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Conserved domains on  [gi|281361089|ref|NP_001162792|]
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PDGF- and VEGF-related factor 1, isoform B [Drosophila melanogaster]

Protein Classification

PDGF domain-containing protein( domain architecture ID 10065270)

PDGF domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
129-215 2.68e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


:

Pssm-ID: 238079  Cd Length: 86  Bit Score: 99.37  E-value: 2.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089 129 ASCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAAtSGRRPFTIITVEQHT 208
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEEHT 79

                 ....*..
gi 281361089 209 QCRCDCR 215
Cdd:cd00135   80 ECECRPR 86
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
129-215 2.68e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 99.37  E-value: 2.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089 129 ASCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAAtSGRRPFTIITVEQHT 208
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEEHT 79

                 ....*..
gi 281361089 209 QCRCDCR 215
Cdd:cd00135   80 ECECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
131-212 5.08e-26

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 98.51  E-value: 5.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089  131 CSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAATSGRRPFTIITVEQHTQC 210
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHVQC 80

                  ..
gi 281361089  211 RC 212
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
100-216 5.32e-12

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 62.72  E-value: 5.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089 100 DYDVSGEMPSSKENFKRSIMKStvrnatpaSCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVE 179
Cdd:PHA02661  25 SGSTGSSSASSLSSWLDTSDKS--------SCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETS 96
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 281361089 180 QVQLRVRKVDRAATSGRRP-FTIITVEQHTQCRCDCRT 216
Cdd:PHA02661  97 NVTVTVMLTSVSGSTGATSnFQTISVEEHTKCKCEFKT 134
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
129-212 8.79e-12

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 60.13  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089   129 ASCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAATSGRRPftiITVEQHT 208
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVE---VSFEEHT 77

                   ....
gi 281361089   209 QCRC 212
Cdd:smart00141  78 KCEC 81
 
Name Accession Description Interval E-value
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
129-215 2.68e-26

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 99.37  E-value: 2.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089 129 ASCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAAtSGRRPFTIITVEQHT 208
Cdd:cd00135    1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEEHT 79

                 ....*..
gi 281361089 209 QCRCDCR 215
Cdd:cd00135   80 ECECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
131-212 5.08e-26

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 98.51  E-value: 5.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089  131 CSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAATSGRRPFTIITVEQHTQC 210
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHVQC 80

                  ..
gi 281361089  211 RC 212
Cdd:pfam00341  81 EC 82
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
100-216 5.32e-12

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 62.72  E-value: 5.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089 100 DYDVSGEMPSSKENFKRSIMKStvrnatpaSCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVE 179
Cdd:PHA02661  25 SGSTGSSSASSLSSWLDTSDKS--------SCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDESQICTPTETS 96
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 281361089 180 QVQLRVRKVDRAATSGRRP-FTIITVEQHTQCRCDCRT 216
Cdd:PHA02661  97 NVTVTVMLTSVSGSTGATSnFQTISVEEHTKCKCEFKT 134
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
129-212 8.79e-12

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 60.13  E-value: 8.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281361089   129 ASCSPQPTIVELKPPAEDEANYYYMPACTRISRCNGCCGSTLISCQPTEVEQVQLRVRKVDRAATSGRRPftiITVEQHT 208
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVE---VSFEEHT 77

                   ....
gi 281361089   209 QCRC 212
Cdd:smart00141  78 KCEC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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