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Conserved domains on  [gi|386771335|ref|NP_001246814|]
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cadherin 74A, isoform C [Drosophila melanogaster]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 487-581 4.00e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 4.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  487 TYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVL-KGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG-- 563
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                          90
                  ....*....|....*...
gi 386771335  564 QREANANLFVGVTDVNDN 581
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1293-1390 3.36e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 3.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1293 ANVTENAVTGAPVFQVIASDPDdeSTPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQP 1372
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPD--SGENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 386771335 1373 KQSATRILQIAILDVDDH 1390
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 713-810 3.71e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 3.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  713 SYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSpqARIDRDSnMNSFEIIVNAVDS 789
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSGNEDglFSIDPSTGEITTA--KPLDREE-QSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 386771335  790 GTPiPETATTTVYVNVKDIND 810
Cdd:cd11304    78 GGP-PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1175-1279 2.10e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 2.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1175 YSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNeGEANGLFKIDTKSGLISTRRNLTGKGRAHpYVLIVRAQDNGN 1254
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                          90       100
                  ....*....|....*....|....*
gi 386771335 1255 qmpkqPTLSTDTDVRIYIGDVsaND 1279
Cdd:cd11304    80 -----PPLSSTATVTITVLDV--ND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1402-1513 1.27e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1402 PLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNeslAILKTKKPIDREQVESFTLTIKCLKL 1481
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST---GEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 386771335 1482 GEPGYKfigdpydrqdlSHLRINVRVLDIDDN 1513
Cdd:cd11304    78 GGPPLS-----------STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1057-1166 1.48e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1057 SYQATIIENRPHPERVIRVRALDKDAVLNARderlgyhkIIYSLQGEHAM-LFDINNTTGEIIVAsgQTIDRERTPRIQL 1135
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE--------VTYSIVSGNEDgLFSIDPSTGEITTA--KPLDREEQSSYTL 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 386771335 1136 QIKAEDSPGRPtdaKQSVVELQIEVLDVNDN 1166
Cdd:cd11304    71 TVTATDGGGPP---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-361 1.46e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  249 PYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSL-EDEPFGHFELvpfgDPRDGtaVLqTTSEPLDRENAEilqnggV 327
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTG--EI-TTAKPLDREEQS------S 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 386771335  328 YVFSIRATeliDGAIPAEHSLTRVTIVVTDVDDH 361
Cdd:cd11304    68 YTLTVTAT---DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-124 1.21e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   33 RFSLSENTPVGSPVFQLKGTDP---EGGRLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEgiyGT 105
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGnedgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG---GG 79

                          90
                  ....*....|....*....
gi 386771335  106 EPNTVSQRRVIPVRDYNDN 124
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-686 1.26e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  589 EYSRTIREGAALFEPQFFVRAHDADGPSqgNGRVKYSIVSENSiaGNVFRIEPDTGEIVIqkaARSMDTE-RGEYELVVS 667
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE--DGLFSIDPSTGEITT---AKPLDREeQSSYTLTVT 73

                          90
                  ....*....|....*....
gi 386771335  668 ATDFGIPPLSNTTRVLVRV 686
Cdd:cd11304    74 ATDGGGPPLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 132-240 8.14e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 8.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  132 PYTASVSESLPVGSELSVeppIVVVDRDEGINSEVQmKCLEENDICDIFEVRAvkisdgnYTARVALKQQLDFESRPSYI 211
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT---VSATDPDSGENGEVT-YSIVSGNEDGLFSIDP-------STGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....*....
gi 386771335  212 LTISASDSAlDNRLSSLATISINVIDIQD 240
Cdd:cd11304    70 LTVTATDGG-GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 953-1049 1.25e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  953 VKIKEEMPIDSALFILQAEDP-VTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEalgdTGPEFELQVRA-NSAD 1030
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTAtDGGG 79

