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    Lpin Lipin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lpinprovided by FlyBase
    Official Full Name
    Lipinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263593
    Locus tag
    Dmel_CG8709
    See related
    AllianceGenome:FB:FBgn0263593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.133; CG8709; dLipin; DLpin; Dmel\CG8709; DmLipin; DmLpin; EP2431; LIPIN
    Summary
    Enables phosphatidate phosphatase activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; regulation of signal transduction; and triglyceride biosynthetic process. Located in cytosol; female germline ring canal inner rim; and nucleus. Is expressed in several structures, including Malpighian tubule; fat body; follicle cell; glial cell; and midgut. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN1 (lipin 1); LPIN2 (lipin 2); and LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lpin in Genome Data Viewer
    Location:
    44B4-44B5; 2-58 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8136986..8156654, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4024491..4044159, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Pabp2 Neighboring gene Odorant-binding protein 44a Neighboring gene kermit Neighboring gene transfer RNA:Isoleucine-AAT 1-2 Neighboring gene long non-coding RNA:CR44068 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipin is a central regulator of adipose tissue development and function in Drosophila melanogaster. Ugrankar R, et al. Mol Cell Biol, 2011 Apr. PMID 21300783, Free PMC Article
    2. Lipin knockdown in pan-neuron of Drosophila induces reduction of lifespan, deficient locomotive behavior, and abnormal morphology of motor neuron. Nguyen YDH, et al. Neuroreport, 2023 Aug 2. PMID 37470742, Free PMC Article
    3. Deciphering the key mechanisms leading to alteration of lipid metabolism in Drosophila model of Huntington's disease. Singh A, et al. Biochim Biophys Acta Mol Basis Dis, 2021 Jul 1. PMID 33722743
    4. Drosophila melanogaster lipins are tissue-regulated and developmentally regulated and present specific subcellular distributions. Valente V, et al. FEBS J, 2010 Nov. PMID 20977671
    5. Overexpression of kermit/dGIPC is associated with lethality in Drosophila melanogaster. Pereira GB, et al. Braz J Med Biol Res, 2011 Apr. PMID 21344130

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila.
      Title: Nuclear translocation ability of Lipin differentially affects gene expression and survival in fed and fasting Drosophila.
    2. Lipin knockdown in pan-neuron of Drosophila induces reduction of lifespan, deficient locomotive behavior, and abnormal morphology of motor neuron.
      Title: Lipin knockdown in pan-neuron of Drosophila induces reduction of lifespan, deficient locomotive behavior, and abnormal morphology of motor neuron.
    3. Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms.
      Title: Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms.
    4. dLipin is involved in DNA replication during normal cell cycle progression in wing development of Drosophila melanogaster.
      Title: The Function of Lipin in the Wing Development of Drosophila melanogaster.
    5. data show that dLipin is subject to intricate control by the insulin and TORC1 pathways, and that the cellular status of dLipin impacts how fat body cells respond to signals relayed through the PI3K-Akt pathway.
      Title: Drosophila Lipin interacts with insulin and TOR signaling pathways in the control of growth and lipid metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to insulin stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear membrane biogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ketone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in female germline ring canal inner rim IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipin
    Names
    CG8709-PA
    CG8709-PB
    CG8709-PC
    CG8709-PD
    CG8709-PE
    CG8709-PG
    CG8709-PH
    CG8709-PJ
    CG8709-PK
    CG8709-PL
    CG8709-PM
    DmLipin
    EP2431
    Lpin-PA
    Lpin-PB
    Lpin-PC
    Lpin-PD
    Lpin-PE
    Lpin-PG
    Lpin-PH
    Lpin-PJ
    Lpin-PK
    Lpin-PL
    Lpin-PM
    dLipin
    NP_001097228.1
    NP_001188874.1
    NP_001188875.1
    NP_001188876.1
    NP_001188878.1
    NP_001188879.1
    NP_001188881.1
    NP_001188882.1
    NP_001188883.1
    NP_001188884.1
    NP_610359.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8136986..8156654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201953.3 → NP_001188882.1  lipin, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY69, F0JAG5
      Conserved Domains (4) summary
      pfam15017
      Location:975 → 1028
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:760 → 984
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:562 → 671
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    2. NM_001201945.2 → NP_001188874.1  lipin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD00, F0JAG5
      Conserved Domains (4) summary
      pfam15017
      Location:974 → 1027
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:759 → 983
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:561 → 670
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    3. NM_001201954.2 → NP_001188883.1  lipin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD31, F0JAG5
      Conserved Domains (4) summary
      pfam15017
      Location:932 → 985
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:717 → 941
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:562 → 628
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    4. NM_001103758.3 → NP_001097228.1  lipin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DY69, F0JAG5
      Conserved Domains (4) summary
      pfam15017
      Location:975 → 1028
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:760 → 984
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:562 → 671
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    5. NM_001201952.1 → NP_001188881.1  lipin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E5DK16, F0JAG5
      Conserved Domains (4) summary
      pfam15017
      Location:902 → 955
      AF1Q; Drug resistance and apoptosis regulator
      pfam04571
      Location:1 → 30
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:687 → 911
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:489 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    6. NM_001201955.2 → NP_001188884.1  lipin, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188884.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAG5, Q8SXP0, Q9V374
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:760 → 985
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:562 → 671
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    7. NM_001201950.2 → NP_001188879.1  lipin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAG5, I0E2I4
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:714 → 939
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:516 → 625
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    8. NM_136515.3 → NP_610359.2  lipin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610359.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAG5, Q8SXP0, Q9V374
      Related
      FBpp0087891
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:760 → 985
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:562 → 671
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    9. NM_001201947.2 → NP_001188876.1  lipin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD27, F0JAG5
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:716 → 941
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:561 → 627
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    10. NM_001201946.2 → NP_001188875.1  lipin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCQ5, F0JAG5
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 103
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:759 → 984
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:561 → 670
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

    11. NM_001201949.1 → NP_001188878.1  lipin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCS1, F0JAG5
      Conserved Domains (3) summary
      pfam04571
      Location:1 → 30
      Lipin_N; lipin, N-terminal conserved region
      pfam08235
      Location:687 → 912
      LNS2; LNS2 (Lipin/Ned1/Smp2)
      pfam16876
      Location:489 → 598
      Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCQ5 A0A0B4JCQ5
    A0A0B4JCS1 A0A0B4JCS1
    A0A0B4JD00 A0A0B4JD00
    A0A0B4JD27 A0A0B4JD27
    A0A0B4JD31 A0A0B4JD31
    A8DY69 A8DY69
    E5DK16 E5DK16
    I0E2I4 I0E2I4
    Q8SXP0 Q8SXP0

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