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Conserved domains on  [gi|665391076|ref|NP_001285194|]
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coenzyme Q5, isoform C [Drosophila melanogaster]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10011316)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259|GO:1904047
PubMed:  9045837|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 50-301 2.14e-119

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


:

Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 342.13  E-value: 2.14e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  50 FQTVRESEKEQKVHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLnnqpnpq 129
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAV------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 130 QRPSHVTVSDINQHMLNVGEERAKRLGLTTDqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRV 209
Cdd:PRK00216  74 GKTGEVVGLDFSEGMLAVGREKLRDLGLSGN------VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 210 LQPGGRFMCLEFSHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLT 289
Cdd:PRK00216 148 LKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLT 227

                        250
                 ....*....|..
gi 665391076 290 FGVVSIHSGFKL 301
Cdd:PRK00216 228 GGIVALHVGYKP 239
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 50-301 2.14e-119

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 342.13  E-value: 2.14e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  50 FQTVRESEKEQKVHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLnnqpnpq 129
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAV------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 130 QRPSHVTVSDINQHMLNVGEERAKRLGLTTDqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRV 209
Cdd:PRK00216  74 GKTGEVVGLDFSEGMLAVGREKLRDLGLSGN------VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 210 LQPGGRFMCLEFSHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLT 289
Cdd:PRK00216 148 LKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLT 227

                        250
                 ....*....|..
gi 665391076 290 FGVVSIHSGFKL 301
Cdd:PRK00216 228 GGIVALHVGYKP 239
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 62-300 1.22e-103

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 301.87  E-value: 1.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076   62 VHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLNNQPNpqqrpshVTVSDIN 141
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDRGK-------VTGVDFS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  142 QHMLNVGEERAKRLGlttdqlsncTVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEF 221
Cdd:TIGR01934  74 SEMLEVAKKKSELPL---------NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEF 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665391076  222 SHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLTFGVVSIHSGFK 300
Cdd:TIGR01934 145 SKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHVGKK 223
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
59-300 2.05e-96

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 283.56  E-value: 2.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076   59 EQKVHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLnnqpnpqqRPS-HVTV 137
Cdd:pfam01209   1 EQRVGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSA--------GSSgKVVG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  138 SDINQHMLNVGEERAKRLGLTTdqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFM 217
Cdd:pfam01209  73 LDINENMLKEGEKKAKEEGKYN-------IEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  218 CLEFSHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLTFGVVSIHS 297
Cdd:pfam01209 146 CLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHW 225


                  ...
gi 665391076  298 GFK 300
Cdd:pfam01209 226 GIK 228
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 66-239 1.15e-33

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 120.10  E-value: 1.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  66 FEQVANSYDVmndamslgihrvwKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRylnnqpnpqqRPSHVTVSDINQHML 145
Cdd:COG2226    1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAE----------RGARVTGVDISPEML 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 146 NVGEERAKRLGLTtdqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEFSHLT 225
Cdd:COG2226   58 ELARERAAEAGLN--------VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD 129

                        170
                 ....*....|....
gi 665391076 226 NETMQWLYDQYSFQ 239
Cdd:COG2226  130 LAELEELLAEAGFE 143
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 103-218 1.68e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.66  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 103 RLLDMAGGTGDITFRYLRYLnnqpnpqqrPSHVTVSDINQHMLNVGEERAKRLGLttdqlSNCTVAwqCADAEKLPF-PD 181
Cdd:cd02440    1 RVLDLGCGTGALALALASGP---------GARVTGVDISPVALELARKAAAALLA-----DNVEVL--KGDAEELPPeAD 64

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665391076 182 ASF-TAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMC 218
Cdd:cd02440   65 ESFdVIISDPPLHHLVEDLARFLEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 50-301 2.14e-119

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 342.13  E-value: 2.14e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  50 FQTVRESEKEQKVHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLnnqpnpq 129
Cdd:PRK00216   1 FMTVAEEEKQEKVAEMFDSIAPKYDLMNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAV------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 130 QRPSHVTVSDINQHMLNVGEERAKRLGLTTDqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRV 209
Cdd:PRK00216  74 GKTGEVVGLDFSEGMLAVGREKLRDLGLSGN------VEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 210 LQPGGRFMCLEFSHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLT 289
Cdd:PRK00216 148 LKPGGRLVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLT 227

