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    itga6a integrin, alpha 6a [ Danio rerio (zebrafish) ]

    Gene ID: 503893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    itga6aprovided by ZNC
    Official Full Name
    integrin, alpha 6aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050309-23
    See related
    Ensembl:ENSDARG00000042282 AllianceGenome:ZFIN:ZDB-GENE-050309-23
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    itga6; fb80g02; im:6897425; wu:fb80g02; si:dkey-32o22.1
    Summary
    Predicted to enable integrin binding activity. Acts upstream of or within skeletal muscle tissue development. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including axial chorda mesoderm; hypodermis; retina; solid lens vesicle; and trunk. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See itga6a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (3429630..3485927)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (3458101..3514959)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496440 Neighboring gene distal-less homeobox 1a Neighboring gene distal-less homeobox 2a Neighboring gene cytochrome b reductase 1 Neighboring gene ddb1 and cul4 associated factor 17 Neighboring gene methyltransferase 8, methylcytidine

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Lysosomal Function Impacts the Skeletal Muscle Extracellular Matrix. Coffey EC, et al. J Dev Biol, 2021 Nov 23. PMID 34842731, Free PMC Article
    2. NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy. Goody MF, et al. PLoS Biol, 2012. PMID 23109907, Free PMC Article
    3. Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish. Sonawane M, et al. Development, 2009 Apr. PMID 19261700
    4. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. Subramanian A, et al. Elife, 2014 Jun 18. PMID 24941943, Free PMC Article
    5. Epistatic dissection of laminin-receptor interactions in dystrophic zebrafish muscle. Sztal TE, et al. Hum Mol Genet, 2012 Nov 1. PMID 22859503

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leukocyte migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-6
    Names
    integrin, alpha 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      3429630..3485927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167409.3 → XP_005167466.1  integrin alpha-6 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BER2, A8WHQ8, E7F087
      Related
      ENSDARP00000098022.3, ENSDART00000114168.5
      Conserved Domains (2) summary
      smart00191
      Location:378 → 431
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:476 → 939
      Integrin_alpha2; Integrin alpha

    2. XM_005167411.5 → XP_005167468.1  integrin alpha-6 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFG1, A8WHQ7
      Related
      ENSDARP00000076590.5, ENSDART00000082153.6
      Conserved Domains (2) summary
      smart00191
      Location:378 → 431
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:476 → 939
      Integrin_alpha2; Integrin alpha

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001144781.1: Suppressed sequence

      Description
      NM_001144781.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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