slif slimfast [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: slifprovided by FlyBase
Official Full Name: slimfastprovided by FlyBase
Primary source: FLYBASE:FBgn0037203
Locus tag: Dmel_CG11128
See related: AllianceGenome:FB:FBgn0037203
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11128; Dmel\CG11128; Slif; SLIF; SLIMFAST
Summary: Enables basic amino acid transmembrane transporter activity. Involved in amino acid import across plasma membrane; lipid homeostasis; and regulation of growth. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic salivary gland duct; embryonic/larval fat body; embryonic/larval salivary gland common duct; and gland. Orthologous to human SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22881045..22893821)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22874145..22886921)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-arginine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lysine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-ornithine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables basic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-arginine import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ornithine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in amino acid import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	HMP more info	PubMed
involved_in regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

Names: CG11128-PA; CG11128-PB; CG11128-PC; slif-PA; slif-PB; slif-PC; slim fast

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