U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IntS14 Integrator 14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33300, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
IntS14provided by FlyBase
Official Full Name
Integrator 14provided by FlyBase
Primary source
FLYBASE:FBgn0031314
Locus tag
Dmel_CG4785
See related
AllianceGenome:FB:FBgn0031314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4785; Dmel\CG4785; Q9VPY0
Summary
Involved in snRNA 3'-end processing. Located in nucleus. Part of integrator complex. Is expressed in organism. Orthologous to human INTS14 (integrator complex subunit 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IntS14 in Genome Data Viewer
Location:
21F1-21F1; 2-2 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1164443..1166425)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1164443..1166425)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43767 Neighboring gene Transport and Golgi organization 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phospholipase A2 activator protein Neighboring gene uncharacterized protein Neighboring gene charon

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332
  2. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Albrecht TR, et al. Nucleic Acids Res, 2018 May 4. PMID 29471365, Free PMC Article
  3. Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination. Huang KL, et al. Mol Cell, 2020 Oct 15. PMID 32966759, Free PMC Article
  4. IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events. Fujiwara R, et al. Mol Cell, 2023 Dec 21. PMID 37995689, Free PMC Article
  5. The Integrator complex cleaves nascent mRNAs to attenuate transcription. Tatomer DC, et al. Genes Dev, 2019 Nov 1. PMID 31530651, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional and biochemical experiments revealed that Asunder and CG4785 are additional core members of the Integrator complex.
    Title: An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
integrator 14
Names
CG4785-PA
IntS14-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1164443..1166425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_134735.2 → NP_608579.1  integrator 14 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608579.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VPY0
    Related
    FBpp0077627
    Conserved Domains (1) summary
    smart00327
    Location:5 → 164
    VWA; von Willebrand factor (vWF) type A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPY0.1 Q9VPY0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous