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    Slc25a15 solute carrier family 25 member 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306574, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a15provided by RGD
    Official Full Name
    solute carrier family 25 member 15provided by RGD
    Primary source
    RGD:1311488
    See related
    EnsemblRapid:ENSRNOG00000011881 AllianceGenome:RGD:1311488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ornt1; Ab1-114
    Summary
    Enables L-ornithine transmembrane transporter activity and antiporter activity. Predicted to be involved in L-arginine transmembrane transport; L-lysine transmembrane transport; and mitochondrial L-ornithine transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to human SLC25A15 (solute carrier family 25 member 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 328.3), Kidney (RPKM 152.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a15 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76334037..76357325)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69631581..69654869)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74505318..74554523)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 20 member 2 Neighboring gene small integral membrane protein 19 Neighboring gene uncharacterized LOC120097532 Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene lncRNA derived from hepatocytes Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Neighboring gene transfer RNA alanine (anticodon AGC) 82 Neighboring gene SUB1 regulator of transcription, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA. Morris SM Jr, et al. Biochem Biophys Res Commun, 2002 Jun 21. PMID 12061769
    2. The purified and reconstituted ornithine/citrulline carrier from rat liver mitochondria: electrical nature and coupling of the exchange reaction with H+ translocation. Indiveri C, et al. Biochem J, 1997 Oct 15. PMID 9359400, Free PMC Article
    3. Three novel mutations (G27E, insAAC, R179X) in the ORNT1 gene of Japanese patients with hyperornithinemia, hyperammonemia, and homocitrullinuria syndrome. Tsujino S, et al. Ann Neurol, 2000 May. PMID 10805333
    4. Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. Camacho JA, et al. Nat Genet, 1999 Jun. PMID 10369256
    5. Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder. Camacho JA, et al. Mol Genet Metab, 2003 Aug. PMID 12948741

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptional Activation of ORNT1 mRNA by dexamethasone in hepatocytes.
      Title: Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-lysine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-ornithine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-ornithine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-ornithine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-lysine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ornithine transporter 1
    Names
    ornithine transporter) member 15
    solute carrier family 25 (mitochondrial carrier
    solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047880.3 → NP_001041345.1  mitochondrial ornithine transporter 1

      See identical proteins and their annotated locations for NP_001041345.1

      Status: VALIDATED

      Source sequence(s)
      AY325139, CA339807, DY310527
      UniProtKB/TrEMBL
      A0A8I6A3Y8, Q7TPA1
      Related
      ENSRNOP00000072459.2, ENSRNOT00000078971.3
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 332
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76334037..76357325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094589.1 → XP_038950517.1  mitochondrial ornithine transporter 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A3Y8, Q7TPA1
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 332
      Mito_carr; Mitochondrial carrier protein

    2. XM_006253351.4 → XP_006253413.1  mitochondrial ornithine transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006253413.1

      UniProtKB/Swiss-Prot
      A0A0G2K309
      UniProtKB/TrEMBL
      A0A8I6A3Y8
      Related
      ENSRNOP00000045952.4, ENSRNOT00000050637.7
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 295
      Mito_carr; Mitochondrial carrier protein

    3. XM_006253350.5 → XP_006253412.1  mitochondrial ornithine transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006253412.1

      UniProtKB/Swiss-Prot
      A0A0G2K309
      UniProtKB/TrEMBL
      A0A8I6A3Y8
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 295
      Mito_carr; Mitochondrial carrier protein

    4. XM_039094588.2 → XP_038950516.1  mitochondrial ornithine transporter 1 isoform X1

      UniProtKB/Swiss-Prot
      A0A0G2K309
      UniProtKB/TrEMBL
      A0A8I6A3Y8
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 295
      Mito_carr; Mitochondrial carrier protein

    5. XM_006253352.5 → XP_006253414.1  mitochondrial ornithine transporter 1 isoform X1

      See identical proteins and their annotated locations for XP_006253414.1

      UniProtKB/Swiss-Prot
      A0A0G2K309
      UniProtKB/TrEMBL
      A0A8I6A3Y8
      Conserved Domains (1) summary
      pfam00153
      Location:205 → 295
      Mito_carr; Mitochondrial carrier protein

    6. XM_006253353.4 → XP_006253415.1  mitochondrial ornithine transporter 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3Y8
      Conserved Domains (1) summary
      pfam00153
      Location:173 → 263
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0G2K309.1 GenPept UniProtKB/Swiss-Prot:A0A0G2K309

    Gene LinkOut

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