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    Pcnt pericentrin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309692, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pcntprovided by RGD
    Official Full Name
    pericentrinprovided by RGD
    Primary source
    RGD:1595865
    See related
    EnsemblRapid:ENSRNOG00000001276 AllianceGenome:RGD:1595865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in microtubule nucleation; mitotic spindle organization; and positive regulation of intracellular protein transport. Predicted to act upstream of or within several processes, including embryonic organ development; limb morphogenesis; and nervous system development. Predicted to be located in several cellular components, including cis-Golgi network; intercellular bridge; and microtubule organizing center. Human ortholog(s) of this gene implicated in microcephalic osteodysplastic primordial dwarfism type II. Orthologous to human PCNT (pericentrin). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Muscle (RPKM 102.2), Heart (RPKM 83.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pcnt in Genome Data Viewer
    Location:
    20p12
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (12189767..12278179)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (12190597..12278723)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (12943523..13038615)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene minichromosome maintenance complex component 3 associated protein Neighboring gene similar to human chromosome 21 open reading frame 58 Neighboring gene ybeY metalloendoribonuclease Neighboring gene uncharacterized LOC134483886 Neighboring gene disco-interacting protein 2 homolog A Neighboring gene uncharacterized LOC134483887 Neighboring gene U6 spliceosomal RNA Neighboring gene S100 calcium binding protein B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    acts_upstream_of_or_within brain morphogenesis  
    acts_upstream_of_or_within camera-type eye development  
    acts_upstream_of_or_within cerebellar cortex morphogenesis  
    acts_upstream_of_or_within cilium assembly  
    acts_upstream_of_or_within embryonic brain development  
    acts_upstream_of_or_within embryonic heart tube development  
    acts_upstream_of_or_within head development  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within kidney development  
    acts_upstream_of_or_within limb morphogenesis  
    involved_in microtubule cytoskeleton organization  
    involved_in microtubule nucleation  
    involved_in mitotic spindle organization  
    acts_upstream_of_or_within mitotic spindle organization  
    involved_in mitotic spindle organization  
    acts_upstream_of_or_within multicellular organism growth  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    acts_upstream_of_or_within neural precursor cell proliferation  
    acts_upstream_of_or_within neuron migration  
    acts_upstream_of_or_within olfactory bulb development  
    involved_in positive regulation of intracellular protein transport  
    involved_in signal transduction  
    acts_upstream_of_or_within spindle organization  
    acts_upstream_of_or_within vasculature development  
    Component Evidence Code Pubs
    located_in centriolar satellite  
    located_in centriole  
    located_in centrosome  
    located_in ciliary basal body  
    located_in cis-Golgi network  
    located_in cytosol  
    located_in cytosol  
    located_in intercellular bridge  
    located_in microtubule organizing center  
    located_in motile cilium  
    located_in pericentriolar material  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427002.1NP_001413931.1  pericentrin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      D3ZMY8
      Related
      ENSRNOP00000039329.5, ENSRNOT00000048218.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      12189767..12278179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099203.2XP_038955131.1  pericentrin isoform X1

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (4) summary
      PTZ00121
      Location:154858
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:13101561
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10431434
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27542832
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    2. XM_039099208.2XP_038955136.1  pericentrin isoform X8

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (4) summary
      PTZ00121
      Location:154858
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:13101561
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10431434
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27142792
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    3. XM_039099209.2XP_038955137.1  pericentrin isoform X10

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (4) summary
      PTZ00121
      Location:154858
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:21372479
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10431434
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:26772755
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    4. XM_063279161.1XP_063135231.1  pericentrin isoform X13

      UniProtKB/TrEMBL
      D3ZMY8
    5. XM_017601880.3XP_017457369.1  pericentrin isoform X6

      UniProtKB/TrEMBL
      D3ZMY8
    6. XM_063279159.1XP_063135229.1  pericentrin isoform X9

      UniProtKB/TrEMBL
      D3ZMY8
    7. XM_039099210.2XP_038955138.1  pericentrin isoform X11

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (4) summary
      PTZ00121
      Location:154858
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:21372461
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10431434
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:26592737
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    8. XM_063279162.1XP_063135232.1  pericentrin isoform X14

      UniProtKB/TrEMBL
      D3ZMY8
    9. XM_039099205.2XP_038955133.1  pericentrin isoform X3

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (4) summary
      PTZ00121
      Location:154858
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:13161554
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10431427
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27472825
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    10. XM_039099206.2XP_038955134.1  pericentrin isoform X4

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (4) summary
      PTZ00121
      Location:154858
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:12991550
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:10431423
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27432821
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    11. XM_006256312.5XP_006256374.1  pericentrin isoform X18

      See identical proteins and their annotated locations for XP_006256374.1

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (7) summary
      TIGR02168
      Location:4621423
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07106
      Location:12971405
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam09455
      Location:10501217
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      pfam10495
      Location:27252803
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
      pfam12474
      Location:156310
      PKK; Polo kinase kinase
      cd16269
      Location:311321
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:198345
      GBP_C; Guanylate-binding protein, C-terminal domain
    12. XM_063279160.1XP_063135230.1  pericentrin isoform X12

      UniProtKB/TrEMBL
      D3ZMY8
    13. XM_039099204.2XP_038955132.1  pericentrin isoform X2

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (3) summary
      COG1196
      Location:158533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:4621433
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27532831
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    14. XM_039099207.2XP_038955135.1  pericentrin isoform X5

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (3) summary
      COG1196
      Location:158533
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:4621422
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:27422820
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
    15. XM_002728936.6XP_002728982.2  pericentrin isoform X17

      See identical proteins and their annotated locations for XP_002728982.2

      UniProtKB/TrEMBL
      D3ZMY8
      Conserved Domains (7) summary
      TIGR02168
      Location:4621422
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam07106
      Location:12961404
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam09455
      Location:10491216
      Cas_DxTHG; CRISPR-associated (Cas) DxTHG family
      pfam10495
      Location:26472725
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
      pfam12474
      Location:156310
      PKK; Polo kinase kinase
      cd16269
      Location:311321
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:198345
      GBP_C; Guanylate-binding protein, C-terminal domain
    16. XM_063279158.1XP_063135228.1  pericentrin isoform X7

      UniProtKB/TrEMBL
      D3ZMY8
    17. XM_063279163.1XP_063135233.1  pericentrin isoform X15

      UniProtKB/TrEMBL
      A0A8I6ANK0
    18. XM_039099211.2XP_038955139.1  pericentrin isoform X16

      Conserved Domains (3) summary
      COG0419
      Location:108645
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:13911643
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10495
      Location:18351913
      PACT_coil_coil; Pericentrin-AKAP-450 domain of centrosomal targeting protein
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