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    IntS1 Integrator 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37840, updated on 27-Dec-2024

    Summary

    Official Symbol
    IntS1provided by FlyBase
    Official Full Name
    Integrator 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034964
    Locus tag
    Dmel_CG3173
    See related
    AllianceGenome:FB:FBgn0034964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3173; Dmel\CG3173; Int1; intS1
    Summary
    Involved in positive regulation of neuron differentiation and snRNA 3'-end processing. Part of integrator complex. Is active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Orthologous to human INTS1 (integrator complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See IntS1 in Genome Data Viewer
    Location:
    60B5-60B5; 2-106 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24037943..24044458)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19925466..19931981)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene MAN1 Neighboring gene CCR4-NOT transcription complex subunit 11 Neighboring gene twinstar Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in U2 snRNA 3'-end processing  
    involved_in U2 snRNA 3'-end processing  
    involved_in positive regulation of neuron differentiation PubMed 
    involved_in snRNA 3'-end processing PubMed 
    involved_in snRNA processing PubMed 
    Component Evidence Code Pubs
    part_of integrator complex  
    part_of integrator complex PubMed 
    part_of integrator complex  
    part_of integrator complex PubMed 
    is_active_in nucleus PubMed 

    General protein information

    Preferred Names
    integrator 1
    Names
    CG3173-PA
    IntS1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24037943..24044458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138031.3 → NP_611875.1  integrator 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGA9, Q9W1C5
      Related
      FBpp0072077
      Conserved Domains (1) summary
      pfam12432
      Location:327 → 407
      DUF3677; Protein of unknown function (DUF3677)
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