BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE-NPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24640002 110 LAVQG 114
Cdd:cd18315  81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE-NPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24640002 110 LAVQG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002     33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP--HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*.
gi 24640002    111 AVQGLT 116
Cdd:smart00225  81 QIPGLV 86

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE-NPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                ....*
gi 24640002 110 LAVQG 114
Cdd:cd18315  81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002     33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP--HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELL 110
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*.
gi 24640002    111 AVQGLT 116
Cdd:smart00225  81 QIPGLV 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  14 YLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKEN--PHPHPVIIFKFIKFEDLNSIIEFMYQG 91
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNlsEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100
                ....*....|....*....|....*..
gi 24640002  92 EVNVQQEALQSFLQTAELLAVQGLTAE 118
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIKLVLKE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  17 HLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIFKfIKFEDLNSIIEFMYQGE 92
Cdd:cd18265   9 RILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFgghlKES-RQAVVEIQK-VSAAAMEVLLDYMYGGG 86

                        90       100
                ....*....|....*....|...
gi 24640002  93 VNVQQEALQSFLQTAELLAVQGL 115
Cdd:cd18265  87 LRIQEDNVESVLEASDLLQVSKL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  18 LTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHP----VIIFKFIKFEDLNSIIEFMYQGEV 93
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQI 80

                        90
                ....*....|....*..
gi 24640002  94 NVQQEALQSFLQTAELL 110
Cdd:cd18245  81 KLSEDNIQDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  22 LDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHpHPVIIFKFIKFEDLNSIIEFMYQGEVNVQ-QEAL 100
Cdd:cd18221   9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQ-EPLVEIEGVSNMAFRHLIEFTYTAKLMVQgEEEA 87

                        90       100
                ....*....|....*....|....*
gi 24640002 101 QSFLQTAELL----AVQGLTAEEKE 121
Cdd:cd18221  88 NDVWKAAEYLqmqeAIKALEFRNKE 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  18 LTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIfKFIKFEDLNSIIEFMYQGEV 93
Cdd:cd18236  11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFcndlKEK-YEEKIII-KGVDAETMQILLDYTYTSKV 88

                        90
                ....*....|....*.
gi 24640002  94 NVQQEALQSFLQTAEL 109
Cdd:cd18236  89 LITKQNVQRVLEAASL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  22 LDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKeNPHPHP---VIIFKFIKFEDLNSIIEFMYQGEVNVQQE 98
Cdd:cd18253   9 FNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC-NDHRESremLVEINGILAEAMDCFLQYVYTGKVKITTE 87

                        90
                ....*....|....*..
gi 24640002  99 ALQSFLQTAELLAVQGL 115
Cdd:cd18253  88 NVQYLFETSSLFQISPL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENPHPHpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAE 108
Cdd:cd18235  23 DVILVADGVEIPAHRVVLASCSPYFHAMFtgdlSESRANR--VTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAAN 100

                ..
gi 24640002 109 LL 110
Cdd:cd18235 101 LL 102

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  31 FVDVSLCVDGR-RIKAHKVVLSSCSSYFKEIFKenpHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAEL 109
Cdd:cd18299  12 CADVVFILQGGvRIFAHRIVLAAASSVFADLFL---MMTVVTLDSDITPEAFRRVLEFLYTGVLDENEDDLKELKDAAEL 88

                ....*..
gi 24640002 110 LAVQGLT 116
Cdd:cd18299  89 LELFDLV 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  10 RWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFK---ENPHPHPVIIFKfIKFEDLNSIIE 86
Cdd:cd18266   4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmREAHQKEVELVG-ASYIGLKAVID 82

                        90       100
                ....*....|....*....|....*.
gi 24640002  87 FMYQGEVNVQQEALQSFLQTAELLAV 112
Cdd:cd18266  83 FLYSSELPLDGGNIDYVLETAHLLQI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  17 HLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIFKfIKFEDLNSIIEFMYQGE 92
Cdd:cd18250   7 HLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFagelRES-RADRVVLHG-VSAEILGLLLDFSYTGR 84

                        90
                ....*....|....*...
gi 24640002  93 VNVQQEALQSFLQTAELL 110
Cdd:cd18250  85 VTVTQDNVEALLRAADLF 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF---------KEnphphpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSF 103
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFthdmveskqDE-------ITMQGIEPSALEALINFAYSGRIAIDTSNVQSL 93

                        90
                ....*....|
gi 24640002 104 LQTAELLAVQ 113
Cdd:cd18247  94 LVGASFLQLQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF-------KENPhphpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQ 105
Cdd:cd18234   3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFtndvreaTEEE-----IKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLA 77