                        250
                 ....*....|..
gi 665391076 290 FGVVSIHSGFKL 301
Cdd:PRK00216 228 GGIVALHVGYKP 239
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 62-300 1.22e-103

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 301.87  E-value: 1.22e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076   62 VHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLNNQPNpqqrpshVTVSDIN 141
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDRGK-------VTGVDFS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  142 QHMLNVGEERAKRLGlttdqlsncTVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEF 221
Cdd:TIGR01934  74 SEMLEVAKKKSELPL---------NIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVILEF 144

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665391076  222 SHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLTFGVVSIHSGFK 300
Cdd:TIGR01934 145 SKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAIHVGKK 223
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
59-300 2.05e-96

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 283.56  E-value: 2.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076   59 EQKVHEVFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLnnqpnpqqRPS-HVTV 137
Cdd:pfam01209   1 EQRVGDVFSSVASKYDLMNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSA--------GSSgKVVG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  138 SDINQHMLNVGEERAKRLGLTTdqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFM 217
Cdd:pfam01209  73 LDINENMLKEGEKKAKEEGKYN-------IEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVV 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  218 CLEFSHLTNETMQWLYDQYSFQVIPPMGQLLAGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLTFGVVSIHS 297
Cdd:pfam01209 146 CLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAIHW 225


                  ...
gi 665391076  298 GFK 300
Cdd:pfam01209 226 GIK 228
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 66-239 1.15e-33

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 120.10  E-value: 1.15e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  66 FEQVANSYDVmndamslgihrvwKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRylnnqpnpqqRPSHVTVSDINQHML 145
Cdd:COG2226    1 FDRVAARYDG-------------REALLAALGLRPGARVLDLGCGTGRLALALAE----------RGARVTGVDISPEML 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 146 NVGEERAKRLGLTtdqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEFSHLT 225
Cdd:COG2226   58 ELARERAAEAGLN--------VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD 129

                        170
                 ....*....|....
gi 665391076 226 NETMQWLYDQYSFQ 239
Cdd:COG2226  130 LAELEELLAEAGFE 143
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 65-293 1.72e-26

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 104.59  E-value: 1.72e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  65 VFEQVANSYDVMNDAMSLGIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITFRYLRYLNNQpnpqqrpSHVTVSDINQHM 144
Cdd:PLN02233  38 LFNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDLAFLLSEKVGSD-------GKVMGLDFSSEQ 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 145 LNVGEERAKRLGLTTdqLSNctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEF--- 221
Cdd:PLN02233 111 LAVAASRQELKAKSC--YKN--IEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSILDFnks 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665391076 222 -SHLTNETMQWLYDqysfQVIPPMGQLLaGQWQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLTFGVV 293
Cdd:PLN02233 187 tQPFTTSMQEWMID----NVVVPVATGY-GLAKEYEYLKSSINEYLTGEELEKLALEAGFSSAKHYEISGGLM 254
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 105-214 1.48e-19

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 81.46  E-value: 1.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  105 LDMAGGTGDITFRYLRYLNnqpnpqqrpSHVTVSDINQHMLNVGEERAKRLGLTtdqlsnctVAWQCADAEKLPFPDASF 184
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG---------ARVTGVDLSPEMLERARERAAEAGLN--------VEFVQGDAEDLPFPDGSF 64

                          90       100       110
                  ....*....|....*....|....*....|..
gi 665391076  185 TAYTIAFGIRNCTHVD--KVLSEAYRVLQPGG 214
Cdd:pfam13649  65 DLVVSSGVLHHLPDPDleAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 105-218 2.38e-18

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 78.09  E-value: 2.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  105 LDMAGGTGditfRYLRYLnnqpnpQQRPSHVTVSDINQHMLNVGEERAKRLGLTtdqlsnctvaWQCADAEKLPFPDASF 184
Cdd:pfam08241   1 LDVGCGTG----LLTELL------ARLGARVTGVDISPEMLELAREKAPREGLT----------FVVGDAEDLPFPDNSF 60

