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    Stim Stromal interaction molecule [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32556, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stimprovided by FlyBase
    Official Full Name
    Stromal interaction moleculeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045073
    Locus tag
    Dmel_CG9126
    See related
    AllianceGenome:FB:FBgn0045073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    C-Stim; CG9126; D-Stim; D-STIM; Dmel\CG9126; dstim; dStim; dSTIM; stim; STIM; stim1; STIM1
    Summary
    Enables calcium ion binding activity; calcium-induced calcium release activity; and store-operated calcium channel activity. Involved in several processes, including chaeta development; detection of calcium ion; and store-operated calcium entry. Located in endoplasmic reticulum-plasma membrane contact site. Is expressed in several structures, including adult head; ectoderm; embryonic/larval midgut primordium; epithelial furrow; and imaginal disc. Used to study dilated cardiomyopathy; hypertrophic cardiomyopathy; and obesity. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to several human genes including STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Stim in Genome Data Viewer
    Location:
    14A1-14A1; 1-52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15934495..15940451, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15828528..15834484, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45000 Neighboring gene Ligand-gated chloride channel homolog 3 Neighboring gene Ranbp16 Neighboring gene uncharacterized protein Neighboring gene Ribosomal RNA processing 47

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel regulator activity  
    enables calcium channel regulator activity  
    enables calcium ion binding  
    enables calcium ion binding PubMed 
    enables calcium-induced calcium release activity PubMed 
    enables store-operated calcium channel activity PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system PubMed 
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum-plasma membrane contact site PubMed 
    located_in membrane PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    stromal interaction molecule
    Names
    CG9126-PA
    CG9126-PD
    CG9126-PF
    CG9126-PG
    Stim-PA
    Stim-PD
    Stim-PF
    Stim-PG
    drosophila stromal interaction molecule
    stromal interaction molecule 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15934495..15940451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206747.3 → NP_996470.2  stromal interaction molecule, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996470.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAI2, H1UUK4, Q7KUZ1
      Conserved Domains (5) summary
      cd09504
      Location:209 → 282
      SAM_STIM-1,2-like; SAM domain of STIM-1,2-like proteins
      smart00454
      Location:210 → 271
      SAM; Sterile alpha motif
      pfam16533
      Location:410 → 507
      SOAR; STIM1 Orai1-activating region
      cd16269
      Location:360 → 372
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:312 → 392
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. NM_078633.4 → NP_523357.2  stromal interaction molecule, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523357.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83094
      UniProtKB/TrEMBL
      C7LAI2
      Related
      FBpp0073955
      Conserved Domains (5) summary
      cd09504
      Location:209 → 282
      SAM_STIM-1,2-like; SAM domain of STIM-1,2-like proteins
      smart00454
      Location:210 → 271
      SAM; Sterile alpha motif
      pfam16533
      Location:410 → 507
      SOAR; STIM1 Orai1-activating region
      cd16269
      Location:360 → 372
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:312 → 392
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. NM_001258774.2 → NP_001245703.1  stromal interaction molecule, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF82
    4. NM_001298380.1 → NP_001285309.1  stromal interaction molecule, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF82
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