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    Cad74A Cadherin 74A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39936, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cad74Aprovided by FlyBase
    Official Full Name
    Cadherin 74Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036715
    Locus tag
    Dmel_CG6445
    See related
    AllianceGenome:FB:FBgn0036715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cad74A; Cad74B; CG6445; CT20086; DCad74B; Dmel\CG6445
    Summary
    Enables calcium ion binding activity and protein homodimerization activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and dorsal appendage formation. Located in apical plasma membrane and microvillus. Is expressed in several structures, including anlage in statu nascendi; follicle cell; gut section; head epidermis primordium; and midline glial cell. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; autosomal recessive nonsyndromic deafness; autosomal recessive nonsyndromic deafness 12; and pituitary adenoma 5. Orthologous to human CDH23 (cadherin related 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Cad74A in Genome Data Viewer
    Location:
    74A5-74A6; 3-45 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17367753..17379530, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17360853..17372630, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene target of Poxn Neighboring gene long non-coding RNA:CR45688 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding PubMed 
    enables calcium ion binding  
    enables protein homodimerization activity PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in microvillus PubMed 
    located_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    cadherin 74A
    Names
    CG6445-PA
    CG6445-PB
    CG6445-PC
    Cad74A-PA
    Cad74A-PB
    Cad74A-PC

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17367753..17379530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140716.2 → NP_648973.1  cadherin 74A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648973.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGX4, Q9VVG0
      Related
      FBpp0075002
      Conserved Domains (1) summary
      cd11304
      Location:487 → 581
      Cadherin_repeat; Cadherin tandem repeat domain
    2. NM_168724.2 → NP_730261.1  cadherin 74A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGX4, Q9VVG0
      Related
      FBpp0075001
      Conserved Domains (1) summary
      cd11304
      Location:487 → 581
      Cadherin_repeat; Cadherin tandem repeat domain
    3. NM_001259885.1 → NP_001246814.1  cadherin 74A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGX4, Q9VVG0
      Conserved Domains (1) summary
      cd11304
      Location:487 → 581
      Cadherin_repeat; Cadherin tandem repeat domain
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