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    CG12236 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31523, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12236provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029822
    Locus tag
    Dmel_CG12236
    See related
    AllianceGenome:FB:FBgn0029822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DDO; Dmel\CG12236
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryonic brain; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12236 in Genome Data Viewer
    Location:
    5C7-5C7; 1-14 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5908135..5913079)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5802168..5807112)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Actin 5C Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44108 Neighboring gene Serine hydroxymethyl transferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative-enhancer-FACS-seq (QeFS) reveals epistatic interactions among motifs within transcriptional enhancers in developing Drosophila tissue. Waters CT, et al. Genome Biol, 2021 Dec 20. PMID 34930411, Free PMC Article
    2. Thermal evolution of gene expression profiles in Drosophila subobscura. Laayouni H, et al. BMC Evol Biol, 2007 Mar 19. PMID 17371595, Free PMC Article
    3. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    4. Faint gray bands in Drosophila melanogaster polytene chromosomes are formed by coding sequences of housekeeping genes. Demakova OV, et al. Chromosoma, 2020 Mar. PMID 31820086
    5. Accelerated sequence divergence of conserved genomic elements in Drosophila melanogaster. Holloway AK, et al. Genome Res, 2008 Oct. PMID 18583644, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12236-PA
    CG12236-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5908135..5913079
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167054.2 → NP_727050.1  uncharacterized protein Dmel_CG12236, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W458
      Related
      FBpp0070790
      Conserved Domains (4) summary
      smart00225
      Location:33 → 116
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00020
      Location:483 → 512
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 116
      BTB; BTB/POZ domain
      pfam06112
      Location:376 → 467
      Herpes_capsid; Gammaherpesvirus capsid protein

    2. NM_132049.5 → NP_572277.2  uncharacterized protein Dmel_CG12236, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZ93
      Related
      FBpp0070791
      Conserved Domains (5) summary
      smart00225
      Location:33 → 116
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:417 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:451 → 471
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:478 → 500
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 116
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YZ93 Q7YZ93
    Q8T0B7 Q8T0B7
    Q95T56 Q95T56
    Q9W458 Q9W458

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