U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Gcn2 Gcn2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43709, updated on 17-Dec-2024

    Summary

    Official Symbol
    Gcn2provided by FlyBase
    Official Full Name
    Gcn2provided by FlyBase
    Primary source
    FLYBASE:FBgn0019990
    Locus tag
    Dmel_CG1609
    See related
    AllianceGenome:FB:FBgn0019990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1609; dGcn2; dGCN2; DGCN2; Dmel\CG1609; Gcn-2; GCN-2; gcn2; GCN2
    Summary
    Enables eukaryotic translation initiation factor 2alpha kinase activity. Involved in positive regulation of cell size and regulation of translational initiation. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including amnioproctodeal invagination; embryonic/larval midgut primordium; epithelial furrow; ganglia; and gut section. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease 2. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gcn2 in Genome Data Viewer
    Location:
    100C3-100C3; 3-102 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31395660..31402013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27221382..27227735)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene UDP-glycosyltransferase family 35 member D1 Neighboring gene Polynucleotide phosphorylase Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene uncharacterized protein Neighboring gene Lysyl oxidase-like 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    Gcn2
    Names
    CG1609-PA
    CG1609-PB
    CG1609-PC
    GC nonderepressing 2 kinase
    Gcn2-PA
    Gcn2-PB
    Gcn2-PC
    general control nonderepressible 2
    general control nonderepressing 2 kinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31395660..31402013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057882.4 → NP_477230.1  Gcn2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477230.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01712, O61651, Q9V9X8
      Related
      FBpp0085148
      Conserved Domains (6) summary
      smart00220
      Location:523 → 893
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00591
      Location:17 → 130
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG0124
      Location:972 → 1412
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:259 → 474
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:516 → 896
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00268
      Location:972 → 1135
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    2. NM_001276213.1 → NP_001263142.1  Gcn2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHX7, O01712, O61651
      Conserved Domains (6) summary
      smart00220
      Location:525 → 895
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00591
      Location:17 → 130
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG0124
      Location:974 → 1414
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:261 → 476
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:518 → 898
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00268
      Location:974 → 1137
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    3. NM_001276212.1 → NP_001263141.1  Gcn2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263141.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01712, O61651, Q9V9X8
      Conserved Domains (6) summary
      smart00220
      Location:523 → 893
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00591
      Location:17 → 130
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG0124
      Location:972 → 1412
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:259 → 474
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:516 → 896
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00268
      Location:972 → 1135
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    External link. Please review our privacy policy.