                          90
                  ....*....|....*....
gi 386771335 1031 RQRSTVSRVNITVENVNDN 1049
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 819-936 2.43e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  819 SYATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPVAattkagvsianrsnyrlQEAFRVDSQSGEIFVNGTLRHD 896
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNE-----------------DGLFSIDPSTGEITTAKPLDRE 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 386771335  897 VAAIIIFTVGVRDLNaevdPEGQVDTTEVTVYVqsfQDTN 936
Cdd:cd11304    64 EQSSYTLTVTATDGG----GPPLSSTATVTITV---LDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1523-1628 1.72e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.77  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1523 TVGIRINVPIDTVVTTLKASDADAEAPPvglsieNVTFvpqfykrsrSLAVGNLHNLFTLNNRTGELRTGGSFaDY-VDG 1601
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG------EVTY---------SIVSGNEDGLFSIDPSTGEITTAKPL-DReEQS 66

                          90       100
                  ....*....|....*....|....*..
gi 386771335 1602 YFLMRVMANNSVQPKRQAHSNLKVFVI 1628
Cdd:cd11304    67 SYTLTVTATDGGGPPLSSTATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 487-581 4.00e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 4.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  487 TYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVL-KGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG-- 563
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                          90
                  ....*....|....*...
gi 386771335  564 QREANANLFVGVTDVNDN 581
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1293-1390 3.36e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 3.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1293 ANVTENAVTGAPVFQVIASDPDdeSTPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQP 1372
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPD--SGENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 386771335 1373 KQSATRILQIAILDVDDH 1390
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 713-810 3.71e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 3.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  713 SYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSpqARIDRDSnMNSFEIIVNAVDS 789
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSGNEDglFSIDPSTGEITTA--KPLDREE-QSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 386771335  790 GTPiPETATTTVYVNVKDIND 810
Cdd:cd11304    78 GGP-PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1175-1279 2.10e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 2.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1175 YSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNeGEANGLFKIDTKSGLISTRRNLTGKGRAHpYVLIVRAQDNGN 1254
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                          90       100
                  ....*....|....*....|....*
gi 386771335 1255 qmpkqPTLSTDTDVRIYIGDVsaND 1279
Cdd:cd11304    80 -----PPLSSTATVTITVLDV--ND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1402-1513 1.27e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1402 PLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNeslAILKTKKPIDREQVESFTLTIKCLKL 1481
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST---GEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 386771335 1482 GEPGYKfigdpydrqdlSHLRINVRVLDIDDN 1513
Cdd:cd11304    78 GGPPLS-----------STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1057-1166 1.48e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1057 SYQATIIENRPHPERVIRVRALDKDAVLNARderlgyhkIIYSLQGEHAM-LFDINNTTGEIIVAsgQTIDRERTPRIQL 1135
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE--------VTYSIVSGNEDgLFSIDPSTGEITTA--KPLDREEQSSYTL 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 386771335 1136 QIKAEDSPGRPtdaKQSVVELQIEVLDVNDN 1166
Cdd:cd11304    71 TVTATDGGGPP---LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 506-583 5.68e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 5.68e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    506 KATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG--QREANANLFVGVTDVNDNH 582
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVNDNA 80


                    .
gi 386771335    583 P 583
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-361 1.46e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  249 PYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSL-EDEPFGHFELvpfgDPRDGtaVLqTTSEPLDRENAEilqnggV 327
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTG--EI-TTAKPLDREEQS------S 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 386771335  328 YVFSIRATeliDGAIPAEHSLTRVTIVVTDVDDH 361
Cdd:cd11304    68 YTLTVTAT---DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-124 1.21e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   33 RFSLSENTPVGSPVFQLKGTDP---EGGRLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEgiyGT 105
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGnedgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG---GG 79

                          90
                  ....*....|....*....
gi 386771335  106 EPNTVSQRRVIPVRDYNDN 124
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-686 1.26e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  589 EYSRTIREGAALFEPQFFVRAHDADGPSqgNGRVKYSIVSENSiaGNVFRIEPDTGEIVIqkaARSMDTE-RGEYELVVS 667
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE--DGLFSIDPSTGEITT---AKPLDREeQSSYTLTVT 73

