eukaryotes - 16290 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25387411..25390227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125733.3 → NP_201143.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84P23, Q9FGW4
      UniProtKB/TrEMBL
      A0A178UTX3
      Conserved Domains (1) summary
      cd05904
      Location:45 → 550
      4CL; 4-Coumarate-CoA Ligase (4CL)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84P23.2

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