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    Coq5 Coenzyme Q5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coq5provided by FlyBase
    Official Full Name
    Coenzyme Q5provided by FlyBase
    Primary source
    FLYBASE:FBgn0030460
    Locus tag
    Dmel_CG2453
    See related
    AllianceGenome:FB:FBgn0030460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2453; Dmel\CG2453
    Summary
    Predicted to enable 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be part of ubiquinone biosynthesis complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Coq5 in Genome Data Viewer
    Location:
    11E3-11E3; 1-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13193094..13194551, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13087127..13088584, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene strawberry notch Neighboring gene uncharacterized protein Neighboring gene Proteasome regulator gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q(10) Supplementation. Zhu JY, et al. J Am Soc Nephrol, 2017 Sep. PMID 28428331, Free PMC Article
    2. Invertebrate models for coenzyme q10 deficiency. Fernández-Ayala DJ, et al. Mol Syndromol, 2014 Jul. PMID 25126050, Free PMC Article
    3. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article
    4. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquinone biosynthesis complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q5
    Names
    CG2453-PA
    CG2453-PB
    CG2453-PC
    Coq5-PA
    Coq5-PB
    Coq5-PC
    NP_001285193.1
    NP_001285194.1
    NP_572865.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13193094..13194551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298265.1 → NP_001285194.1  coenzyme Q5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR39, Q9VYF8
      UniProtKB/TrEMBL
      X2JES4
      Conserved Domains (1) summary
      PRK00216
      Location:50 → 301
      ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed

    2. NM_001298264.1 → NP_001285193.1  coenzyme Q5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285193.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR39, Q9VYF8
      UniProtKB/TrEMBL
      X2JES4
      Conserved Domains (1) summary
      PRK00216
      Location:50 → 301
      ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed

    3. NM_132637.2 → NP_572865.1  coenzyme Q5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR39, Q9VYF8
      UniProtKB/TrEMBL
      X2JES4
      Related
      FBpp0073568
      Conserved Domains (1) summary
      PRK00216
      Location:50 → 301
      ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYF8.1 Q9VYF8
    X2JES4 X2JES4

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