Atg9 Autophagy-related 9 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg9provided by FlyBase
Official Full Name: Autophagy-related 9provided by FlyBase
Primary source: FLYBASE:FBgn0034110
Locus tag: Dmel_CG3615
See related: AllianceGenome:FB:FBgn0034110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg9; ATG9; Atg9a; CG3615; dAtg9; Dmel\CG3615
Summary: Involved in several processes, including intestinal epithelial structure maintenance; macroautophagy; and regulation of intracellular signal transduction. Located in cell junction and cytoplasm. Is expressed in several structures, including adult head; antennal anlage; central brain anlage; dorsal head epidermis anlage; and visual anlage. Used to study Parkinson's disease. Orthologous to several human genes including ATG9A (autophagy related 9A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53B1-53B2; 2-79 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16294400..16297232)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12181905..12184737)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Title: A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
Title: ZnT7 RNAi favors Raf(GOF)scrib(-/-)-induced tumor growth and invasion in Drosophila through JNK signaling pathway.
Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
Title: Drosophila Atg9 regulates the actin cytoskeleton via interactions with profilin and Ena.
These findings provide the first direct evidence of the importance of Atg2-Atg18/Atg9 autophagy complex in the maintenance of mitochondrial integrity and, regulation of heart and muscle functions in Drosophila.
Title: Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila.
These findings revealed an antagonistic relationship between Atg9 and TOR signaling in the regulation of cell growth and tissue homeostasis.
Title: Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in Drosophila.
The transmembrane protein Atg9 accumulates on refractory to Sigma P (Ref(2)P) aggregates in Atg7, Atg8a and Atg2 mutants
Title: Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila.
Our findings indicate a dual role for Atg9 in the regulation of JNK signaling and autophagy under oxidative stress conditions.
Title: Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction.
Evidence of a link between Atg1 and the control of Atg9-mediated autophagosome formation through the myosin II motor protein.
Title: Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal epithelial structure maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISM Inferred from Sequence Model more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info