                          90       100       110
                  ....*....|....*....|....*....|....
gi 665391076  185 TAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMC 218
Cdd:pfam08241  61 DLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 94-221 4.32e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 70.35  E-value: 4.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  94 ERLGPTHGMRLLDMAGGTGDItfryLRYLNNQPNPQqrpSHVTVSDINQHMLNVGEERAKRLGLTtdqlsnctVAWQCAD 173
Cdd:PRK08317  13 ELLAVQPGDRVLDVGCGPGND----ARELARRVGPE---GRVVGIDRSEAMLALAKERAAGLGPN--------VEFVRGD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665391076 174 AEKLPFPDASFTAytiAFGIRNCTHV---DKVLSEAYRVLQPGGRFMCLEF 221
Cdd:PRK08317  78 ADGLPFPDGSFDA---VRSDRVLQHLedpARALAEIARVLRPGGRVVVLDT 125
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 101-261 8.08e-13

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 64.75  E-value: 8.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  101 GMRLLDMAGGTGDITFRYLRYLNNQpnpqqrpSHVTVSDINQHMLNVGEERAKRLGLttdqlSNCTVawQCADAEKLP-- 178
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPN-------AEVVGIDISEEAIEKARENAQKLGF-----DNVEF--EQGDIEELPel 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  179 FPDASFTaYTIAFGIRNC-THVDKVLSEAYRVLQPGGRFMCLEFSHLTNETMQWLYDQYSFQVIPPMgqllAGQWQAYQY 257
Cdd:pfam13847  70 LEDDKFD-VVISNCVLNHiPDPDKVLQEILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGG----AILKKKLYE 144


                  ....
gi 665391076  258 LVES 261
Cdd:pfam13847 145 LLEE 148
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 76-216 2.35e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 62.73  E-value: 2.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  76 MNDAMSLGIHRVWKDVFVERLGPtHGMRLLDMAGGTGditfRYLRYLnnqpnpQQRPSHVTVSDINQHMLNVGEERAKRL 155
Cdd:COG2227    1 MSDPDARDFWDRRLAALLARLLP-AGGRVLDVGCGTG----RLALAL------ARRGADVTGVDISPEALEIARERAAEL 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665391076 156 GLTtdqlsnctvaWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRF 216
Cdd:COG2227   70 NVD----------FVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLL 120
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 152-291 2.60e-12

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 63.55  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 152 AKRLGLTTDQLSNCtVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEFSH----LTNE 227
Cdd:PLN02232  14 ATRQSLKARSCYKC-IEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILDFNKsnqsVTTF 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665391076 228 TMQWLYDqysfQVIPPMGQL--LAgqwQAYQYLVESIRRFPKQEQFKQMIEQAGFDQVSYENLTFG 291
Cdd:PLN02232  93 MQGWMID----NVVVPVATVydLA---KEYEYLKYSINGYLTGEELETLALEAGFSSACHYEISGG 151
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 90-217 5.79e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 56.86  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  90 DVFVERLGPTHGMRLLDMAGGTGditfRYLRYLNnqpnpQQRPSHVTVSDINQHMLNVGEERAKRLGLTtdqlsnCTVAW 169
Cdd:COG2230   41 DLILRKLGLKPGMRVLDIGCGWG----GLALYLA-----RRYGVRVTGVTLSPEQLEYARERAAEAGLA------DRVEV 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665391076 170 QCADAEKLPfPDASFTA-----YTIAFGIRNcthVDKVLSEAYRVLQPGGRFM 217
Cdd:COG2230  106 RLADYRDLP-ADGQFDAivsigMFEHVGPEN---YPAYFAKVARLLKPGGRLL 154
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
62-217 7.01e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 57.32  E-value: 7.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  62 VHEVFEQVANSYD--VMNDAMSLGIHRVwKDVFVERLGPTHGMRLLDMAGGTGditfRYLRYLnnqpnpQQRPSHVTVSD 139
Cdd:COG4976    7 VEALFDQYADSYDaaLVEDLGYEAPALL-AEELLARLPPGPFGRVLDLGCGTG----LLGEAL------RPRGYRLTGVD 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665391076 140 INQHMLnvgeERAKRLGLTtdqlsnctVAWQCADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFM 217
Cdd:COG4976   76 LSEEML----AKAREKGVY--------DRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFI 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 103-218 1.68e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 51.66  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 103 RLLDMAGGTGDITFRYLRYLnnqpnpqqrPSHVTVSDINQHMLNVGEERAKRLGLttdqlSNCTVAwqCADAEKLPF-PD 181
Cdd:cd02440    1 RVLDLGCGTGALALALASGP---------GARVTGVDISPVALELARKAAAALLA-----DNVEVL--KGDAEELPPeAD 64