                          90
                  ....*....|....*....
gi 386771335  668 ATDFGIPPLSNTTRVLVRV 686
Cdd:cd11304    74 ATDGGGPPLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1310-1392 6.45e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 6.45e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1310 ASDPDDEstPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDD 1389
Cdd:smart00112    2 ATDADSG--ENGKVTYSILSGNDD-GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 386771335   1390 HEP 1392
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
488-576 1.48e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 1.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   488 YRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQ-- 564
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|..
gi 386771335   565 REANANLFVGVT 576
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
714-805 8.20e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 8.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   714 YRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIV--GANDNFEIDEISGLITVspQARIDRDSnMNSFEIIVNAVDSG 790
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILggGPGGNFRIDPDTGDIST--TKPLDRES-IGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 386771335   791 TPiPETATTTVYVNV 805
Cdd:pfam00028   78 GP-PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1293-1385 2.91e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 2.91e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1293 ANVTENAVTGAPVFQVIASDPDDesTPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQP 1372
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 386771335  1373 KQSATRILQIAIL 1385
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1404-1485 5.92e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 5.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1404 SMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNeslAILKTKKPIDREQVESFTLTIKCLKLGE 1483
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT---GDISTTKPLDRESIGEYELTVEATDSGG 78


                   ..
gi 386771335  1484 PG 1485
Cdd:pfam00028   79 PP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 132-240 8.14e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 8.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  132 PYTASVSESLPVGSELSVeppIVVVDRDEGINSEVQmKCLEENDICDIFEVRAvkisdgnYTARVALKQQLDFESRPSYI 211
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT---VSATDPDSGENGEVT-YSIVSGNEDGLFSIDP-------STGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....*....
gi 386771335  212 LTISASDSAlDNRLSSLATISINVIDIQD 240
Cdd:cd11304    70 LTVTATDGG-GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
590-686 1.89e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 1.89e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   590 YSRTIREGAALfePQFF--VRAHDADGPSqgNGRVKYSIVSENSiaGNVFRIEPDTGEIviqKAARSMDTE-RGEYELVV 666
Cdd:pfam00028    1 YSASVPENAPV--GTEVltVTATDPDLGP--NGRIFYSILGGGP--GGNFRIDPDTGDI---STTKPLDREsIGEYELTV 71

                           90       100
                   ....*....|....*....|
gi 386771335   667 SATDFGIPPLSNTTRVLVRV 686
Cdd:pfam00028   72 EATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 732-813 5.21e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 5.21e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    732 SAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSpqARIDRDSnMNSFEIIVNAVDSGTPiPETATTTVYVNVKDI 808
Cdd:smart00112    1 SATDADsGENGKVTYSILSGNDDglFSIDPETGEITTT--KPLDREE-QPEYTLTVEATDGGGP-PLSSTATVTITVLDV 76


                    ....*
gi 386771335    809 NDERP 813
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1175-1272 5.61e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 5.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1175 YSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVnEGEANGLFKIDTKSGLISTRRNLTgkgRAHP--YVLIVRAQDN 1252
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLD---RESIgeYELTVEATDS 76

                           90       100
                   ....*....|....*....|
gi 386771335  1253 GnqmpkQPTLSTDTDVRIYI 1272
Cdd:pfam00028   77 G-----GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 608-686 3.77e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 3.77e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    608 RAHDADGPSqgNGRVKYSIVSENsiAGNVFRIEPDTGEIVIQKaarSMDTE-RGEYELVVSATDFGIPPLSNTTRVLVRV 686
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGN--DDGLFSIDPETGEITTTK---PLDREeQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1421-1515 5.25e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.25e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1421 SALDEDLGENAAIDYVIIDGNNEQLFTIERNNEslaILKTKKPIDREQVESFTLTIKCLKLGEPgykfigdpydrQDLSH 1500
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGP-----------PLSST 66

                            90
                    ....*....|....*
gi 386771335   1501 LRINVRVLDIDDNLP 1515
Cdd:smart00112   67 ATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1076-1168 5.36e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.36e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1076 RALDKDAVLNARderlgyhkIIYSL-QGEHAMLFDINNTTGEIIVAsgQTIDRERTPRIQLQIKAEDSPGRPtdaKQSVV 1154
Cdd:smart00112    1 SATDADSGENGK--------VTYSIlSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGPP---LSSTA 67

                            90
                    ....*....|....
gi 386771335   1155 ELQIEVLDVNDNAP 1168
Cdd:smart00112   68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
34-106 8.17e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 8.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    34 FSLSENTPVGSPVFQLKGTDPEGG---RLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTE 106
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGgpggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 953-1049 1.25e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  953 VKIKEEMPIDSALFILQAEDP-VTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEalgdTGPEFELQVRA-NSAD 1030
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTAtDGGG 79

