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    Atg9 Autophagy-related 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36821, updated on 9-Dec-2024

    Summary

    Official Symbol
    Atg9provided by FlyBase
    Official Full Name
    Autophagy-related 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0034110
    Locus tag
    Dmel_CG3615
    See related
    AllianceGenome:FB:FBgn0034110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg9; ATG9; Atg9a; CG3615; dAtg9; Dmel\CG3615
    Summary
    Involved in several processes, including intestinal epithelial structure maintenance; macroautophagy; and regulation of intracellular signal transduction. Located in cell junction and cytoplasm. Is expressed in several structures, including adult head; antennal anlage; central brain anlage; dorsal head epidermis anlage; and visual anlage. Used to study Parkinson's disease. Orthologous to several human genes including ATG9A (autophagy related 9A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Atg9 in Genome Data Viewer
    Location:
    53B1-53B2; 2-79 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16294400..16297232)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12181905..12184737)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43730 Neighboring gene Juvenile hormone-inducible protein 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45232 Neighboring gene NADPH oxidase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in autophagosome assembly  
    involved_in autophagy  
    involved_in autophagy PubMed 
    involved_in cellular response to oxidative stress PubMed 
    involved_in cellular response to starvation PubMed 
    involved_in glycophagy PubMed 
    involved_in intestinal epithelial structure maintenance PubMed 
    involved_in larval midgut cell programmed cell death PubMed 
    involved_in larval midgut histolysis PubMed 
    involved_in macroautophagy PubMed 
    involved_in mitophagy  
    involved_in mitophagy PubMed 
    involved_in negative regulation of TOR signaling PubMed 
    involved_in piecemeal microautophagy of the nucleus  
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of JNK cascade PubMed 
    involved_in protein localization to phagophore assembly site  
    involved_in reticulophagy  
    involved_in reticulophagy PubMed 
    Component Evidence Code Pubs
    is_active_in autophagosome  
    located_in cell junction PubMed 
    located_in cytoplasm PubMed 
    located_in membrane  
    is_active_in phagophore assembly site  

    General protein information

    Preferred Names
    Autophagy-related 9
    Names
    Atg9-PA
    Atg9-PB
    Autophagy-specific gene 9
    CG3615-PA
    CG3615-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16294400..16297232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137270.4 → NP_611114.1  Autophagy-related 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611114.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2XY38, Q7JQL5
      Related
      FBpp0086285
      Conserved Domains (1) summary
      pfam04109
      Location:219 → 573
      APG9; Autophagy protein Apg9
    2. NM_001274094.2 → NP_001261023.1  Autophagy-related 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261023.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF86, Q2XY38
      Conserved Domains (1) summary
      pfam04109
      Location:219 → 573
      APG9; Autophagy protein Apg9
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