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665391076 182 ASF-TAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMC 218
Cdd:cd02440   65 ESFdVIISDPPLHHLVEDLARFLEEARRLLKPGGVLVL 102
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 102-283 1.75e-08

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 54.90  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 102 MRLLDMAGGTGDITFRYLRYLNnqpnpqqrPSHVTVSDINQHMLnvgeERAKRlgltTDQLSNCTVAWqcADAEKLPFPD 181
Cdd:PLN02490 115 LKVVDVGGGTGFTTLGIVKHVD--------AKNVTILDQSPHQL----AKAKQ----KEPLKECKIIE--GDAEDLPFPT 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 182 ASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGRFMCLEFSHLTNetmqWLydqysfqvippmGQLLAGQWQAyqylves 261
Cdd:PLN02490 177 DYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGKACLIGPVHPTF----WL------------SRFFADVWML------- 233

                        170       180
                 ....*....|....*....|..
gi 665391076 262 irrFPKQEQFKQMIEQAGFDQV 283
Cdd:PLN02490 234 ---FPKEEEYIEWFTKAGFKDV 252
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 103-217 1.04e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.37  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 103 RLLDMAGGTGditfRYLRYLNNQPNpqqrpSHVTVSDINQHMLNVGEERAKRLGLttdqlSNCTVawQCADAEKL-PFPD 181
Cdd:COG0500   29 RVLDLGCGTG----RNLLALAARFG-----GRVIGIDLSPEAIALARARAAKAGL-----GNVEF--LVADLAELdPLPA 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 665391076 182 ASFtAYTIAFGIrnCTHVD-----KVLSEAYRVLQPGGRFM 217
Cdd:COG0500   93 ESF-DLVVAFGV--LHHLPpeereALLRELARALKPGGVLL 130
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 60-215 2.36e-06

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 47.83  E-value: 2.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076  60 QKVHEVFEQVANSYDVMNDamslgIHRVWKDVFVERLGPTHGMRLLDMAGGTGDITfRYLRylnnqpnpqQRPSHVTVSD 139
Cdd:PRK10258   7 QAIAAAFGRAAAHYEQHAE-----LQRQSADALLAMLPQRKFTHVLDAGCGPGWMS-RYWR---------ERGSQVTALD 71

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665391076 140 INQHMLnvgeERAKRLGLTTDQLSnctvawqcADAEKLPFPDASFTAYTIAFGIRNCTHVDKVLSEAYRVLQPGGR 215
Cdd:PRK10258  72 LSPPML----AQARQKDAADHYLA--------GDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGV 135
arsM PRK11873
arsenite methyltransferase;
139-216 1.20e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 45.71  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 139 DINQHMLNVGEERAKRLGLTTdqlsnctVAWQCADAEKLPFPDASFTAYtiafgIRNCthV-------DKVLSEAYRVLQ 211
Cdd:PRK11873 109 DMTPEMLAKARANARKAGYTN-------VEFRLGEIEALPVADNSVDVI-----ISNC--VinlspdkERVFKEAFRVLK 174


                 ....*
gi 665391076 212 PGGRF 216
Cdd:PRK11873 175 PGGRF 179
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 138-215 1.36e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 44.55  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 138 SDINQHMLNVGEERAKRLGLTtdqlsNCTVAwqCADAEKLPFPDASFTA------YTIAFGI--RNCTH-VDKVLSEAYR 208
Cdd:COG1041   54 SDIDPKMVEGARENLEHYGYE-----DADVI--RGDARDLPLADESVDAivtdppYGRSSKIsgEELLElYEKALEEAAR 126


                 ....*..
gi 665391076 209 VLQPGGR 215
Cdd:COG1041  127 VLKPGGR 133
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
145-218 1.07e-03

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 39.08  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391076 145 LNVGEERAKRLG-LTTDQLSNCTVAWQCADAEKLPFPDASFTA-YtiafgirnCTHV---------DKVLSEAYRVLQPG 213
Cdd:COG4627    7 LNIGCGPKRLPGwLNVDIVPAPGVDIVGDLTDPLPFPDNSVDAiY--------SSHVlehldyeeaPLALKECYRVLKPG 78


                 ....*
gi 665391076 214 GRFMC 218
Cdd:COG4627   79 GILRI 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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