                          90
                  ....*....|....*....
gi 386771335 1031 RQRSTVSRVNITVENVNDN 1049
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 819-936 2.43e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  819 SYATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPVAattkagvsianrsnyrlQEAFRVDSQSGEIFVNGTLRHD 896
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNE-----------------DGLFSIDPSTGEITTAKPLDRE 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 386771335  897 VAAIIIFTVGVRDLNaevdPEGQVDTTEVTVYVqsfQDTN 936
Cdd:cd11304    64 EQSSYTLTVTATDGG----GPPLSSTATVTITV---LDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1194-1282 2.04e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 2.04e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1194 AVDADEGLGGEVRYELVnEGEANGLFKIDTKSGLISTRRNLTGKGRAHpYVLIVRAQDNGNqmpkqPTLSTDTDVRIYIG 1273
Cdd:smart00112    2 ATDADSGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGG-----PPLSSTATVTITVL 74


                    ....*....
gi 386771335   1274 DVsaNDGVP 1282
Cdd:smart00112   75 DV--NDNAP 81
Cadherin pfam00028
Cadherin domain;
1058-1161 4.10e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 4.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1058 YQATIIENRPHPERVIRVRALDKDAVLNARderlgyhkIIYSLQGEHAM-LFDINNTTGEIIVAsgQTIDRERTPRIQLQ 1136
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGR--------IFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|....*
gi 386771335  1137 IKAEDSPGRPtdaKQSVVELQIEVL 1161
Cdd:pfam00028   71 VEATDSGGPP---LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 981-1051 2.02e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 2.02e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386771335    981 SFELIEPKQVDYFQVAERTGEVILKKRLDYEalgdTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSP 1051
Cdd:smart00112   14 TYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEAtDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 53-126 6.03e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 6.03e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386771335     53 DPEGGRLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEGiygtEPNTVSQRRV-IPVRDYNDNQP 126
Cdd:smart00112    7 SGENGKVTYSILSGnddgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG----GPPLSSTATVtITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-243 8.40e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 8.40e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    154 VVVDRDEGINSEVQMKcLEENDICDIFEVRAVkisdgnyTARVALKQQLDFESRPSYILTISASDSAlDNRLSSLATISI 233
Cdd:smart00112    1 SATDADSGENGKVTYS-ILSGNDDGLFSIDPE-------TGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTI 71

                            90
                    ....*....|
gi 386771335    234 NVIDIQDQPP 243
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
250-356 3.93e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 3.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   250 YSATVPENTPAGVSILTVKAVDGDVGIPREIFLS-LEDEPFGHFELvpfgDPRDGTavLQTTsEPLDREnaeilqNGGVY 328
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRI----DPDTGD--ISTT-KPLDRE------SIGEY 67

                           90       100
                   ....*....|....*....|....*...
gi 386771335   329 VFSIRATeliDGAIPAEHSLTRVTIVVT 356
Cdd:pfam00028   68 ELTVEAT---DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-363 6.49e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 6.49e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    268 KAVDGDVGIPREIFLSLEDE-PFGHFELvpfgDPRDGTAvlqTTSEPLDRENaeilqnGGVYVFSIRATeliDGAIPAEH 346
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSI----DPETGEI---TTTKPLDREE------QPEYTLTVEAT---DGGGPPLS 64

                            90
                    ....*....|....*..
gi 386771335    347 SLTRVTIVVTDVDDHQP 363
Cdd:smart00112   65 STATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
133-236 6.65e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 6.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   133 YTASVSESLPVGSELSVeppIVVVDRDEGINSEVQMKCLEENdICDIFEVravkisdGNYTARVALKQQLDFESRPSYIL 212
Cdd:pfam00028    1 YSASVPENAPVGTEVLT---VTATDPDLGPNGRIFYSILGGG-PGGNFRI-------DPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|....
gi 386771335   213 TISASDSALDNRlSSLATISINVI 236
Cdd:pfam00028   70 TVEATDSGGPPL-SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
820-930 1.40e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   820 YATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPvaattkagvsiaNRSNYrlqeaFRVDSQSGEIFVNGTLRHDV 897
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGG------------GPGGN-----FRIDPDTGDISTTKPLDRES 63

