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    MRPS18C mitochondrial ribosomal protein S18C [ Homo sapiens (human) ]

    Gene ID: 51023, updated on 9-Dec-2024

    Summary

    Official Symbol
    MRPS18Cprovided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S18Cprovided by HGNC
    Primary source
    HGNC:HGNC:16633
    See related
    Ensembl:ENSG00000163319 MIM:611983; AllianceGenome:HGNC:16633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bS18m; CGI-134; S18mt-c; MRPS18-1; mrps18-c; MRP-S18-1; MRP-S18-c
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 12.8), testis (RPKM 12.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MRPS18C in Genome Data Viewer
    Location:
    4q21.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (83456058..83462298)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86786125..86792364)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (84377211..84383451)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C18orf21 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:84309555-84310754 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:84311240-84312057 Neighboring gene helicase, POLQ like Neighboring gene Sharpr-MPRA regulatory region 5990 Neighboring gene abraxas 1, BRCA1 A complex subunit Neighboring gene solute carrier family 25 member 14 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15542 Neighboring gene ribosomal protein L30 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11146, FLJ22967

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables small ribosomal subunit rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    small ribosomal subunit protein bS18m
    Names
    28S ribosomal protein S18-1, mitochondrial
    28S ribosomal protein S18c, mitochondrial
    mitochondrial ribosomal protein S18-1
    mitochondrial small ribosomal subunit protein bS18c
    mitochondrial small ribosomal subunit protein bS18m
    mitochondrial small ribosomal subunit protein bS18m-C
    small ribosomal subunit protein bS18c

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297767.2NP_001284696.1  small ribosomal subunit protein bS18m isoform 2

      See identical proteins and their annotated locations for NP_001284696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096768, CN262115
      Consensus CDS
      CCDS75159.1
      UniProtKB/TrEMBL
      D6RCM2, H0YAG5
      Related
      ENSP00000427169.1, ENST00000507019.5
      Conserved Domains (1) summary
      pfam01084
      Location:5092
      Ribosomal_S18; Ribosomal protein S18
    2. NM_001297769.2NP_001284698.1  small ribosomal subunit protein bS18m isoform 3

      See identical proteins and their annotated locations for NP_001284698.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the central coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus.
      Source sequence(s)
      AC096768, AF151892, BE874586, DA446717
      UniProtKB/TrEMBL
      H0Y9W2
      Related
      ENSP00000425268.1, ENST00000505719.1
    3. NM_001297770.2NP_001284699.1  small ribosomal subunit protein bS18m isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two consecutive exons in the central coding region, which leads to a frameshift, compared to variant 1. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096768, AF151892, CA455563
      Consensus CDS
      CCDS77933.1
      UniProtKB/TrEMBL
      D6RE70
      Related
      ENSP00000426930.1, ENST00000507349.5
    4. NM_016067.4NP_057151.1  small ribosomal subunit protein bS18m isoform 1

      See identical proteins and their annotated locations for NP_057151.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC096768, AF151892
      Consensus CDS
      CCDS3604.1
      UniProtKB/Swiss-Prot
      Q9Y3D5
      Related
      ENSP00000295491.4, ENST00000295491.9
      Conserved Domains (1) summary
      pfam01084
      Location:70120
      Ribosomal_S18; Ribosomal protein S18

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      83456058..83462298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      86786125..86792364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)