Pvf1 PDGF- and VEGF-related factor 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pvf1provided by FlyBase
Official Full Name: PDGF- and VEGF-related factor 1provided by FlyBase
Primary source: FLYBASE:FBgn0030964
Locus tag: Dmel_CG7103
See related: AllianceGenome:FB:FBgn0030964
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7103; Dmel\CG7103; DmVEGF-1; EP1624; l(1)G0146; Pvf; PVF; Pvf-1; pvf1; PVF1; PVFs; VEGF; vegf1; Vegf17E; Vegf17e-a; Vegf17e-b; VEGF2-B; VEGFA
Summary: Enables heparin binding activity; receptor ligand activity; and vascular endothelial growth factor receptor binding activity. Involved in several processes, including anterior Malpighian tubule development; morphogenesis of an epithelium; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including Malpighian tubule; anal pad primordium; embryonic primordium of adult salivary gland; embryonic proventriculus; and embryonic/larval salivary gland. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFA (platelet derived growth factor subunit A) and PDGFB (platelet derived growth factor subunit B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 17E1-17E1; 1-61 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (18832682..18842901)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (18726715..18736934)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity.
Title: Drosophila PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity.
The Pvf1 receptor PVR acts in hemocytes to induce a macrophage-like morphology which is required to limit tissue loss after irradiation.
Title: Schnurri regulates hemocyte function to promote tissue recovery after DNA damage.
PVF1 and PVF3 are specifically deposited within the apical extracellular space of the wing disc
Title: Apical accumulation of the Drosophila PDGF/VEGF receptor ligands provides a mechanism for triggering localized actin polymerization.
PVF1/PVR signaling functions not only in apoptotic phenomena but are also required during rotation and dorsal closure of the Drosophila male genital disc
Title: PVF1/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemocyte migration	IEP Inferred from Expression Pattern more info	PubMed
involved_in hemocyte migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of border follicle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PDGF- and VEGF-related factor 1

Names: CG7103-PA; CG7103-PB; CG7103-PC; PDGF (platelet-derived growth factor)- and VEGF (vascular endothelial growth factor)-related factor 1; Pvf1-PA; Pvf1-PB; Pvf1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

18832682..18842901

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298486.1 → NP_001285415.1 PDGF- and VEGF-related factor 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285415.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JCH3

Conserved Domains (1) summary

pfam00341
Location:142 → 223

PDGF; PDGF/VEGF domain
NM_078683.3 → NP_523407.1 PDGF- and VEGF-related factor 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523407.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960Z8, Q9VWP6

Related

FBpp0074411

Conserved Domains (1) summary

pfam00341
Location:142 → 223

PDGF; PDGF/VEGF domain
NM_001169321.2 → NP_001162792.1 PDGF- and VEGF-related factor 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162792.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9BLX1

Conserved Domains (1) summary

pfam00341
Location:131 → 212

PDGF; PDGF/VEGF domain