                           90       100       110
                   ....*....|....*....|....*....|...
gi 386771335   898 AAIIIFTVGVRDLnaevDPEGQVDTTEVTVYVQ 930
Cdd:pfam00028   64 IGEYELTVEATDS----GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1523-1628 1.72e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.77  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1523 TVGIRINVPIDTVVTTLKASDADAEAPPvglsieNVTFvpqfykrsrSLAVGNLHNLFTLNNRTGELRTGGSFaDY-VDG 1601
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG------EVTY---------SIVSGNEDGLFSIDPSTGEITTAKPL-DReEQS 66

                          90       100
                  ....*....|....*....|....*..
gi 386771335 1602 YFLMRVMANNSVQPKRQAHSNLKVFVI 1628
Cdd:cd11304    67 SYTLTVTATDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
955-1044 2.71e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 2.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   955 IKEEMPIDSALFILQAEDP-VTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGdtgpEFELQVRA-NSADRQ 1032
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG----EYELTVEAtDSGGPP 80

                           90
                   ....*....|..
gi 386771335  1033 RSTVSRVNITVE 1044
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 838-936 2.02e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    838 KAIDKDL--NSKLEYSMVGPVAAttkagvsianrsnyrlqEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDlnaeVD 915
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGNDD-----------------GLFSIDPETGEITTTKPLDREEQPEYTLTVEATD----GG 59

                            90       100
                    ....*....|....*....|.
gi 386771335    916 PEGQVDTTEVTVYVqsfQDTN 936
Cdd:smart00112   60 GPPLSSTATVTITV---LDVN 77
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 487-581 4.00e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 4.00e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  487 TYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVL-KGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG-- 563
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                          90
                  ....*....|....*...
gi 386771335  564 QREANANLFVGVTDVNDN 581
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1293-1390 3.36e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.24  E-value: 3.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1293 ANVTENAVTGAPVFQVIASDPDdeSTPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQP 1372
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPD--SGENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 386771335 1373 KQSATRILQIAILDVDDH 1390
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 713-810 3.71e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 3.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  713 SYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSpqARIDRDSnMNSFEIIVNAVDS 789
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDsGENGEVTYSIVSGNEDglFSIDPSTGEITTA--KPLDREE-QSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 386771335  790 GTPiPETATTTVYVNVKDIND 810
Cdd:cd11304    78 GGP-PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1175-1279 2.10e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.45  E-value: 2.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1175 YSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNeGEANGLFKIDTKSGLISTRRNLTGKGRAHpYVLIVRAQDNGN 1254
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-GNEDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGG 79

                          90       100
                  ....*....|....*....|....*
gi 386771335 1255 qmpkqPTLSTDTDVRIYIGDVsaND 1279
Cdd:cd11304    80 -----PPLSSTATVTITVLDV--ND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1402-1513 1.27e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1402 PLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNeslAILKTKKPIDREQVESFTLTIKCLKL 1481
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPST---GEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100       110
                  ....*....|....*....|....*....|..
gi 386771335 1482 GEPGYKfigdpydrqdlSHLRINVRVLDIDDN 1513
Cdd:cd11304    78 GGPPLS-----------STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1057-1166 1.48e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 1.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1057 SYQATIIENRPHPERVIRVRALDKDAVLNARderlgyhkIIYSLQGEHAM-LFDINNTTGEIIVAsgQTIDRERTPRIQL 1135
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGE--------VTYSIVSGNEDgLFSIDPSTGEITTA--KPLDREEQSSYTL 70

                          90       100       110
                  ....*....|....*....|....*....|.
gi 386771335 1136 QIKAEDSPGRPtdaKQSVVELQIEVLDVNDN 1166
Cdd:cd11304    71 TVTATDGGGPP---LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 506-583 5.68e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.86  E-value: 5.68e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    506 KATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG--QREANANLFVGVTDVNDNH 582
Cdd:smart00112    1 SATDADSGENGKVTYsILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVNDNA 80