                ....*
gi 24640002 106 TAELL 110
Cdd:cd18234  78 TACLL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  13 NYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENpHPHPVIIFKfIKFEDLNSIIEFM 88
Cdd:cd18256   2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFaggmSES-SKDVVQIHG-VEPDIFHILLDFI 79

                        90       100
                ....*....|....*....|..
gi 24640002  89 YQGEVNVQQEALQSFLQTAELL 110
Cdd:cd18256  80 YTGVVEVTVSNVQELLVAADML 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  21 SLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPH-PHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEA 99
Cdd:cd18212  13 NFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEvGQSIYMLEGMVAETFGALLEFIYTGCLQVGEKS 92

                        90
                ....*....|....*.
gi 24640002 100 LQSFLQTAELLAVQGL 115
Cdd:cd18212  93 LEQILATAQFLKVNDL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  21 SLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYF-KEIFKENPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEA 99
Cdd:cd18277  17 SLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFhSRIVGQADAELNITLPEEVTVKGFEPLIQFAYTAKLILSKDN 96

                        90
                ....*....|....*.
gi 24640002 100 LQSFLQTAELLAVQGL 115
Cdd:cd18277  97 VDEVCKCVEFLSVHNI 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  16 RHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHphpVIIFKFIKFEDLNSIIEFMYQGEVNV 95
Cdd:cd18206   7 QHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKD---VVHLDISNAAGLGQVLEFMYTAKLSL 83

                        90
                ....*....|....*...
gi 24640002  96 QQEALQSFLQTAELLAVQ 113
Cdd:cd18206  84 SPENVDDVLAVATFLQMQ 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  26 RLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENPHPHpvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQ 101
Cdd:cd18255  13 RAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFtggmRESSQDE--IELKGVSAKGLKHILDFAYTSELTLDLDCIQ 90

                        90
                ....*....|.
gi 24640002 102 SFLQTAELLAV 112
Cdd:cd18255  91 DVLGAAVHLQM 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 24640002  22 LDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKE 63
Cdd:cd18202  10 LNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIE 51

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  18 LTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKEN--PHPHPVIIFKFIKFEDLNSIIEFMYQGEVNV 95
Cdd:cd18268  10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNfrESSQAKVDLKGIDSDVLDQIVDYVYTGEILI 89

                        90
                ....*....|....*
gi 24640002  96 QQEALQSFLQTAELL 110
Cdd:cd18268  90 TRDNVLPLMEAASML 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  34 VSLCVDGRRIKAHKVVLSSCSSYFKEIFK---ENPHPHPvIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELL 110
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRggfRESGQAE-INLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  12 NNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF----KENPHPHPVIIFKFIKFEDLNSIIEF 87
Cdd:cd18201   2 NSYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYcftnKESCDQTTVTHLDVVAVQGFSVILDF 81

                        90       100
                ....*....|....*....|....*....
gi 24640002  88 MYQGE-VNVQQEALQ-----SFLQTAELL 110
Cdd:cd18201  82 MYSGNlVLTSQNAIEvmsvaSYLQMTEVV 110

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  29 DDFVDVSL-CVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHPVIIF-KFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQT 106
Cdd:cd18311  12 TEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMpNELQADAVVPVINFMYTGQLEFEEKSYGKLLRT 91

                ....*....
gi 24640002 107 AELLAVQGL 115
Cdd:cd18311  92 AKELNMTVL 100

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24640002  29 DDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENPHPHPVIIFKFIKF----EDLNSIIEFMYQGEVNVQQE 98
Cdd:cd18309  18 GDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMvpsrQAFDSLLRYIYYGDVTMPPE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  27 LNDDFVDVSL-CVDGRRIKAHKVVLSSCSSYFKEIF----KENphPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQ 101
Cdd:cd18252  17 LDGLFTDITLqCASGQIFHCHKAALAACSSYFKVMFtadmKEK--SNNVIKLSGIDHDILEALVNYVYTSQICITERNVQ 94

                ....*....
gi 24640002 102 SFLQTAELL 110
Cdd:cd18252  95 SLLEAADLL 103

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  31 FVDVSLCVDGRRIKAHKVVLSSCSSYFKEIF-------KENPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSF 103
Cdd:cd18296  17 FPDVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhfaesEENNGSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDV 96

                        90
                ....*....|..
gi 24640002 104 LQTAELLAVQGL 115
Cdd:cd18296  97 LYVADMYLLPGL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640002  33 DVSLCVDGRRIKAHKVVLSSCSSYFKEIF--KENPHPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELL 110
Cdd:cd18338  23 DVTIVAEDVEIAAHRVVLAACSPYFHAMFtgEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLL 102

                ...
gi 24640002 111 AVQ 113
Cdd:cd18338 103 QLQ 105