                    .
gi 386771335    583 P 583
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 249-361 1.46e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  249 PYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSL-EDEPFGHFELvpfgDPRDGtaVLqTTSEPLDRENAEilqnggV 327
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSI----DPSTG--EI-TTAKPLDREEQS------S 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 386771335  328 YVFSIRATeliDGAIPAEHSLTRVTIVVTDVDDH 361
Cdd:cd11304    68 YTLTVTAT---DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-124 1.21e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   33 RFSLSENTPVGSPVFQLKGTDP---EGGRLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEgiyGT 105
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGnedgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG---GG 79

                          90
                  ....*....|....*....
gi 386771335  106 EPNTVSQRRVIPVRDYNDN 124
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 589-686 1.26e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 1.26e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  589 EYSRTIREGAALFEPQFFVRAHDADGPSqgNGRVKYSIVSENSiaGNVFRIEPDTGEIVIqkaARSMDTE-RGEYELVVS 667
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNE--DGLFSIDPSTGEITT---AKPLDREeQSSYTLTVT 73

                          90
                  ....*....|....*....
gi 386771335  668 ATDFGIPPLSNTTRVLVRV 686
Cdd:cd11304    74 ATDGGGPPLSSTATVTITV 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1310-1392 6.45e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 6.45e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1310 ASDPDDEstPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDD 1389
Cdd:smart00112    2 ATDADSG--ENGKVTYSILSGNDD-GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 386771335   1390 HEP 1392
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
488-576 1.48e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 1.48e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   488 YRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQ-- 564
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|..
gi 386771335   565 REANANLFVGVT 576
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
714-805 8.20e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.34  E-value: 8.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   714 YRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRIV--GANDNFEIDEISGLITVspQARIDRDSnMNSFEIIVNAVDSG 790
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlGPNGRIFYSILggGPGGNFRIDPDTGDIST--TKPLDRES-IGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 386771335   791 TPiPETATTTVYVNV 805
Cdd:pfam00028   78 GP-PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1293-1385 2.91e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 2.91e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1293 ANVTENAVTGAPVFQVIASDPDDesTPSGTITYRILPDTPDaEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQP 1372
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDL--GPNGRIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 386771335  1373 KQSATRILQIAIL 1385
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1404-1485 5.92e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 5.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1404 SMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNeslAILKTKKPIDREQVESFTLTIKCLKLGE 1483
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT---GDISTTKPLDRESIGEYELTVEATDSGG 78


                   ..
gi 386771335  1484 PG 1485
Cdd:pfam00028   79 PP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 132-240 8.14e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 8.14e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  132 PYTASVSESLPVGSELSVeppIVVVDRDEGINSEVQmKCLEENDICDIFEVRAvkisdgnYTARVALKQQLDFESRPSYI 211
Cdd:cd11304     1 SYEVSVPENAPPGTVVLT---VSATDPDSGENGEVT-YSIVSGNEDGLFSIDP-------STGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....*....
gi 386771335  212 LTISASDSAlDNRLSSLATISINVIDIQD 240
Cdd:cd11304    70 LTVTATDGG-GPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
590-686 1.89e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 1.89e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   590 YSRTIREGAALfePQFF--VRAHDADGPSqgNGRVKYSIVSENSiaGNVFRIEPDTGEIviqKAARSMDTE-RGEYELVV 666
Cdd:pfam00028    1 YSASVPENAPV--GTEVltVTATDPDLGP--NGRIFYSILGGGP--GGNFRIDPDTGDI---STTKPLDREsIGEYELTV 71

                           90       100
                   ....*....|....*....|
gi 386771335   667 SATDFGIPPLSNTTRVLVRV 686
Cdd:pfam00028   72 EATDSGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 732-813 5.21e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.61  E-value: 5.21e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    732 SAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSpqARIDRDSnMNSFEIIVNAVDSGTPiPETATTTVYVNVKDI 808
Cdd:smart00112    1 SATDADsGENGKVTYSILSGNDDglFSIDPETGEITTT--KPLDREE-QPEYTLTVEATDGGGP-PLSSTATVTITVLDV 76


                    ....*
gi 386771335    809 NDERP 813
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1175-1272 5.61e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.95  E-value: 5.61e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1175 YSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVnEGEANGLFKIDTKSGLISTRRNLTgkgRAHP--YVLIVRAQDN 1252
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLD---RESIgeYELTVEATDS 76

                           90       100
                   ....*....|....*....|
gi 386771335  1253 GnqmpkQPTLSTDTDVRIYI 1272
Cdd:pfam00028   77 G-----GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 608-686 3.77e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 3.77e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    608 RAHDADGPSqgNGRVKYSIVSENsiAGNVFRIEPDTGEIVIQKaarSMDTE-RGEYELVVSATDFGIPPLSNTTRVLVRV 686
Cdd:smart00112    1 SATDADSGE--NGKVTYSILSGN--DDGLFSIDPETGEITTTK---PLDREeQPEYTLTVEATDGGGPPLSSTATVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1421-1515 5.25e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.25e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1421 SALDEDLGENAAIDYVIIDGNNEQLFTIERNNEslaILKTKKPIDREQVESFTLTIKCLKLGEPgykfigdpydrQDLSH 1500
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGP-----------PLSST 66

                            90
                    ....*....|....*
gi 386771335   1501 LRINVRVLDIDDNLP 1515
Cdd:smart00112   67 ATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1076-1168 5.36e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.36e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1076 RALDKDAVLNARderlgyhkIIYSL-QGEHAMLFDINNTTGEIIVAsgQTIDRERTPRIQLQIKAEDSPGRPtdaKQSVV 1154
Cdd:smart00112    1 SATDADSGENGK--------VTYSIlSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGPP---LSSTA 67

                            90
                    ....*....|....
gi 386771335   1155 ELQIEVLDVNDNAP 1168
Cdd:smart00112   68 TVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
34-106 8.17e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 8.17e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    34 FSLSENTPVGSPVFQLKGTDPEGG---RLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTE 106
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGpngRIFYSILGGgpggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 953-1049 1.25e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  953 VKIKEEMPIDSALFILQAEDP-VTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEalgdTGPEFELQVRA-NSAD 1030
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE----EQSSYTLTVTAtDGGG 79

                          90
                  ....*....|....*....
gi 386771335 1031 RQRSTVSRVNITVENVNDN 1049
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 819-936 2.43e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.64  E-value: 2.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  819 SYATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPVAattkagvsianrsnyrlQEAFRVDSQSGEIFVNGTLRHD 896
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVSGNE-----------------DGLFSIDPSTGEITTAKPLDRE 63

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 386771335  897 VAAIIIFTVGVRDLNaevdPEGQVDTTEVTVYVqsfQDTN 936
Cdd:cd11304    64 EQSSYTLTVTATDGG----GPPLSSTATVTITV---LDVN 96
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1194-1282 2.04e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 2.04e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   1194 AVDADEGLGGEVRYELVnEGEANGLFKIDTKSGLISTRRNLTGKGRAHpYVLIVRAQDNGNqmpkqPTLSTDTDVRIYIG 1273
Cdd:smart00112    2 ATDADSGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGG-----PPLSSTATVTITVL 74


                    ....*....
gi 386771335   1274 DVsaNDGVP 1282
Cdd:smart00112   75 DV--NDNAP 81
Cadherin pfam00028
Cadherin domain;
1058-1161 4.10e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.16  E-value: 4.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335  1058 YQATIIENRPHPERVIRVRALDKDAVLNARderlgyhkIIYSLQGEHAM-LFDINNTTGEIIVAsgQTIDRERTPRIQLQ 1136
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGR--------IFYSILGGGPGgNFRIDPDTGDISTT--KPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|....*
gi 386771335  1137 IKAEDSPGRPtdaKQSVVELQIEVL 1161
Cdd:pfam00028   71 VEATDSGGPP---LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 981-1051 2.02e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 2.02e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 386771335    981 SFELIEPKQVDYFQVAERTGEVILKKRLDYEalgdTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSP 1051
Cdd:smart00112   14 TYSILSGNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEAtDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 53-126 6.03e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.36  E-value: 6.03e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 386771335     53 DPEGGRLKYSISGP----VFSVDRETGVVRLRQELDRETQDTVEVIISITDEGiygtEPNTVSQRRV-IPVRDYNDNQP 126
Cdd:smart00112    7 SGENGKVTYSILSGnddgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG----GPPLSSTATVtITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 154-243 8.40e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 8.40e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    154 VVVDRDEGINSEVQMKcLEENDICDIFEVRAVkisdgnyTARVALKQQLDFESRPSYILTISASDSAlDNRLSSLATISI 233
Cdd:smart00112    1 SATDADSGENGKVTYS-ILSGNDDGLFSIDPE-------TGEITTTKPLDREEQPEYTLTVEATDGG-GPPLSSTATVTI 71

                            90
                    ....*....|
gi 386771335    234 NVIDIQDQPP 243
Cdd:smart00112   72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
250-356 3.93e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.38  E-value: 3.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   250 YSATVPENTPAGVSILTVKAVDGDVGIPREIFLS-LEDEPFGHFELvpfgDPRDGTavLQTTsEPLDREnaeilqNGGVY 328
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRI----DPDTGD--ISTT-KPLDRE------SIGEY 67

                           90       100
                   ....*....|....*....|....*...
gi 386771335   329 VFSIRATeliDGAIPAEHSLTRVTIVVT 356
Cdd:pfam00028   68 ELTVEAT---DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 268-363 6.49e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 6.49e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    268 KAVDGDVGIPREIFLSLEDE-PFGHFELvpfgDPRDGTAvlqTTSEPLDRENaeilqnGGVYVFSIRATeliDGAIPAEH 346
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSI----DPETGEI---TTTKPLDREE------QPEYTLTVEAT---DGGGPPLS 64

                            90
                    ....*....|....*..
gi 386771335    347 SLTRVTIVVTDVDDHQP 363
Cdd:smart00112   65 STATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
133-236 6.65e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 6.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   133 YTASVSESLPVGSELSVeppIVVVDRDEGINSEVQMKCLEENdICDIFEVravkisdGNYTARVALKQQLDFESRPSYIL 212
Cdd:pfam00028    1 YSASVPENAPVGTEVLT---VTATDPDLGPNGRIFYSILGGG-PGGNFRI-------DPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|....
gi 386771335   213 TISASDSALDNRlSSLATISINVI 236
Cdd:pfam00028   70 TVEATDSGGPPL-SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
820-930 1.40e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   820 YATYVSERTAVGESVLRVKAIDKDL--NSKLEYSMVGPvaattkagvsiaNRSNYrlqeaFRVDSQSGEIFVNGTLRHDV 897
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGG------------GPGGN-----FRIDPDTGDISTTKPLDRES 63

                           90       100       110
                   ....*....|....*....|....*....|...
gi 386771335   898 AAIIIFTVGVRDLnaevDPEGQVDTTEVTVYVQ 930
Cdd:pfam00028   64 IGEYELTVEATDS----GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1523-1628 1.72e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 50.77  E-value: 1.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335 1523 TVGIRINVPIDTVVTTLKASDADAEAPPvglsieNVTFvpqfykrsrSLAVGNLHNLFTLNNRTGELRTGGSFaDY-VDG 1601
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG------EVTY---------SIVSGNEDGLFSIDPSTGEITTAKPL-DReEQS 66

                          90       100
                  ....*....|....*....|....*..
gi 386771335 1602 YFLMRVMANNSVQPKRQAHSNLKVFVI 1628
Cdd:cd11304    67 SYTLTVTATDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
955-1044 2.71e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.30  E-value: 2.71e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335   955 IKEEMPIDSALFILQAEDP-VTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGdtgpEFELQVRA-NSADRQ 1032
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIG----EYELTVEAtDSGGPP 80

                           90
                   ....*....|..
gi 386771335  1033 RSTVSRVNITVE 1044
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 838-936 2.02e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386771335    838 KAIDKDL--NSKLEYSMVGPVAAttkagvsianrsnyrlqEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDlnaeVD 915
Cdd:smart00112    1 SATDADSgeNGKVTYSILSGNDD-----------------GLFSIDPETGEITTTKPLDREEQPEYTLTVEATD----GG 59

                            90       100
                    ....*....|....*....|.
gi 386771335    916 PEGQVDTTEVTVYVqsfQDTN 936
Cdd:smart00112   60 GPPLSSTATVTITV---LDVN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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